Mutagenicity of the malondialdehyde oligomerization products 2-(3′-oxo-1′-propenyl)-malondialdehyde and 2,4-dihydroxymethylene-3-(2,2-dimethoxyethyl)glutaraldehyde in Salmonella

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 497, Issue 1-2, 2001, Pages 153-157

  Riggins, James N ^a   Marnett, Lawrence J ^a  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Frameshift mutation; MDA; MDA polymerization products

Indexed keywords

2 (3' OXO 1' PROPENYL)MALONALDEHYDE; 2,4 DIHYDROXYMETHYLENE 3 (2,2 DIMETHOXYETHYL)GLUTARALDEHYDE; MALONALDEHYDE; UNCLASSIFIED DRUG;

AMES TEST; ARTICLE; CONTROLLED STUDY; FRAMESHIFT MUTATION; HYDROLYSIS; LIPID PEROXIDATION; MUTAGENICITY; NONHUMAN; OLIGOMERIZATION; POLYMERIZATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SALMONELLA; THERMODYNAMICS;

DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTARAL; MALONDIALDEHYDE; MUTAGENICITY TESTS; MUTAGENS; SALMONELLA TYPHIMURIUM; THERMODYNAMICS;

EID: 0035909483     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(01)00253-4     Document Type: Article

References (17)

1. 1α
2. Conversion of prostaglandin endoperoxides to C17-hydroxyacids by human platelet thromboxane synthase
3. A suggested mechanism for the production of malondialdehyde during the autoxidation of polyunsaturated fatty acids. Non-enzymatic production of prostaglandin endoperoxides during autoxidation
4. Reaction of malondialdehyde with guanine nucleosides: Formation of adducts containing oxadiazabicyclononene residues in the base-pairing region
5. Identification of adducts formed by reaction of guanine nucleosides with malondialdehyde and structurally related aldehydes
6. Structure of a new modified nucleoside formed by guanosine malonaldehyde reaction
7. Novel adducts from the modification of nucleic acid bases by malondialdehyde
8. Mutagenicity of malondialdehyde, a decomposition product of peroxidized polyunsaturated fatty acids
9. Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escherichia coli: Determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced
10. Mutagenicity and cytotoxicity of malondialdehyde in mammalian cells
11. Comparison of the mutagenicities of malondialdehyde and side products formed during its chemical synthesis
12. Dimer and trimer of malondialdehyde
13. Cleavage and oligomerization of malondialdehyde
14. Unequivocal demonstration that malondialdehyde is a mutagen
15. Revised methods for the Salmonella mutagenicity test
16. Molecular requirements for the mutagenicity of malondialdehyde and related acroleins
17. Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA 104