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Volumn 7, Issue , 2012, Pages

Identifying the mechanisms of intron gain: progress and trends

Author keywords

Evolution; Gene structure; Intron; Intron evolution; Intron gain; Mechanism

Indexed keywords

CELL NUCLEUS; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; EUKARYOTE; GENE DUPLICATION; GENETICS; INTRON; METABOLISM; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; REVIEW; RNA SPLICING; SPLICEOSOME; TRANSPOSON;

EID: 84865845484     PISSN: None     EISSN: 17456150     Source Type: Journal    
DOI: 10.1186/1745-6150-7-29     Document Type: Review
Times cited : (60)

References (103)
  • 1
    • 84859729407 scopus 로고    scopus 로고
    • Origin and evolution of spliceosomal introns
    • 10.1186/1745-6150-7-11, 22507701
    • Rogozin IB, Carmel L, Csuros M, Koonin EV. Origin and evolution of spliceosomal introns. Biol Direct 2012, 7:11. 10.1186/1745-6150-7-11, 22507701.
    • (2012) Biol Direct , vol.7 , pp. 11
    • Rogozin, I.B.1    Carmel, L.2    Csuros, M.3    Koonin, E.V.4
  • 2
    • 69249211050 scopus 로고    scopus 로고
    • Intron-dominated genomes of early ancestors of eukaryotes
    • 10.1093/jhered/esp056, 2877545, 19617525
    • Koonin EV. Intron-dominated genomes of early ancestors of eukaryotes. J Hered 2009, 100:618-623. 10.1093/jhered/esp056, 2877545, 19617525.
    • (2009) J Hered , vol.100 , pp. 618-623
    • Koonin, E.V.1
  • 3
    • 0035252410 scopus 로고    scopus 로고
    • Alternative splicing: increasing diversity in the proteomic world
    • 10.1016/S0168-9525(00)02176-4, 11173120
    • Graveley BR. Alternative splicing: increasing diversity in the proteomic world. Trends Genet 2001, 17:100-107. 10.1016/S0168-9525(00)02176-4, 11173120.
    • (2001) Trends Genet , vol.17 , pp. 100-107
    • Graveley, B.R.1
  • 4
    • 0025906388 scopus 로고
    • A generic intron increases gene expression in transgenic mice
    • 360146, 2038318
    • Choi T, Huang M, Gorman C, Jaenisch R. A generic intron increases gene expression in transgenic mice. Mol Cell Biol 1991, 11:3070-3074. 360146, 2038318.
    • (1991) Mol Cell Biol , vol.11 , pp. 3070-3074
    • Choi, T.1    Huang, M.2    Gorman, C.3    Jaenisch, R.4
  • 5
    • 0037398519 scopus 로고    scopus 로고
    • How introns influence and enhance eukaryotic gene expression
    • 10.1016/S0968-0004(03)00052-5, 12713906
    • Le HH, Nott A, Moore MJ. How introns influence and enhance eukaryotic gene expression. Trends Biochem Sci 2003, 28:215-220. 10.1016/S0968-0004(03)00052-5, 12713906.
    • (2003) Trends Biochem Sci , vol.28 , pp. 215-220
    • Le, H.H.1    Nott, A.2    Moore, M.J.3
  • 6
    • 42149178405 scopus 로고    scopus 로고
    • Splicing promotes rapid and efficient mRNA export in mammalian cells
    • 10.1073/pnas.0800250105, 2265164, 18287003
    • Valencia P, Dias AP, Reed R. Splicing promotes rapid and efficient mRNA export in mammalian cells. Proc Natl Acad Sci USA 2008, 105:3386-3391. 10.1073/pnas.0800250105, 2265164, 18287003.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3386-3391
    • Valencia, P.1    Dias, A.P.2    Reed, R.3
  • 9
    • 0022416122 scopus 로고
    • Exon shuffling and intron insertion in serine protease genes
    • 10.1038/315458a0, 3889660
    • Rogers J. Exon shuffling and intron insertion in serine protease genes. Nature 1985, 315:458-459. 10.1038/315458a0, 3889660.
