-
1
-
-
28244469090
-
Regulation of growth arrest in senescence: Telomere damage is not the end of the story
-
DOI 10.1016/j.mad.2005.09.002, PII S0047637405002198
-
Herbig U, Sedivy JM. Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev 2006;127:16-24. (Pubitemid 41713510)
-
(2006)
Mechanisms of Ageing and Development
, vol.127
, Issue.1
, pp. 16-24
-
-
Herbig, U.1
Sedivy, J.M.2
-
2
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004;23:2919-2933
-
(2004)
Oncogene
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
3
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
-
DOI 10.1016/S0092-8674(00)81902-9
-
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602. (Pubitemid 27152402)
-
(1997)
Cell
, vol.88
, Issue.5
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
4
-
-
33845292259
-
A negative feedback signaling network underlies oncogene-induced senescence
-
DOI 10.1016/j.ccr.2006.10.003, PII S1535610806002893
-
Courtois-Cox S, Genther Williams SM, Reczek EE, et al. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 2006;10:459-472 (Pubitemid 44872980)
-
(2006)
Cancer Cell
, vol.10
, Issue.6
, pp. 459-472
-
-
Courtois-Cox, S.1
Genther Williams, S.M.2
Reczek, E.E.3
Johnson, B.W.4
McGillicuddy, L.T.5
Johannessen, C.M.6
Hollstein, P.E.7
MacCollin, M.8
Cichowski, K.9
-
5
-
-
34548186667
-
Cellular senescence: When bad things happen to good cells
-
Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007;8:729-740
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 729-740
-
-
Campisi, J.1
D'Adda Di Fagagna, F.2
-
6
-
-
34447543913
-
Cellular senescence in cancer and aging
-
Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell 2007;130:223-233
-
(2007)
Cell
, vol.130
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
8
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
-
DOI 10.1016/j.cell.2005.02.003
-
Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005;120:513-522 (Pubitemid 40269765)
-
(2005)
Cell
, vol.120
, Issue.4
, pp. 513-522
-
-
Campisi, J.1
-
9
-
-
1542781659
-
When cells get stressed: An integrative view of cellular senescence
-
DOI 10.1172/JCI200420663
-
Ben-Porath I, Weinberg RA. When cells get stressed: an integrative view of cellular senescence. J Clin Invest 2004;113:8-13. (Pubitemid 38541623)
-
(2004)
Journal of Clinical Investigation
, vol.113
, Issue.1
, pp. 8-13
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
10
-
-
0030609861
-
Bypass of senescence after disruption of p21CIP1/WAF1gene in normal diploid human fibroblasts
-
Brown JP, Wei W, Sedivy JM. Bypass of senescence after disruption of p21CIP1/WAF1gene in normal diploid human fibroblasts. Science1997;277:831-834
-
(1997)
Science
, vol.277
, pp. 831-834
-
-
Brown, J.P.1
Wei, W.2
Sedivy, J.M.3
-
11
-
-
0028261160
-
Escape from senescence in human diploid fibroblasts induced directly by mutant p53
-
Bond JA, Wyllie FS, Wynford-Thomas D. Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 1994;9:1885-1889 (Pubitemid 24194154)
-
(1994)
Oncogene
, vol.9
, Issue.7
, pp. 1885-1889
-
-
Bond, J.A.1
Wyllie, F.S.2
Wynford-Thomas, D.3
-
12
-
-
0041966056
-
Reversal of human cellular senescence: Roles of the p53 and p16 pathways
-
DOI 10.1093/emboj/cdg417
-
Beausejour CM, Krtolica A, Galimi F, et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 2003;22:4212-4222 (Pubitemid 37021749)
-
(2003)
EMBO Journal
, vol.22
, Issue.16
