MicroRNAs regulate key effector pathways of senescence

Journal of Aging Research

Volumn 2011, Issue , 2011, Pages

  Feliciano, Andrea ^a   Sánchez Sendra, Beatriz ^a   Kondoh, Hiroshi ^b   Lleonart, Matilde E ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; LIPOSOME; MESSENGER RNA; MICRORNA; NANOPARTICLE; PARVOVIRUS VECTOR; TUMOR SUPPRESSOR PROTEIN;

3' UNTRANSLATED REGION; APOPTOSIS; BASE PAIRING; CANCER INHIBITION; CARCINOGENESIS; CELL AGING; CELL PROLIFERATION; DRUG TARGETING; GENE EXPRESSION REGULATION; GENETIC CODE; HUMAN; LIVER CELL CARCINOMA; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN TARGETING; REVIEW; SENESCENCE; VIRAL GENE DELIVERY SYSTEM;

EID: 84866429995     PISSN: 20902204     EISSN: 20902212     Source Type: Journal    
DOI: 10.4061/2011/205378     Document Type: Review

References (119)

1. Davis B. N., Hata A., Regulation of microRNA biogenesis: a miRiad of mechanisms. Cell Communication and Signaling 2009 7 18
2. Bartel D. P., MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004 116 2 281 297 2-s2.0-0347444723 10.1016/S0092-8674(04)00045-5 (Pubitemid 38167318)
3. Murchison E. P., Hannon G. J., miRNAs on the move: miRNA biogenesis and the RNAi machinery. Current Opinion in Cell Biology 2004 16 3 223 229 2-s2.0-2342485506 10.1016/j.ceb.2004.04.003 (Pubitemid 38610401)
4. Pfeffer S., Zavolan M., Grässer F. A., Chien H., Russo J. J., Ju J., John B., Enright A. J., Marks D., Sander C., Tuschl T., Identification of virus-encoded microRNAs. Science 2004 304 5671 734 736 2-s2.0-2342420041 10.1126/science.1096781 (Pubitemid 38560879)
5. Lewis B. P., Shih I. H., Jones-Rhoades M. W., Bartel D. P., Burge C. B., Prediction of Mammalian MicroRNA Targets. Cell 2003 115 7 787 798 2-s2.0-0346094457 10.1016/S0092-8674(03)01018-3 (Pubitemid 38058492)
6. Orom U. A., Nielsen F. C., Lund A. H., MicroRNA-10a Binds the 5′-UTR of Ribosomal Protein mRNAs and Enhances Their Translation. Molecular Cell 2008 30 4 460 471 2-s2.0-43449090367 10.1016/j.molcel.2008.05.001 (Pubitemid 351672378)
7. Lee I., Ajay S. S., Jong I. Y., Hyun S. K., Su H. H., Nam H. K., Dhanasekaran S. M., Chinnaiyan A. M., Athey B. D., New class of microRNA targets containing simultaneous 5′ -UTR and 3′ -UTR interaction sites. Genome Research 2009 19 7 1175 1183 2-s2.0-67650087599 10.1101/gr.089367.108
8. Eiring A. M., Harb J. G., Neviani P., Garton C., Oaks J. J., Spizzo R., Liu S., Schwind S., Santhanam R., Hickey C. J., Becker H., Chandler J. C., Andino R., Cortes J., Hokland P., Huettner C. S., Bhatia R., Roy D. C., Liebhaber S. A., Caligiuri M. A., Marcucci G., Garzon R., Croce C. M., Calin G. A., Perrotti D., miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 2010 140 5 652 665 2-s2.0-77649133970 10.1016/j.cell.2010.01.007
9. Blower P. E., Chung J. H., Verducci J. S., Lin S., Park J. K., Dai Z., Liu C. G., Schmittgen T. D., Reinhold W. C., Croce C. M., Weinstein J. N., Sadee W., MicroRNAs modulate the chemosensitivity of tumor cells. Molecular Cancer Therapeutics 2008 7 1 1 9 2-s2.0-38349190243 10.1158/1535-7163.MCT-07-0573
10. Iorio M. V., Croce C. M., MicroRNAs in cancer: small molecules with a huge impact. Journal of Clinical Oncology 2009 27 34 5848 5856 2-s2.0-73349125465 10.1200/JCO.2009.24.0317
11. Volinia S., Calin G. A., Liu C. G., Ambs S., Cimmino A., Petrocca F., Visone R., Iorio M., Roldo C., Ferracin M., Prueitt R. L., Yanaihara N., Lanza G., Scarpa A., Vecchione A., Negrini M., Harris C. C., Croce C. M., A microRNA expression signature of human solid tumors defines cancer gene targets. Proceedings of the National Academy of Sciences of the United States of America 2006 103 7 2257 2261 2-s2.0-33144490646 10.1073/pnas.0510565103 (Pubitemid 43271657)
12. Lu J., Getz G., Miska E. A., Alvarez-Saavedra E., Lamb J., Peck D., Sweet-Cordero A., Ebert B. L., Mak R. H., Ferrando A. A., Downing J. R., Jacks T., Horvitz H. R., Golub T. R., MicroRNA expression profiles classify human cancers. Nature 2005 435 7043 834 838 2-s2.0-20444460289 10.1038/nature03702 (Pubitemid 40839735)
13. Garzon R., ramiro.garzon@osumc.edu Marcucci G., Croce C. M., carlo.croce@osumc.edu Targeting microRNAs in cancer: rationale, strategies and challenges. Nature Reviews Drug Discovery 2010 9 10 775 789 10.1038/nrd3179
14. Lee Y., Kim M., Han J., Yeom K. H., Lee S., Baek S. H., Kim V. N., MicroRNA genes are transcribed by RNA polymerase II. EMBO Journal 2004 23 20 4051 4060 2-s2.0-8144225486 10.1038/sj.emboj.7600385 (Pubitemid 39472426)
15. Borchert G. M., Lanier W., Davidson B. L., RNA polymerase III transcribes human microRNAs. Nature Structural and Molecular Biology 2006 13 12 1097 1101 2-s2.0-33845370280 10.1038/nsmb1167 (Pubitemid 44885920)
16. Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., Lee J., Provost P., Rådmark O., Kim S., Kim V. N., The nuclear RNase III Drosha initiates microRNA processing. Nature 2003 425 6956 415 419 2-s2.0-0141843656 10.1038/nature01957 (Pubitemid 37187272)
17. Gregory R. I., Yan K. P., Amuthan G., Chendrimada T., Doratotaj B., Cooch N., Shiekhattar R., The Microprocessor complex mediates the genesis of microRNAs. Nature 2004 432 7014 235 240 2-s2.0-9144225636 10.1038/nature03120 (Pubitemid 39545855)
18. Han J., Lee Y., Yeom K. H., Kim Y. K., Jin H., Kim V. N., The Drosha-DGCR8 complex in primary microRNA processing. Genes and Development 2004 18 24 3016 3027 2-s2.0-10644234841 10.1101/gad.1262504 (Pubitemid 39658171)
19. Zeng Y., Cullen B. R., Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences. The Journal of Biological Chemistry 2005 280 30 27595 27603 2-s2.0-23044502585 10.1074/jbc.M504714200 (Pubitemid 41076871)
20. Han J., Lee Y., Yeom K. H., Nam J. W., Heo I., Rhee J. K., Sohn S. Y., Cho Y., Zhang B. T., Kim V. N., Molecular basis for the recognition of primary microRNAs by the drosha-DGCR8 complex. Cell 2006 125 5 887 901 2-s2.0-33744520104 10.1016/j.cell.2006.03.043 (Pubitemid 43810154)
21. Yi R., Qin Y., Macara I. G., Cullen B. R., Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes and Development 2003 17 24 3011 3016 2-s2.0-0347361541 10.1101/gad.1158803 (Pubitemid 38040764)
22. Okamura K., Hagen J. W., Duan H., Tyler D. M., Lai E. C., The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell 2007 130 1 89 100 2-s2.0-34447107760 10.1016/j.cell.2007.06.028 (Pubitemid 47031325)
23. Ruby J. G., Jan C. H., Bartel D. P., Intronic microRNA precursors that bypass Drosha processing. Nature 2007 448 7149 83 86 2-s2.0-34447097693 10.1038/nature05983 (Pubitemid 47037009)
24. Berezikov E., Chung W. J., Willis J., Cuppen E., Lai E. C., Mammalian Mirtron Genes. Molecular Cell 2007 28 2 328 336 2-s2.0-35348933779 10.1016/j.molcel.2007.09.028 (Pubitemid 47600007)
25. Kim V. N., Han J., Siomi M. C., Biogenesis of small RNAs in animals. Nature Reviews Molecular Cell Biology 2009 10 2 126 139 2-s2.0-58849112575 10.1038/nrm2632
26. Chendrimada T. P., Gregory R. I., Kumaraswamy E., Norman J., Cooch N., Nishikura K., Shiekhattar R., TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005 436 7051 740 744 2-s2.0-23644433363 10.1038/nature03868 (Pubitemid 41117280)
27. Haase A. D., Jaskiewicz L., Zhang H., Lainé S., Sack R., Gatignol A., Filipowicz W., TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Reports 2005 6 10 961 967 2-s2.0-27144550559 10.1038/sj.embor.7400509 (Pubitemid 41521952)
28. Carthew R. W., Sontheimer E. J., Origins and Mechanisms of miRNAs and siRNAs. Cell 2009 136 4 642 655 2-s2.0-60149088848 10.1016/j.cell.2009.01.035
