Non-viral gene therapy for GDNF production in RCS rat: The crucial role of the plasmid dose

Gene Therapy

Volumn 19, Issue 9, 2012, Pages 886-898

  Touchard, E ^a,b   Heiduschka, P ^c,d   Berdugo, M ^a,b   Kowalczuk, L ^a,b   Bigey, P ^b,e,f,g   Chahory, S ^h   Gandolphe, C ^e   Jeanny, J C ^a,b   Behar Cohen, F ^a,b,i  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^e INSERM   (France)

^f Centre National de la Recherche Scientifique   (France)

^g PSL RESEARCH UNIVERSITY   (France)

^h ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

ⁱ HÔTEL DIEU   (France)

Author keywords

electroporation; GDNF; retina; retinal degeneration; toxicity

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CILIARY MUSCLE; CONTROLLED STUDY; DRUG EFFICACY; ELECTROPORATION; ELECTRORETINOGRAM; FEMALE; GENE MUTATION; MALE; MORPHOMETRICS; NONHUMAN; NONVIRAL GENE THERAPY; OPTOKINETIC STIMULATION; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RAT STRAIN; RETINA DEGENERATION; RETINITIS PIGMENTOSA;

ANIMALS; CILIARY NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; ELECTROPORATION; GENETIC THERAPY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; PHOTORECEPTOR CELLS, VERTEBRATE; PLASMIDS; RATS; RETINAL DEGENERATION; RETINITIS PIGMENTOSA;

RATTUS;

EID: 84866138813     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.154     Document Type: Article

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