Neuroprotective effect of subretinal implants in the RCS rat

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 2, 2005, Pages 674-682

  Pardue, Machelle T ^a,b   Phillips, Michael J ^a,b   Yin, Hang ^a,b   Sippy, Brian D ^b   Webb Wood, Sarah ^a,b   Chow, Alan Y ^c   Ball, Sherry L ^d  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Optobionics Corporation   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIC FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL DEGENERATION; CONTROLLED STUDY; ELECTRORETINOGRAPHY; ELECTROSTIMULATION; HISTOPATHOLOGY; IMPLANT; INTRAOCULAR FOREIGN BODY; NEUROPROTECTION; NONHUMAN; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA; RETINA MACULA AGE RELATED DEGENERATION; RETINA NEUROEPITHELIAL LAYER; RETINITIS PIGMENTOSA;

ANIMALS; CELL COUNT; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION THERAPY; ELECTRODES, IMPLANTED; ELECTRORETINOGRAPHY; NEUROPROTECTIVE AGENTS; PHOTORECEPTORS, VERTEBRATE; PROSTHESES AND IMPLANTS; PROSTHESIS IMPLANTATION; RATS; RATS, MUTANT STRAINS; RETINA; RETINAL DEGENERATION;

EID: 13944267454     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0515     Document Type: Article

References (54)

