Automatic liquid handling for life science: A critical review of the current state of the art

Journal of Laboratory Automation

Volumn 17, Issue 3, 2012, Pages 169-185

  Kong, Fanwei ^a,b   Yuan, Liang ^a,b   Zheng, Yuan F ^b   Chen, Weidong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Automation; High throughput; Life science; Liquid handling

Indexed keywords

AUTOMATION; COMPUTER APPLICATIONS;

AUTOMATED LIQUID HANDLING; CRITICAL REVIEW; HIGH THROUGHPUT; LIFE-SCIENCES; LIQUID HANDLING; PROTEIN CRYSTALLIZATION; RESEARCH INSTITUTIONS; STATE OF THE ART;

LIQUIDS;

AUTOMATIC LIQUID HANDLING; BIOMEDICINE; CALIBRATION; EQUIPMENT DESIGN; EVAPORATION; LABORATORY AUTOMATION; MATERIALS HANDLING; MEDICAL TECHNOLOGY; MICROELECTROMECHANICAL SYSTEM; PIEZOELECTRICITY; PROCESS DEVELOPMENT; REVIEW; ROBOTICS; SENSOR; STATIC ELECTRICITY; SYRINGE; ANIMAL; COMBINATORIAL CHEMISTRY; CRYSTALLIZATION; DRUG SCREENING; ELECTRONICS; HIGH THROUGHPUT SCREENING; HUMAN; INSTRUMENTATION; LABORATORY DIAGNOSIS; METHODOLOGY;

ANIMALS; AUTOMATION, LABORATORY; BIOLOGICAL SCIENCE DISCIPLINES; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLIZATION; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MINIATURIZATION; ROBOTICS; SPECIMEN HANDLING;

EID: 84865988636     PISSN: 22110682     EISSN: 22110690     Source Type: Journal    
DOI: 10.1177/2211068211435302     Document Type: Review

References (132)

1. Meldrum, D. Automation for Genomics, Part One: Preparation for Sequencing. Genome Res. 2000, 10(8), 1081-1092.
2. Peddi, A.; Zheng, Y.; Cherezov, V.; Caffrey, M. In Automating the Dispensing of Viscous Biomaterials, Proceedings of IEEE/RSJ International Conference on Intelligent Robots and Systems, Sendai, Japan, Sep 28-Oct 2, 2004, pp. 1281-1286.
3. Georgiev, A.; Allen, P.; Edstrom, W. In Visually-Guided Protein Crystal Manipulation Using Micromachined Silicon Tools, Proceedings of IEEE/RSJ International Conference on Intelligent Robots and Systems, Sendai, Japan, Sep 28-Oct 2, 2004, pp. 236-241.
4. Georgiev, A.; Allen, P.; Mezouar, Y. In Microrobotic Crystal Mounting Using Computer Vision, Proceedings of IEEE International Conference on Intelligent Robots and Systems, Las Vegas, NV, Oct 27-31, 2003, pp. 36-49.
5. Hansen, C.; Skordalakes, E.; Berger, J.; Quake, S. A Robust and Scalable Microfluidic Metering Method That Allows Protein Crystal Growth by Free Interface Diffusion. Proc. Natl. Acad. Sci. U. S. A. 2002, 99(26), 16531-16536.
6. http://www.ornl.gov/sci/techresources/Human_Genome/ faq/genenumber.shtml
7. Muthusubramaniam, L.; Peddi, A.; Zheng, Y.; Cherezov, V.; Caffrey, M. In Automating Crystallization of Membrane Protein by Robot with Soft Coordinate Measuring, Proceedings of IEEE International Conference on Robotics and Automation, New Orleans, LA, Apr 26-May 1, 2004, pp. 1450-1455.
8. Watts, D.; Muller-Dieckmann, J.; Tsakanova, G.; Lamzin, V.; Groves, M. Quantitative Evaluation of Macromolecular Crystallization Experiments Using 1,8-ANS Fluorescence. Acta Crystallographica Section D: Biological Crystallography. 2010, D66, 901-908.
9. Stevens, R. High-Throughput Protein Crystallization. Curr. Opin. Struct. Biol. 2000, 10(5), 558-563.
10. Zhu, X.; Sun, S.; Bern, M. In Classification of Protein Crystallization Imagery, Proceedings of the 26th Annual International Conference of IEEE Engineering in Medicine and Biology Society, San Francisco, CA, Sep 1-5, 2004, pp. 1628-1631.
