AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 38, 2006, Pages 13991-13996

  Shimaoka, Motomu ^a   Kim, Minsoo ^b   Cohen, Edward H ^c   Yang, Wei ^a   Astrof, Nathan ^a   Peer, Dan ^a   Salas, Azucena ^a   Ferrand, Audrey ^a   Springer, Timothy A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROWN UNIVERSITY   (United States)

^c Dyax Corp   (United States)

Author keywords

Activation; Cell adhesion; Conformational changes; Phage display

Indexed keywords

CHEMOKINE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY AL 57; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIGAND BINDING; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; BINDING SITES; CELL LINE; CHEMOKINE CXCL12; CHEMOKINES, CXC; EPITOPES; HUMANS; LIGANDS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE; UP-REGULATION;

EID: 33748996774     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0605716103     Document Type: Article

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