Antitumor effects of the novel quinazolinone MJ-33: Inhibition of metastasis through the MAPK, AKT, NF-κB and AP-1 signaling pathways in DU145 human prostate cancer cells

International Journal of Oncology

Volumn 41, Issue 4, 2012, Pages 1513-1519

  Hour, Mann Jen ^a   Tsai, Shih Chang ^a   Wu, Hsi Chin ^b,c   Lin, Meng Wei ^a   Chung, Jing Gung ^a   Wu, Jin Bin ^a   Chiang, Jo Hua ^d   Tsuzuki, Minoru ^a,e   Yang, Jai Sing ^a,b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Human prostate cancer DU145 cells; Invasion, migration and adhesion; MAPK, AKT, NF B and AP 1 signaling pathways; Quinazolinone MJ 33

Indexed keywords

(2 (3 ETHOXYPHENYL) 6 PYRROLIDINYLQUINAZOLINONE); ANTINEOPLASTIC AGENT; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE B; QUINAZOLINONE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; UROKINASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL ADHESION; CELL INVASION; CELL MIGRATION; DOWN REGULATION; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WOUND HEALING;

CELL ADHESION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCEROPHOSPHATES; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOPLASM METASTASIS; NF-KAPPA B; ONCOGENE PROTEIN V-AKT; PROSTATIC NEOPLASMS; QUINAZOLINONES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84866503944     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1560     Document Type: Article

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