Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- andcaspase-3 dependent mechanism and NF-κB down-regulation

In Vivo

Volumn 21, Issue 6, 2007, Pages 1003-1010

  Chuang, Jing Yuan ^a   Huang, Yung Feng ^a   Lu, Hsu Feng ^b   Ho, Heng Chen ^a   Yang, Jai Sing ^a   Li, Te Mao ^a   Chang, Nai Wen ^a   Chung, Jing Gung ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHENG HSIN REHABILITATION MEDICAL CENTER   (Taiwan)

Author keywords

Apoptosis; Caspase 3; Cell cycle; Coumarin; Mitochondria; NF B

Indexed keywords

BETA ACTIN; CALCIUM; CASPASE 3; CASPASE 9; COUMARIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P15; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR RELA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DEPOLARIZATION; DNA DAMAGE; DRUG CONCENTRATION; DRUG MECHANISM; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; MITOCHONDRIAL MEMBRANE; PROTEIN EXPRESSION; UTERINE CERVIX CANCER;

EID: 37349116050     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Marshall ME, Kervin K, Benefield C, Umerani A, Albainy-Jenei S, Zhao Q and Khazaefi MB: Growth-inhibitory effects of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin on human malignant cell lines in vitro. J Cancer Res Clin Oncol 120(Suppl): S3-10, 1994.
2. Myers RB, Parker M and Grizzle WE: The effects of coumarin and suramin on the growth of malignant renal and prostatic cell lines. J Cancer Res Clin Oncol 120(Suppl): S11-13, 1994.
3. Kawaii S, Tomono Y, Ogawa K, Sugiura M, Yano M and Yoshizawa Y: The anti-proliferative effect of coumarins on several cancer cell lines. Anticancer Res 21: 917-923, 2001.
4. Thornes RD, Daly L, Lynch G, Breslin B, Browne H, Browne HY, Corrigan T, Daly P, Edwards G and Gaffney E: Treatment with coumarin to prevent or delay recurrence of malignant melanoma. J Cancer Res Clin Oncol 120(Suppl): S32-34, 1994.
5. Marshall ME, Mohler JL, Edmonds K, Williams B, Butler K, Ryles M, Weiss L, Urban D, Bueschen A and Markiewicz M: An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin. J Cancer Res Clin Oncol 120(Suppl): S39-42, 1994.
6. Mohler JL, Williams BT, Thompson IM and Marshall ME: Coumarin (1,2-benzopyrone) for the treatment of prostatic carcinoma. J Cancer Res Clin Oncol 120(Suppl): S35-38, 1994.
7. Angerer E von, Kager M and Maucher A: Anti-tumour activity of coumarin in prostate and mammary cancer models. J Cancer Res Clin Oncol 120(Suppl): S14-16, 1994.
8. Lake BG: Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment. Food Chem Toxicol 37: 423-453, 1999.
9. Marshall ME, Butler K and Fried A: Phase I evaluation of coumarin (1,2-benzopyrone) and cimetidine in patients with advanced malignancies. Mol Biother 3: 170-178, 1991.
10. Su CC, Chen GW, Lin JG, Wu LT and Chung JG: Curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa B/p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions. Anticancer Res 26: 1281-1288, 2006.
11. Li TM, Chen GW, Su CC, Lin JG, Yeh CC, Cheng KC and Chung JG: Ellagic acid induced p53/p21 expression, G1 arrest and apoptosis in human bladder cancer T24 cells. Anticancer Res 25: 971-979, 2005.
12. Kuo HM, Chang LS, Lin YL, Lu HF, Yang JS, Lee JH and Chung JG: Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway. Anticancer Res 27(14): 395-405, 2007.
13. +2 on rhein-induced apoptosis in human cervical cancer Ca Ski cells. Anticancer Res 27(1A): 379-389, 2007.
14. Quentin F, Xiong WC, Sun D, Sarkar S, Singh KP, Parkash J and Roy D: Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers. Biochemistry 44: 6900-6909, 2005.
15. +2 in diallyl disulfide-induced apoptotic cell death of HCT-15 cells. Exp Mol Med 34: 250-257, 2002.
16. Loop T, Dovi-Akue D, Frick M, Roesslein M, Egger L, Humar M, Hoetzel A, Schmidt R, Borner C, Pahl HL, Geiger KK and Pannen BH: Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Anesthesiology 102: 1147-1157, 2005.
17. Finn GJ, Creaven B and Egan DA: Study of the in vitro cytotoxic potential of natural and synthetic coumarin derivatives using human normal and neoplastic skin cell lines. Melanoma Res 11: 461-467, 2001.
18. Seliger B and Pettersson H: 7-Hydroxycoumarin inhibits oncogene-induced transformation of murine fibroblasts. J Cancer Res Clin Oncol 120(Suppl): S23-27, 1994.
19. Kahn J, Preis P, Waldman F and Tseng A: Coumarin modulates the cell cycle progression of an MTV-EJ ras cell line. J Cancer Res Clin Oncol 120(Suppl): S19-22, 1994.
20. Lopez-Gonzalez JS, Prado-Garcia H, Aguilar-Cazares D, Molina-Guarneros JA, Morales-Fuentes J and Mandoki JJ: Apoptosis and cell cycle disturbances induced by coumarin and 7-hydroxycoumarin on human lung carcinoma cell lines. Lung Cancer 43(3): 275-283, 2004.
21. Caamano J, Ruggeri B, Momiki S, Sickler A, Zhang SY and Klein-Szanto JP: Detection of p53 in primary lung tumors and non-small cell lung carcinoma cell lines. Am J Pathol 139: 839-845, 1991.