The role of chemokines in acute liver injury

Frontiers in Physiology

Volumn 3 JUN, Issue , 2012, Pages

  Saiman, Yedidya ^a   Friedman, Scott L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Acute liver injury; Chemokines

Indexed keywords

EID: 84866376202     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00213     Document Type: Review

References (130)

1. Ajuebor, M. N., Carey, J. A., and Swain, M. G. (2006). CCR5 in T cell-mediated liver diseases: what's going on? J. Immunol. 177, 2039-2045.
2. Ajuebor, M. N., Hogaboam, C. M., Le, T., and Swain, M. G. (2003). C-C chemokine ligand 2/mono-cyte chemoattractant protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotec-tive in T cell-mediated hepatitis in the mouse. J. Immunol. 170, 5252-5259.
3. Ajuebor, M. N., Wondimu, Z., Hogaboam, C. M., Le, T., Proudfoot, A. E., and Swain, M. G. (2007). CCR5 deficiency drives enhanced natural killer cell trafficking to and activation within the liver in murine T cell-mediated hepatitis. Am. J. Pathol. 170, 1975-1988.
4. Antoniades, C. G., Quaglia, A., Taams, L. S., Mitry, R. R., Hussain, M., Abeles, R., Possamai, L. A., Bruce, M., Mcphail, M., Starling, C., Wagner, B., Barnardo, A., Pomplun, S., Auzinger, G., Bernal, W., Heaton, N., Vergani, D., Thursz, M. R., and Wen-don, J. (2012). Source and characterisation of hepatic macrophages in acetaminophen-induced acute liver failure in humans. Hepatology. doi: 10.1002/hep.25657. [Epub ahead of print].
5. Aoyama, T., Inokuchi, S., Brenner, D. A., and Seki, E. (2010). CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology 52, 1390-1400.
6. Apolinario, A., Majano, P. L., Alvarez-Perez, E., Saez, A., Lozano, C., Vargas, J., and Garcia-Monzon, C. (2002). Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease. Am. J. Gastroenterol. 97, 2861-2870.
7. Bajetto, A., Bonavia, R., Barbero, S., and Schettini, G. (2002). Characterization of chemokines and their receptors in the central nervous system: physiopathologi-cal implications. J. Neurochem. 82, 1311-1329.
8. Baldo, G., Giugliani, R., Uribe, C., Belar-dinelli, M. C., Duarte, M. E., Meurer, L., Da Silveira, T. R., and Matte, U. (2010). Bone marrow mononu-clear cell transplantation improves survival and induces hepatocyte proliferation in rats after CCl(4) acute liver damage. Dig. Dis. Sci. 55, 3384-3392.
9. Berres, M. L., Trautwein, C., Zaldivar, M. M., Schmitz, P., Pauels, K., Lira, S. A., Tacke, F., and Wasmuth, H. E. (2009). The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo. Biol. Chem. 390, 1039-1045.
10. Bone-Larson, C. L., Hogaboam, C. M., Evanhoff, H., Strieter, R. M., and Kunkel, S. L. (2001). IFN-gamma-inducible protein-10 (CXCL10) is hepatoprotective during acute liver injury through the induction of CXCR2 on hepatocytes. J. Immunol. 167, 7077-7083.
11. Bromley, S. K., Mempel, T. R., and Luster, A. D. (2008). Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat. Immunol. 9, 970-980.
12. Campbell, J. J., Hedrick, J., Zlotnik, A., Siani, M. A., Thompson, D. A., and Butcher, E. C. (1998). Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 279, 381-384.
13. Cao, X., Zhang, W., Wan, T., He, L., Chen, T., Yuan, Z., Ma, S., Yu, Y., and Chen, G. (2000). Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells. J. Immunol. 165, 2588-2595.
14. Chen, S., Tuttle, D. L., Oshier, J. T., Knot, H. J., Streit, W J., Good-enow, M. M., and Harrison, J. K. (2005). Transforming growth factor-beta1 increases CXCR4 expression, stromal-derived factor-1alpha-stimulated signalling and human immunodeficiency virus-1 entry in human monocyte-derived macrophages. Immunology 114, 565-574.
15. Chen, X., Xu, C., Zhang, F., and Ma, J. (2010). Comparative analysis of expression profiles of chemokines, chemokine receptors, and components of signaling pathways mediated by chemokines in eight cell types during rat liver regeneration. Genome 53, 608-618.
