A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability

Human Molecular Genetics

Volumn 21, Issue 19, 2012, Pages 4225-4236

  Xiao, Hong ^a   Yu, Zhigang ^a   Wu, Yipin ^a   Nan, John ^a   Merry, Diane E ^b   Sekiguchi, JoAnn M ^a   Ferguson, David O ^a   Lieberman, Andrew P ^a   Dressler, Gregory R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; PAX TRANSACTIVATION DOMAIN INTERACTING PROTEIN; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA DAMAGE; DNA REPAIR; GENOMIC INSTABILITY; HUMAN; IONIZING RADIATION; KENNEDY DISEASE; MOUSE; MUSCLE ATROPHY; NONHUMAN; POLYGLUTAMINE EXPANSION DISEASE; PRIORITY JOURNAL;

ANIMALS; BULBO-SPINAL ATROPHY, X-LINKED; CARRIER PROTEINS; DNA REPAIR; GENOMIC INSTABILITY; HUMANS; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANDROGEN; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84866419085     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds246     Document Type: Article

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