    • (1985) Nature , vol.315 , pp. 458-459
    • Rogers, J.1
  • 10
    • 4143150876 scopus 로고    scopus 로고
    • Preferential loss and gain of introns in 3' portions of genes suggests a reverse-transcription mechanism of intron insertion
    • 10.1016/j.gene.2004.05.027, 15302409
    • Sverdlov AV, Babenko VN, Rogozin IB, Koonin EV. Preferential loss and gain of introns in 3' portions of genes suggests a reverse-transcription mechanism of intron insertion. Gene 2004, 338:85-91. 10.1016/j.gene.2004.05.027, 15302409.
    • (2004) Gene , vol.338 , pp. 85-91
    • Sverdlov, A.V.1    Babenko, V.N.2    Rogozin, I.B.3    Koonin, E.V.4
  • 11
    • 0042921194 scopus 로고    scopus 로고
    • Remarkable interkingdom conservation of intron positions and massive, lineage-specific intron loss and gain in eukaryotic evolution
    • 10.1016/S0960-9822(03)00558-X, 12956953
    • Rogozin IB, Wolf YI, Sorokin AV, Mirkin BG, Koonin EV. Remarkable interkingdom conservation of intron positions and massive, lineage-specific intron loss and gain in eukaryotic evolution. Curr Biol 2003, 13:1512-1517. 10.1016/S0960-9822(03)00558-X, 12956953.
    • (2003) Curr Biol , vol.13 , pp. 1512-1517
    • Rogozin, I.B.1    Wolf, Y.I.2    Sorokin, A.V.3    Mirkin, B.G.4    Koonin, E.V.5
  • 12
    • 0037795455 scopus 로고    scopus 로고
    • Large-scale comparison of intron positions in mammalian genes shows intron loss but no gain
    • 10.1073/pnas.1232297100, 165846, 12777620
    • Roy SW, Fedorov A, Gilbert W. Large-scale comparison of intron positions in mammalian genes shows intron loss but no gain. Proc Natl Acad Sci USA 2003, 100:7158-7162. 10.1073/pnas.1232297100, 165846, 12777620.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7158-7162
    • Roy, S.W.1    Fedorov, A.2    Gilbert, W.3
  • 13
    • 14044252770 scopus 로고    scopus 로고
    • Patterns of intron gain and loss in fungi
    • 10.1371/journal.pbio.0020422, 532390, 15562318
    • Nielsen CB, Friedman B, Birren B, Burge CB, Galagan JE. Patterns of intron gain and loss in fungi. PLoS Biol 2004, 2:e422. 10.1371/journal.pbio.0020422, 532390, 15562318.
    • (2004) PLoS Biol , vol.2
    • Nielsen, C.B.1    Friedman, B.2    Birren, B.3    Burge, C.B.4    Galagan, J.E.5
  • 14
    • 33744789972 scopus 로고    scopus 로고
    • Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number
    • 10.1101/gr.4845406, 1473185, 16702411
    • Roy SW, Hartl DL. Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number. Genome Res 2006, 16:750-756. 10.1101/gr.4845406, 1473185, 16702411.
    • (2006) Genome Res , vol.16 , pp. 750-756
    • Roy, S.W.1    Hartl, D.L.2
  • 15
    • 33745088890 scopus 로고    scopus 로고
    • Intron gain and loss in segmentally duplicated genes in rice
    • 10.1186/gb-2006-7-5-r41, 1779517, 16719932
    • Lin H, Zhu W, Silva JC, Gu X, Buell CR. Intron gain and loss in segmentally duplicated genes in rice. Genome Biol 2006, 7:R41. 10.1186/gb-2006-7-5-r41, 1779517, 16719932.
