Stable coordination of the inhibitory Ca 2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: Implications for integrin regulation and structure-based drug design

Journal of Immunology

Volumn 187, Issue 12, 2011, Pages 6393-6401

  Mahalingam, Bhuvaneshwari ^a   Ajroud, Kaouther ^a,c   Alonso, José Luis ^a   Anand, Saurabh ^a   Adair, Brian D ^a   Horenstein, Alberto L ^b   Malavasi, Fabio ^b   Xiong, Jian Ping ^a   Arnaout, M Amin ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CALCIUM ION; CD11B ANTIGEN; CD18 ANTIGEN; GLUTAMIC ACID; IMMUNOGLOBULIN F(AB) FRAGMENT; MAGNESIUM ION; MONOCLONAL ANTIBODY;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; HUMAN; HUMAN CELL; METAL ION DEPENDENT ADHESION SITE; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE;

ANIMALS; ANTIBODIES, BLOCKING; ANTIGENS, CD11B; ANTIGENS, CD18; ASPARTIC ACID; BINDING SITES, ANTIBODY; CALCIUM; CATIONS, DIVALENT; CELL ADHESION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DRUG DESIGN; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; K562 CELLS; LIGANDS; NEUTROPHILS; RATS;

EID: 83755195810     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102394     Document Type: Article

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