, pp. 4212-4222
-
-
Beausejour, C.M.1
Krtolica, A.2
Galimi, F.3
Narita, M.4
Lowe, S.W.5
Yaswen, P.6
Campisi, J.7
-
13
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
DOI 10.1038/nature03918
-
Chen Z, Trotman LC, Shaffer D, et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005;436:725-730 (Pubitemid 41117277)
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
Lin, H.-K.4
Dotan, Z.A.5
Niki, M.6
Koutcher, J.A.7
Scher, H.I.8
Ludwig, T.9
Gerald, W.10
Cordon-Cardo, C.11
Pandolfi, P.P.12
-
14
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
DOI 10.1038/nature05529, PII NATURE05529
-
Xue W, Zender L, Miething C, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 2007;445:656-660 (Pubitemid 46232886)
-
(2007)
Nature
, vol.445
, Issue.7128
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
Dickins, R.A.4
Hernando, E.5
Krizhanovsky, V.6
Cordon-Cardo, C.7
Lowe, S.W.8
-
15
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998;12:3008-3019 (Pubitemid 28469303)
-
(1998)
Genes and Development
, vol.12
, Issue.19
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
Van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
16
-
-
33646514141
-
P53-dependent and -independent functions of the Arf tumor suppressor
-
DOI 10.1101/sqb.2005.70.004
-
Sherr CJ, Bertwistle D,W DENB, et al. p53-Dependent and -independent functions of the Arf tumor suppressor. Cold Spring Harb Symp Quant Biol 2005;70:129-137 (Pubitemid 44124864)
-
(2005)
Cold Spring Harbor Symposia on Quantitative Biology
, vol.70
, pp. 129-137
-
-
Sherr, C.J.1
Bertwistle, D.2
Den Besten, W.3
Kuo, M.-L.4
Sugimoto, M.5
Tago, K.6
Williams, R.T.7
Zindy, F.8
Roussel, M.F.9
-
17
-
-
34047254893
-
Dissecting the senescence-like program in tumor cells activated by ras signaling
-
DOI 10.1074/jbc.M608127200
-
Bihani T, Chicas A, Lo CP, Lin AW. Dissecting the senescence-like program in tumor cells activated by Ras signaling. J Biol Chem 2007;282:2666-2675 (Pubitemid 47076800)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.4
, pp. 2666-2675
-
-
Bihani, T.1
Chicas, A.2
Lo, C.P.-K.3
Lin, A.W.4
-
18
-
-
36048965126
-
Breaking news: High-speed race ends in arrest - How oncogenes induce senescence
-
Di Micco R, Fumagalli M, d'Adda di Fagagna F. Breaking news: high-speed race ends in arrest - how oncogenes induce senescence.Trends Cell Biol 2007;17:529-536
-
(2007)
Trends Cell Biol
, vol.17
, pp. 529-536
-
-
Di Micco, R.1
Fumagalli, M.2
D'Adda Di Fagagna, F.3
-
19
-
-
41549149451
-
Cellular senescence in vivo: A barrier to tumorigenesis
-
Prieur A, Peeper DS. Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol 2008;20:150-155
-
(2008)
Curr Opin Cell Biol
, vol.20
, pp. 150-155
-
-
Prieur, A.1
Peeper, D.S.2
-
20
-
-
33845235459
-
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
-
DOI 10.1038/nature05268, PII NATURE05268
-
Bartkova J, Rezaei N, Liontos M, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006;444:633-637 (Pubitemid 44864442)
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 633-637
-
-
Bartkova, J.1
Rezaei, N.2
Liontos, M.3
Karakaidos, P.4
Kletsas, D.5
Issaeva, N.6
Vassiliou, L.-V.F.7
Kolettas, E.8
Niforou, K.9
Zoumpourlis, V.C.10
Takaoka, M.11
Nakagawa, H.12
Tort, F.13
Fugger, K.14
Johansson, F.15
Sehested, M.16
Andersen, C.L.17
Dyrskjot, L.18
Orntoft, T.19
Lukas, J.20
Kittas, C.21
Helleday, T.22
Halazonetis, T.D.23
Bartek, J.24
Gorgoulis, V.G.25
more..
