Therapeutic targeting of the PDGF and TGF-Β-signaling pathways in hepatic stellate cells by PTK787/ZK22258

Laboratory Investigation

Volumn 89, Issue 10, 2009, Pages 1152-1160

  Liu, Yuqing ^a,b,c   Wen, Xiao Ming ^a   Lui, Eric Lik Hang ^c   Friedman, Scott L ^d   Cui, Wei ^b   Ho, Nancy Pei Shan ^b   Li, Lei ^c   Ye, Tao ^a,b   Fan, Sheung Tat ^c   Zhang, Hui ^a,e  

^a PEKING UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e NEVADA CANCER INSTITUTE   (United States)

Author keywords

Akt; HSC; PDGF; PTK787 ZK22258; TGF 1

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VATALANIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; FIBROGENESIS; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DOWN-REGULATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEPATIC STELLATE CELLS; LIVER CIRRHOSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHTHALAZINES; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RAF KINASES; RATS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 70349556686     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.77     Document Type: Article

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