16. Chen, Y. X., Sato, M., Kawachi, K., and Abe, Y. (2006). Neutrophil-mediated liver injury during hepatic ischemia-reperfusion in rats. HBPD INT 5, 436-442.
17. Christopher, M. J., and Link, D. C. (2007). Regulation of neutrophil homeostasis. Curr. Opin. Hematol. 14, 3-8.
18. Clarke, C., Kuboki, S., Sakai, N., Kas-ten, K. R., Tevar, A. D., Schuster, R., Blanchard, J., Caldwell, C. C., Edwards, M. J., and Lentsch, A. B. (2011). CXC chemokine receptor-1 is expressed by hepatocytes and regulates liver recovery after hepatic ischemia/reperfusion injury. Hepatology 53, 261-271.
19. Cole, K. E., Strick, C. A., Paradis, T. J., Ogborne, K. T., Loetscher, M., Gladue, R. P., Lin, W., Boyd, J. G., Moser, B., Wood, D. E., Sahagan, B. G., and Neote, K. (1998). Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J. Exp. Med. 187, 2009-2021.
20. Crosby, H. A., Lalor, P. F., Ross, E., Newsome, P. N., and Adams, D. H. (2009). Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4. J.Hepatol. 51, 734-749.
21. Dai, S., Yuan, F., Mu, J., Li, C., Chen, N., Guo, S., Kingery, J., Prabhu, S. D., Bolli, R., and Rokosh, G. (2010). Chronic AMD3100 antagonism of SDF-1alpha-CXCR4 exacerbates cardiac dysfunction and remodeling after myocardial infarction. J. Mol. Cell. Cardiol. 49, 587-597.
22. Dambach, D. M., Watson, L. M., Gray, K. R., Durham, S. K., and Laskin, D. L. (2002). Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotox-icity in the mouse. Hepatology 35, 1093-1103.
23. Damon, L. E. (2009). Mobilization of hematopoietic stem cells into the peripheral blood. Expert Rev. Hematol. 2, 717-733.
24. Dong, Z., Zhang, C., Wei, H., Sun, R., and Tian, Z. (2005). Impaired NK cell cytotoxicity by high level of interferon-gamma in concanavalin A-induced hepatitis. Can. J. Physiol. Pharmacol. 83, 1045-1053.
25. Duffield, J. S. (2003). The inflammatory macrophage: a story of Jekyll and Hyde. Clin. Sci. 104, 27-38.
26. Duffield, J. S., Forbes, S. J., Constandi-nou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., and Iredale, J. P. (2005). Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.J. Clin. Invest. 115, 56-65.
27. Efsen, E., Grappone, C., Defranco, R. M., Milani, S., Romanelli, R. G., Bonac-chi,A., Caligiuri,A.,Failli,P.,Annun-ziato, F., Pagliai, G., Pinzani, M., Laffi, G., Gentilini, P., and Marra, F. (2002). Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans. J. Hepatol. 37, 39-47.
28. Erhardt, A., Wegscheid, C., Claass, B., Carambia, A., Herkel, J., Mit-trucker, H. W., Panzer, U., and Tiegs, G. (2011). CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis. J. Immunol. 186, 5284-5293.
29. Farber, J. M. (1990). A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines. Proc. Natl. Acad. Sci. U.S.A. 87, 5238-5242.
30. Fernandez, E. J., and Lolis, E. (2002). Structure, function, and inhibition of chemokines. Annu. Rev. Pharmacol. Toxicol. 42, 469-499.
31. Friedman, S. L. (2008a). Hepatic fibrosis-overview. Toxicology 254, 120-129.
32. Friedman, S. L. (2008b). Hepatic stellate cells - protean, multifunctional, and enigmatic cells of the liver. Physiol. Rev. 88, 125-172.
33. Gangavarapu, P., Rajagopalan, L., Kolli, D., Guerrero-Plata, A., Garofalo, R. P., and Rajarathnam, K. (2012). The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment. J. Leukoc. Biol. 91, 259-265.
34. Gerritsma, J. S., Van Kooten, C., Ger-ritsen, A. F., Van Es, L. A., and Daha, M. R. (1998). Transforming growth factor-beta 1 regulates chemokine and complement production by human proximal tubular epithelial cells. Kidney Int. 53, 609-616.
35. Goddard, S., Williams, A., Morland, C., Qin, S., Gladue, R., Hubscher, S. G., and Adams, D. H. (2001). Differential expression of chemokines and chemokine receptors shapes the inflammatory response in rejecting human liver transplants. Transplantation 72, 1957-1967.
36. Groom, J. R., and Luster, A. D. (2011). CXCR3 ligands: redundant, collaborative and antagonistic functions. Immunol. Cell Biol. 89, 207-215.
37. Haringman, J. J., Gerlag, D. M., Smeets, T. J., Baeten, D., Van Den Bosch, E, Bresnihan, B., Breedveld, F. C., Dinant, H. J., Legay, F., Gram, H., Loetscher, P., Schmouder, R., Wood-worth, T., and Tak, P. P. (2006). A randomized controlled trial with an anti-CCL2 (anti-monocyte chemo-tactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum. 54, 2387-2392.
38. Harvey, C. E., Post, J. J., Palladinetti, P., Freeman, A. J.,Ffrench,R. A., Kumar, R. K., Marinos, G., and Lloyd, A. R. (2003). Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation. J. Leukoc. Biol. 74, 360-369.
39. Hassan, M., Selimovic, D., Ghozlan, H., and Abdel-Kader, O. (2007). Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation. Cell Signal. 19, 301-311.
40. Hitchon, C., Wong, K., Ma, G., Reed, J., Lyttle, D., and El-Gabalawy, H. (2002). Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by syn-ovialfibroblasts. Arthritis Rheum. 46, 2587-2597.
41. Hogaboam, C. M., Bone-Larson, C. L., Steinhauser, M. L., Lukacs, N. W., Colletti, L. M., Simpson, K. J., Strieter, R. M., and Kunkel, S. L. (1999a). Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines. FASEB J. 13, 1565-1574.
42. Hogaboam, C. M., Simpson, K. J., Chensue, S. W., Steinhauser, M. L., Lukacs, N. W., Gauldie, J., Strieter, R. M., and Kunkel, S. L. (1999b). Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury. Gene Ther. 6, 573-584.
43. Hogaboam, C. M., Bone-Larson, C. L., Steinhauser, M. L., Matsukawa, A., Gosling, J., Boring, L., Charo, I. E, Simpson, K. J., Lukacs, N. W., and Kunkel, S. L. (2000). Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2. Am. J. Pathol. 156, 1245-1252.
44. Hokeness, K. L., Deweerd, E. S., Munks, M. W., Lewis, C. A., Gladue, R. P., and Salazar-Mather, T. P. (2007). CXCR3-dependent recruitment of antigen-specific T lymphocytes to the liver during murine cytomegalovirus infection. J. Virol. 81, 1241-1250.
45. Hokeness, K. L., Kuziel, W. A., Biron, C. A., and Salazar-Mather, T. P. (2005). Monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha/beta-induced inflammatory responses and antiviral defense in liver. J. Immunol. 174, 1549-1556.
46. Holt, M. P., Cheng, L., and Ju, C. (2008). Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury.J. Leukoc. Biol. 84, 1410-1421.
47. Hong, F., Tuyama, A., Lee, T. F., Loke, J., Agarwal, R., Cheng, X., Garg, A., Fiel, M. I., Schwartz, M., Walewski, J., Branch, A., Schecter, A. D., and Bansal, M. B. (2009). Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation. Hepatology 49, 2055-2067.
48. Horiguchi, K., Kitagawa-Sakakida, S., Sawa, Y., Li, Z. Z., Fukushima, N., Shirakura, R., and Matsuda, H. (2002). Selective chemokine and receptor gene expressions in allo-grafts that develop transplant vascu-lopathy.J. HeartLungTransplant. 21, 1090-1100.
49. Hu, B., and Colletti, L. M. (2010). CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity. Hepatology 52, 691-702.
50. Ilmakunnas, M., Hockerstedt, K., Mak-isalo, H., Siitonen, S., Repo, H., and Pesonen, E. J. (2010). Hepatic IL-8 release during graft procurement is associated with impaired graft function after human liver transplantation. Clin. Transplant. 24, 29-35.
