Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells

Apoptosis

Volumn 13, Issue 10, 2008, Pages 1232-1242

  Lamy, Virginie ^a   Roussi, Stamatiki ^a   Chaabi, Mehdi ^a   Gossé, Francine ^a   Lobstein, Annelise ^a   Raul, Francis ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Apoptosis; Caspases; Colon cancer; DR4 DR5; Lupulone; Mitochondria; TRAIL

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR 4; DEATH RECEPTOR 5; LUPULON; PROTEIN BID; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR;

ARTICLE; CELL DEATH; COLON CANCER; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; METASTASIS; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANTIBODIES, BLOCKING; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASES; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYTOCHROMES C; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ENZYME INHIBITORS; HUMANS; MITOCHONDRIAL MEMBRANES; MODELS, BIOLOGICAL; NEOPLASM METASTASIS; OXIDATIVE STRESS; PERMEABILITY; REACTIVE OXYGEN SPECIES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TERPENES; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 51749087895     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-008-0250-5     Document Type: Article

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