Chronological aging in Saccharomyces cerevisiae

Sub-Cellular Biochemistry

Volumn 57, Issue , 2015, Pages 101-121

  Longo, Valter D ^a   Fabrizio, Paola ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITÉ DE LYON   (France)

Author keywords

Adaptive regrowth; Caloric restriction; Chronological aging; RAS; TOR (target of rapamycin)

Indexed keywords

MAMMALIA; SACCHAROMYCES CEREVISIAE;

AGING; ANIMAL; BIOLOGICAL MODEL; CALORIC INTAKE; CELL DIVISION; DNA DAMAGE; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; LONGEVITY; METABOLISM; NEOPLASM; OXIDATIVE STRESS; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TIME;

AGING; ANIMALS; CELL DIVISION; DNA DAMAGE; ENERGY INTAKE; ENERGY METABOLISM; GENE EXPRESSION REGULATION, FUNGAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LONGEVITY; MODELS, BIOLOGICAL; NEOPLASMS; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84866360129     PISSN: 03060225     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-94-007-2561-4_5     Document Type: Article

References (113)

1. Allen C, Buttner S, Aragon AD, Thomas JA, Meirelles O et al (2006) Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures. J Cell Biol 174:89–100
2. Ashrafi K, Sinclair D, Gordon JI, Guarente L (1999) Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 96:9100–9105
3. Barker MG, Walmsley RM (1999) Replicative ageing in the fission yeast Schizosaccharomyces pombe. Yeast 15:1511–1518
4. Borghouts C, Benguria A, Wawryn J, Jazwinski SM (2004) Rtg2 protein links metabolism and genome stability in yeast longevity. Genetics 166:765–777
5. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A (1996) Dwarf mice and the ageing process. Nature 384:33
6. Burtner CR, Murakami CJ, Kennedy BK, Kaeberlein M (2009) A molecular mechanism of chronological aging in yeast. Cell Cycle 8:1256–1270
7. Busuttil RA, Garcia AM, Cabrera C, Rodriguez A, Suh Y et al (2005) Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res 65:11271–11275
8. Castelein N, Hoogewijs D, De Vreese A, Braeckman BP, Vanfleteren JR (2008) Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Biotechnol J 3:803–812
9. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H et al (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292:104–106
10. Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB et al (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459:802–807
11. D’Mello NP, Childress AM, Franklin DS, Kale SP, Pinswasdi C et al (1994) Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J Biol Chem 269:15451–15459
12. Egilmez NK, Jazwinski SM (1989) Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. J Bacteriol 171:37–42
13. Enns LC, Morton JF, Treuting PR, Emond MJ, Wolf NS et al (2009) Disruption of protein kinase A in mice enhances healthy aging. PLoS One 4:e5963
14. Fabrizio P et al (2010), Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet 6(8):1227–1228
15. Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL et al (2004a) Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol 166:1055–1067
16. Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C et al (2005a) Sir2 blocks extreme life-span extension. Cell 123:655–667
17. Fabrizio P, Li L, Longo VD (2005b) Analysis of gene expression profile in yeast aging chronologically. Mech Ageing Dev 126:11–16
18. Fabrizio P, Liou LL, Moy VN, Diaspro A, Selverstone-Valentine J et al (2003) SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163:35–46
19. Fabrizio P, Longo VD (2003) The chronological life span of Saccharomyces cerevisiae. Aging Cell 2:73–81
20. Fabrizio P, Longo VD (2007) The chronological life span of Saccharomyces cerevisiae. Meth Mol Biol 371:89–95 View Article
21. Fabrizio P, Pletcher SD, Minois N, Vaupel JW, Longo VD (2004b) Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett 557:136–142
22. Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292:288–290
23. Flurkey K, Papaconstantinou J, Harrison DE (2002) The Snell dwarf mutation Pit1(dw) can increase life span in mice. Mech Ageing Dev 123:121–130
24. Friedman DB, Johnson TE (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118:75–86
25. Guevara-Aguirre J et al (2011) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med 3(70):70ra13
26. Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F et al (2007) Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem 282:32844–32855
27. Hansen M, Hsu AL, Dillin A, Kenyon C (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet 1:119–128
28. Hansen M, Taubert S, Crawford D, Libina N, Lee SJ et al (2007) Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 6:95–110
29. Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298–300
30. Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM et al (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392–395
31. Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J (2003) Aging and genome maintenance: lessons from the mouse? Science 299:1355–1359
32. Hertweck M, Gobel C, Baumeister R (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6:577–588
33. Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A et al (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421:182–187