51. Inagaki, Y., Nemoto, T., Kushida, M., Sheng, Y., Higashi, K., Ikeda, K., Kawada, N., Shirasaki, F., Take-hara, K., Sugiyama, K., Fujii, M., Yamauchi, H., Nakao, A., De Crom-brugghe, B., Watanabe, T., and Okazaki, I. (2003). Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology 38, 890-899.
52. Ishida, Y., Kondo, T., Kimura, A., Tsuneyama, K., Takayasu, T., and Mukaida, N. (2006). Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Eur. J. Immunol. 36, 1028-1038.
53. Jaeschke, H., Bautista, A. P., Spolar-ics, Z., and Spitzer, J. J. (1991). Superoxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Radic. Res. Commun. 15, 277-284.
54. Jaeschke, H., and Farhood, A. (2002). Kupffer cell activation after no-flow ischemia versus hemorrhagic shock. Free Radic. Biol. Med. 33, 210-219.
55. Jaeschke, H., Gores, G. J., Cederbaum, A. I., Hinson, J. A., Pessayre, D., and Lemasters, J. J. (2002). Mechanisms of hepatotoxicity. Toxicol. Sci. 65, 166-176.
56. James, L. P., Farrar, H. C., Darville, T. L., Sullivan, J. E., Givens, T. G., Kearns, G. L., Wasserman, G. S., Simpson, P. M., and Hinson, J. A. (2001). Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents. Clin. Pharmacol. Ther. 70, 280-286.
57. Jaruga, B., Hong, F., Kim, W. H., and Gao, B. (2004). IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role ofIRF-1. Am. J. Physiol. Gastrointest. Liver Physiol. 287, G1044-G1052.
58. Jin, S. Z., Meng, X. W., Han, M. Z., Sun, X., Sun, L. Y., and Liu, B. R. (2009). Stromal cell derived factor-1 enhances bone marrow mononu-clear cell migration in mice with acute liver failure. World J. Gastroen-terol. 15, 2657-2664.
59. Jin, S. Z., Meng, X. W., Sun, X., Han, M. Z., Liu, B. R., Wang, X. H., Sun, L. Y., Huang, Q., Zhao, R. B., Ban, X., Yu, H. Y., and Yu, H. W. (2010). Granulocyte colony-stimulating factor enhances bone marrow mononuclear cell homing to the liver in a mouse model of acute hepatic injury. Dig. Dis. Sci. 55, 2805-2813.
60. Ju, C., Reilly, T. P., Bourdi, M., Radonovich, M. F., Brady, J. N., George, J. W., and Pohl, L. R. (2002). Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice. Chem. Res. Toxicol. 15, 1504-1513.
61. Jujo, K., Hamada, H., Iwakura, A., Thorne, T., Sekiguchi, H., Clarke, T., Ito, A., Misener, S., Tanaka, T., Kly-achko, E., Kobayashi, K., Tongers, J., Roncalli, J., Tsurumi, Y., Hagi-wara, N., and Losordo, D. W. (2010). CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction. Proc. Natl. Acad. Sci. U.S.A. 107, 11008-11013.
62. Karlmark, K. R., Wasmuth, H. E., Trautwein, C., and Tacke, F. (2008). Chemokine-directed immune cell infiltration in acute and chronic liver disease. Expert Rev. Gastroenterol. Hepatol. 2, 233-242.
63. Karlmark, K. R., Weiskirchen, R., Zim-mermann, H. W., Gassler, N., Gin-houx, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., and Tacke, F. (2009). Hepatic recruitment of the inflammatory Gr1 + monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 50, 261-274.
64. Khurana, S., and Mukhopadhyay, A. (2007). Characterization of the potential subpopulation of bone marrow cells involved in the repair of injured liver tissue. Stem Cells 25, 1439-1447.
65. Kim, H. K., Kim, J. E., Chung, J., Han, K. S., and Cho, H. I. (2007). Surface expression of neutrophil CXCR4 is down-modulated by bacterial endo-toxin. Int. J. Hematol. 85, 390-396.
66. Kisseleva, T., Gigante, E., and Brenner, D A. (2010). Recent advances in liver stem cell therapy. Curr. Opin. Gastroenterol. 26, 395-402.
67. Kobayashi, Y (2008). The role of chemokines in neutrophil biology. Front. Biosci. 13, 2400-2407.
68. Kolios, G., Valatas, V., Manousou, P., Xidakis, C., Notas, G., and Kouroumalis, E. (2008). Nitric oxide and MCP-1 regulation in LPS activated rat Kupffer cells. Mol. Cell. Biochem. 319, 91-98.
