Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a

Toxicology and Applied Pharmacology

Volumn 251, Issue 1, 2011, Pages 70-78

  Liu, Wen bin ^a   Cui, Zhi hong ^a   Ao, Lin ^a   Zhou, Zi yuan ^a   Zhou, Yan hong ^a   Yuan, Xiao yan ^a   Xiang, Yun long ^a   Liu, Jin yi ^a   Cao, Jia ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Carcinogenesis; Cell adhesion; DNA methylation; DNA methyltransferase; Lung cancer

Indexed keywords

3 METHYLCHOLANTHRENE; 5 AZA 2' DEOXYCYTIDINE; DIETHYLNITROSAMINE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE SILENCING; GENOTOXICITY; IMMUNOHISTOCHEMISTRY; LUNG CARCINOGENESIS; MALE; MICRODISSECTION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RAT; TUMOR CELL LINE;

ANIMALS; AZACITIDINE; CADHERINS; CELL ADHESION; CELL ADHESION MOLECULES; CELL TRANSFORMATION, NEOPLASTIC; DIETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENZYME INHIBITORS; FEMALE; GENE SILENCING; IMMUNOGLOBULINS; LUNG NEOPLASMS; MALE; METHYLCHOLANTHRENE; RATS; RATS, WISTAR; TISSUE INHIBITOR OF METALLOPROTEINASE-3; UP-REGULATION;

RATTUS;

EID: 78751610586     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.12.002     Document Type: Article

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