29. LLeonart M. E., Artero-Castro A., Kondoh H., Senescence induction; a possible cancer therapy. Molecular Cancer 2009 8, article 3 2-s2.0-60649100864 10.1186/1476-4598-8-3
30. Collado M., Serrano M., Senescence in tumours: evidence from mice and humans. Nature Reviews Cancer 2010 10 1 51 57 2-s2.0-72949096792 10.1038/nrc2772
31. Serrano M., Lin A. W., McCurrach M. E., Beach D., Lowe S. W., Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a). Cell 1997 88 5 593 602 2-s2.0-0030944985 10.1016/S0092-8674(00) 81902-9 (Pubitemid 27152402)
32. Campisi J., D'Adda Di Fagagna F., Cellular senescence: when bad things happen to good cells. Nature Reviews Molecular Cell Biology 2007 8 9 729 740 2-s2.0-34548186667 10.1038/nrm2233 (Pubitemid 47312822)
33. Sherr C. J., McCormick F., The RB and p53 pathways in cancer. Cancer Cell 2002 2 2 103 112 2-s2.0-0001510491 10.1016/S1535-6108(02)00102-2 (Pubitemid 41039110)
34. Olsen C. L., Gardie B., Yaswen P., Stampfer M. R., Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene 2002 21 41 6328 6339 2-s2.0-0037068753 10.1038/sj.onc.1205780
35. Collado M., Gil J., Efeyan A., Guerra C., Schuhmacher A. J., Barradas M., Benguría A., Zaballos A., Flores J. M., Barbacid M., Beach D., Serrano M., Tumour biology: senescence in premalignant tumours. Nature 2005 436 7051 642 2-s2.0-23244447893 10.1038/436642a (Pubitemid 41117258)
36. Braig M., Schmitt C. A., Oncogene-induced senescence: putting the brakes on tumor development. Cancer Research 2006 66 6 2881 2884 2-s2.0-33645526114 10.1158/0008-5472.CAN-05-4006
37. Campisi J., Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005 120 4 513 522 2-s2.0-13944270339 10.1016/j.cell.2005.02.003 (Pubitemid 40269765)
38. Jeyapalan J. C., Ferreira M., Sedivy J. M., Herbig U., Accumulation of senescent cells in mitotic tissue of aging primates. Mechanisms of Ageing and Development 2007 128 1 36 44 2-s2.0-33846090789 10.1016/j.mad.2006.11.008 (Pubitemid 46073058)
39. Castro P., Giri D., Lamb D., Ittmann M., Cellular senescence in the pathogenesis of benign prostatic hyperplasia. Prostate 2003 55 1 30 38 2-s2.0-0037382970 10.1002/pros.10204 (Pubitemid 36397742)
40. Bommer G. T., Gerin I., Feng Y., Kaczorowski A. J., Kuick R., Love R. E., Zhai Y., Giordano T. J., Qin Z. S., Moore B. B., MacDougald O. A., Cho K. R., Fearon E. R., p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Current Biology 2007 17 15 1298 1307 2-s2.0-34547458550 10.1016/j.cub.2007.06.068 (Pubitemid 47176893)
41. Chang T. C., Wentzel E. A., Kent O. A., Ramachandran K., Mullendore M., Lee K., Feldmann G., Yamakuchi M., Ferlito M., Lowenstein C. J., Arking D., Beer M. A., Maitra A., Mendell J. T., Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Molecular Cell 2007 26 5 745 752 2-s2.0-34249817549 10.1016/j.molcel.2007.05.010 (Pubitemid 46856245)
42. Tazawa H., Tsuchiya N., Izumiya M., Nakagama H., Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proceedings of the National Academy of Sciences of the United States of America 2007 104 39 15472 15477 2-s2.0-34848868157 10.1073/pnas.0707351104 (Pubitemid 47502941)
43. Yamakuchi M., Lowenstein C. J., MiR-34, SIRT1 and p53: the feedback loop. Cell Cycle 2009 8 5 712 715 2-s2.0-62449117918
44. Christoffersen N. R., Shalgi R., Frankel L. B., Leucci E., Lees M., Klausen M., Pilpel Y., Nielsen F. C., Oren M., Lund A. H., P53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death and Differentiation 2010 17 2 236 245 2-s2.0-74249124132 10.1038/cdd.2009.109
45. Langley E., Pearson M., Faretta M., Bauer U. M., Frye R. A., Minucci S., Pelicci P. G., Kouzarides T., Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO Journal 2002 21 10 2383 2396 2-s2.0-0037093346 10.1093/emboj/21.10.2383 (Pubitemid 34546711)
