Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways

Chemico-Biological Interactions

Volumn 156, Issue 2-3, 2005, Pages 141-150

  Chen, Pei Ni ^a   Hsieh, Yih Shou ^a   Chiou, Hui Ling ^a   Chu, Shu Chen ^b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Akt; Invasion; MAPK; MMP 2; Silibinin; u PA

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN C FOS; SILIBININ; STRESS ACTIVATED PROTEIN KINASE; UROKINASE;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL ACTIVATION; CELL INVASION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTICARCINOGENIC AGENTS; BUTADIENES; CELL LINE, TUMOR; CELL MOVEMENT; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MILK THISTLE; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NITRILES; PHOSPHORYLATION; PLANT EXTRACTS; SILYMARIN; URINARY PLASMINOGEN ACTIVATOR;

SILYBUM MARIANUM;

EID: 26044455880     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.08.005     Document Type: Article

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