    • (2006) Genome Biol , vol.7
    • Lin, H.1    Zhu, W.2    Silva, J.C.3    Gu, X.4    Buell, C.R.5
  • 16
    • 33646904207 scopus 로고    scopus 로고
    • Evidence of mRNA-mediated intron loss in the human-pathogenic fungus Cryptococcus neoformans
    • 10.1128/EC.5.5.789-793.2006, 1459680, 16682456
    • Stajich JE, Dietrich FS. Evidence of mRNA-mediated intron loss in the human-pathogenic fungus Cryptococcus neoformans. Eukaryot Cell 2006, 5:789-793. 10.1128/EC.5.5.789-793.2006, 1459680, 16682456.
    • (2006) Eukaryot Cell , vol.5 , pp. 789-793
    • Stajich, J.E.1    Dietrich, F.S.2
  • 18
    • 33748029468 scopus 로고    scopus 로고
    • High rate of recent intron gain and loss in simultaneously duplicated Arabidopsis genes
    • 10.1093/molbev/msl017, 16720694
    • Knowles DG, McLysaght A. High rate of recent intron gain and loss in simultaneously duplicated Arabidopsis genes. Mol Biol Evol 2006, 23:1548-1557. 10.1093/molbev/msl017, 16720694.
    • (2006) Mol Biol Evol , vol.23 , pp. 1548-1557
    • Knowles, D.G.1    McLysaght, A.2
  • 19
    • 33845982198 scopus 로고    scopus 로고
    • Characterization of intron loss events in mammals
    • 1716263, 17108319
    • Coulombe-Huntington J, Majewski J. Characterization of intron loss events in mammals. Genome Res 2007, 17:23-32. 1716263, 17108319.
    • (2007) Genome Res , vol.17 , pp. 23-32
    • Coulombe-Huntington, J.1    Majewski, J.2
  • 20
    • 39749196163 scopus 로고    scopus 로고
    • Investigation of loss and gain of introns in the compact genomes of pufferfishes (Fugu and Tetraodon)
    • 10.1093/molbev/msm278, 18089580
    • Loh YH, Brenner S, Venkatesh B. Investigation of loss and gain of introns in the compact genomes of pufferfishes (Fugu and Tetraodon). Mol Biol Evol 2008, 25:526-535. 10.1093/molbev/msm278, 18089580.
    • (2008) Mol Biol Evol , vol.25 , pp. 526-535
    • Loh, Y.H.1    Brenner, S.2    Venkatesh, B.3
  • 21
    • 46149104413 scopus 로고    scopus 로고
    • Mechanisms of intron gain and loss in Cryptococcus
    • 10.1186/gb-2008-9-1-r24, 2395259, 18234113
    • Sharpton TJ, Neafsey DE, Galagan JE, Taylor JW. Mechanisms of intron gain and loss in Cryptococcus. Genome Biol 2008, 9:R24. 10.1186/gb-2008-9-1-r24, 2395259, 18234113.
    • (2008) Genome Biol , vol.9
    • Sharpton, T.J.1    Neafsey, D.E.2    Galagan, J.E.3    Taylor, J.W.4
  • 22
    • 78649999037 scopus 로고    scopus 로고
    • Evaluation of models of the mechanisms underlying intron loss and gain in Aspergillus fungi
    • 10.1007/s00239-010-9391-6, 20862581
    • Zhang LY, Yang YF, Niu DK. Evaluation of models of the mechanisms underlying intron loss and gain in Aspergillus fungi. J Mol Evol 2010, 71:364-373. 10.1007/s00239-010-9391-6, 20862581.
    • (2010) J Mol Evol , vol.71 , pp. 364-373
    • Zhang, L.Y.1    Yang, Y.F.2    Niu, D.K.3
  • 23
    • 83655182609 scopus 로고    scopus 로고
    • Mechanisms of intron gain and loss in Drosophila
    • 10.1186/1471-2148-11-364, 3296678, 22182367
    • Yenerall P, Krupa B, Zhou L. Mechanisms of intron gain and loss in Drosophila. BMC Evol Biol 2011, 11:364. 10.1186/1471-2148-11-364, 3296678, 22182367.