-
21
-
-
13444309091
-
Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells
-
Trost TM, Lausch EU, Fees SA, et al. Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res 2005;65:840-849
-
(2005)
Cancer Res
, vol.65
, pp. 840-849
-
-
Trost, T.M.1
Lausch, E.U.2
Fees, S.A.3
-
22
-
-
23244447037
-
E600-associated senescence-like cell cycle arrest of human naevi
-
DOI 10.1038/nature03890
-
Michaloglou C, Vredeveld LC, Soengas MS, et al. BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 2005;436:720-724 (Pubitemid 41117276)
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.W.2
Soengas, M.S.3
Denoyelle, C.4
Kuilman, T.5
Van Der Horst, C.M.A.M.6
Majoor, D.M.7
Shay, J.W.8
Mooi, W.J.9
Peeper, D.S.10
-
23
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
DOI 10.1038/nature03485
-
Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005;434:907-913 (Pubitemid 40559004)
-
(2005)
Nature
, vol.434
, Issue.7035
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.-V.F.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
Ditullio Jr., R.A.8
Kastrinakis, N.G.9
Levy, B.10
Kletsas, D.11
Yoneta, A.12
Herlyn, M.13
Kittas, C.14
Halazonetis, T.D.15
-
24
-
-
23244447893
-
Tumour biology: Senescence in premalignant tumours
-
DOI 10.1038/436642a
-
Collado M, Gil J, Efeyan A, et al. Tumour biology: senescence in premalignant tumours. Nature 2005;436:642. (Pubitemid 41117258)
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
Benguria, A.7
Zaballos, A.8
Flores, J.M.9
Barbacid, M.10
Beach, D.11
Serrano, M.12
-
25
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
DOI 10.1038/nature03841
-
Braig M, Lee S, Loddenkemper C, et al. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 2005;436:660-665 (Pubitemid 41117262)
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
Rudolph, C.4
Peters, A.H.F.M.5
Schlegelberger, B.6
Stein, H.7
Dorken, B.8
Jenuwein, T.9
Schmitt, C.A.10
-
26
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
DOI 10.1038/nature02371
-
Berns K, Hijmans EM, Mullenders J, et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 2004;428:431-437 (Pubitemid 38419689)
-
(2004)
Nature
, vol.428
, Issue.6981
, pp. 431-437
-
-
Berns, K.1
Hijmans, E.M.2
Mullenders, J.3
Brummelkamp, T.R.4
Velds, A.5
Heimerikx, M.6
Kerkhoven, R.M.7
Madlredjo, M.8
Nijkamp, W.9
Weigelt, B.10
Agami, R.11
Ge, W.12
Cavet, G.13
Linsley, P.S.14
Beijersbergen, R.L.15
Bernards, R.16
-
27
-
-
0040175067
-
Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
-
DOI 10.1016/S0303-7207(99)00061-1, PII S0303720799000611
-
Frodin M, Gammeltoft S. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol 1999;151:65-77. (Pubitemid 29295514)
-
(1999)
Molecular and Cellular Endocrinology
, vol.151
, Issue.1-2
, pp. 65-77
-
-
Frodin, M.1
Gammeltoft, S.2
-
28
-
-
17144370207
-
Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types
-
DOI 10.1074/jbc.M408194200
-
Dummler BA, Hauge C, Silber J, et al. Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. J Biol Chem 2005;280:13304-13314 (Pubitemid 40517216)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.14
, pp. 13304-13314
-
-
Dummler, B.A.1
Hauge, C.2
Silber, J.3
Yntema, H.G.4
Kruse, L.S.5
Kofoed, B.6
Hemmings, B.A.7
Alessi, D.R.8
Frodin, M.9
-
29
-
-
33748320817
-
RSK aand MSK in MAP kinase signalling
-
DOI 10.1242/jcs.02950
-
Hauge C, Frodin M. RSK and MSK in MAP kinase signalling. J Cell Sci 2006;119:3021-3023 (Pubitemid 44322115)
-
(2006)
Journal of Cell Science
, vol.119
, Issue.15
, pp. 3021-3023
-
-
Hauge, C.1
Frodin, M.2
-
30
-
-
14944361815
-
RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain
-
DOI 10.1124/mol.104.008672
-
Niehof M, Borlak J. RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain. Mol Pharmacol 2005;67:604-611 (Pubitemid 40365307)
-
(2005)
Molecular Pharmacology
, vol.67
, Issue.3
, pp. 604-611
-
-
Niehof, M.1
Borlak, J.2
-
31
-
-
33749187263
-
