Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma

PLoS ONE

Volumn 2, Issue 6, 2007, Pages

  Kress, Christina L ^a   Konopleva, Marina ^b   Martínez García, Vanesa ^a,c   Krajewska, Maryla ^a   Lefebvre, Sophie ^a   Hyer, Marc L ^a   McQueen, Teresa ^b   Andreeff, Michael ^b   Reed, John C ^a   Zapata, Juan M ^a,c  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID DERIVATIVE; LIPOSOME; TRITERPENOID; UNCLASSIFIED DRUG; 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; DRUG DERIVATIVE; OLEANOLIC ACID; PROTEIN BCL 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; BLOOD CELL; CANCER INFILTRATION; CELL MIGRATION; CELL VIABILITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG FORMULATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EX VIVO STUDY; EXPERIMENTAL NEOPLASM; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG; LYMPHOCYTOMA; LYMPHOID ORGAN; MONOTHERAPY; MOUSE; NONHUMAN; SPLEEN CELL; T LYMPHOCYTE; TRANSGENIC MOUSE; ANIMAL; BAGG ALBINO MOUSE; CELL SURVIVAL; DISEASE MODEL; DRUG EFFECT; ENZYME IMMUNOASSAY; FEMALE; FLOW CYTOMETRY; GENE DELETION; MALE; PATHOLOGY; PHYSIOLOGY;

MUS; MUS MUSCULUS;

ANIMALS; B-LYMPHOCYTES; CELL SURVIVAL; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; GENE DELETION; HUMANS; IMMUNOENZYME TECHNIQUES; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOMA, B-CELL; MALE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; OLEANOLIC ACID; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTES; TNF RECEPTOR-ASSOCIATED FACTOR 2;

EID: 39349100310     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000559     Document Type: Article

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