    • (2011) BMC Evol Biol , vol.11 , pp. 364
    • Yenerall, P.1    Krupa, B.2    Zhou, L.3
  • 24
    • 3843113189 scopus 로고    scopus 로고
    • Origins of recently gained introns in Caenorhabditis
    • 10.1073/pnas.0308192101, 509176, 15243155
    • Coghlan A, Wolfe KH. Origins of recently gained introns in Caenorhabditis. Proc Natl Acad Sci USA 2004, 101:11362-11367. 10.1073/pnas.0308192101, 509176, 15243155.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 11362-11367
    • Coghlan, A.1    Wolfe, K.H.2
  • 27
    • 70849137211 scopus 로고    scopus 로고
    • Extensive, recent intron gains in Daphnia populations
    • 10.1126/science.1179302, 19965475
    • Li W, Tucker AE, Sung W, Thomas WK, Lynch M. Extensive, recent intron gains in Daphnia populations. Science 2009, 326:1260-1262. 10.1126/science.1179302, 19965475.
    • (2009) Science , vol.326 , pp. 1260-1262
    • Li, W.1    Tucker, A.E.2    Sung, W.3    Thomas, W.K.4    Lynch, M.5
  • 28
    • 76749130220 scopus 로고    scopus 로고
    • Nonsense-mediated decay enables intron gain in Drosophila
    • 10.1371/journal.pgen.1000819, 2809761, 20107520
    • Farlow A, Meduri E, Dolezal M, Hua L, Schlotterer C. Nonsense-mediated decay enables intron gain in Drosophila. PLoS Genet 2010, 6:e1000819. 10.1371/journal.pgen.1000819, 2809761, 20107520.
    • (2010) PLoS Genet , vol.6
    • Farlow, A.1    Meduri, E.2    Dolezal, M.3    Hua, L.4    Schlotterer, C.5
  • 29
    • 80053442983 scopus 로고    scopus 로고
    • A detailed history of intron-rich eukaryotic ancestors inferred from a global survey of 100 complete genomes
    • 10.1371/journal.pcbi.1002150, 3174169, 21935348
    • Csuros M, Rogozin IB, Koonin EV. A detailed history of intron-rich eukaryotic ancestors inferred from a global survey of 100 complete genomes. PLoS Comput Biol 2011, 7:e1002150. 10.1371/journal.pcbi.1002150, 3174169, 21935348.
    • (2011) PLoS Comput Biol , vol.7
    • Csuros, M.1    Rogozin, I.B.2    Koonin, E.V.3
  • 30
    • 78650616014 scopus 로고    scopus 로고
    • DNA double-strand break repair and the evolution of intron density
    • 3020277, 21106271
    • Farlow A, Meduri E, Schlotterer C. DNA double-strand break repair and the evolution of intron density. Trends Genet 2010, 27:1-6. 3020277, 21106271.
    • (2010) Trends Genet , vol.27 , pp. 1-6
    • Farlow, A.1    Meduri, E.2    Schlotterer, C.3
  • 31
    • 0031593151 scopus 로고    scopus 로고
    • A variable intron distribution in globin genes of Chironomus: evidence for recent intron gain
    • 10.1016/S0378-1119(97)00518-0, 9461389
    • Hankeln T, Friedl H, Ebersberger I, Martin J, Schmidt ER. A variable intron distribution in globin genes of Chironomus: evidence for recent intron gain. Gene 1997, 205:151-160. 10.1016/S0378-1119(97)00518-0, 9461389.
    • (1997) Gene , vol.205 , pp. 151-160
    • Hankeln, T.1    Friedl, H.2    Ebersberger, I.3    Martin, J.4    Schmidt, E.R.5
  • 32
    • 0142092553 scopus 로고    scopus 로고
    • Mystery of intron gain
    • 10.1101/gr.1029803, 403686, 12975308
    • Fedorov A, Roy S, Fedorova L, Gilbert W. Mystery of intron gain. Genome Res 2003, 13:2236-2241. 10.1101/gr.1029803, 403686, 12975308.