46. Welch C., Chen Y., Stallings R. L., MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 2007 26 34 5017 5022 2-s2.0-34249812122 10.1038/sj.onc.1210293 (Pubitemid 47172643)
47. Martinez I., Cazalla D., Almstead L. L., Steitz J. A., DiMaio D., miR-29 and miR-30 regulate B-Myb expression during cellular senescence. Proceedings of the National Academy of Sciences of the United States of America 2011 108 2 522 527 10.1073/pnas.1017346108
48. Zhao J. J., Lin J., Lwin T., Yang H., Guo J., Kong W., Dessureault S., Moscinski L. C., Rezania D., Dalton W. S., Sotomayor E., Tao J., Cheng J. Q., MicroRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood 2010 115 13 2630 2639 2-s2.0-77951003346 10.1182/blood-2009-09-243147
49. Fabbri M., Garzon R., Cimmino A., Liu Z., Zanesi N., Callegari E., Liu S., Alder H., Costinean S., Fernandez-Cymering C., Volinia S., Guler G., Morrison C. D., Chan K. K., Marcucci G., Calin G. A., Huebner K., Croce C. M., MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proceedings of the National Academy of Sciences of the United States of America 2007 104 40 15805 15810 2-s2.0-35649020283 10.1073/pnas.0707628104 (Pubitemid 350035380)
50. Palamarchuk A., Efanov A., Nazaryan N., Santanam U., Alder H., Rassenti L., Kipps T., Croce C. M., Pekarsky Y., 13q14 deletions in CLL involve cooperating tumor suppressors. Blood 2010 115 19 3916 3922 2-s2.0-77952993039 10.1182/blood-2009-10-249367
51. Zhong X., Li N., Liang S., Huang Q., Coukos G., Zhang L., linzhang@mail.med.upenn.edu Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. The Journal of Biological Chemistry 2010 285 53 41961 41971 10.1074/jbc.M110.169607
52. Marasa B. S., Srikantan S., Martindale J. L., Kim M. M., Lee E. K., Gorospe M., Abdelmohsen K., MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging 2010 2 6 333 343
53. Noonan E. J., Place R. F., Basak S., Pookot D., Li L. C., miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells. Oncotarget 2010 1 5 349 358
54. Yang X., Feng M., Jiang X., miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes and Development 2009 23 20 2388 2393 2-s2.0-70350111289 10.1101/gad.1819009
55. Venkataraman S., Alimova I., Fan R., Harris P., Foreman N., Vibhakar R., Rajeev.Vibhakar@ucdenver.edu MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. PLoS ONE 2010 5 6 e10748 10.1371/journal.pone.0010748
56. Slaby O., Lakomy R., Fadrus P., Hrstka R., Kren L., Lzicarova E., Smrcka M., Svoboda M., Dolezalova H., Novakova J., Valik D., Vyzula R., Michalek J., MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients. Neoplasma 2010 57 3 264 269 10.4149/neo201003264
57. Garzon R., Garofalo M., Martelli M. P., Briesewitz R., Wang L., Fernandez-Cymering C., Volinia S., Liu C. G., Schnittger S., Haferlach T., Liso A., Diverio D., Mancini M., Meloni G., Foa R., Martelli M. F., Mecucci C., Croce C. M., Falini B., Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proceedings of the National Academy of Sciences of the United States of America 2008 105 10 3945 3950 2-s2.0-41649119008 10.1073/pnas.0800135105 (Pubitemid 351723504)
58. Menghini R., Casagrande V., Cardellini M., Martelli E., Terrinoni A., Amati F., Vasa-Nicotera M., Ippoliti A., Novelli G., Melino G., Lauro R., Federici M., MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation 2009 120 15 1524 1532 2-s2.0-70350134022 10.1161/CIRCULATIONAHA.109.864629
59. Zhao W. G., Yu S. N., Lu Z. H., Ma Y. H., Gu Y. M., Chen J., xhblk@163.com The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS. Carcinogenesis 2010 31 10 1726 1733 10.1093/carcin/bgq160
60. Borgdorff V., Lleonart M. E., Bishop C. L., Fessart D., Bergin A. H., Overhoff M. G., Beach D. H., Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21 Waf1/Cip1. Oncogene 2010 29 15 2262 2271 2-s2.0-77951054607 10.1038/onc.2009.497