11. Ohara, K.; Ohba, K.; Tanikawa, T.; Hiraki, M.; Wakatsuki, S.; Mizukawa, M. In Hands Free Micro Operation for Protein Crystal Analysis, Proceedings of IEEE/RSJ International Conference on Intelligent Robots and Systems, Sendai, Japan, Sep 28-Oct 2, 2004, pp. 1728-1733.
12. Mezouar, Y.; Allen, P. In Visual Servoed Micropositioning for Protein Manipulation Tasks, Proceedings of IEEE/RSJ International Conference on Intelligent Robots and Systems, EPFL, Lausanne, Switzerland, Sep 30-Oct 5, 2002, pp. 1766-1771.
13. Meldrum, D. Automation for Genomics, Part Two: Sequencers, Microarrays, and Future Trends. Genome Res. 2000, 10(9), 1288-1303.
14. Kwon, J.; Kamal-Bahl, S.; Kim, E. In Situ DNA Synthesis on Glass Substrate for Microarray Fabrication Using Self-Focusing Acoustic Transducer. IEEE Trans. Autom. Sci. Eng. 2006, 3(2), 152-158.
15. Dorris, D.; Ramakrishnan, R.; Trakas, D.; Dudzik, F.; Belval, R.; Zhao, C.; Nguyen, A.; Domanus, M.; Mazumder, A. A Highly Reproducible, Linear, and Automated Sample Preparation Method for DNA Microarrays. Genome Res. 2002, 12(6), 976-984.
16. Nagarajan, R.; Upreti, M. Correlation Statistics for cDNA Microarray Image Analysis. IEEE/ACM Trans. Comp. Biol. Bioinform. 2006, 3(3), 232-238.
17. Cai, X.; Giannakis, G. B. Identifying Differentially Expressed Genes in Microarray Experiments with Model-Based Variance Estimation. IEEE Trans. Signal Processing 2006, 54(6), 2418-2426.
18. Zhang, C.; Lu, X.; Zhang, X. Significance of Gene Ranking for Classification of Microarray Samples. IEEE/ACM Trans. Comp. Biol. Bioinform. 2006, 3(3), 312-320.
19. Templin, M.; Stoll, D.; Schrenk, M.; Traub, P.; Vöhringer, C.; Joos, T. Protein Microarray Technology. Trends Biotechnol. 2002, 20(4), 160-166.
20. Zhang, M.; Felder, R.; Kim, E.; Nelson, B.; Pruitt, B.; Zheng, Y.; Meldrum, D. Editorial: Special Issue on Life Science Automation. IEEE Trans. Autom. Sci. Eng. 2006, 3(2), 137-140.
21. Dunn, D.; Feygin, I. Challenges and Solutions to Ultra-High-Throughput Screening Assay Miniaturization: Submicroliter Fluid Handling. Drug Discov. Today 2000, 5(12), 84-91.
22. Nguyen, Q.; Yun, B.; Choi, S. Performance Characteristics of a High Frequency Jetting Dispenser Featuring Piezoelectric Actuator. Proc. SPIE 2008, 6928, 69281U1-11.
23. Cooley, P.; Wallace, D.; Antohe, B. Applications of Ink-Jet Printing Technology to BioMEMS and Microfluidic Systems. J. Assoc. Lab. Autom. 2002, 7(5), 33-39.
24. Boehm, R.; Gittard, S.; Byrne, J.; Doraiswamy, A.; Wilker, J.; Dunaway, T.; Crombez, R.; Shen, W.; Lee, Y.; Narayan, R. Piezoelectric Inkjet Printing of Medical Adhesives and Sealants. JOM 2010, 62(7), 56-60.
25. Lemmo, A.; Rose, D.; Tisone, T. Inkjet Dispensing Technology: Applications in Drug Discovery. Curr. Opin. Biotechnol. 1998, 9(6), 615-617.
26. Liu, Y.; Chen, L.; Sun, L. In Automated Precise Liquid Dispensing System for Protein Crystallization, Proceedings of the IEEE International Conference on Mechatronics and Automation, Harbin, China, Aug 5-8, 2007, pp. 3616-3620.
27. Wixforth, A. Acoustically Driven Programmable Microfluidics for Biological and Chemical Applications. J. Assoc. Lab. Autom. 2006, 11(6), 399-405.