34. Hu D, Cao P, Thiels E, Chu CT, Wu GY et al (2007) Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol Learn Mem 87:372–384
35. Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A (2003) Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J Gerontol A Biol Sci Med Sci 58:291–296
36. Jia K, Chen D, Riddle DL (2004) The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131:3897–3906
37. Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13:2570–2580
38. Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D et al (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310:1193–1196
39. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V et al (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14:885–890
40. Kennedy BK, Austriaco NRJ, Guarente L (1994) Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol 127:1985–1993
41. Kenyon C (2005) The plasticity of aging: insights from long-lived mutants. Cell 120:449–460
42. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (1997) daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277:942–946
43. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A et al (2005) Suppression of aging in mice by the hormone Klotho. Science 309:1829–1833
44. Ladiges W, Van Remmen H, Strong R, Ikeno Y, Treuting P et al (2009) Lifespan extension in genetically modified mice. Aging Cell 8:346–352
45. LaFever L, Drummond-Barbosa D (2005) Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila. Science 309:1071–1073
46. Larsen PL, Albert PS, Riddle DL (1995) Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139:1567–1583
47. Laun P, Rinnerthaler M, Bogengruber E, Heeren G, Breitenbach M (2006) Yeast as a model for chronological and reproductive aging – a comparison. Exp Gerontol 41:1208–1212
48. Lee CK, Klopp RG, Weindruch R, Prolla TA (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285:1390–1393
49. Lin K, Dorman JB, Rodan A, Kenyon C (1997) daf-16: An HNF-3/forkhead family member that can function to double the life-span ofCaenorhabditis elegans. Science 278:1319–1322
50. Lin YY, Lu JY, Zhang J, Walter W, Dang W et al (2009) Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell 136:1073–1084
51. Longo V (1997) The chronological life span of Saccharomyces cerevisiae. Studies of superoxide dismutase, Ras and Bcl-2. Thesis, University of California, Los Angeles, CA
52. Longo VD (2009) Linking sirtuins, IGF-I signaling, and starvation. Exp Gerontol 44:70–74
53. Longo VD, Fabrizio P (2002) Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans? Cell Mol Life Sci 59:903–908
54. Longo VD, Finch CE (2003) Evolutionary medicine: from dwarf model systems to healthy centenarians. Science 299:1342–1346
55. Longo VD, Gralla EB, Valentine JS (1996) Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo. J Biol Chem 271:12275–12280
56. Longo VD, Kennedy BK (2006) Sirtuins in aging and age-related disease. Cell 126:257–268
57. Longo VD, Lieber MR, Vijg J (2008) Turning anti-ageing genes against cancer. Nat Rev Mol Cell Biol 9:903–910
58. Longo VD, Liou LL, Valentine JS, Gralla EB (1999) Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 365:131–142
59. Longo VD, Mitteldorf J, Skulachev VP (2005) Programmed and altruistic ageing. Nat Rev Genet 6:866–872
60. Ludovico P, Sousa MJ, Silva MT, Leao C, Corte-Real M (2001) Saccharomyces cerevisiae commits to a programmed cell death process in response to acetic acid. Microbiology 147:2409–2415
61. Madeo F, Herker E, Wissing S, Jungwirth H, Eisenberg T et al (2004) Apoptosis in yeast. Curr Opin Microbiol 7:655–660
62. Madia F, Gattazzo C, Fabrizio P, Longo VD (2007) A simple model system for age-dependent DNA damage and cancer. Mech Ageing Dev 128(1):45–49
63. Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC et al (2008) Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. J Cell Biol 180:67–81
64. Madia F, Wei M, Yuan V, Hu J, Gattazzo C et al (2009) Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism. J Cell Biol 186:509–523
65. Mair W, Dillin A (2008) Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem 77:727–754
66. McElwee JJ, Schuster E, Blanc E, Thornton J, Gems D (2006) Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. Mech Ageing Dev 127:458–472
67. Medvedik O, Lamming DW, Kim KD, Sinclair DA (2007) MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol 5:e261
68. Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P et al (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402:309–313
69. Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phospatidylinositol-3-OH kinase family member regulating longevity and diapause inCaenorhbditis elegans. Nature 382:536–539
70. Mortimer RK (1959) Life span of individual yeast cells. Nature 183:1751–1752
71. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L et al (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389:994–999
72. Orr WC, Sohal RS (1994) Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263:1128–1130
73. Pages V, Bresson A, Acharya N, Prakash S, Fuchs RP et al (2008) Requirement of Rad5 for DNA polymerase zeta-dependent translesion synthesis in Saccharomyces cerevisiae. Genetics 180:73–82