    • (2003) Genome Res , vol.13 , pp. 2236-2241
    • Fedorov, A.1    Roy, S.2    Fedorova, L.3    Gilbert, W.4
  • 33
    • 44449093240 scopus 로고    scopus 로고
    • Alternative splicing: a missing piece in the puzzle of intron gain
    • 10.1073/pnas.0802941105, 2438231, 18463286
    • Tarrio R, Ayala FJ, Rodriguez-Trelles F. Alternative splicing: a missing piece in the puzzle of intron gain. Proc Natl Acad Sci USA 2008, 105:7223-7228. 10.1073/pnas.0802941105, 2438231, 18463286.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7223-7228
    • Tarrio, R.1    Ayala, F.J.2    Rodriguez-Trelles, F.3
  • 34
    • 59349107038 scopus 로고    scopus 로고
    • Mystery of intron gain: new data and new models
    • 10.1016/j.tig.2008.11.004, 19070397
    • Roy SW, Irimia M. Mystery of intron gain: new data and new models. Trends Genet 2009, 25:67-73. 10.1016/j.tig.2008.11.004, 19070397.
    • (2009) Trends Genet , vol.25 , pp. 67-73
    • Roy, S.W.1    Irimia, M.2
  • 35
    • 84855888714 scopus 로고    scopus 로고
    • The role of reverse-transcriptase in intron gain and loss mechanisms
    • Cohen NE, Shen R, Carmel L. The role of reverse-transcriptase in intron gain and loss mechanisms. Mol Biol Evol 2011, 29:179-186.
    • (2011) Mol Biol Evol , vol.29 , pp. 179-186
    • Cohen, N.E.1    Shen, R.2    Carmel, L.3
  • 36
    • 0027446476 scopus 로고
    • A role for reverse transcripts in gene conversion
    • 10.1038/361170a0, 8380627
    • Derr LK, Strathern JN. A role for reverse transcripts in gene conversion. Nature 1993, 361:170-173. 10.1038/361170a0, 8380627.
    • (1993) Nature , vol.361 , pp. 170-173
    • Derr, L.K.1    Strathern, J.N.2
  • 37
    • 33644847698 scopus 로고    scopus 로고
    • The evolution of spliceosomal introns: patterns, puzzles and progress
    • Roy SW, Gilbert W. The evolution of spliceosomal introns: patterns, puzzles and progress. Nat Rev Genet 2006, 7:211-221.
    • (2006) Nat Rev Genet , vol.7 , pp. 211-221
    • Roy, S.W.1    Gilbert, W.2
  • 38
    • 0022131865 scopus 로고
    • On the origin of RNA splicing and introns
    • 10.1016/0092-8674(85)90092-3, 2411416
    • Sharp PA. On the origin of RNA splicing and introns. Cell 1985, 42:397-400. 10.1016/0092-8674(85)90092-3, 2411416.
    • (1985) Cell , vol.42 , pp. 397-400
    • Sharp, P.A.1
  • 39
    • 0018758145 scopus 로고
    • Split genes and RNA splicing
    • 10.1126/science.373120, 373120
    • Crick F. Split genes and RNA splicing. Science 1979, 204:264-271. 10.1126/science.373120, 373120.
    • (1979) Science , vol.204 , pp. 264-271
    • Crick, F.1
  • 40
    • 0024365086 scopus 로고
    • How were introns inserted into nuclear genes?
    • Rogers JH. How were introns inserted into nuclear genes?. Trends Genet 1989, 5:213-216.
    • (1989) Trends Genet , vol.5 , pp. 213-216
    • Rogers, J.H.1
  • 41
    • 47249165090 scopus 로고    scopus 로고
    • Origin of introns by 'intronization' of exonic sequences
    • 10.1016/j.tig.2008.05.007, 18597887
    • Irimia M, Rukov JL, Penny D, Vinther J, Garcia-Fernandez J, Roy SW. Origin of introns by 'intronization' of exonic sequences. Trends Genet 2008, 24:378-381. 10.1016/j.tig.2008.05.007, 18597887.