69. Kollet, O., Shivtiel, S., Chen, Y. Q., Suriawinata, J., Thung, S. N., Dabeva, M. D., Kahn, J., Spiegel, A., Dar, A., Samira, S., Goichberg, P., Kalinkovich, A., Arenzana-Seisdedos, F., Nagler, A., Hardan, I., Revel, M., Shafritz, D. A., and Lapidot, T. (2003). HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver. J. Clin. Invest. 112, 160-169.
70. Krohn, N., Kapoor, S., Enami, Y., Fol-lenzi, A., Bandi, S., Joseph, B., and Gupta, S. (2009). Hepato-cyte transplantation-induced liver inflammation is driven by cytokines-chemokines associated with neutrophils and Kupffer cells. Gastroen-terology 136, 1806-1817.
71. Kuboki, S., Shin, T., Huber, N., Eis-mann, T., Galloway, E., Schuster, R., Blanchard, J., Edwards, M. J., and Lentsch, A. B. (2008). Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice. Hepatology 48, 1213-1223.
72. Laskin, D. L., Gardner, C. R., Price, V. E, and Jollow, D. J. (1995). Mod ulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology 21, 1045-1050.
73. Lei, Y., Liu, Z., Han, Q., Kang, W., Zhang, L., and Lou, S. (2010). G-CSF enhanced SDF-1 gradient between bone marrow and liver associated with mobilization of peripheral blood CD34+ cells in rats with acute liver failure. Dig. Dis. Sci. 55, 285-291.
74. Leifeld, L., Dumoulin, F. L., Purr, I., Janberg, K., Trautwein, C., Wolff, M., Manns, M. P., Sauerbruch, T., and Spengler, U. (2003). Early up-regulation of chemokine expression in fulminant hepatic failure. J. Pathol. 199, 335-344.
75. Li, N., Zhang, L., Li, H., and Fang, B. (2010). Human CD34+ cells mobilized by granulocyte colony-stimulating factor ameliorate radiation-induced liver damage in mice. Stem Cell Res. Ther. 1, 22.
76. Liekens, S., Schols, D., and Hatse, S. (2010). CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization. Curr. Pharm. Des. 16, 3903-3920.
77. Link, D. C. (2005). Neutrophil home-ostasis: a new role for stromal cell-derived factor-1. Immunol. Res. 32, 169-178.
78. Luker, K. E., Lewin, S. A., Mihalko, L. A., Schmidt, B. T., Winkler, J. S., Cog-gins, N. L., Thomas, D. G., and Luker, G. D. (2012). Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells. Oncogene. doi: 10.1038/onc.2011.633. [Epub ahead of print].
79. Luster, A. D., Unkeless, J. C., and Ravetch, J. V. (1985). Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315, 672-676.
80. Macias, J., Viloria, M. M., Rivero, A., De Los Santos, I., Marquez, M., Portilla, J., Di Lello, F., Camacho, A., Sanz-Sanz, J., Ojeda, G., Mata, R., Gomez-Mateos, J., and Pineda, J. A. (2012). Lack of short-term increase in serum mediators of fibro-genesis and in non-invasive markers of liver fibrosis in HIV/hepatitis C virus-coinfected patients starting maraviroc-based antiretroviral therapy. Eur. J. Clin. Microbiol. Infect. Dis. doi: 10.1007/s10096-012-1546-5. [Epub ahead of print].
81. Majumder, S., Zhou, L. Z., Chaturvedi, P., Babcock, G., Aras, S., and Ran-sohoff, R. M. (1998). p48/STAT-1alpha-containing complexes play a predominant role in induction of IFN-gamma-inducible protein, 10kDa(IP-10)byIFN-gammaalone or in synergy with TNF-alpha. J. Immunol. 161, 4736-4744.
82. Maksym, R. B., Tarnowski, M., Gry-mula, K., Tarnowska, J., Wysoczyn-ski, M., Liu, R., Czerny, B., Ratajczak, J., Kucia, M., and Ratajczak, M. Z. (2009). The role of stromal-derived factor-1-CXCR7 axis in development and cancer. Eur. J. Pharmacol. 625, 31-40.
83. Mark, A. L., Sun, Z., Warren, D. S., Lonze, B. E., Knabel, M. K., Melville Williams, G. M., Locke, J. E., Montgomery, R. A., and Cameron, A. M. (2010). Stem cell mobilization is life saving in an animal model of acute liver failure. Ann.Surg. 252, 591-596.
84. Medoff, B. D., Wain, J. C., Seung, E., Jackobek, R., Means, T. K., Ginns, L. C., Farber, J. M., and Luster, A. D. (2006). CXCR3 and its ligands in a murine model of obliterative bron-chiolitis: regulation and function. J. Immunol. 176, 7087-7095.
85. Michael, S. L., Pumford, N. R., Mayeux, P. R., Niesman, M. R., and Hinson, J. A. (1999). Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. Hepatology 30, 186-195.
86. Mukaida, N., and Baba, T. (2012). Chemokines in tumor development and progression. Exp. Cell Res. 318, 95-102.
87. Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kita-mura, Y., Yoshida, N., Kikutani, H., and Kishimoto, T. (1996). Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382, 635-638.
88. Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Mat-sushima, K., Yamamoto, K., Morita, Y., and Hirai, K. (2002). Cytokine-mediated regulation of CXCR4 expression in human neutrophils. J. Leukoc.Biol. 71, 711-717.
89. Nasser, M. W., Raghuwanshi, S. K., Grant, D. J., Jala, V. R., Rajarath-nam, K., and Richardson, R. M. (2009). Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer. J. Immunol. 183, 3425-3432.
90. Oertel, M., and Shafritz, D. A. (2008). Stem cells, cell transplantation and liver repopulation. Biochim. Biophys. Acta 1782, 61-74.
91. Ohmori, Y., and Hamilton, T. A. (1993). Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. J. Biol. Chem. 268, 6677-6688.
92. Ohmori, Y., and Hamilton, T. A. (1997). IL-4-induced STAT6 suppresses IFN-gamma-stimulated STAT1-dependent transcription in mouse macrophages. J. Immunol. 159, 5474-5482.
93. Ohmori, Y., Schreiber, R. D., and Hamilton, T. A. (1997). Syn-ergybetween interferon-gamma and tumor necrosis factor-alpha in tran-scriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB. J. Biol. Chem. 272, 14899-14907.
94. Ohmori, Y., Wyner, L., Narumi, S., Armstrong, D., Stoler, M., and Hamilton, T. A. (1993). Tumor necrosis factor-alpha induces cell type and tissue-specific expression of chemoattrac-tant cytokines in vivo. Am. J. Pathol. 142, 861-870.
95. Oo, Y. H., Shetty, S., and Adams, D. H. (2010). The role of chemokines in the recruitment of lymphocytes to the liver. Dig. Dis. 28, 31-44.
96. Peled, A., Grabovsky, V., Habler, L., Sandbank, J., Arenzana-Seisdedos, E, Petit, I., Ben-Hur, H., Lapidot, T., andAlon, R. (1999). The chemokine SDF-1 stimulates integrin-mediated arrest of CD34(+) cells on vascular endothelium under shear flow. J. Clin. Invest. 104, 1199-1211.
97. Possamai, L. A., Antoniades, C. G., Anstee, Q. M., Quaglia, A., Ver-gani, D., Thursz, M., and Wendon, J. (2010). Role of monocytes and macrophages in experimental and human acute liver failure. World J. Gastroenterol. 16,1811-1819.
98. Proudfoot, A. E., Power, C. A., and Schwarz, M. K. (2010). Anti-chemokine small molecule drugs: a promising future? Expert Opin. Investig. Drugs 19, 345-355.
99. Ramaiah, S. K., and Jaeschke, H. (2007). Role of neutrophils in the patho-genesis of acute inflammatory liver injury. Toxicol. Pathol. 35, 757-766.
100. Rossi, D. L., Hurst, S. D., Xu, Y., Wang, W., Menon, S., Coffman, R. L., and Zlotnik, A. (1999). Lungkine, a novel CXC chemokine, specifically expressed by lung bron-choepithelial cells. J. Immunol. 162, 5490-5497.
101. Sahin, H., Borkham-Kamphorst, E., Kuppe, C., Zaldivar, M. M., Grouls, C., Al-Samman, M., Nellen, A., Schmitz, P., Heinrichs, D., Berres, M. L., Doleschel, D., Scholten, D., Weiskirchen, R., Moeller, M. J., Kiessling, F., Trautwein, C., and Wasmuth, H. E. (2012). The chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice. Hepatology. doi: 10.1002/hep.25545. [Epub ahead of print].
