Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 24882-24895

  Albershardt, Tina C ^a   Salerni, Bethany L ^a   Soderquist, Ryan S ^a   Bates, Darcy J P ^a   Pletnev, Alexandre A ^a,b   Kisselev, Alexei F ^a,b   Eastman, Alan ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b Dartmouth College ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-APOPTOTIC PROTEIN; ANTIAPOPTOTIC; CANCER CELLS; CELL-BASED; ENDOPLASMIC RETICULUM STRESS RESPONSE; IN-VITRO; LEUKEMIA CELLS; MIMETICS; NOVEL STRATEGIES; SIGNALING PATHWAYS; SMALL MOLECULES;

CELL CULTURE; CELL DEATH; CHEMOTHERAPY; DISEASES;

PROTEINS;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 2 METHOXY ANTIMYCIN A3; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENT; APOGOSSYPOL; BH3 PROTEIN; BIM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; GOSSYPOL; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OBATOCLAX; PROTEIN BAD; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; PROTEIN NOXA; PUMA PROTEIN; UNCLASSIFIED DRUG; VINBLASTINE;

APOPTOSIS; ARTICLE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG CYTOTOXICITY; DRUG SENSITIZATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOSIS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; APOPTOSIS REGULATORY PROTEINS; BCL-ASSOCIATED DEATH PROTEIN; BIPHENYL COMPOUNDS; ENDOPLASMIC RETICULUM STRESS; HUMANS; K562 CELLS; MEMBRANE PROTEINS; NITROPHENOLS; PEPTIDE FRAGMENTS; PEPTIDOMIMETICS; PIPERAZINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; SULFONAMIDES; UP-REGULATION;

EID: 79960119761     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.255828     Document Type: Article

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