61. Voorhoeve P. M., le Sage C., Schrier M., Gillis A. J. M., Stoop H., Nagel R., Liu Y. P., van Duijse J., Drost J., Griekspoor A., Zlotorynski E., Yabuta N., De Vita G., Nojima H., Looijenga L. H. J., Agami R., A genetic screen implicates miRNA-372 and miRNA-373 As oncogenes in testicular germ cell tumors. Cell 2006 124 6 1169 1181 2-s2.0-33646056975 10.1016/j.cell.2006.02.037
62. Cho W. J., Shin J. M., Kim J. S., Lee M. R., Hong K. S., Lee J. H., Koo K. H., Park J. W., Kim K. S., MiR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2. Molecules and Cells 2009 28 6 521 527 2-s2.0-76649106069 10.1007/s10059-009-0158-0
63. Lee K. H., Goan Y. G., Hsiao M., Lee C. H., Jian S. H., Lin J. T., Chen Y. L., Lu P. J., MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer. Experimental Cell Research 2009 315 15 2529 2538 2-s2.0-67651045805 10.1016/j.yexcr.2009.06.001
64. Yu J., Ohuchida K., kenoki@med.kyushu-u.ac.jp Mizumoto K., mizumoto@med.kyushu-u.ac.jp Fujita H., Nakata K., Tanaka M., MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis and involved in cancer cell proliferation and invasion. Cancer Biology and Therapy 2010 10 8 748 757 10.4161/cbt.10.8.13083
65. Wong T. S., Liu X. B., Wong B. Y. H., Ng R. W. M., Yuen A. P. W., Wei W. I., Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clinical Cancer Research 2008 14 9 2588 2592 2-s2.0-52049121293 10.1158/1078-0432.CCR-07-0666
66. Li H., Bian C., Liao L., Li J., Zhao R. C., miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1. Breast Cancer Research and Treatment 2010 126 3 565 575 2-s2.0-77952623049 10.1007/s10549-010-0954-4
67. Yang F., Yin Y., Wang F., Wang Y., Zhang L., Tang Y., Sun S., miR-17-5p promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology 2010 51 5 1614 1623 2-s2.0-77951491943 10.1002/hep.23566
68. Chow T. F. F., Mankaruos M., Scorilas A., Youssef Y., Girgis A., Mossad S., Metias S., Rofael Y., Honey R. J., Stewart R., Pace K. T., Yousef G. M., The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma. Journal of Urology 2010 183 2 743 751 2-s2.0-73749083718 10.1016/j.juro.2009.09.086
69. Takakura S., Mitsutake N., Nakashima M., Namba H., Saenko V. A., Rogounovitch T. I., Nakazawa Y., Hayashi T., Ohtsuru A., Yamashita S., Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells. Cancer Science 2008 99 6 1147 1154 2-s2.0-43549098845 10.1111/j.1349-7006.2008.00800.x (Pubitemid 351676626)
70. Lai K. W., Koh K. X., Loh M., Tada K., Subramaniam M. M., Lim X. Y., Vaithilingam A., Salto-Tellez M., Iacopetta B., Ito Y., Soong R., MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric cancer. European Journal of Cancer 2010 46 8 1456 1463 2-s2.0-77951666669 10.1016/j.ejca.2010.01.036
71. Marasa B. S., Srikantan S., Masuda K., Abdelmohsen K., Kuwano Y., Yang X., Martindale J. L., Rinker-Schaeffer C. W., Gorospe M., Increased MKK4 abundance with replicative senescence is linked to the joint reduction of multiple microRNAs. Science Signaling 2009 2 94 ra69 2-s2.0-74049111298 10.1126/scisignal.2000442
72. Satzger I., satzger.imke@mh-hannover.de Mattern A., Kuettler U., Weinspach D., Voelker B., Kapp A., Gutzmer R., MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma. International Journal of Cancer 2010 126 11 2553 2562 10.1002/ijc.24960
73. Scapoli L., Palmieri A., Lo Muzio L., Pezzetti F., Rubini C., Girardi A., Farinella F., Mazzotta M., Carinci F., MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression. International Journal of Immunopathology and Pharmacology 2010 23 4 1229 1234