28. http://www.dddmag.com/leaps-in-dispensing-changeliquid. aspx
29. Roth, E.; Xu, T.; Das, M.; Gregory, C.; Hickman, J.; Boland, T. Inkjet Printing for High-Throughput Cell Patterning. Biomaterials 2004, 25, 3707-3715.
30. Xu, T.; Jin, J.; Gregory, C.; Hickman, J.; Boland, T. Inkjet Printing of Viable Mammalian Cells. Biomaterials 2005, 26, 93-99.
31. Cheng, S.; Chandra, S. A Pneumatic Droplet-on-Demand Generator. Experiments Fluids 2003, 34, 755-762.
32. Cheng, S. X.; Li, T.; Chandra, S. Producing Molten Metal Droplets with a Pneumatic Droplet-on-Demand Generator. J. Materials Processing Technol. 2005, 159, 295-302.
33. Jetha, N.; Marziali, A. Liquid-Handling Technology and the Method of Electrostatic Drop Transfer to Improve Dispensing Performance. J. Assoc. Lab. Autom. 2006, 11(4), 278-280.
34. Jetha, N.; Marziali, A. Electrostatic Device for Active Transfer of Submicroliter Samples from Syringe Pipettors. BioTechniques 2006, 40, 148-151.
35. Husbanda, B.; Melvina, T.; Evansa, A. A Superparamagnetic Bead Driven Fluidic Device. Proc. SPIE 2005, 5116, 607-615.
36. Tseng, F.; Lin, K.; Hsu, H.; Chieng, C. A Surface-Tension-Driven Fluidic Network for Precise Enzyme Batch-Dispensing and Glucose Detection. Sensors Actuators A 2004, 111, 107-117.
37. Deshpande, M.; Saggere, L. Light-Driven Actuation of Fluids at Microscale. Proc. SPIE 2004, 5389, 286-297.
38. Chiou, P.; Chang, Z.; Wu, M. Droplet Manipulation with Light on Optoelectrowetting Device. J. Microelectromech. Syst. 2008, 17(1), 133-138.
39. http://www.hamiltoncompany.com/products/syringes/c/795/
40. http://www.matrixtechcorp.com/handheld/pipettor.aspx?id=4
41. http://www.hamiltoncompany.com/Syringes/
42. Cherezov, V.; Caffrey, M. A Simple and Inexpensive Nanoliter-Volume Dispenser for Highly Viscous Materials Used in Membrane Protein Crystallization. J. Appl. Crystallogr. 2005, 38, 398-400.
43. http://www.hamiltoncompany.com/products/syringes/c/81/
44. http://www.matrixtechcorp.com/handheld/pipettor. aspx?id=8
45. http://www.matrixtechcorp.com/automated/pipetting. aspx?id=11
46. http://www.hudsoncontrol.com/Products/Product/6
47. http://www.hudsoncontrol.com/Products/Product/24
48. http://www.hudsoncontrol.com/Products/Type/16
49. http://www.hudsoncontrol.com/Products/Product/8#
50. Peddi, A.; Muthusubramaniam, L.; Zheng, Y.; Cherezov, V.; Misquitta, Y.; Caffrey, M. High-Throughput Automated System for Crystallizing Membrane Proteins in Lipidic Mesophases. IEEE Trans. Autom. Sci. Eng. 2007, 4(2), 129-140.
51. http://www.vp-scientific.com/96_solid_pin_replicator.htm
52. http://www.vp-scientific.com/slot_pin_replicator.htm
53. http://www.thermoscientific.com/wps/portal/ts/products/ detail?navigationId=L10690&categoryId=81971&produc tId=11954409
54. http://www.caliperls.com/products/lab-automation/zephyrspe-workstation37627.htm
55. http://www.vp-scientific.com/floating_pin_replicators.htm
56. http://www.matrixtechcorp.com/handheld/pipettor.aspx?id=38
57. Steinert, C.; Goutier, I.; Gutmarm, O.; Sandmaier, H.; Messner, S.; Daub, M.; Heij, B.; Zengerle, R. In An Improved 24 Channel Picoliter Dispenser Based on Direct Liquid Displacement, 12th International Conference on Solid State Sensors, Actuators and Microsystems, Boston, MA, Jun 8-12, 2003, vol. 1, pp. 376-379.
58. Takagi, F.; Kurosawa, R.; Sawaki, D.; Kamisuki, S.; Takai, M.; Ishihara, K.; Atobe, M. In Pico Liter Dispenser with 128 Independent Nozzles for High Throughput Biochip Fabrication, 17th IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Maastricht Exhibition & Congress Center, Maastricht, Netherlands, Jan 25-29, 2004, pp. 276-279.
59. Tsai, J.; Kim, C. In A Silicon-Micromachined Pin for Contact Droplet Printing, Proceeding of the Second Joint EMBS/BMES Conference, Houston, TX, Oct 23-26, 2002, vol. 3, pp. 1632-1633.
60. Metz, T.; Birkle, G.; Zengerle, R.; Koltay, P. In StarJet: Pneumatic Dispensing of Nano-to Picoliter Droplets of Liquid Metal, 22nd IEEE International Conference on Micro Electro Mechanical Systems, Sorrento, Italy, Jan 26-29, 2009, pp. 43-46.
61. Lee, C.; Bahl, S.; Yu, H.; Kwon, J.; Kim, E. On-Demand DNA Synthesis on Solid Surface by Four Directional Ejectors on a Chip. J. Microelectromech. Syst. 2007, 16(5), 1130-1139.
62. Lindemann, T.; Ashauer, H.; Yu, Y.; Sassano, D.; Zengerle, R.; Koltay, P. One Inch Thermal Bubble Jet Printhead with Laser Structured Integrated Polyimide Nozzle Plate. J. Microelectromech. Syst. 2007, 16(2), 420-428.
63. Samel, B.; Sandström, N.; Griss, P.; Stemme, G. Liquid Aspiration and Dispensing Based on an Expanding PDMS Composite. J. Microelectromech. Syst. 2008, 17(5), 1254-1262.
64. Koltay, P.; Steger, R.; Bohl, B.; Zengerle, R. The Dispensing Well Plate: A Novel Nanodispenser for the Multiparallel Delivery of Liquids (DWP Part I). Sensors Actuators A 2004, 116, 483-491.
65. Koltay, P.; Kalix, J.; Zengerle, R. Theoretical Evaluation of the Dispensing Well Plate Method (DWP part II). Sensors Actuators A 2004, 116, 472-482.
66. Svensson, S.; Sharma, G.; Ogden, S.; Hjort, K.; Klintberg, L. High-Pressure Peristaltic Membrane Micropump with Temperature Control. J. Microelectromech. Syst. 2010, 19(6), 1462-1469.
67. Hatch, A.; Kamholz, A.; Holman, G.; Yager, P.; Böhringer, K. A Ferrofluidic Magnetic Micropump. J. Microelectromech. Syst. 2001, 10(2), 215-221.
68. Guo, S.; Sun, X.; Ishii, K.; Guo, J. In SMA Actuator-Based Novel Type of Peristaltic Micropump, Proceedings of the IEEE International Conference on Information and Automation, Changsha, China, Jun 20-23, 2008, pp. 1620-1625.
69. Pan, T.; Kai, E.; Stay, M.; Barocas, V.; Ziaie, B. In A Magnetically Driven PDMS Peristaltic Micropump, Proceedings of the 26th Annual International Conference of the IEEE in Engineering in Medicine and Biology Society, San Francisco, CA, Sep 1-5, 2004, pp. 2639-2642.
70. http://aurorabiotechnologies.com/pdf/Aurora_brochure_ 1-23.PDF
71. Dehring, K.; Workman, H.; Miller, K.; Mandagere, A.; Poole, S. Automated Robotic Liquid Handling/Laser-Based Nephelometry System for High-Throughput Measurement of Kinetic Aqueous Solubility. J. Pharm. Biomed. Anal. 2004, 36(3), 447-456.
72. http://aurorabiotechnologies.com/qual_tech.html
73. Ngatchou, P.; Holl, M.; Fisher, C.; Saini, M.; Dong, J.; Ren, T.; Pence, W.; Cunningham, D.; Moody, S.; Donaldson, D.; et al. A Real-Time PCR Analyzer Compatible with High-Throughput Automated Processing of 2 μL Reactions in Glass Capillaries. IEEE Trans. Autom. Sci. Eng. 2006, 3(2), 141-151.