74. Pan Y, Shadel GS (2009) Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density. Aging 1:131–145
75. Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G (1999) A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 13:1438–1452
76. Paradis S, Ruvkun G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12:2488–2498
77. Pfeifer GP (2000) p53 mutational spectra and the role of methylated CpG sequences. Mutat Res 450:155–166
78. Pinkston JM, Garigan D, Hansen M, Kenyon C (2006) Mutations that increase the life span of C. elegans inhibit tumor growth. Science 313:971–975
79. Polak P, Hall MN (2009) mTOR and the control of whole body metabolism. Curr Opin Cell Biol 21:209–218
80. Pollak MN, Schernhammer ES, Hankinson SE (2004) Insulin-like growth factors and neoplasia. Nat Rev Cancer 4:505–518
81. Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20:174–184
82. Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I et al (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras [see comments]. Nature 370:527–532
83. Rogina B, Helfand SL (2004) Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 101:15998–16003
84. Rohde JR, Bastidas R, Puria R, Cardenas ME (2008) Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr Opin Microbiol 11:153–160
85. Roux AE, Leroux A, Alaamery MA, Hoffman CS, Chartrand P et al (2009) Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast. PLoS Genet 5:e1000408
86. Roux AE, Quissac A, Chartrand P, Ferbeyre G, Rokeach LA (2006) Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell 5:345–357
87. Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE et al (2005) Extension of murine lifespan by overexpression of catalase targeted to mitochondria. Science 308(5730):1909–1911
88. Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ et al (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326:140–144
89. Sinclair DA, Guarente L (1997) Extrachromosomal rDNA circles – a cause of aging in yeast. Cell 91:1033–1042
90. Skeen JE, Bhaskar PT, Chen CC, Chen WS, Peng XD et al (2006) Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell 10:269–280
91. Steinkraus KA, Kaeberlein M, Kennedy BK (2008) Replicative aging in yeast: the means to the end. Annu Rev Cell Dev Biol 24:29–54
92. Strauss E (2001) Longevity. Growing old together. Science 292:41–43
93. Sun J, Folk D, Bradley TJ, Tower J (2002) Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics 161:661–672
94. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM et al (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292:107–110
95. Tatar M, Yin C (2001) Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms. Exp Gerontol 36:723–738
96. Tissenbaum HA, Guarente L (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410:227–230
97. Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D et al (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26:663–674
98. Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N et al (2003) Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 16:29–37
99. Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L et al (2003) Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426:620
100. Vergara M, Smith-Wheelock M, Harper JM, Sigler R, Miller RA (2004) Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant. J Gerontol A Biol Sci Med Sci 59:1244–1250
101. Vijg J (2007) Aging of the genome. Oxford University Press, Oxford
102. Wei M, Fabrizio P, Hu J, Ge H, Cheng C et al (2008) Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet 4:e13
103. Wei M, Fabrizio P, Madia F, Hu J, Ge H et al (2009) Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet 5:e1000467
104. Weinberger M, Feng L, Paul A, Smith DL Jr, Hontz RD et al (2007) DNA replication stress is a determinant of chronological lifespan in budding yeast. PLoS One 2:e748
105. Werner-Washburne M, Braun E, Johnston GC, Singer RA (1993) Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol Rev 57:383–401
106. Williams KD, Busto M, Suster ML, So AK, Ben-Shahar Y et al (2006) Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase. Proc Natl Acad Sci USA 103:15911–15915
107. Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A et al (2005) Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem 280:38029–38034
108. Yan L, Vatner DE, O’Connor JP, Ivessa A, Ge H et al (2007) Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130:247–258
109. Yoeli-Lerner M, Toker A (2006) Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle 5:603–605
110. Zaman S, Lippman SI, Schneper L, Slonim N, Broach JR (2009) Glucose regulates transcription in yeast through a network of signaling pathways. Mol Syst Biol 5:245
111. Zambrano MM, Kolter R (1996) GASPing for life in stationary phase. Cell 86:181–184
112. Zambrano MM, Siegele DA, Almiron M, Tormo A, Kolter R (1993) Microbial competition: Escherichia coli mutants that take over stationary phase cultures. Science 259:1757–1760
113. Zinser ER, Kolter R (2004) Escherichia coli evolution during stationary phase. Res Microbiol 155:328–336