74. Zhangy L., Dengy T., Li X., Liu H., Zhou H., Ma J., majian@mail.csu.edu. cn Wu M., Zhou M., Shen S., Li X., Niu Z., Zhang W., Shi L., Xiang B., Lu J., Wang L., Li D., Tang H., Li G., ligy@xysm.net microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis 2010 31 4 559 566 10.1093/carcin/bgp335
75. Poliseno L., Pitto L., Simili M., Mariani L., Riccardi L., Ciucci A., Rizzo M., Evangelista M., Mercatanti A., Pandolfi P. P., Rainaldi G., The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence. PLoS ONE 2008 3 7 2-s2.0-49749136970 10.1371/journal.pone.0002542 e2542
76. Pitto L., Rizzo M., Simili M., Colligiani D., Evangelista M., Mercatanti A., Mariani L., Cremisi F., Rainaldi G., miR-290 acts as a physiological effector of senescence in mouse embryo fibroblasts. Physiological Genomics 2009 39 3 210 218 2-s2.0-72949109544 10.1152/physiolgenomics.00085.2009
77. Liu H., Deng S., Zhao Z., Zhang H., Xiao J., Song W., Gao F., Guan Y., harbinguan.2010@yahoo.com.cn Oct4 regulates the miR-302 cluster in P19 mouse embryonic carcinoma cells. Molecular Biology Reports 2011 38 3 2155 2160 10.1007/s11033-010-0343-4
78. Palmer R. D., Murray M. J., Saini H. K., Van Dongen S., Abreu-Goodger C., Muralidhar B., Pett M. R., Thornton C. M., Nicholson J. C., Enright A. J., Coleman N., Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. Cancer Research 2010 70 7 2911 2923 2-s2.0-77950839553 10.1158/0008-5472.CAN-09-3301
79. López-Vicente L., Armengol G., Pons B., Coch L., Argelaguet E., Lleonart M., Hernández-Losa J., De Torres I., Ramon Y Cajal S., Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors. Clinical Cancer Research 2009 15 14 4546 4553 2-s2.0-68049102317 10.1158/1078-0432.CCR-08-3159
80. Chang B. D., Broude E. V., Dokmanovic M., Zhu H., Ruth A., Xuan Y., Kandel E. S., Lausch E., Christov K., Roninson I. B., A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Research 1999 59 15 3761 3767 2-s2.0-17444388849 (Pubitemid 29381884)
81. Ewald J. A., Desotelle J. A., Wilding G., Jarrard D. F., jarrard@surgery.wisc.edu Therapy-induced senescence in cancer. Journal of the National Cancer Institute 2010 102 20 1536 1546 10.1093/jnci/djq364
82. Krtolica A., Parrinello S., Lockett S., Desprez P. Y., Campisi J., Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proceedings of the National Academy of Sciences of the United States of America 2001 98 21 12072 12077 2-s2.0-0035834121 10.1073/pnas.211053698 (Pubitemid 32959828)
83. Bhaumik D., Scott G. K., Schokrpur S., Patil C. K., Orjalo A. V., Rodier F., Lithgow G. J., Campisi J., MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging 2009 1 4 402 411 2-s2.0-67649318940
84. Krützfeldt J., Rajewsky N., Braich R., Rajeev K. G., Tuschl T., Manoharan M., Stoffel M., Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005 438 7068 685 689 2-s2.0-28444469246 10.1038/nature04303 (Pubitemid 41740580)
85. Stenvang J., Kauppinen S., MicroRNAs as targets for antisense-based therapeutics. Expert Opinion on Biological Therapy 2008 8 1 59 81 2-s2.0-38949133928 10.1517/14712598.8.1.59 (Pubitemid 351233723)
86. Asangani I. A., Rasheed S. A. K., Nikolova D. A., Leupold J. H., Colburn N. H., Post S., Allgayer H., MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008 27 15 2128 2136 2-s2.0-41749113108 10.1038/sj.onc.1210856 (Pubitemid 351485639)
87. Frankel L. B., Christoffersen N. R., Jacobsen A., Lindow M., Krogh A., Lund A. H., Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. The Journal of Biological Chemistry 2008 283 2 1026 1033 2-s2.0-38149042783 10.1074/jbc.M707224200
88. Lu Z., Liu M., Stribinskis V., Klinge C. M., Ramos K. S., Colburn N. H., Li Y., MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 2008 27 31 4373 4379 2-s2.0-47549109566 10.1038/onc.2008.72 (Pubitemid 352010003)
89. Zhu S., Si M. L., Wu H., Mo Y. Y., MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). The Journal of Biological Chemistry 2007 282 19 14328 14336 2-s2.0-34347266556 10.1074/jbc.M611393200 (Pubitemid 47100416)
90. Meng F., Henson R., Wehbe-Janek H., Ghoshal K., Jacob S. T., Patel T., MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007 133 2 647 658 2-s2.0-34547524771 10.1053/j.gastro.2007.05.022 (Pubitemid 47187346)
91. Zhang J. G., Wang J. J., Zhao F., Liu Q., Jiang K., Yang G. H., MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clinica Chimica Acta 2010 411 11-12 846 852
92. Connolly E. C., van Doorslaer K., Rogler L. E., Rogler C. E., Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB. Molecular Cancer Research 2010 8 5 691 700 2-s2.0-77952948062 10.1158/1541-7786.MCR-09-0465
93. Zheng J., Xue H., Wang T., Jiang Y., Liu B., Li J., Liu Y., Wang W., Zhang B., binzhang@fmmu.edu.cn Sun M., moyisun@163.com miR-21 downregulates the tumor suppressor P12CDK2AP1and stimulates cell proliferation and invasion. Journal of Cellular Biochemistry 2011 112 3 872 880 10.1002/jcb.22995
94. Si M. L., Zhu S., Wu H., Lu Z., Wu F., Mo Y. Y., miR-21-mediated tumor growth. Oncogene 2007 26 19 2799 2803 2-s2.0-34247495591 10.1038/sj.onc.1210083 (Pubitemid 46663837)
95. Lu Y., Xiao J., Lin H., Bai Y., Luo X., Wang Z., Yang B., yangbf@ems.hrbmu.edu.cn A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference. Nucleic Acids Research 2009 37 3, article e24 10.1093/nar/gkn1053
96. Ebert M. S., Neilson J. R., Sharp P. A., MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nature Methods 2007 4 9 721 726 2-s2.0-34548316982 10.1038/nmeth1079 (Pubitemid 47338166)
97. Loya C. M., Lu C. S., Van Vactor D., Fulga T. A., Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nature Methods 2009 6 12 897 903 2-s2.0-73349122330 10.1038/nmeth.1402
98. Xiao J., Yang B., Lin H., Lu Y., Luo X., Wang Z., Novel approaches for gene-specific interference via manipulating actions of microRNAs: examination on the pacemaker channel genes HCN2 and HCN4. Journal of Cellular Physiology 2007 212 2 285 292 2-s2.0-34347381752 10.1002/jcp.21062 (Pubitemid 47025616)
99. Akao Y., yakao@giib.or.jp Nakagawa Y., Naoe T., let-7 microRNA functions as a potential growth suppressor in human colon cancer cells. Biological and Pharmaceutical Bulletin 2006 29 5 903 906 10.1248/bpb.29.903
100. Xiong Y., Fang J. H., Yun J. P., Yang J., Zhang Y., Jia W. H., Zhuang S. M., Effects of microrna-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 2010 51 3 836 845 2-s2.0-77950602604 10.1002/hep.23380
101. Johnson S. M., Grosshans H., Shingara J., Byrom M., Jarvis R., Cheng A., Labourier E., Reinert K. L., Brown D., Slack F. J., RAS is regulated by the let-7 microRNA family. Cell 2005 120 5 635 647 2-s2.0-20044395613 10.1016/j.cell.2005.01.014 (Pubitemid 40343076)
102. Mayr C., Hemann M. T., Bartel D. P., Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 2007 315 5818 1576 1579 2-s2.0-33947431322 10.1126/science.1137999 (Pubitemid 46449474)
103. Müller D. W., Bosserhoff A. K., Integrin β expression is regulated by let-7a miRNA in malignant melanoma. Oncogene 2008 27 52 6698 6706 2-s2.0-56149110341 10.1038/onc.2008.282
104. Schultz J., Lorenz P., Gross G., Ibrahim S., Kunz M., manfred.kunz@med.uni-rostock.de MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Research 2008 18 5 549 557 10.1038/cr.2008.45 (Pubitemid 351630945)
105. Shimizu S., Takehara T., Hikita H., Kodama T., Miyagi T., Hosui A., Tatsumi T., Ishida H., Noda T., Nagano H., Doki Y., Mori M., Hayashi N., The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma. Journal of Hepatology 2010 52 5 698 704 2-s2.0-77951620660 10.1016/j.jhep.2009.12.024