    • (2008) Trends Genet , vol.24 , pp. 378-381
    • Irimia, M.1    Rukov, J.L.2    Penny, D.3    Vinther, J.4    Garcia-Fernandez, J.5    Roy, S.W.6
  • 42
    • 70349100354 scopus 로고    scopus 로고
    • Intronization, de-intronization and intron sliding are rare in Cryptococcus
    • 10.1186/1471-2148-9-192, 2740785, 19664208
    • Roy SW. Intronization, de-intronization and intron sliding are rare in Cryptococcus. BMC Evol Biol 2009, 9:192. 10.1186/1471-2148-9-192, 2740785, 19664208.
    • (2009) BMC Evol Biol , vol.9 , pp. 192
    • Roy, S.W.1
  • 43
    • 33750938326 scopus 로고    scopus 로고
    • Smoke without fire: most reported cases of intron gain in nematodes instead reflect intron losses
    • 10.1093/molbev/msl098, 16943250
    • Roy SW, Penny D. Smoke without fire: most reported cases of intron gain in nematodes instead reflect intron losses. Mol Biol Evol 2006, 23:2259-2262. 10.1093/molbev/msl098, 16943250.
    • (2006) Mol Biol Evol , vol.23 , pp. 2259-2262
    • Roy, S.W.1    Penny, D.2
  • 44
    • 82955233922 scopus 로고    scopus 로고
    • Evidence for extensive recent intron transposition in closely related fungi
    • 10.1016/j.cub.2011.10.041, 22100062
    • Torriani SF, Stukenbrock EH, Brunner PC, McDonald BA, Croll D. Evidence for extensive recent intron transposition in closely related fungi. Curr Biol 2011, 21:2017-2022. 10.1016/j.cub.2011.10.041, 22100062.
    • (2011) Curr Biol , vol.21 , pp. 2017-2022
    • Torriani, S.F.1    Stukenbrock, E.H.2    Brunner, P.C.3    McDonald, B.A.4    Croll, D.5
  • 45
    • 38049125555 scopus 로고    scopus 로고
    • The endless tale of non-homologous end-joining
    • 10.1038/cr.2008.3, 18166980
    • Weterings E, Chen DJ. The endless tale of non-homologous end-joining. Cell Res 2008, 18:114-124. 10.1038/cr.2008.3, 18166980.
    • (2008) Cell Res , vol.18 , pp. 114-124
    • Weterings, E.1    Chen, D.J.2
  • 46
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • 10.1146/annurev.biochem.052308.093131, 3079308, 20192759
    • Lieber MR. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 2010, 79:181-211. 10.1146/annurev.biochem.052308.093131, 3079308, 20192759.
    • (2010) Annu Rev Biochem , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 47
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
    • 10.1042/BJ20080413, 2975036, 19133841
    • Mahaney BL, Meek K, Lees-Miller SP. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J 2009, 417:639-650. 10.1042/BJ20080413, 2975036, 19133841.
    • (2009) Biochem J , vol.417 , pp. 639-650
    • Mahaney, B.L.1    Meek, K.2    Lees-Miller, S.P.3
  • 48
    • 4544362838 scopus 로고    scopus 로고
    • The mechanism of non-homologous end-joining: a synopsis of synapsis
    • Weterings E, van Gent DC. The mechanism of non-homologous end-joining: a synopsis of synapsis. DNA Repair (Amst) 2004, 3:1425-1435.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1425-1435
    • Weterings, E.1    van Gent, D.C.2
  • 49
    • 32444441109 scopus 로고    scopus 로고
    • Models of spliceosomal intron proliferation in the face of widespread ectopic expression
    • 10.1016/j.gene.2005.09.004, 16288838
    • Rodriguez-Trelles F, Tarrio R, Ayala FJ. Models of spliceosomal intron proliferation in the face of widespread ectopic expression. Gene 2006, 366:201-208. 10.1016/j.gene.2005.09.004, 16288838.