102. Sakai, N., Kuboki, S., Van Sweringen, H. L., Tevar, A. D., Schuster, R., Blan-chard, J., Edwards, M. J.,and Lentsch, A. B. (2011). CXCR1 deficiency does not alter liver regeneration after partial hepatectomy in mice. Transplant. Proc. 43, 1967-1970.
103. Santiago, B., Calonge, E., Del Rey, M. J., Gutierrez-Canas, I., Izquierdo, E., Usategui, A., Galindo, M., Alcami, J., and Pablos, J. L. (2011). CXCL12 gene expression is upregulated by hypoxia and growth arrest but not by inflammatory cytokines in rheumatoid synovial fibroblasts. Cytokine 53, 184-190.
104. Sartina, E., Suguihara, C., Ramchan-dran, S., Nwajei, P., Rodriguez, M., Torres, E., Hehre, D., Devia, C., Walters, M. J., Penfold, M. E., and Young, K. C. (2012). Antagonism of CXCR7 attenuates chronic hypoxia-induced pulmonary hypertension. Pediatr. Res. 71, 682-688.
105. Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., and Takahashi, T. A. (2000). TGF-beta 1 reciprocally controls chemotaxis of human peripheral blood monocyte-derived dendritic cells via chemokine receptors. J. Immunol. 164, 2285-2295.
106. Sawitza, I., Kordes, C., Reister, S., and Haussinger, D. (2009). The niche of stellate cells within rat liver. Hepatology 50, 1617-1624.
107. Schioppa, T., Uranchimeg, B., Saccani, A., Biswas, S. K., Doni, A., Rapis-arda, A., Bernasconi, S., Saccani, S., Nebuloni, M., Vago, L., Mantovani, A., Melillo, G., and Sica, A. (2003). Regulation of the chemokine receptor CXCR4 by hypoxia. J. Exp. Med. 198, 1391-1402.
108. Schrage, A., Wechsung, K., Neumann, K., Schumann, M., Schulzke, J. D., Engelhardt, B., Zeitz, M., Hamann, A., and Klugewitz, K. (2008). Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines. Hepatology 48, 1262-1272.
109. Schwabe, R. F., Bataller, R., and Brenner, D. A. (2003). Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am. J. Physiol. Gastrointest. Liver Physiol. 285, G949-G958.
110. Seki, E., De Minicis, S., Gwak, G. Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., and Schwabe, R. F. (2009). CCR1 and CCR5 promote hepatic fibrosis in mice.J. Clin. Invest. 119, 1858-1870.
111. Shafritz, D. A., Oertel, M., Menthena, A., Nierhoff, D., and Dabeva, M. D. (2006). Liver stem cells and prospects for liver reconstitution by transplanted cells. Hepatology 43, S89-S98.
112. Shi, X. L., Gu, J. Y., Han, B., Xu, H. Y., Fang, L., and Ding, Y. T. (2010). Magnetically labeled mes-enchymal stem cells after autologous transplantation into acutely injured liver. World J. Gastroenterol. 16, 3674-3679.
113. Shibuta, K., Mori, M., Shimoda, K., Inoue, H., Mitra, P., and Barnard, G. F. (2002). Regional expression of CXCL12/CXCR4 in liver and hepatocellular carcinoma and cell-cycle variation during in vitro differentiation. Jpn. J. Cancer Res. 93, 789-797.
114. Shields, P. L., Morland, C. M., Salmon, M., Qin, S., Hubscher, S. G., and Adams, D. H. (1999). Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. J. Immunol. 163, 6236-6243.
115. Stefanovic, L., and Stefanovic, B. (2006). Mechanism of direct hepatotoxic effect of KC chemokine: sequential activation of gene expression and progression from inflammation to necrosis. J. Interferon Cytokine Res. 26, 760-770.
116. Steib, C. J., Bilzer, M., Hartl, J. M., Beitinger, F., Gulberg, V., Goke, B., and Gerbes, A. L. (2010). Kupffer cell activation by hydrogen peroxide: a new mechanism of portal pressure increase. Shock 33, 412-418.
