Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain

Journal of Biological Chemistry

Volumn 287, Issue 39, 2012, Pages 32897-32912

  Weinreb, Paul H ^a   Li, Sheng ^b   Gao, Sharon X ^a   Liu, Tong ^b   Pepinsky, R Blake ^a   Caravella, Justin A ^a   Lee, Jun H ^b   Woods, Virgil L ^b  

^a BIOGEN   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; COLLAGEN; COMPLEXATION; DEUTERIUM; DIFFERENTIAL SCANNING CALORIMETRY; DYNAMICS; ION EXCHANGE; MASS SPECTROMETRY; METAL IONS; METALS; MONOCLONAL ANTIBODIES; POSITIVE IONS;

ADHESION SITES; CA 2+; DYNAMIC STRUCTURAL CHANGES; EXCHANGE RATES; HYDROGEN/DEUTERIUM EXCHANGE; INTEGRIN ACTIVATION; INTEGRINS; METAL ION BINDING; METALS IONS; SOLUTION DYNAMICS;

LIGANDS;

ALPHA1 INTEGRIN; CALCIUM ION; COLLAGEN TYPE 4; MAGNESIUM ION; MANGANESE; METAL ION; MONOCLONAL ANTIBODY;

ALLOSTERISM; ALPHA HELIX; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DEUTERIUM HYDROGEN EXCHANGE MASS SPECTROMETRY; DIFFERENTIAL SCANNING CALORIMETRY; LIGAND BINDING; MASS SPECTROMETRY; METAL BINDING; METAL ION DEPENDENT ADHESION SITE LOOP; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN UNFOLDING; THERMOSTABILITY;

EID: 84866540561     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.354365     Document Type: Article

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