Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells

Oncology Reports

Volumn 26, Issue 1, 2011, Pages 109-114

  Lamy, Virginie ^a,b   Bousserouel, Souad ^a,b   Gossé, Francine ^a,b   Minker, Carole ^a   Lobstein, Annelise ^a   Raul, Francis ^a,b  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b IRCAD   (France)

Author keywords

Apoptosis; Mcl 1; p53; SW620 cells; TRAIL

Indexed keywords

DEATH RECEPTOR 4; DEATH RECEPTOR 5; LUPULON; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL DEATH; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; METASTASIS POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

APOPTOSIS; CELL DEATH; COLONIC NEOPLASMS; DNA FRAGMENTATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MODELS, BIOLOGICAL; NEOPLASM METASTASIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TERPENES; TIME FACTORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR SUPPRESSOR PROTEIN P53;

EID: 79955827807     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2011.1273     Document Type: Article

References (34)

1. Dhillon AS, Hagan S, Rath O and Kolch W: MAP kinase signalling pathways in cancer. Oncogene 26: 3279-3290, 2007. (Pubitemid 46763021)
2. Roux PP and Blenis J: ERK and p38 MAPK-activated protein kinases: a family of proteine kinases with diverse biological functions. Microbiol Mol Biol Rev 68: 320-344, 2004. (Pubitemid 38756868)
3. Ouyang X, Jessen WJ, Al-Ahmadie H, Serio AM, Lin Y, Shih WJ, Reuter VE, Scardino PT, Shen MM, Aronow BJ, Vickers AJ, Gerald WL and Abate-Shen C: Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer. Cancer Res 68: 2132-2144, 2008. (Pubitemid 351521785)
4. Wang X, Martindale JL and Holbrook N: Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem 275: 39435-39443, 2000. (Pubitemid 32058968)
5. Fan M and Chambers TC: Role of mitogen-activated protein kinases in the response of tumor cells to chemotherapy. Drug Resist Updat 5: 253-267, 2001. (Pubitemid 34456379)
6. Kim HJ, Oh JE, Kim SW, Chun YJ and Kim MY: Ceramide induces p38 MAPK-dependent apoptosis and Bax translocation via inhibition of Akt in HL-60 cells. Cancer Lett 260: 88-95, 2008.
7. Brantley-Finley C, Lyle CS, Du L, Goodwin ME, Hall T, Szwedo D and Kaushal GP TC: The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin and etoposide. Biochem Pharmacol 66: 459-469, 2003. (Pubitemid 36937031)
8. Tewari R, Sharma V, Koul N and Sen E: Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation. J Neurochem 107: 616-627, 2008.
9. Aesoy R, Sanchez BC, Norum JH, Lewensohn R, Viktorsson K and Linderholm B: An autocrine VEGF/VEGFR2 and p38 signalling loop confer resistance to 4-hydoxytamoxifen in MCF-7 breast cancer cells. Mol Cancer Res 6: 1630-1638, 2008.
10. Xia Z, Dickens M, Raingeaud J, Davis RJ and Greenberg ME Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.
11. Zhang CC and Shapiro D: Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis. J Biol Chem 275: 479-486, 2000. (Pubitemid 30039009)
12. Lamy V, Roussi S, Chaabi M, Gossé F, Lobstein A and Raul F: Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells. Apoptosis 13: 1232-1242, 2008.
13. Lamy V, Bousserouel S, Gossé F, Minker C. Lobstein A and Raul F: P53 activates either survival or apoptotic signaling responses in lupulone-treated human colon adenocarcinoma cells and derived metastatic cells. Trans Oncol 5: 286-292, 2010.
14. Lamy V, Roussi S, Chaabi M, Gosse F, Schall N, Lobstein A and Raul F: Chemopreventive effects of lupulone, a hop beta-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis 28: 1575-1581, 2007. (Pubitemid 47241808)
15. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
16. Hu R, Kim BR, Chen C, Hebbar V and Kong AN: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. Carcinogenesis 24: 1361-1367, 2003. (Pubitemid 37038826)
17. Olson JM and Hallahan A: p38 MAP kinase: a convergence point in cancer therapy. Trends Mol Med 10: 125-129, 2004 (Pubitemid 38293348)
18. Beaulieu JM, Sotnikova TD, Gainetdinov RR and Caron MG: Paradoxical striatal cellular signalling responses to psychostimulants in hyperactive mice. J Biol Chem 281: 32072-32080, 2006. (Pubitemid 46036761)
19. Riccardi C and Nicoletti I: Analysis of apoptosis propidium iodide staining and flow cytometry. Nat Protoc 1: 1458-1461, 2006.
20. Wang H, Wang Z, Chen J and Wu J: Apoptosis induced by NO via phosphorylation of p38 MAPK that stimulates NF-κB, p53 and caspase-3 activation in rabbit articular chondrocytes. Cell Biol Int 31: 1027-1035, 2007. (Pubitemid 46830901)
21. Rochette PJ, Bastien N, Lavoie J, Guérin SL and Drouin R: SW480, a p53 double-mutant cell line retains proficiency for some p53 functions. J Mol Biol 352: 44-57, 2005. (Pubitemid 41207440)
22. Armstrong JS: Mitochondria: a target for cancer therapy. Br J Pharmacol 147: 239-248, 2006.
23. Widlak P and Garrard WT: Roles of the major apoptotic nuclease-DNA fragmentation factor in biology and disease. Cell Mol Life Sci 66: 263-274, 2009.
24. Gavrieli Y, Sherman Y and Ben-Sasson SA: Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 119: 493-501, 1992.
25. Ballif BA and Blenis J: Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ 12: 397-408, 2001. (Pubitemid 32762689)
26. Wada T and Penninger JM: Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23: 2838-2849, 2004 (Pubitemid 38638846)
27. Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV Valerie K, Dent P and Fisher PB: Mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci USA 99: 10054-10059, 2002. (Pubitemid 34831171)
28. Zarubin T and Han J: Activation and signalling of p38 MAP kinase pathway. Cell Res 15: 11-18, 2005. (Pubitemid 41653958)
29. So KS, Oh JE, Han JH, Jung HK, Lee YS, Kim SH, Chun YJ and Kim MY: Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt. Arch Pharm Res 31: 438-444, 2008.
30. Van Laethem A, Van Kelst S, Lippens S, Declerq W, Vandenabeele P, Janssens S, Vandenheede JR, Garmyn M and Agostinis P: Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes. FASEB J 18: 1946-1948, 2004.
31. Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ Jr and Appella E: Amplification of PPMlD in human tumors abrogates p53 tumor-suppressor activity. Nat Genet 31: 210-215, 2002.
32. Bradham C and McClay DR: P38 MAPK in development and cancer. Cell Cycle 5: 824-828, 2006.
33. Chen C and Kong AN: Dietary cancer-chemopreventive compounds: from signaling and gene expression to pharmacological effects. Trends Pharmacol Sci 26: 318-326, 2005. (Pubitemid 40733525)
34. Hsu WH, Hsieh YS, Kuo HC, Teng CY, Huang HI, Wang CJ, Yang SF, Liou YS and Kuo WH: Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. Arch Toxicol 81: 719-728, 2007.