Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis

Neurobiology of Disease

Volumn 7, Issue 6, 2000, Pages 586-599

  Nandrot, Emeline ^a   Dufour, Eric M ^a   Provost, Alexandra C ^a   Péquignot, Marie O ^a   Bonnel, Sébastien ^a   Gogat, Karïn ^a   Marchant, Dominique ^a   Rouillac, Christelle ^a   Sépulchre de Condé, Bertille ^a   Bihoreau, Marie Thérèse ^b   Shaver, Cindi ^a   Dufier, Jean Louis ^a   Marsac, Cécile ^a   Lathrop, Mark ^c   Menasche, Maurice ^a   Abitbol, Marc M ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CENTRE NATIONAL DE GÉNOTYPAGE   (France)

Author keywords

Apoptosis; C mer; Macrophages; Phagocytosis; RCS rats; Retinal pigment epithelium

Indexed keywords

COMPLEMENTARY DNA; TYROSINE KINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CELL ADHESION; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE MAPPING; GENETIC SCREENING; HOMOZYGOSITY; MALE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; RETINA ROD OUTER SEGMENT; RETINITIS PIGMENTOSA; SEQUENCE ANALYSIS;

EID: 0034525303     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0328     Document Type: Article

References (61)

1. A linkage map of the rat genome derived from three F2 crosses
2. Hereditary degeneration of rat retina
3. An integrated genetic linkage map of the laboratory rat
4. Identification of Gas6 as a ligand for Mer, a neural cell adhesion molecule related receptor tyrosine kinase implicated in cellular transformation
5. Exposure of phosphatidylserine in the outer leaflet of human red blood cells
6. Ultrastructure of remnant photoreceptors in advanced hereditary retinal degeneration
7. Identification of a novel receptor tyrosine kinase expressed in acute myeloid leukemic blasts
8. The Dtk receptor tyrosine kinase, which binds protein S, is expressed during hematopoiesis
9. Molecular cloning of a novel receptor tyrosine kinase, tif, highly expressed in human ovary and testis
10. Mutation of the receptor tyrosine kinase gene mertk in the retinal dystrophic RCS rat
11. A new procedure for fundus photography and fluorescein angiography in small laboratory animal eyes
12. Inherited retinal dystrophy in the rat
13. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
14. The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
15. A receptor for phosphatidylserine-specific clearance of apoptotic cells
16. Macrophage and retinal pigment epithelium phagocytosis: Apoptotic cells and photoreceptors compete for αVβ3 and αVβ5 integrins, and protein kinase C regulates αVβ5 binding and cytoskeletal linkage
17. Brt, a mouse gene encoding a novel receptor-type protein-tyrosine kinase, is preferentially expressed in the brain
18. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
19. A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes
20. Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3
21. Cloning and mRNA expression analysis of a novel human protooncogene, c-mer
22. Cloning and developmental expression analysis of the murine c-mer tyrosine kinase
23. Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6
24. A genetic linkage map of the laboratory rat, Rattus norvegicus
25. A novel putative tyrosine kinase receptor with oncogenic potential
26. The proto-oncogene of v-eyk (v-ryk) is a novel receptor-type protein tyrosine kinase with extracellular Ig/GN-III domains
27. Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages
28. Truncating mutations in CCM1, encoding KRIT1, cause hereditary cavernous angiomas
29. Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase
30. Rod outer segment disk shedding in the rat retina: Relationship to cyclic lighting
31. Assignment of retinal dystrophy (rdy) to linkage group IV of the rat
32. Photoreceptor characteristics in congenic strains of RCS rats
33. A PvuII-polymorphism within the AXL gene on chromosome 19q13.1
34. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
35. The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S; a negative cofactor in the blood coagulation cascade
36. Rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain
37. Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl
38. Quantitative and morphological changes in the choroid vasculature in RCS rats and their congenic controls
39. Inherited retinal dystrophy: Primary defect in pigment epithelium determined with experimental rat chimeras
40. Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky and Mer receptor tyrosine kinases
41. Prevention of growth arrest-induced cell death of vascular smooth muscle cells by a product of growth arrest-specific gene, gas6
42. Cell adhesion to phosphatidylserine mediated by a product of growth arrest-specific gene 6
43. Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency
44. The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage
45. Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain
46. Stimulation of Sky receptor tyrosine kinase by the product of growth arrest-specific gene 6
47. Molecular cloning and in situ localization in the brain of rat Sky receptor tyrosine kinase
48. Functionnal consequences of oncogene-induced horizontal cell degeneration in the retinas of transgenic mice
49. Phagocytosis by retinal pigment epithelium explants in culture
50. The human TYRO3 gene and pseudogene are located in chromosome 15q14q25
51. Gas6, a ligand for the receptor protein-tyrosine kinase Tyro-3, is widely expressed in the central nervous system
52. The genomic structure of the human UFO receptor
53. Isolation and expression analysis of Tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain
54. Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat
55. Role of class B scavenger receptor type I in phagocytosis of apoptotic rat spermatogenic cells by Sertoli cells
56. The Royal College of Surgeons rat: An animal model for inherited retinal degeneration with a still unknown genetic defect
57. Inferring regulatory elements from a whole genome. An analysis of Helicobacter pylori sigma(80) family of promoter signals
58. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth arrest-specific gene 6
59. The asymmetric distribution of phospholipids in the human red cell membrane
60. A radiation hybrid map of the rat genome containing 5,255 markers
61. Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization