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Volumn 3 MAR, Issue , 2012, Pages

Physiological antioxidative network of the bilirubin system in aging and age-related diseases

Author keywords

Aging; Antioxidant; Bilirubin; Biliverdin reductase; Cellular senescence; Heme oxygenase; Lipid peroxidation; Reactive oxygen species

Indexed keywords

ALLOPURINOL; AMYLOID BETA PROTEIN; ATORVASTATIN; BILIRUBIN; BILIVERDIN; BILIVERDIN REDUCTASE; HEME OXYGENASE; HEME OXYGENASE 2; OXIDOREDUCTASE; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 84865967056     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2012.00045     Document Type: Article
Times cited : (29)

References (132)
  • 1
    • 34547925606 scopus 로고    scopus 로고
    • Role of lipids in brain injury and diseases
    • Adibhatla, R.M., and Hatcher, J.F. (2007). Role of lipids in brain injury and diseases. Future Lipidol. 2, 403-422.
    • (2007) Future Lipidol , vol.2 , pp. 403-422
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 2
    • 50949124960 scopus 로고    scopus 로고
    • Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies
    • Adibhatla, R.M., and Hatcher, J.F. (2008). Phospholipase A(2), reactive oxygen species, and lipid peroxidation in CNS pathologies. BMB Rep. 41, 560-567.
    • (2008) BMB Rep , vol.41 , pp. 560-567
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 3
    • 71549144988 scopus 로고    scopus 로고
    • Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities
    • Adibhatla, R.M., and Hatcher, J.F. (2010). Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid. Redox Signal. 12, 125-169.
    • (2010) Antioxid. Redox Signal. , vol.12 , pp. 125-169
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 4
    • 33646812935 scopus 로고    scopus 로고
    • Lipids and lipidomics in brain injury and diseases
    • Adibhatla, R.M., Hatcher, J.F., and Dempsey, R.J. (2006). Lipids and lipidomics in brain injury and diseases. AAPS J. 8, E314-E321.
    • (2006) AAPS J , vol.8
    • Adibhatla, R.M.1    Hatcher, J.F.2    Dempsey, R.J.3
  • 5
    • 0033453987 scopus 로고    scopus 로고
    • Baseline diene conjugation in LDL lipids: an indicator of circulating oxidized LDL
    • Ahotupa, M., and Asankari, T.J. (1999). Baseline diene conjugation in LDL lipids: an indicator of circulating oxidized LDL. Free Radic. Biol. Med. 27, 1141-1150.
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 1141-1150
    • Ahotupa, M.1    Asankari, T.J.2
  • 6
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
    • Alcorta, D.A., Xiong, Y., Phelps, D., Hannon, G., Beach, D., and Barrett, J. C. (1996). Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 93, 13742-13747.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Phelps, D.3    Hannon, G.4    Beach, D.5    Barrett, J.C.6
  • 7
    • 33749989103 scopus 로고    scopus 로고
    • Bilirubin toxicity to human erythrocytes: a review
    • Alexandra Brito, M., Silva, R.F., and Brites, D. (2006). Bilirubin toxicity to human erythrocytes: a review. Clin. Chim. Acta 374, 46-56.
    • (2006) Clin. Chim. Acta , vol.374 , pp. 46-56
    • Alexandra Brito, M.1    Silva, R.F.2    Brites, D.3
  • 9
    • 0036596625 scopus 로고    scopus 로고
    • Endogenous oxidative stress: relationship to aging, longevity and caloric restriction
    • Barja, G. (2002). Endogenous oxidative stress: relationship to aging, longevity and caloric restriction. Ageing Res. Rev. 1, 397-411.
    • (2002) Ageing Res. Rev. , vol.1 , pp. 397-411
    • Barja, G.1
  • 10
    • 80052829260 scopus 로고    scopus 로고
    • Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment
    • Barone, E., Di Domenico, F., Cenini, G., Sultana, R., Coccia, R., Preziosi, P., Perluigi, M., Mancuso, C., and Butterfield, D.A. (2011a). Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment. J. Alzheimers Dis. 25, 623-633
    • (2011) J. Alzheimers Dis. , vol.25 , pp. 623-633
    • Barone, E.1    Di Domenico, F.2    Cenini, G.3    Sultana, R.4    Coccia, R.5    Preziosi, P.6    Perluigi, M.7    Mancuso, C.8    Butterfield, D.A.9
  • 11
    • 83755221773 scopus 로고    scopus 로고
    • Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease
    • Barone, E., Mancuso, C., Di Domenico, F., Sultana, R., Paul Murphy, M., Head, E., and Allan Butterfield, D. (2011b). Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J. Neurochem. 120, 135-146.
    • (2011) J. Neurochem. , vol.120 , pp. 135-146
    • Barone, E.1    Mancuso, C.2    Di Domenico, F.3    Sultana, R.4    Paul Murphy, M.5    Head, E.6    Allan Butterfield, D.7
  • 12
    • 0021253232 scopus 로고
    • Molecular requirements for the mutagenicity of malondialdehyde and related acroleins
    • Basu, A.K., and Marnett, L.J. (1984). Molecular requirements for the mutagenicity of malondialdehyde and related acroleins. Cancer Res. 44, 2848-2854.
    • (1984) Cancer Res , vol.44 , pp. 2848-2854
    • Basu, A.K.1    Marnett, L.J.2
  • 13
    • 0033817812 scopus 로고    scopus 로고
    • Free radical generation and oxidative stress with ageing and exercise: differential effects in the myocardium and liver
    • Bejma,J.,Ramires,P., and Ji,L. L. (2000). Free radical generation and oxidative stress with ageing and exercise: differential effects in the myocardium and liver. Acta Physiol. Scand. 169, 343-351.
    • (2000) Acta Physiol. Scand. , vol.169 , pp. 343-351
    • Bejma, J.1    Ramires, P.2    Ji, L.L.3
  • 14
    • 0022020501 scopus 로고
    • Role of bilirubin as a natural antioxidant in regulating lipid peroxidation intensity in acute viral hepatitis
    • Bliuger, A.F., Dudnik, L.B., Maiore, A., and Mieze, I.E. (1985). Role of bilirubin as a natural antioxidant in regulating lipid peroxidation intensity in acute viral hepatitis. Biull. Eksp. Biol. Med. 99, 166-168.
    • (1985) Biull. Eksp. Biol. Med. , vol.99 , pp. 166-168
    • Bliuger, A.F.1    Dudnik, L.B.2    Maiore, A.3    Mieze, I.E.4
  • 15
    • 0023806330 scopus 로고
    • Free radicals, polyunsaturated fatty acids, cell death, brain aging
    • Bourre, J.M. (1988). Free radicals, polyunsaturated fatty acids, cell death, brain aging. C.R. Seances Soc. Biol. Fil. 182, 5-36.
    • (1988) C.R. Seances Soc. Biol. Fil. , vol.182 , pp. 5-36
    • Bourre, J.M.1
  • 16
    • 0033588022 scopus 로고    scopus 로고
    • Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate
    • Brash, A.R. (1999). Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J. Biol. Chem. 274, 23679-23682.
    • (1999) J. Biol. Chem. , vol.274 , pp. 23679-23682
    • Brash, A.R.1
  • 17
    • 0034065857 scopus 로고    scopus 로고
    • Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension
    • Butler, R., Morris, A.D., Belch, J.J., Hill, A., and Struthers, A.D. (2000). Allopurinol normalizes endothelial dysfunction in type 2 diabetics with mild hypertension. Hypertension 35, 746-751.
    • (2000) Hypertension , vol.35 , pp. 746-751
    • Butler, R.1    Morris, A.D.2    Belch, J.J.3    Hill, A.4    Struthers, A.D.5
  • 18
    • 0036591849 scopus 로고    scopus 로고
    • Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress
    • Butterfield, D.A., and Lauderback, C.M. (2002). Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress. Free Radic. Biol. Med. 32, 1050-1060.
    • (2002) Free Radic. Biol. Med. , vol.32 , pp. 1050-1060
    • Butterfield, D.A.1    Lauderback, C.M.2
  • 19
    • 33644987632 scopus 로고    scopus 로고
    • Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment
    • Butterfield, D.A., Reed, T., Perluigi, M., De Marco, C., Coccia, R., Cini, C., and Sultana, R. (2006). Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment. Neurosci. Lett. 397, 170-173.
    • (2006) Neurosci. Lett. , vol.397 , pp. 170-173
    • Butterfield, D.A.1    Reed, T.2    Perluigi, M.3    De Marco, C.4    Coccia, R.5    Cini, C.6    Sultana, R.7
  • 20
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: when bad things happen to good cells
    • Campisi, J., and d'Adda di Fagagna, F. (2007). Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729-740.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 729-740
    • Campisi, J.1    D'Adda di Fagagna, F.2
  • 21
    • 57249095767 scopus 로고    scopus 로고
    • Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions
    • Catalá, A. (2009). Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions. Chem. Phys. Lipids 157, 1-11.
    • (2009) Chem. Phys. Lipids , vol.157 , pp. 1-11
    • Catalá, A.1
  • 22
    • 0038206550 scopus 로고    scopus 로고
    • Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury
    • Chang, E.F., Wong, R.J., Vreman, H.J., Igarashi, T., Galo, E., Sharp, F.R., Stevenson, D.K., and Noble-Haeusslein, L.J. (2003). Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. J. Neurosci. 23, 3689-3696.
    • (2003) J. Neurosci. , vol.23 , pp. 3689-3696
    • Chang, E.F.1    Wong, R.J.2    Vreman, H.J.3    Igarashi, T.4    Galo, E.5    Sharp, F.R.6    Stevenson, D.K.7    Noble-Haeusslein, L.J.8
  • 23
    • 0037903477 scopus 로고    scopus 로고
    • Heme oxygenase-1 and heme oxygenase-2 have distinct roles in the proliferation and survival of olfactory receptor neurons mediated by cGMP and bilirubin, respectively
    • Chen, J., Tu, Y., Moon, C., Nagata, E., and Ronnett, G.V. (2003). Heme oxygenase-1 and heme oxygenase-2 have distinct roles in the proliferation and survival of olfactory receptor neurons mediated by cGMP and bilirubin, respectively. J. Neurochem. 85, 1247-1261.
    • (2003) J. Neurochem. , vol.85 , pp. 1247-1261
    • Chen, J.1    Tu, Y.2    Moon, C.3    Nagata, E.4    Ronnett, G.V.5
  • 24
    • 0028345161 scopus 로고
    • Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
    • Chen, Q., and Ames, B.N. (1994). Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc. Natl. Acad. Sci. U.S.A. 91, 4130-4134.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 4130-4134
    • Chen, Q.1    Ames, B.N.2
  • 26
    • 0032524563 scopus 로고    scopus 로고
    • Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication
    • Chen,Q.M., Bartholomew,J.C., Campisi, J., Acosta, M., Reagan, J.D., and Ames,B.N. (1998). Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem. J. 332(Pt 1), 43-50.
    • (1998) Biochem. J. , vol.332 , Issue.PART 1 , pp. 43-50
    • Chen, Q.M.1    Bartholomew, J.C.2    Campisi, J.3    Acosta, M.4    Reagan, J.D.5    Ames, B.N.6
  • 27
    • 84864101453 scopus 로고    scopus 로고
    • High total bilirubin as a protective factor for diabetes mellitus: an analysis of NHANES data from 1999-2006
    • Cheriyath, P., Gorrepati, V.S., Peters, I., Nookala, V., Murphy, M.E., Srouji, N., and Fischman, D. (2010). High total bilirubin as a protective factor for diabetes mellitus: an analysis of NHANES data from 1999-2006. J. Clin. Med. Res. 2, 201-206.
    • (2010) J. Clin. Med. Res. , vol.2 , pp. 201-206
    • Cheriyath, P.1    Gorrepati, V.S.2    Peters, I.3    Nookala, V.4    Murphy, M.E.5    Srouji, N.6    Fischman, D.7
  • 29
    • 0034083227 scopus 로고    scopus 로고
    • Role of oxidative stress in cardiovascular diseases
    • Dhalla, N.S., Temsah, R.M., and Netticadan, T. (2000). Role of oxidative stress in cardiovascular diseases. J. Hypertens. 18, 655-673.
    • (2000) J. Hypertens. , vol.18 , pp. 655-673
    • Dhalla, N.S.1    Temsah, R.M.2    Netticadan, T.3
  • 31
    • 79251569558 scopus 로고    scopus 로고
    • The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction
    • Ding, B., Gibbs, P.E., Brookes, P.S., and Maines, M.D. (2011). The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction. FASEB J. 25, 301-313.
    • (2011) FASEB J , vol.25 , pp. 301-313
    • Ding, B.1    Gibbs, P.E.2    Brookes, P.S.3    Maines, M.D.4
  • 32
    • 0035873227 scopus 로고    scopus 로고
    • Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study
    • Djousse, L., Levy, D., Cupples, L.A., Evans, J.C., D'Agostino, R.B., and Ellison, R.C. (2001). Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am. J. Cardiol. 87, 1196-1200
    • (2001) Am. J. Cardiol. , vol.87 , pp. 1196-1200
    • Djousse, L.1    Levy, D.2    Cupples, L.A.3    Evans, J.C.4    D'Agostino, R.B.5    Ellison, R.C.6
  • 33
    • 0037441715 scopus 로고    scopus 로고
    • Effect of serum albumin and bilirubin on the risk of myocardial infarction (the Framingham Offspring Study)
    • 0
    • Djousse, L., Rothman, K.J., Cupples, L.A., Levy, D., and Ellison, R.C. (2003). Effect of serum albumin and bilirubin on the risk of myocardial infarction (the Framingham Offspring Study). Am. J. Cardiol. 91, 485-488.0
    • (2003) Am. J. Cardiol. , vol.91 , pp. 485-488
    • Djousse, L.1    Rothman, K.J.2    Cupples, L.A.3    Levy, D.4    Ellison, R.C.5
  • 36
    • 0033374730 scopus 로고    scopus 로고
    • Neuroprotective action of bilirubin against oxidative stress in primary hippocampal cultures
    • Dore, S., and Snyder, S.H. (1999). Neuroprotective action of bilirubin against oxidative stress in primary hippocampal cultures. Ann. N. Y. Acad. Sci. 890, 167-172.
    • (1999) Ann. N. Y. Acad. Sci. , vol.890 , pp. 167-172
    • Dore, S.1    Snyder, S.H.2
  • 38
    • 0034603580 scopus 로고    scopus 로고
    • Agerelated changes in reactive oxygen species production in rat brain homogenates
    • Driver, A.S., Kodavanti, P.R., and Mundy, W.R. (2000). Agerelated changes in reactive oxygen species production in rat brain homogenates. Neurotoxicol. Teratol. 22, 175-181.
    • (2000) Neurotoxicol. Teratol. , vol.22 , pp. 175-181
    • Driver, A.S.1    Kodavanti, P.R.2    Mundy, W.R.3
  • 39
    • 0035437687 scopus 로고    scopus 로고
    • Effect of bilirubin on lipid peroxidation, sphingomyelinase activity, and apoptosis induced by sphingosine and UV irradiation
    • Dudnik, L.B., Tsyupko, A.N., Khrenov, A.V., and Alessenko, A.V. (2001). Effect of bilirubin on lipid peroxidation, sphingomyelinase activity, and apoptosis induced by sphingosine and UV irradiation. Biochemistry Mosc. 66, 1019-1027.
    • (2001) Biochemistry Mosc , vol.66 , pp. 1019-1027
    • Dudnik, L.B.1    Tsyupko, A.N.2    Khrenov, A.V.3    Alessenko, A.V.4
  • 45
    • 33645099414 scopus 로고    scopus 로고
    • Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes
    • Gil, L., Siems, W., Mazurek, B., Gross, J., Schroeder, P., Voss, P., and Grune, T. (2006). Age-associated analysis of oxidative stress parameters in human plasma and erythrocytes. Free Radic. Res. 40, 495-505.
    • (2006) Free Radic. Res. , vol.40 , pp. 495-505
    • Gil, L.1    Siems, W.2    Mazurek, B.3    Gross, J.4    Schroeder, P.5    Voss, P.6    Grune, T.7
  • 46
    • 0027161461 scopus 로고
    • Aging retards spin clearance from mouse brain and food restriction prevents its agedependent retardation
    • Gomi, F., Utsumi, H., Hamada, A., and Matsuo, M. (1993). Aging retards spin clearance from mouse brain and food restriction prevents its agedependent retardation. Life Sci. 52, 2027-2033.
    • (1993) Life Sci , vol.52 , pp. 2027-2033
    • Gomi, F.1    Utsumi, H.2    Hamada, A.3    Matsuo, M.4
  • 48
  • 49
    • 77955887671 scopus 로고    scopus 로고
    • High serum bilirubin is associated with the reduced risk of diabetes mellitus and diabetic nephropathy
    • Han, S. S., Na, K. Y., Chae, D. W., Kim,Y. S., Kim, S., and Chin, H. J. (2010). High serum bilirubin is associated with the reduced risk of diabetes mellitus and diabetic nephropathy. Tohoku J. Exp. Med. 221, 133-140.
    • (2010) Tohoku J. Exp. Med. , vol.221 , pp. 133-140
    • Han, S.S.1    Na, K.Y.2    Chae, D.W.3    Kim, Y.S.4    Kim, S.5    Chin, H.J.6
  • 50
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 52
    • 0042886948 scopus 로고    scopus 로고
    • Serum bilirubin concentration in patients with amyotrophic lateral sclerosis
    • Ilzecka, J., and Stelmasiak, Z. (2003). Serum bilirubin concentration in patients with amyotrophic lateral sclerosis. Clin. Neurol. Neurosurg. 105, 237-240.
    • (2003) Clin. Neurol. Neurosurg. , vol.105 , pp. 237-240
    • Ilzecka, J.1    Stelmasiak, Z.2
  • 54
    • 1542724438 scopus 로고    scopus 로고
    • Apoptotic cells as sources for biologically active oxidized phospholipids
    • Kadl, A., Bochkov, V. N., Huber, J., and Leitinger, N. (2004). Apoptotic cells as sources for biologically active oxidized phospholipids. Antioxid. Redox Signal. 6, 311-320.
    • (2004) Antioxid. Redox Signal. , vol.6 , pp. 311-320
    • Kadl, A.1    Bochkov, V.N.2    Huber, J.3    Leitinger, N.4
  • 55
    • 0024414262 scopus 로고
    • Mechanism for depression of heart sarcolemmal Ca2+ pump by oxygen free radicals
    • Kaneko, M., Elimban, V., and Dhalla, N. S. (1989). Mechanism for depression of heart sarcolemmal Ca2+ pump by oxygen free radicals. Am. J. Physiol. 257, H804-H811.
    • (1989) Am. J. Physiol. , vol.257
    • Kaneko, M.1    Elimban, V.2    Dhalla, N.S.3
  • 56
    • 0032840013 scopus 로고    scopus 로고
    • Matsuhisa, M., Yamasaki, Y., and Hori, M
    • Kaneto, H., Kajimoto, Y., Fujitani, Y., Matsuoka, T., Sakamoto, K., Matsuhisa, M., Yamasaki, Y., and Hori, M. (1999). Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in betacell dysfunction. Diabetologia 42, 1093-1097.
    • (1999) Diabetologia , vol.42 , pp. 1093-1097
    • Kaneto, H.1    Kajimoto, Y.2    Fujitani, Y.3    Matsuoka, T.4    Sakamoto, K.5
  • 57
    • 61549122310 scopus 로고    scopus 로고
    • Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin
    • Kapitulnik,J.,and Maines,M. D. (2009). Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin. Trends Pharmacol. Sci. 30, 129-137.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 129-137
    • Kapitulnik, J.1    Maines, M.D.2
  • 58
    • 77957672432 scopus 로고    scopus 로고
    • Reduction of Nup107 attenuates the growth factor signaling in the senescent cells
    • Kim, S. Y., Kang, H. T., Choi, H. R., and Park, S. C. (2010a). Reduction of Nup107 attenuates the growth factor signaling in the senescent cells. Biochem. Biophys. Res. Commun. 401, 131-136.
    • (2010) Biochem. Biophys. Res. Commun. , vol.401 , pp. 131-136
    • Kim, S.Y.1    Kang, H.T.2    Choi, H.R.3    Park, S.C.4
  • 59
    • 72949116994 scopus 로고    scopus 로고
    • Senescencerelated functional nuclear barrier by down-regulation of nucleocytoplasmic trafficking gene expression
    • Kim, S. Y., Ryu, S. J., Ahn, H. J., Choi, H. R., Kang, H. T., and Park, S. C. (2010b). Senescencerelated functional nuclear barrier by down-regulation of nucleocytoplasmic trafficking gene expression. Biochem. Biophys. Res. Commun. 391, 28-32.
    • (2010) Biochem. Biophys. Res. Commun. , vol.391 , pp. 28-32
    • Kim, S.Y.1    Ryu, S.J.2    Ahn, H.J.3    Choi, H.R.4    Kang, H.T.5    Park, S.C.6
  • 60
    • 79251615651 scopus 로고    scopus 로고
    • Biliverdin reductase A in the prevention of cellular senescence against oxidative stress
    • Kim, S. Y., Kang, H. T., Choi, H. R., and Park, S. C. (2011a). Biliverdin reductase A in the prevention of cellular senescence against oxidative stress. Exp. Mol. Med. 43, 15-23.
    • (2011) Exp. Mol. Med. , vol.43 , pp. 15-23
    • Kim, S.Y.1    Kang, H.T.2    Choi, H.R.3    Park, S.C.4
  • 61
    • 80051548324 scopus 로고    scopus 로고
    • Defective nuclear translocation of stressactivated signaling in senescent diploid human fibroblasts: a possible explanation for aging-associated apoptosis resistance
    • Kim, S. Y., Ryu, S. J., Kang, H. T., Choi, H. R.,and Park,S. C. (2011b). Defective nuclear translocation of stressactivated signaling in senescent diploid human fibroblasts: a possible explanation for aging-associated apoptosis resistance. Apoptosis 16, 795-807.
    • (2011) Apoptosis , vol.16 , pp. 795-807
    • Kim, S.Y.1    Ryu, S.J.2    Kang, H.T.3    Choi, H.R.4    Park, S.C.5
  • 62
    • 0037366104 scopus 로고    scopus 로고
    • Oxidative stress, cell cycle, and neurodegeneration
    • Klein, J. A., and Ackerman, S. L. (2003). Oxidative stress, cell cycle, and neurodegeneration. J. Clin. Invest. 111, 785-793.
    • (2003) J. Clin. Invest. , vol.111 , pp. 785-793
    • Klein, J.A.1    Ackerman, S.L.2
  • 63
    • 0028608788 scopus 로고
    • Serum albumin bilirubin, and uric acid and the anatomic site-specific incidence of colon cancer
    • Ko, W. F., Helzlsouer, K. J., and Comstock, G. W. (1994). Serum albumin, bilirubin, and uric acid and the anatomic site-specific incidence of colon cancer. J. Natl. Cancer Inst. 86, 1874-1875.
    • (1994) J. Natl. Cancer Inst , vol.86 , pp. 1874-1875
    • Ko, W.F.1    Helzlsouer, K.J.2    Comstock, G.W.3
  • 64
    • 2442594982 scopus 로고    scopus 로고
    • Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1
    • Kravets, A., Hu, Z., Miralem, T., Torno, M. D., and Maines, M. D. (2004). Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1. J. Biol. Chem. 279, 19916-19923.
    • (2004) J. Biol. Chem. , vol.279 , pp. 19916-19923
    • Kravets, A.1    Hu, Z.2    Miralem, T.3    Torno, M.D.4    Maines, M.D.5
  • 65
    • 0026684967 scopus 로고
    • Structure elucidation of oxygenated lipids in human atherosclerotic lesions
    • Kuhn, H., Belkner, J., Wiesner, R., Schewe, T., Lankin, V. Z., and Tikhaze,A. K. (1992). Structure elucidation of oxygenated lipids in human atherosclerotic lesions. Eicosanoids 5, 17-22.
    • (1992) Eicosanoids , vol.5 , pp. 17-22
    • Kuhn, H.1    Belkner, J.2    Wiesner, R.3    Schewe, T.4    Lankin, V.Z.5    Tikhaze, A.K.6
  • 67
    • 44349190488 scopus 로고    scopus 로고
    • Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
    • Lerner-Marmarosh, N., Miralem, T., Gibbs, P. E., and Maines, M. D. (2008). Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling. Proc. Natl. Acad. Sci. U.S.A. 105, 6870-6875.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 6870-6875
    • Lerner-Marmarosh, N.1    Miralem, T.2    Gibbs, P.E.3    Maines, M.D.4
  • 68
    • 18844371482 scopus 로고    scopus 로고
    • Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity
    • Lerner-Marmarosh, N., Shen, J., Torno, M. D., Kravets, A., Hu, Z., and Maines, M. D. (2005). Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity. Proc. Natl. Acad. Sci. U.S.A. 102, 7109-7114.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 7109-7114
    • Lerner-Marmarosh, N.1    Shen, J.2    Torno, M.D.3    Kravets, A.4    Hu, Z.5    Maines, M.D.6
  • 69
    • 0036884733 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease: dopamine, vesicles and alphasynuclein
    • Lotharius, J., and Brundin, P. (2002). Pathogenesis of Parkinson's disease: dopamine, vesicles and alphasynuclein. Nat. Rev. Neurosci. 3, 932-942.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 932-942
    • Lotharius, J.1    Brundin, P.2
  • 70
    • 0025109916 scopus 로고
    • Multiple forms of biliverdin reductase: age-related change in pattern of expression in rat liver and brain
    • Maines, M. D. (1990). Multiple forms of biliverdin reductase: age-related change in pattern of expression in rat liver and brain. Mol. Pharmacol. 38, 481-485.
    • (1990) Mol. Pharmacol. , vol.38 , pp. 481-485
    • Maines, M.D.1
  • 71
    • 28844493391 scopus 로고    scopus 로고
    • New insights into biliverdin reductase functions: linking heme metabolism to cell signaling
    • Maines, M. D. (2005). New insights into biliverdin reductase functions: linking heme metabolism to cell signaling. Physiology (Bethesda) 20, 382-389.
    • (2005) Physiology (Bethesda) , vol.20 , pp. 382-389
    • Maines, M.D.1
  • 72
    • 79952277022 scopus 로고    scopus 로고
    • Potential application of biliverdin reductase and its fragments to modulate insulin/IGF1/MAPK/PI3-K signaling pathways in therapeutic settings
    • Maines, M. D. (2010). Potential application of biliverdin reductase and its fragments to modulate insulin/IGF1/MAPK/PI3-K signaling pathways in therapeutic settings. Curr. Drug Targets 11, 1586-1594.
    • (2010) Curr. Drug Targets , vol.11 , pp. 1586-1594
    • Maines, M.D.1
  • 73
    • 0035123138 scopus 로고    scopus 로고
    • Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1
    • Maines, M. D., Ewing, J. F., Huang, T. J., and Panahian, N. (2001). Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1. J. Pharmacol. Exp. Ther. 296, 1091-1097.
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 1091-1097
    • Maines, M.D.1    Ewing, J.F.2    Huang, T.J.3    Panahian, N.4
  • 74
    • 0027483676 scopus 로고
    • Heme oxygenase, a likely regulator of cGMP production in the brain: induction in vivo of HO-1 compensates for depression in NO Synthase Activity
    • Maines, M. D., Mark, J. A., and Ewing, J. F. (1993). Heme oxygenase, a likely regulator of cGMP production in the brain: induction in vivo of HO-1 compensates for depression in NO Synthase Activity. Mol. Cell. Neurosci. 4, 396-405.
    • (1993) Mol. Cell. Neurosci. , vol.4 , pp. 396-405
    • Maines, M.D.1    Mark, J.A.2    Ewing, J.F.3
  • 75
    • 0032856531 scopus 로고    scopus 로고
    • The oxidoreductase biliverdin reductase, is induced in human renal carcinoma-pH and cofactor-specific increase in activity
    • Maines, M. D., Mayer, R. D., Erturk, E., Huang, T. J., and Disantagnese, A. (1999). The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma-pH and cofactor-specific increase in activity. J. Urol. 162, 1467-1472.
    • (1999) J. Urol. , vol.162 , pp. 1467-1472
    • Maines, M.D.1    Mayer, R.D.2    Erturk, E.3    Huang, T.J.4    Disantagnese, A.5
  • 76
    • 4544312434 scopus 로고    scopus 로고
    • Heme oxygenase and its products in the nervous system
    • Mancuso, C. (2004). Heme oxygenase and its products in the nervous system. Antioxid. Redox Signal. 6, 878-887.
    • (2004) Antioxid. Redox Signal. , vol.6 , pp. 878-887
    • Mancuso, C.1
  • 79
    • 34447279020 scopus 로고    scopus 로고
    • Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment
    • Markesbery, W. R., and Lovell, M. A. (2007). Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch. Neurol. 64, 954-956.
    • (2007) Arch. Neurol. , vol.64 , pp. 954-956
    • Markesbery, W.R.1    Lovell, M.A.2
  • 80
    • 0033257520 scopus 로고    scopus 로고
    • Chemistry and biology of DNA damage by malondialdehyde
    • Marnett, L. J. (1999). Chemistry and biology of DNA damage by malondialdehyde. IARC Sci. Publ. 17-27.
    • (1999) IARC Sci. Publ. , pp. 17-27
    • Marnett, L.J.1
  • 81
    • 34548761301 scopus 로고    scopus 로고
    • "Iatrogenic Gilbert syndrome" - a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin
    • McCarty, M. F. (2007). " Iatrogenic Gilbert syndrome" - a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. Med. Hypotheses 69, 974-994.
    • (2007) Med. Hypotheses , vol.69 , pp. 974-994
    • McCarty, M.F.1
  • 82
    • 77955092575 scopus 로고    scopus 로고
    • The biliverdinbilirubin antioxidant cycle of cellular protection: missing a wheel?
    • McDonagh,A. F. (2010). The biliverdinbilirubin antioxidant cycle of cellular protection: missing a wheel? Free Radic Biol. Med. 49, 814-820.
    • (2010) Free Radic Biol. Med. , vol.49 , pp. 814-820
    • McDonagh, A.F.1
  • 83
    • 58149466868 scopus 로고    scopus 로고
    • Oxidative and inflammatory pathways in Parkinson's disease
    • Miller, R. L., James-Kracke, M., Sun, G. Y., and Sun, A. Y. (2009). Oxidative and inflammatory pathways in Parkinson's disease. Neurochem. Res. 34, 55-65.
    • (2009) Neurochem. Res. , vol.34 , pp. 55-65
    • Miller, R.L.1    James-Kracke, M.2    Sun, G.Y.3    Sun, A.Y.4
  • 84
    • 0032897558 scopus 로고    scopus 로고
    • Antioxidant and cytotoxic effects of bilirubin on neonatal erythrocytes
    • Mireles, L. C., Lum, M. A., and Dennery, P. A. (1999). Antioxidant and cytotoxic effects of bilirubin on neonatal erythrocytes. Pediatr. Res. 45, 355-362.
    • (1999) Pediatr. Res. , vol.45 , pp. 355-362
    • Mireles, L.C.1    Lum, M.A.2    Dennery, P.A.3
  • 85
    • 0034682963 scopus 로고    scopus 로고
    • Aging is associated with increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects
    • Miro, O., Casademont, J., Casals, E., Perea, M., Urbano-Marquez, A., Rustin, P., and Cardellach, F. (2000). Aging is associated with increased lipid peroxidation in human hearts, but not with mitochondrial respiratory chain enzyme defects. Cardiovasc. Res. 47, 624-631.
    • (2000) Cardiovasc. Res. , vol.47 , pp. 624-631
    • Miro, O.1    Casademont, J.2    Casals, E.3    Perea, M.4    Urbano-Marquez, A.5    Rustin, P.6    Cardellach, F.7
  • 86
    • 0025309370 scopus 로고
    • The role of oxygen free radicals in the aging of the brain
    • Mizuno, Y. (1990). The role of oxygen free radicals in the aging of the brain. Nihon Ronen Igakkai Zasshi 27, 182-187.
    • (1990) Nihon Ronen Igakkai Zasshi , vol.27 , pp. 182-187
    • Mizuno, Y.1
  • 87
    • 4544385468 scopus 로고    scopus 로고
    • Oxidative stress in cardiovascular disease: molecular basis of its deleterious effects, its detection, and therapeutic considerations
    • Molavi, B., and Mehta, J. L. (2004). Oxidative stress in cardiovascular disease: molecular basis of its deleterious effects, its detection, and therapeutic considerations. Curr. Opin. Cardiol. 19, 488-493.
    • (2004) Curr. Opin. Cardiol. , vol.19 , pp. 488-493
    • Molavi, B.1    Mehta, J.L.2
  • 88
    • 31344432053 scopus 로고    scopus 로고
    • Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
    • Muralikrishna Adibhatla, R., and Hatcher, J. F. (2006). Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia. Free Radic. Biol. Med. 40, 376-387.
    • (2006) Free Radic. Biol. Med. , vol.40 , pp. 376-387
    • Muralikrishna Adibhatla, R.1    Hatcher, J.F.2
  • 90
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Ning, Y., Venable, S. F., Pereira-Smith, O. M., and Smith, J. R. (1994). Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211, 90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 91
    • 0035292954 scopus 로고    scopus 로고
    • A patient with exacerbation of idiopathic pulmonary fibrosis which was resolved probably due to the coexisting hyperbilirubinemia?
    • Ohrui, T., Higuchi, M., Kanda, A., Matsui,T.,Sato,E.,and Sasaki,H. (2001). A patient with exacerbation of idiopathic pulmonary fibrosis which was resolved probably due to the coexisting hyperbilirubinemia? Tohoku J. Exp. Med. 193, 245-249.
    • (2001) Tohoku J Exp. Med. , vol.193 , pp. 245-249
    • Ohrui, T.1    Higuchi, M.2    Kanda, A.3    Matsui, T.4    Sato, E.5    Sasaki, H.6
  • 92
    • 0036501115 scopus 로고    scopus 로고
    • Effects of light on low nocturnal bilirubin in winter depression: a preliminary report
    • Oren, D. A., Desan, P. H., Boutros, N., Anand, A., and Charney, D. S. (2002). Effects of light on low nocturnal bilirubin in winter depression: a preliminary report. Biol. Psychiatry 51, 422-425.
    • (2002) Biol. Psychiatry , vol.51 , pp. 422-425
    • Oren, D.A.1    Desan, P.H.2    Boutros, N.3    Anand, A.4    Charney, D.S.5
  • 93
    • 0032820186 scopus 로고    scopus 로고
    • Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle
    • Pansarasa, O., Bertorelli, L., Vecchiet, J., Felzani, G., and Marzatico, F. (1999). Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radic. Biol. Med. 27, 617-622.
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 617-622
    • Pansarasa, O.1    Bertorelli, L.2    Vecchiet, J.3    Felzani, G.4    Marzatico, F.5
  • 94
    • 80053898525 scopus 로고    scopus 로고
    • Nuclear barrier hypothesis of aging as mechanism for trade-off growth to survival
    • Park, S. C. (2011). Nuclear barrier hypothesis of aging as mechanism for trade-off growth to survival. Adv. Exp. Med. Biol. 720, 3-13.
    • (2011) Adv. Exp. Med. Biol. , vol.720 , pp. 3-13
    • Park, S.C.1
  • 95
    • 0034485898 scopus 로고    scopus 로고
    • Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and N(epsilon)-oxopropenyllysine
    • Plastaras, J. P., Riggins, J. N., Otteneder, M., and Marnett, L. J. (2000). Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and N(epsilon)-oxopropenyllysine. Chem. Res. Toxicol. 13, 1235-1242.
    • (2000) Chem. Res. Toxicol. , vol.13 , pp. 1235-1242
    • Plastaras, J.P.1    Riggins, J.N.2    Otteneder, M.3    Marnett, L.J.4
  • 97
    • 0035875690 scopus 로고    scopus 로고
    • Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis
    • Pratico, D., Uryu, K., Leight, S., Trojanoswki,J. Q.,and Lee,V. M. (2001). Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J. Neurosci. 21, 4183-4187
    • (2001) J. Neurosci. , vol.21 , pp. 4183-4187
    • Pratico, D.1    Uryu, K.2    Leight, S.3    Trojanoswki, J.Q.4    Lee, V.M.5
  • 98
    • 34147210154 scopus 로고    scopus 로고
    • Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain
    • Qin, J., Goswami, R., Balabanov, R., and Dawson, G. (2007). Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. J. Neurosci. Res. 85, 977-984.
    • (2007) J. Neurosci. Res. , vol.85 , pp. 977-984
    • Qin, J.1    Goswami, R.2    Balabanov, R.3    Dawson, G.4
  • 100
    • 78249284625 scopus 로고    scopus 로고
    • A free radicalgenerating system regulates APP metabolism/processing
    • Recuero, M., Munoz, T., Aldudo, J., Subias, M., Bullido, M. J., and Valdivieso, F. (2010). A free radicalgenerating system regulates APP metabolism/processing. FEBS Lett. 584, 4611-4618.
    • (2010) FEBS Lett , vol.584 , pp. 4611-4618
    • Recuero, M.1    Munoz, T.2    Aldudo, J.3    Subias, M.4    Bullido, M.J.5    Valdivieso, F.6
  • 101
    • 0035909483 scopus 로고    scopus 로고
    • Mutagenicity of the malondialdehyde oligomerization products 2-(3′-oxo-1′- propenyl)-malondialdehyde and 2,4-dihydroxymethylene-3-(2 2-dimethoxyethyl)glutaraldehyde in Salmonella
    • Riggins, J. N., and Marnett, L. J. (2001). Mutagenicity of the malondialdehyde oligomerization products 2-(3′-oxo-1′- propenyl)-malondialdehyde and 2,4-dihydroxymethylene-3-(2,2-dimethoxyethyl)glutaraldehyde in Salmonella. Mutat. Res. 497, 153-157.
    • (2001) Mutat. Res. , vol.497 , pp. 153-157
    • Riggins, J.N.1    Marnett, L.J.2
  • 102
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • Robles, S. J., and Adami, G. R. (1998). Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16, 1113-1123.
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 103
    • 0021669755 scopus 로고
    • Sex-and age-related differences in bilirubin concentrations in serum
    • Rosenthal, P., Pincus, M., and Fink, D. (1984). Sex-and age-related differences in bilirubin concentrations in serum. Clin. Chem. 30, 1380-1382.
    • (1984) Clin. Chem. , vol.30 , pp. 1380-1382
    • Rosenthal, P.1    Pincus, M.2    Fink, D.3
  • 104
    • 71949129504 scopus 로고    scopus 로고
    • Elevated malondialdehyde correlates with the extent of primary tumor and predicts poor prognosis of oropharyngeal cancer
    • Salzman, R., Pacal, L., Tomandl, J., Kankova, K., Tothova, E., Gal, B., Kostrica, R., and Salzman, P. (2009). Elevated malondialdehyde correlates with the extent of primary tumor and predicts poor prognosis of oropharyngeal cancer. Anticancer Res. 29, 4227-4231.
    • (2009) Anticancer Res , vol.29 , pp. 4227-4231
    • Salzman, R.1    Pacal, L.2    Tomandl, J.3    Kankova, K.4    Tothova, E.5    Gal, B.6    Kostrica, R.7    Salzman, P.8
  • 105
    • 0030925429 scopus 로고    scopus 로고
    • Characterization of cyanobacterial biliverdin reductase Conversion of biliverdin to bilirubin is important for normal phycobiliprotein biosynthesis
    • Schluchter, W. M., and Glazer, A. N. (1997). Characterization of cyanobacterial biliverdin reductase. Conversion of biliverdin to bilirubin is important for normal phycobiliprotein biosynthesis. J. Biol. Chem. 272, 13562-13569.
    • (1997) J. Biol. Chem. , vol.272 , pp. 13562-13569
    • Schluchter, W.M.1    Glazer, A.N.2
  • 106
    • 33845338765 scopus 로고    scopus 로고
    • Cellular senescence and cancer treatment
    • Schmitt, C. A. (2007). Cellular senescence and cancer treatment. Biochim. Biophys. Acta 1775, 5-20.
    • (2007) Biochim. Biophys. Acta , vol.1775 , pp. 5-20
    • Schmitt, C.A.1
  • 107
    • 0028084319 scopus 로고
    • Association of low serum concentration of bilirubin with increased risk of coronary artery disease
    • Schwertner, H. A., Jackson, W. G., and Tolan, G. (1994). Association of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin. Chem. 40, 18-23.
    • (1994) Clin. Chem. , vol.40 , pp. 18-23
    • Schwertner, H.A.1    Jackson, W.G.2    Tolan, G.3
  • 109
    • 2542577882 scopus 로고    scopus 로고
    • Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle
    • Sedlak, T. W., and Snyder, S. H. (2004). Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics 113, 1776-1782.
    • (2004) Pediatrics , vol.113 , pp. 1776-1782
    • Sedlak, T.W.1    Snyder, S.H.2
  • 110
    • 0033647999 scopus 로고    scopus 로고
    • HO (heme oxygenase)/CO (carbon monoxide) system
    • Seki, T., Curiel, D. T., Naruse, M., and Takano, K. (2000). HO (heme oxygenase)/CO (carbon monoxide) system. Nihon Rinsho 58(Suppl. 1), 188-191.
    • (2000) Nihon Rinsho , vol.58 , Issue.SUPPL. 1 , pp. 188-191
    • Seki, T.1    Curiel, D.T.2    Naruse, M.3    Takano, K.4
  • 111
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano, M., Lin, A. W., Mccurrach, M. E.,Beach, D.,and Lowe,S. W. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    Mccurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 112
    • 2442701519 scopus 로고    scopus 로고
    • Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden
    • Simpson, E. P., Henry,Y. K., Henkel, J. S., Smith,R. G.,and Appel,S. H. (2004). Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden. Neurology 62, 1758-1765.
    • (2004) Neurology , vol.62 , pp. 1758-1765
    • Simpson, E.P.1    Henry, Y.K.2    Henkel, J.S.3    Smith, R.G.4    Appel, S.H.5
  • 113
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal, R. S., and Weindruch, R. (1996). Oxidative stress, caloric restriction, and aging. Science 273, 59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 114
    • 0025150387 scopus 로고
    • Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
    • Stein, G. H., Beeson, M., and Gordon, L. (1990). Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249, 666-669.
    • (1990) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 115
    • 0023445053 scopus 로고
    • Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile
    • Stocker, R., and Ames, B. N. (1987). Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proc. Natl. Acad. Sci. U.S.A. 84, 8130-8134.
    • (1987) Proc. Natl. Acad. Sci. U. S. A. , vol.84 , pp. 8130-8134
    • Stocker, R.1    Ames, B.N.2
  • 116
    • 0025150585 scopus 로고
    • Antioxidant activities of bile pigments: biliverdin and bilirubin
    • Stocker, R., Mcdonagh, A. F., Glazer, A. N., and Ames, B. N. (1990). Antioxidant activities of bile pigments: biliverdin and bilirubin. Meth. Enzymol. 186, 301-309.
    • (1990) Meth. Enzymol. , vol.186 , pp. 301-309
    • Stocker, R.1    Mcdonagh, A.F.2    Glazer, A.N.3    Ames, B.N.4
  • 117
    • 0031043074 scopus 로고    scopus 로고
    • Nitric oxide activates skeletal and cardiac ryanodine receptors
    • Stoyanovsky, D., Murphy, T., Anno, P. R., Kim, Y. M., and Salama, G. (1997). Nitric oxide activates skeletal and cardiac ryanodine receptors. Cell Calcium 21, 19-29.
    • (1997) Cell Calcium , vol.21 , pp. 19-29
    • Stoyanovsky, D.1    Murphy, T.2    Anno, P.R.3    Kim, Y.M.4    Salama, G.5
  • 119
    • 48249153856 scopus 로고    scopus 로고
    • Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin
    • Tudor, C., Lerner-Marmarosh, N., Engelborghs, Y., Gibbs, P. E., and Maines, M. D. (2008). Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin. Biochem. J. 413, 405-416.
    • (2008) Biochem. J. , vol.413 , pp. 405-416
    • Tudor, C.1    Lerner-Marmarosh, N.2    Engelborghs, Y.3    Gibbs, P.E.4    Maines, M.D.5
  • 121
    • 0035712983 scopus 로고    scopus 로고
    • Serum bilirubin concentration in a Belgian population: the association with smoking status and type of cigarettes
    • Van Hoydonck, P. G., Temme, E. H., and Schouten, E. G. (2001). Serum bilirubin concentration in a Belgian population: the association with smoking status and type of cigarettes. Int. J. Epidemiol. 30, 1465-1472.
    • (2001) Int. J. Epidemiol. , vol.30 , pp. 1465-1472
    • Van Hoydonck, P.G.1    Temme, E.H.2    Schouten, E.G.3
  • 123
    • 23244442108 scopus 로고    scopus 로고
    • Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels
    • 2nd
    • Ward, W. F., Qi, W., Van Remmen, H., Zackert, W. E., Roberts, L. J., 2nd and Richardson, A. (2005). Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J. Gerontol. A Biol. Sci. Med. Sci. 60, 847-851.
    • (2005) J. Gerontol. A Biol. Sci. Med. Sci. , vol.60 , pp. 847-851
    • Ward, W.F.1    Qi, W.2    Van Remmen, H.3    Zackert, W.E.4    Roberts, L.J.5    Richardson, A.6
  • 125
    • 43949135165 scopus 로고    scopus 로고
    • Old biliverdin reductase: links to insulin resistance and may be a novel therapeutic target
    • Wu, B., Liu, X., and Shen, J. (2008). Old biliverdin reductase: links to insulin resistance and may be a novel therapeutic target. Med. Hypotheses 71, 73-76.
    • (2008) Med. Hypotheses , vol.71 , pp. 73-76
    • Wu, B.1    Liu, X.2    Shen, J.3
  • 126
    • 0029868642 scopus 로고    scopus 로고
    • Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins
    • Wu, T. W., Fung, K. P., Wu, J., Yang, C. C., and Weisel, R. D. (1996). Antioxidation of human low density lipoprotein by unconjugated and conjugated bilirubins. Biochem. Pharmacol. 51, 859-862.
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 859-862
    • Wu, T.W.1    Fung, K.P.2    Wu, J.3    Yang, C.C.4    Weisel, R.D.5
  • 127
    • 0348107413 scopus 로고    scopus 로고
    • The iron hypothesis of atherosclerosis and its clinical impact
    • Yuan, X. M., and Li, W. (2003). The iron hypothesis of atherosclerosis and its clinical impact. Ann. Med. 35, 578-591.
    • (2003) Ann. Med. , vol.35 , pp. 578-591
    • Yuan, X.M.1    Li, W.2
  • 128
    • 77957820976 scopus 로고    scopus 로고
    • Caloric restriction improves endothelial dysfunction during vascular aging: effects on nitric oxide synthase isoforms and oxidative stress in rat aorta
    • Zanetti, M., Gortan Cappellari, G., Burekovic, I., Barazzoni, R., Stebel, M., and Guarnieri, G. (2010). Caloric restriction improves endothelial dysfunction during vascular aging: effects on nitric oxide synthase isoforms and oxidative stress in rat aorta. Exp. Gerontol. 45, 848-855.
    • (2010) Exp. Gerontol. , vol.45 , pp. 848-855
    • Zanetti, M.1    Gortan Cappellari, G.2    Burekovic, I.3    Barazzoni, R.4    Stebel, M.5    Guarnieri, G.6
  • 129
    • 0038278597 scopus 로고    scopus 로고
    • The effects of bilirubin on evoked potentials and long-term potentiation in rat hippocampus in vivo
    • Zhang, L., Liu, W., Tanswell, A. K., and Luo, X. (2003). The effects of bilirubin on evoked potentials and long-term potentiation in rat hippocampus in vivo. Pediatr. Res. 53, 939-944.
    • (2003) Pediatr. Res. , vol.53 , pp. 939-944
    • Zhang, L.1    Liu, W.2    Tanswell, A.K.3    Luo, X.4
  • 130
    • 0032192153 scopus 로고    scopus 로고
    • Senescence of human fibroblasts induced by oncogenic Raf
    • Zhu, J., Woods, D., Mcmahon, M., and Bishop, J. M. (1998). Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev. 12, 2997-3007.
    • (1998) Genes Dev , vol.12 , pp. 2997-3007
    • Zhu, J.1    Woods, D.2    Mcmahon, M.3    Bishop, J.M.4
  • 131
    • 33947178563 scopus 로고    scopus 로고
    • Alzheimer disease, the two-hit hypothesis: an update
    • Zhu, X., Lee, H. G., Perry, G., and Smith, M. A. (2007). Alzheimer disease, the two-hit hypothesis: an update. Biochim. Biophys. Acta 1772, 494-502.
    • (2007) Biochim. Biophys. Acta , vol.1772 , pp. 494-502
    • Zhu, X.1    Lee, H.G.2    Perry, G.3    Smith, M.A.4


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