1. Bennett J, Tanabe T, Sun D, et al. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy. Nat Med. 1996;2:649-654.
2. LaVail MM, Yasumura D, Matthes MT, et al. Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and later-stage therapy. Proc Natl Acad Sci USA. 2000;97:11488-11493.
3. Acland GM, Aguirre GD, Ray J, et al. Gene therapy restores vision in a canine model of childhood blindness. Nat Genet. 2001;28: 92-95.
4. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature. 1990;347: 83-86.
5. LaVail MM, Unoki K, Yasumura D, Matthes MT, Yancopoulos GD, Steinberg RH. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc Nat Acad Sci USA. 1992;89:11249-11253.
6. Armant RB, Seiler MJ. Transplanted sheets of human retina and retinal pigmented epithelium develop normally in nude rats. Exp Eye Res. 2002;75:115-125.
7. Lund RD, Ono SJ, Keegan DJ, Lawrence JM. Retinal transplantation: progress and problems in clinical application. J Leukoc Biol. 2003;74:151-160.
8. Peachey NS, Chow AY. Subretinal implantation of semiconductor-based photodiodes: progress and challenges. J Rehab Res Dev. 1999;36:371-376.
9. Rizzo JF III, Wyatt J, Humayaun M, et al. Retinal prosthesis: an encouraging first decade with major challenges ahead. Ophthalmology. 2001;108:13-14.
10. Margalit E, Maia M, Weiland JD, et al. Retinal prosthesis for the blind. Surv Ophthalmol. 2002;47:335-356.
11. Zrenner E. Will retinal implants restore vision? Science. 2002;295: 1022-1025.
12. Tao W, Wren R, Goddard MB, et al. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2002;43: 3292-3298.
13. Lau D, McGee LH, Zhou S, et al. Retinal degeneration is slowed in transgenic rats by AAV-mediated delivery of FGF-2. Invest Ophthalmol Vis Sci. 2000;41:3622-3633.
14. Miyazaki M, Ikeda Y, Yonemitsu Y, et al. Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats. Gene Ther. 2003;10:1503-1511.
15. Rizzo JF III, Wyatt J. Prospects for a visual prosthesis. The Neuroscientist. 1997;3:251-262.
16. Humayun M, Propst R, de Juan E, McCormick K, Hickingbotham D. Bipolar surface electrical stimulation of the vertebrate retina. Arch Ophthalmol. 1994;112:110-116.
17. Humayun MS, Weiland JD, Fuji GY, et al. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vision Res. 2003;43:2573-2581.
18. Chow AY, Chow VY, Peyman GA, Packo KH, Pollack JS, Schuchard R. The artificial silicon retina™ (ASR™) chip for the treatment of vision loss from retinitis pigmentosa. Arch Ophthalmol. 2004;122: 460-469.
19. Hartmann M, Heumann R, Lessmann V. Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. EMBO J. 2001;20:5887-5897.
20. Balkowiec A, Katz DM. Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. J Neurosci. 2002;22:10399-10407.
21. Gartner A, Staiger V. Neurotrophin secretion from hippocampal neurons evoked by long-term-potentiation-inducing electrical stimulation patterns. Proc Natl Acad Sci USA. 2002;99:6383-6391.
22. Andrews RJ. Neuroprotection trek: the next generation-neuromodulation II. Applications: epilepsy, nerve regeneration, neurotrophins. Ann NY Acad Sci. 2003;993:14-24.
23. Morimoto T, Miyoshi T, Fujikado T, Tano Y, Fukuda Y. Electrical stimulation enhances the survival of axotomized retinal ganglion cells in vivo. Neuroreport. 2002;13:227-229.
24. Wen R, Song Y, Cheng T, et al. Injury-induced upregulation of bFGF and CNTF mRNAs in the rat retina. J Neurosci. 1995;15: 7377-7385.
25. Cao W, Wen R, Li F, LaVail MM, Steinberg RH. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina. Exp Eye Res. 1997;65:241-248.
26. Cao W, Li F, Steinberg RH, LaVail MM. Development of normal and injury-induced gene expression of aFGF, bFGF, CNTF, BDNF, GFAP, and IGF-I in the rat retina. Exp Eye Res. 2001;72:591-604.
27. D Cruz PM, Yasumura D, Weir J, et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet. 2000;9:645-651.
28. Bok D, Hall MO. The role of the pigment epithelium in the etiology of inherited retinal dystrophy in the rat. J Cell Biol. 1971;49:664-682.
29. Mullen RJ, LaVail MM. Inherited retinal dystrophy: primary defect in pigment epithelium determined with experimental rat chimeras. Science 1976;192:799-801.
30. LaVail MM, Battelle BA. Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. Exp Eye Res. 1975;21:167-192.
31. Chow AY, Pardue MT, Perlman JI, et al. Subretinal implantation of semiconductor-based-photodiodes: durability of novel implant designs. J Rehabil Res Dev. 2002;39:313-321.
32. Chow AY, Pardue MT, Vhow VY, et al. Implantation of silicon chip microphotodiode arrays into the cat subretinal space. IEEE Trans Neural Syst Rehabil Eng. 2001;9:86-95.
33. Ball SL, Pardue MT, Chow AY, Chow VY, Peachey NS. Subretinal degeneration of photodiodes in rodent models of photoreceptor degeneration. In: Anderson RE, LaVail MM, Hollyfield JG, eds. New Insights into Retinal Degenerative Diseases. New York: Kluwer/Plenum; 2001:175-182.
34. Pardue MT, Stubbs EB Jr, Perlman JI, Narfstrom K, Chow AY, Peachey NS. Immunohistochemical studies of the retina following long-term implantation with subretinal microphotodiode arrays. Exp Eye Res. 2001;73:333-343.
35. Ball SL, Petry HM. Nonninvasive assessment of retinal function in rats using multifocal electroretinography. Invest Ophthalmol Vis Sci. 2000;41:610-617.
36. Al-Majed AA, Neumann CM, Brushart TM, Gordon T. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci. 2000;20:2602-2608.
37. Al-Majed AA, Brushart TM, Gordon T. Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons. Eur J Neurosci. 2000;12:4381-4390.
38. Gottschalk W, Pozzo-Miller LD, Figurov A, Lu B. Presynaptic modulation of synaptic transmission and plasticity by brain-derived neurotrophic factor in the developing hippocampus. J Neurosci. 1998;18:6830-6839.
39. Huber KM, Sawtell NB, Bear MF. Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex. Neuropharmacology. 1998;37:571-579.
40. Carter AR, Chen C, Schwartz PM, Segal RA. Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. J Neurosci. 2002;22:1316-1327.
41. Goldberg JL, Espinose JS, Xu Y, Davidson N, Kovasx GT, Barres BA. Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity. Neuron. 2002;33:689-702.
42. Watanabe M, Fukuda Y. Survival and axonal regeneration of retinal ganglion cells in adult cats. Prog Retin Eye Res. 2002;21:529-553.
43. Chaum E. Retinal neuroprotection by growth factors: a mechanistic perspective. J Cell Biochem. 2003;88:57-75.
44. Ikeda K, Tanihara H, Tatsuno T, Noguchi H, Nakayama C. Brain-derived neurotrophic factor shows a protective effect and improves recovery of the ERG b-wave response in light damage. J Neurochem. 2003;87:290-296.
45. Bok D, Yasumura D, Matthes MT, et al. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res. 2002;74:719-735.
46. Okoye G, Zimmer J, Sung J, et al. Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. J Neurosci. 2003;23:4164-4172.
47. Faktorovich EG, Steinberg RH, Yasumura D, Matthes MT, LaVail MM. Basic fibroblast growth factor and local injury protect photo-receptors from light damage in the rat. J Neurosci. 1992;12:3554-3567.
48. Humphrey MF, Parker C, Chu Y, Constable IJ. Transient preservation of photoreceptors on the flanks of argon laser lesions in the RCS rat. Curr Eye Res. 1993;12:367-372.
49. Gal A, Li Y, Thompson DA, et al. Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet. 2000;26:270-271.
50. Woch G, Aramant RB, Seiler MJ, Sagdullaev BT, McCall MA. Retinal transplants restore visually evoked responses' in rate with photo-receptor degeneration. Invest Ophthalmol Vis Sci. 2001;42:1669-1676.
51. Sagdullaev BT, Aramant RB, Seiler MJ, Woch G, McCall MA. Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2003;44:1686-1695.
52. Xiao M, Sastry MS, Li ZY, et al. Effects of retinal laser photocoagulation on photoreceptor basic fibroblast growth factor and survival. Invest Ophthalmol Vis Sci. 1998;39;618-630.
53. Sieving PA, Frishman LJ, Steinberg RH. Scotopic threshold response of proximal retina in cat. J Neurophys. 1986;56:1049-1061.
54. Bush RA, Hawks KW, Sieving PA. Preservation of inner retinal responses in the aged Royal College of Surgeons rat evidence against glutamate excitotoxicity in photoreceptor degeneration. Invest Ophthalmol Vis Sci. 1995;36:2054-2062.