74. Kearney, R.; Blondeau, F.; McPherson, P.; Bell, A.; Servant, F.; Drapeau, M.; Grandpré, S.; Bergeron, J. In Elimination of Redundant Protein Identifications in High-Throughput Proteomics, Proceedings of the 27th Annual Conference of IEEE Engineering in Medicine and Biology Society, Shanghai, China, Sep 1-4, 2005, pp. 4803-4806.
75. Cherezov, V.; Caffrey, M. Nano-Volume Plates with Excellent Optical Properties for Fast, Inexpensive Crystallization Screening of Membrane Proteins. J. Appl. Crystallogr. 2003, 36(6), 1372-1377.
76. Gan, H.; Shang, Z.; Wang, J. New Affinity Nylon Membrane Used for Adsorption of r-Globulin. J. Chromatogr. A 2000, 867(1-2), 161-168.
77. http://www.matrixtechcorp.com/automated/pipetting. aspx?id=27
78. http://www.protedyne.com/biocube-lx.html
79. http://www.beckmancoulter.com/hr/pressroom/oc_press-Releases_detail.asp?Key=7164
80. http://www.rtslifescience.com/default.asp?id=1409 &fileid=98
81. http://www.tecan.com/platform/apps/product/index.asp?M enuID=2698&ID=5276&Menu=1&Item=21.1.8.4
82. http://www.biodot.com/resource_center/pdf/Datasheet_ AD3400.pdf
83. http://www.tecan.com/platform/apps/product/index.asp?M enuID=3274&ID=6567&Menu=1&Item=21.1.9.20.5
84. http://www.tecan.com/platform/apps/product/index.asp?M enuID=1889&ID=2487&Menu=1&Item=21.2.8.1
85. http://www.biotek.com/microplate-washer-f.htm
86. Uematsu, C.; Makino, I.; Matsunaga, T.; Harada, K. An Automated Liquid Handling System for Polymerase Chain Reaction Sample Preparation. J. Biosci. Bioeng. 2004, 97(6), 432-435.
87. Petersen, J.; Nguyen, J. Comparison of Absorbance and Fluorescence Methods for Determining Liquid Dispensing Precision. J. Assoc. Lab. Autom. 2005, 10(2), 82-87.
88. Cooney, C.; Towe, B. A Thermopneumatic Dispensing Micropump. Sensors Actuators A 2004, 116(3), 519-524.
89. Lefchlel, T.; Saya, D.; Pourciel, J.; Mathieu, F.; Bergaud, C.; Nicu, L. In A Closed-Loop MEMS-Based Spotter Integrating Position Sensors with Nanometric Precision for the Control of Droplet Uniformity, Proceedings of the 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Zhuhai, China, Jan 18-21, 2006, pp. 730-733.
90. Liu, Y.; Chen, L.; Sun, L.; Rong, W. In A Self-Adjusted Precise Liquid Handling System, IEEE International Conference on Robotics and Automation, Kobe International Conference Center, Kobe, Japan, May 12-17, 2009, pp. 538-543.
91. Liu, Y.; Yao, Y.; Chen, L.; Sun, L. In A Closed-Loop Intelligent Control Strategy for Precise Non-Contact Liquid Dispensing, Proceedings of the 2010 IEEE International Conference on Mechatronics and Automation, Xi'an, China, Aug 4-7, 2010, pp. 957-962.
92. Ernst, A.; Streule, W.; Zengerle, R.; Koltay, P. In Non-Contact Detection of Free Flying Nanoliter Droplets, International Conference on Solid-State Sensors, Actuators and Microsystems, Lyon, France, Jun 10-14, 2007, pp. 751-754.
93. Ernst, A.; Streule, W.; Zengerle, R.; Koltay, P. In Quantitative Volume Determination of Dispensed Nanoliter Droplets on the Fly, International Conference on Solid-State Sensors, Actuators and Microsystems, Denver, CO, Jun 21-25, 2009, pp. 1750-1753.
94. Chang, T.; Parthasarathy, S.; Wang, T.; Gandhi, K.; Soteropoulos, P. Automated Liquid Dispensing Pin for DNA Microarray Applications. IEEE Trans. Autom. Sci. Eng. 2006, 3(2),187-191.
95. Li, F.; Robinson, H.; Yeung, E. Automated High-Throughput Nanoliter-Scale Protein Crystallization Screening. Anal. Bioanal. Chem. 2005, 383, 1034-1041.