New p53 related genes in human tumors: Significant downregulation in colon and lung carcinomas
-
Lleonart M, Vidal F, Gallardo D, et al. New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas. Oncol Rep 2006;16:603-608
-
(2006)
Oncol Rep
, vol.16
, pp. 603-608
-
-
Lleonart, M.1
Vidal, F.2
Gallardo, D.3
-
32
-
-
2942529468
-
Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling
-
DOI 10.1128/MCB.24.10.4255-4266.2004
-
Myers AP, Corson LB, Rossant J, Baker JC. Characterization of mouse Rsk4 as an inhibitor of fibroblast growth factor-RAS-extracellular signal-regulated kinase signaling. Mol Cell Biol 2004;24:4255-4266 (Pubitemid 41070997)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.10
, pp. 4255-4266
-
-
Myers, A.P.1
Corson, L.B.2
Rossant, J.3
Baker, J.C.4
-
33
-
-
51649086495
-
Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells
-
Thakur A, Sun Y, Bollig A, et al. Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells. Clin Cancer Res 2008;14:4427-4436
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4427-4436
-
-
Thakur, A.1
Sun, Y.2
Bollig, A.3
-
34
-
-
34548799705
-
Methods to detect biomarkers of cellular senescence: The senescence-associated β-galactosidase assay
-
DOI 10.1385/1-59745-361-7:21, Biological Aging: Methods and Protocols
-
Itahana K, Campisi J, Dimri GP. Methods to detect biomarkers of cellular senescence: the senescence-associated β-galactosidase assay. Methods Mol Biol 2007;371:21-31. (Pubitemid 350183415)
-
(2007)
Methods in Molecular Biology
, vol.371
, pp. 21-31
-
-
Itahana, K.1
Campisi, J.2
Dimri, G.P.3
-
35
-
-
0033606852
-
Role of p53 and p21(waf1/cip1) in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
-
DOI 10.1038/sj.onc.1203078
-
Chang BD, Xuan Y, Broude EV, et al. Role of p53 and p21waf1/cip1in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 1999;18:4808-4818 (Pubitemid 29423564)
-
(1999)
Oncogene
, vol.18
, Issue.34
, pp. 4808-4818
-
-
Chang, B.-D.1
Xuan, Y.2
Broude, E.V.3
Zhu, H.4
Schott, B.5
Fang, J.6
Roninson, I.B.7
-
36
-
-
0343953594
-
Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia
-
Myohanen SK, Baylin SB, Herman JG. Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res 1998;58:591-593
-
(1998)
Cancer Res
, vol.58
, pp. 591-593
-
-
Myohanen, S.K.1
Baylin, S.B.2
Herman, J.G.3
-
37
-
-
0037407415
-
Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis
-
Kohn M, Hameister H, Vogel M, Kehrer-Sawatzki H. Expression pattern of the Rsk2, Rsk4 and Pdk1 genes during murine embryogenesis. Gene Expr Patterns 2003;3:173-177
-
(2003)
Gene Expr Patterns
, vol.3
, pp. 173-177
-
-
Kohn, M.1
Hameister, H.2
Vogel, M.3
Kehrer-Sawatzki, H.4
-
38
-
-
20444370974
-
What has senescence got to do with cancer?
-
Dimri GP. What has senescence got to do with cancer? Cancer Cell 2005;7:505-512
-
(2005)
Cancer Cell
, vol.7
, pp. 505-512
-
-
Dimri, G.P.1
-
39
-
-
0026054961
-
A role for both RB and p53 in the regulation of human cellular senescence
-
Shay JW, Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 1991;196:33-39
-
(1991)
Exp Cell Res
, vol.196
, pp. 33-39
-
-
Shay, J.W.1
Pereira-Smith, O.M.2
Wright, W.E.3
-
40
-
-
0034832956
-
Regulation of cellular senescence by p53
-
Itahana K, Dimri G, Campisi J. Regulation of cellular senescence by p53. Eur J Biochem 2001;268:2784-2791
-
(2001)
Eur J Biochem
, vol.268
, pp. 2784-2791
-
-
Itahana, K.1
Dimri, G.2
Campisi, J.3
-
41
-
-
34548028705
-
4E-binding protein 1: A key molecular funnel factor in human cancer with clinical implications
-
DOI 10.1158/0008-5472.CAN-07-0881
-
Armengol G, Rojo F, Castellvi J, et al. 4E-binding protein 1: a key molecular funnel factor in human cancer with clinical implications. Cancer Res 2007;67:7551-7555 (Pubitemid 47281345)
-
(2007)
Cancer Research
, vol.67
, Issue.16
, pp. 7551-7555
-
-
Armengol, G.1
Rojo, F.2
Castellvi, J.3
Iglesias, C.4
Cuatrecasas, M.5
Pons, B.6
Baselga, J.7
Ramon Y Cajal, S.8
|