106. Wong T. S., thiansze@graduate.hku.hk Man O. Y., oymanvenus@gmail.com Tsang C. M., anna0226@hkusua.hku.hk Tsao S. W., gswtsao@hkucc.hku.hk Tsang R. K.-Y., rkytsang@hku.hk Chan J. Y.-W., jywchan@hotmail.com Ho W. K., wkho@hkucc.hku.hk Wei W. I., hrmswwi@hkucc.hku.hk To V. S.-H., howe@netvigator.com MicroRNA let-7 suppresses nasopharyngeal carcinoma cells proliferation through downregulating c-Myc expression. Journal of Cancer Research and Clinical Oncology 2011 137 3 415 422
107. Esquela-Kerscher A., Trang P., Wiggins J. F., Patrawala L., Cheng A., Ford L., Weidhaas J. B., Brown D., dbrown@asuragen.com Bader A. G., Slack F. J., frank.slack@yale.edu The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell Cycle 2008 7 6 759 764 (Pubitemid 351520040)
108. Kumar M. S., Erkeland S. J., Pester R. E., Chen C. Y., Ebert M. S., Sharp P. A., sharppa@mit.edu Jacks T., tjacks@mit.edu Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proceedings of the National Academy of Sciences of the United States of America 2008 105 10 3903 3908 10.1073/pnas.0712321105 (Pubitemid 351723497)
109. Trang P., Medina P. P., Wiggins J. F., Ruffino L., Kelnar K., Omotola M., Homer R., Brown D., Bader A. G., Weidhaas J. B., Slack F. J., Regression of murine lung tumors by the let-7 microRNA. Oncogene 2010 29 11 1580 1587 2-s2.0-77949658280 10.1038/onc.2009.445
110. Lan F. F., Wang H., Chen Y. C., Chan C. Y., Ng S. S., Li K., Xie D., He M. L., Lin M. C., mcllin@hkusua.hku.hk Kung H. F., hkung@cuhk.edu.hk Hsa-let-7g inhibits proliferation of hepatocellular carcinoma cells by downregulation of c-Myc and upregulation of p16INK4A. International Journal of Cancer 2011 128 2 319 331 10.1002/ijc.25336
111. Wiggins J. F., Ruffino L., Kelnar K., Omotola M., Patrawala L., Brown D., Bader A. G., abader@mirnarx.com Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34. Cancer Research 2010 70 14 5923 5930 10.1158/0008-5472.CAN-10-0655
112. Sun F., Fu H., Liu Q., Tie Y., Zhu J., Xing R., Sun Z., Zheng X., xfzheng100@126.com Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Letters 2008 582 10 1564 1568 10.1016/j.febslet.2008.03.057
113. Wei J. S., Song Y. K., Durinck S., Chen Q. R., Cheuk A. T. C., Tsang P., Zhang Q., Thiele C. J., Slack A., Shohet J., Khan J., The MYCN oncogene is a direct target of miR-34a. Oncogene 2008 27 39 5204 5213 2-s2.0-51349157982 10.1038/onc.2008.154
114. Yamakuchi M., myamaku1@jhmi.edu Ferlito M., Lowenstein C. J., miR-34a repression of SIRT1 regulates apoptosis. Proceedings of the National Academy of Sciences of the United States of America 2008 105 36 13421 13426 10.1073/pnas.0801613105
115. Aagaard L., Rossi J. J., RNAi therapeutics: principles, prospects and challenges. Advanced Drug Delivery Reviews 2007 59 2-3 75 86 2-s2.0-34248682403 10.1016/j.addr.2007.03.005 (Pubitemid 46770900)
116. Kota J., Chivukula R. R., O'Donnell K. A., Wentzel E. A., Montgomery C. L., Hwang H. W., Chang T. C., Vivekanandan P., Torbenson M., Clark K. R., Mendell J. R., Mendell J. T., Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver Cancer Model. Cell 2009 137 6 1005 1017 2-s2.0-66449136951 10.1016/j.cell.2009.04.021
117. Chirila T. V., Rakoczy P. E., Garrett K. L., Lou X., Constable I. J., The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials 2002 23 2 321 342 2-s2.0-0036131650 10.1016/S0142-9612(01)00125-9 (Pubitemid 33051022)
118. Rosi N. L., Giljohann D. A., Thaxton C. S., Lytton-Jean A. K.R., Han M. S., Mirkin C. A., chadnano@northwestern.edu Oligonucleotide-modified gold nanoparticles for infracellular gene regulation. Science 2006 312 5776 1027 1030 10.1126/science.1125559
119. Zuhorn I. S., Engberts J. B. F. N., Hoekstra D., Gene delivery by cationic lipid vectors: overcoming cellular barriers. European Biophysics Journal 2007 36 4-5 349 362 2-s2.0-34247181222 10.1007/s00249-006-0092-4 (Pubitemid 46626209)