117. Takami, T., Terai, S., and Sakaida, I. (2012). Stem cell therapy in chronic liver disease. Curr. Opin. Gastroenterol. 28, 203-208.
118. Tensen, C. P., Flier, J., Rampersad, S. S., Sampat-Sardjoepersad, S., Scheper, R. J., Boorsma, D. M., and Willemze, R. (1999). Genomic organization, sequence and transcriptional regulation of the human CXCL 11(1) gene. Biochim. Biophys. Acta 1446, 167-172.
119. Trebst, C., Sorensen, T. L., Kivisakk, P., Cathcart, M. K., Hesselgesser, J., Horuk, R., Sellebjerg, F., Lass-mann, H., and Ransohoff, R. M. (2001). CCR1+/CCR5+ mononu-clear phagocytes accumulate in the central nervous system of patients with multiple sclerosis. Am. J. Pathol. 159, 1701-1710.
120. Tsou, C. L., Peters, W., Si, Y., Slaymaker, S., Aslanian, A. M., Weisberg, S. P., Mack, M., and Charo, I. F. (2007). Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J. Clin. Invest. 117, 902-909.
121. Vergunst, C. E., Gerlag, D. M., Lopatin-skaya, L., Klareskog, L., Smith, M. D., Van Den Bosch, F., Dinant, H. J., Lee, Y., Wyant, T., Jacobson, E. W., Baeten, D., and Tak, P. P. (2008). Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial. Arthritis Rheum. 58, 1931-1939.
122. Wald, O., Pappo, O., Safadi, R., Dagan-Berger, M., Beider, K., Wald, H., Franitza, S., Weiss, I., Avniel, S., Boaz, P., Hanna, J., Zamir, G., Eid, A., Man-delboim, O., Spengler, U., Galun, E., and Peled, A. (2004). Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Eur. J. Immunol. 34, 1164-1174.
123. Wasmuth, H. E., Lammert, F., Zal-divar, M. M., Weiskirchen, R., Heller-brand, C., Scholten, D., Berres, M. L., Zimmermann, H., Streetz, K. L., Tacke, F., Hillebrandt, S., Schmitz, P., Keppeler, H., Berg, T., Dahl, E., Gassler, N., Friedman, S. L., and Trautwein, C. (2009). Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans. Gastroenterology 137, 309-319;319.e301-319.e303.
124. Wasmuth, H. E., Tacke, F., and Trautwein, C. (2010). Chemokines in liver inflammation and fibrosis. Semin. Liver Dis. 30, 215-225.
125. Yang, C. H., Wei, L., Pfeffer, S. R., Du, Z., Murti, A., Valentine, W J., Zheng, Y., and Pfeffer, L. M. (2007). Identification of CXCL11 as a STAT3-dependent gene induced by IFN. J. Immunol. 178, 986-992.
126. Zaldivar, M. M., Berres, M. L., Sahin, H., Nellen, A., Heinrichs, D., Schmitz, P., Gassler, N., Streetz, K. L., Trautwein, C., and Wasmuth, H. E. (2012). The chemokine receptor CXCR3 limits injury after acute toxic liver damage. Lab. Invest. 92, 724-734.
127. Zernecke, A., Bidzhekov, K., Noels, H., Shagdarsuren, E., Gan, L., Denecke, B., Hristov, M., Koppel, T., Jahantigh, M. N., Lutgens, E., Wang, S., Olson, E. N., Schober, A., and Weber, C. (2009). Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci. Signal. 2, ra81.
128. Zhao, W., Li, J. J., Cao, D. Y., Li, X., Zhang, L. Y., He, Y., Yue, S. Q., Wang, D. S., and Dou, K. F (2012). Intravenous injection of mesenchy-mal stem cells is effective in treating liver fibrosis. World J. Gastroenterol. 18, 1048-1058.
129. Zimmermann, H. W., Seidler, S., Gassler, N., Nattermann, J., Luedde, T., Trautwein, C., and Tacke, F (2011). Interleukin-8 is activated in patients with chronic liver diseases and associated with hepatic macrophage accumulation in human liver fibrosis. PLoS ONE 6, e21381. doi:10.1371/journal.pone.0021381
130. Zlotnik, A., Burkhardt, A. M., and Homey, B. (2011). Homeostatic chemokine receptors and organ-specific metastasis. Nat. Rev. Immunol. 11, 597-606.