96. Lim, B.; Foo, T.; Chong, W.; Puah, C. In A Micro-Fluidic Level Sensing and Dispensing System for Automation of Cell Cultivation Experimentations, Proceedings of the 33rd Annual Conference of the IEEE Industrial Electronics Society (IECON), Taipei, Taiwan, Nov 5-8, 2007, pp. 3007-3012.
97. Ressler, J.; Grothe, H.; Motrescu, E.; Wolf, B. In New Concepts for Chip-Supported Multi-Well-Plates: Realization of a 24-Wellplate with Integrated Impedance-Sensors for Functional Cellular Screening Applications and Automated Microscope Aided Cell-Based Assays, Proceedings of the 26th Annual International Conference of IEEE Engineering in Medicine and Biology Society, San Francisco, CA, Sep 1-5, 2004, pp. 2074-2077.
98. Geisler, T.; Ressler, J.; Harz, H.; Wolf, B.; Uhl, R. Automated Multiparametric Platform for High-Content and High-Throughput Analytical Screening on Living Cells. IEEE Trans. Autom. Sci. Eng. 2006, 3(2), 169-176.
99. Thaysen, J.; Marie, R.; Boisen, A. In Cantilever-Based Bio-Chemical Micro Electro Mechanical Systems, Proceeding of the 14th IEEE International Conference on Micro Electro Mechanical Systems, Interlaken, Switzerland, Jan 21-25, 2001, pp. 401-404.
100. Arai, F.; Motoo, K.; Fukuda, T.; Katsuragi, T. In High Sensitive Micro Touch Sensor with Piezoelectric Thin Film for Micro Pipetting Work Under Microscope, Proceedings of IEEE International Conference on Robotics and Automation, New Orleans, LA, Apr 26-May 1, 2004, vol. 2, pp. 1352-1357.
101. Szita, N.; Sutterb, R.; Duala, J.; Buser, R. A Micropipettor with Integrated Sensors. Sensors Actuators A 2001, 89(1-2), 112-118.
102. Lopez, M.; Caballero, D.; Campo, E.; Castillejos, R.; Errachid, A.; Esteve, J.; Plaza, J. Focused Ion Beam-Assisted Technology in Sub-Picolitre Micro-Dispenser Fabrication. J. Micromech. Microeng. 2008, 18(7), 75021-75028.
103. Ho, C.; Chieng, C.; Chen, M.; Tseng, F. Rapid Micro Array System for Passive Batch-Filling and Parallel Printing Protein Solutions. J. Microelectromech. Syst. 2008, 17(2), 309-317.
104. Kim, S.; Yang, J.; Yang, C.; Kim, Y.; Sim, W.; Oh, Y. In The Fabrication of Monolithic Micro Droplet Ejector Using MEMS, Proceedings of the 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems, Zhuhai, China, Jan 18-21, 2006, pp. 877-881.
105. Huang, S.; Lee, G. Pneumatically Driven Micro-Dispenser for Sub-Micro-Liter Pipetting. J. Micromech. Microeng. 2009, 19(3), 35027-35034.
106. Shikida, M.; Inouchi, K.; Honda, H.; Sato, K. In Magnetic Handling of Droplet in Micro Chemical Analysis System Utilizing Surface Tension and Wettability, Proceedings of the 17th IEEE International Conference on Micro Electro Mechanical Systems, Maastricht, Netherlands, Jan 25-29, 2004, pp. 359-362.
107. Griss, P.; Anderson, H.; Stemme, G. In Liquid Handling Using Expandable Microspheres, Proceedings of the 15th IEEE International Conference on Micro electro Mechanical Systems, Las Vegas, NV, Jan 20-24, 2002, pp. 117-120.
108. Pajak, L.; Zhang, R.; Pittman, C.; Roby, K.; Boyer, S. Automated Genomic and Proteomic Applications on the Biomek NX Laboratory Automation Workstation. J. Assoc. Lab. Autom. 2004, 9(3), 177-184.
109. Meldrum, D.; Evensen, H.; Pence, W.; Moody, S.; Cunningham, D.; Wiktor, P. ACAPELLA-1K, a Capillary-Based Submicroliter Automated Fluid Handling System for Genome Analysis. Genome Res. 2000, 10(1), 95-104.
110. Meldrum, D.; Pence, W.; Moody, S.; Cunningham, D.; Holl, M.; Wiktor, P. In Automated Microfluidics for Genomics, Proceeding of the 23rd Annual EMBS International Conference, Istanbul, Turkey, Oct 25-28, 2001, pp. 2923-2926.
111. http://www.khufash.com/bd/products/products_biochip.htm
112. http://www.scienion.com/innolino/pdfdownload.php?id=57 Scienion sciFLEXARRAYER piezo
113. http://www.labcyte.com/Acoustic_Droplet_Ejection_ADE/ Default.270.html
114. http://www.tecan.com/platform/apps/product/index.asp?M enuID=2580&ID=4940&Menu=1&Item=21.1.9.20
115. http://www.hudsoncontrol.com/Products/Product/14
116. http://www.sias.biz/applications/ELISA.htm
117. http://www.balances.com/sartorius/sartorius-micro-balances. html
118. Lee, C.; Yu, H.; Kim, E. In Microreactions Using Nanoliter Droplets with Oil Encapsulation, Proceedings of IEEE International Conference on Micro Electro Mechanical Systems, Kobe, Japan, Jan 21-25, 2007, pp. 81-84.
119. http://catalog2.corning.com/Lifesciences/media/pdf/ Tecan_TeLidder_Corning_Robolid.pdf
120. Gutmann, O.; Niekrawietz, R.; Kuehlewein, R.; Steinert, C.; Heij, B.; Zengerle, R.; Daub, M. Impact of Medium Properties on Droplet Release in a Highly Parallel Nanoliter Dispenser. Sensors Actuators A 2004, 116(2), 187-194.
121. Nollert, P. Lipidic Cubic Phases as Matrices for Membrane Protein Crystallization. Methods 2004, 34(3), 348-353.
122. Caffrey, M. Membrane Protein Crystallization. J. Struct. Biol. 2003, 142(1), 108-132.
123. Cherezov, V.; Peddi, A.; Muthusubramaniam, L.; Zheng, Y.; Caffrey, M. A Robotic System for Crystallizing Membrane and Soluble Proteins in Lipidic Mesophases. Acta Crystallogr. D Biol. Crystallogr. 2004, 60, 1795-1807.
124. Batista, E.; Pinto, L.; Filipe, E.; Veen, A. Calibration of Micropipettes: Test Methods and Uncertainty Analysis. Measurement 2007, 40(3), 338-342.
125. Englmann, M.; Fekete, A.; Gebefügi, I.; Kopplin, P. The Dosage of Small Volumes for Chromatographic Quantifications Using a Drop-on-Demand Dispenser System. Anal. Bioanal. Chem. 2007, 388(5-6), 1109-1116.
126. Hicks, J.; Harker, B.; Beattie, K.; Doktycz, M. Modification of an Automated Liquid-Handling System for Reagent-Jet, Nanoliter-Level Dispensing. BioTechniques 2001, 30(4), 878-885.
127. Dong, H.; Ouyang, Z.; Liu, J.; Jemal, M. The Use of a Dual Dye Photometric Calibration Method to Identify Possible Sample Dilution from an Automated Multichannel Liquid-Handling System. J. Assoc. Lab. Autom. 2006, 11(2), 60-64.
128. Niekrawietz, R.; Honstein, W.; Gutmann, O.; Heij, B.; Daub, M.; Zengerle, R. In Integrated Process Control for Highly Parallel and Contact-Free Micro Array Printing, 18th IEEE International Conference on Micro Electro Mechanical Systems, Miami, FL, Jan 30-Feb 3, 2005, pp. 738-741.
129. Doktycz, M.; Johnson, J.; Cornett, M. Hybrid Valve Structure for High-Throughput, Low-Volume Liquid-Handling Applications. J. Assoc. Lab. Autom. 2004, 9(4), 250-256.
130. Xie, I.; Wang, M.; Carpenter, R.; Wu, H. Automated Calibration of TECAN Genesis Liquid Handling Workstation Utilizing an Online Balance and Density Meter. Assay Drug Dev. Technol. 2004, 2(1), 71-80.
131. Vessey, A.; Porter, G. Optimization of Liquid-Handling Precision with Neptune Software on a Tecan Genesis. J. Assoc. Lab. Autom. 2002, 7(4), 81-84.
132. Li, H.; Liu, J.; Chen, C.; Deng, H. A Simple Model-Based Approach for Fluid Dispensing Analysis and Control. IEEE/ ASME Trans. Mechatronics 2007, 12(4), 491-503.