    • (2006) Gene , vol.366 , pp. 201-208
    • Rodriguez-Trelles, F.1    Tarrio, R.2    Ayala, F.J.3
  • 50
    • 46449086933 scopus 로고    scopus 로고
    • Both catalytic steps of nuclear pre-mRNA splicing are reversible
    • 10.1126/science.1158993, 18583613
    • Tseng CK, Cheng SC. Both catalytic steps of nuclear pre-mRNA splicing are reversible. Science 2008, 320:1782-1784. 10.1126/science.1158993, 18583613.
    • (2008) Science , vol.320 , pp. 1782-1784
    • Tseng, C.K.1    Cheng, S.C.2
  • 51
    • 77956052286 scopus 로고    scopus 로고
    • Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns
    • 10.1261/rna.2186510, 2924538, 20610656
    • Crabb TL, Lam BJ, Hertel KJ. Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns. RNA 2010, 16:1786-1796. 10.1261/rna.2186510, 2924538, 20610656.
    • (2010) RNA , vol.16 , pp. 1786-1796
    • Crabb, T.L.1    Lam, B.J.2    Hertel, K.J.3
  • 52
    • 0034672093 scopus 로고    scopus 로고
    • The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
    • 10.1093/emboj/19.24.6860, 305905, 11118221
    • Le HH, Izaurralde E, Maquat LE, Moore MJ. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J 2000, 19:6860-6869. 10.1093/emboj/19.24.6860, 305905, 11118221.
    • (2000) EMBO J , vol.19 , pp. 6860-6869
    • Le, H.H.1    Izaurralde, E.2    Maquat, L.E.3    Moore, M.J.4
  • 53
    • 0033634824 scopus 로고    scopus 로고
    • Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
    • 10.1016/S1097-2765(00)00065-4, 11030346
    • Kataoka N, Yong J, Kim VN, Velazquez F, Perkinson RA, Wang F, Dreyfuss G. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm. Mol Cell 2000, 6:673-682. 10.1016/S1097-2765(00)00065-4, 11030346.
    • (2000) Mol Cell , vol.6 , pp. 673-682
    • Kataoka, N.1    Yong, J.2    Kim, V.N.3    Velazquez, F.4    Perkinson, R.A.5    Wang, F.6    Dreyfuss, G.7
  • 54
    • 0031844194 scopus 로고    scopus 로고
    • Evolutionary relationship of plant catalase genes inferred from exon-intron structures: isozyme divergence after the separation of monocots and dicots
    • Iwamoto M, Maekawa M, Saito A, Higo H, Higo K. Evolutionary relationship of plant catalase genes inferred from exon-intron structures: isozyme divergence after the separation of monocots and dicots. TAG Theoretical and Applied Genetics 1998, 97:9-19.
    • (1998) TAG Theoretical and Applied Genetics , vol.97 , pp. 9-19
    • Iwamoto, M.1    Maekawa, M.2    Saito, A.3    Higo, H.4    Higo, K.5
  • 55
    • 0028172882 scopus 로고
    • De novo synthesis of an intron by the maize transposable element Dissociation
    • 10.1073/pnas.91.25.12150, 45394, 7991598
    • Giroux MJ, Clancy M, Baier J, Ingham L, McCarty D, Hannah LC. De novo synthesis of an intron by the maize transposable element Dissociation. Proc Natl Acad Sci USA 1994, 91:12150-12154. 10.1073/pnas.91.25.12150, 45394, 7991598.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12150-12154
    • Giroux, M.J.1    Clancy, M.2    Baier, J.3    Ingham, L.4    McCarty, D.5    Hannah, L.C.6
  • 56
    • 80052409106 scopus 로고    scopus 로고
    • A segmental genomic duplication generates a functional intron
    • 3265369, 21878908
    • Hellsten U, Aspden JL, Rio DC, Rokhsar DS. A segmental genomic duplication generates a functional intron. Nat Commun 2011, 2:454. 3265369, 21878908.
    • (2011) Nat Commun , vol.2 , pp. 454
    • Hellsten, U.1    Aspden, J.L.2    Rio, D.C.3    Rokhsar, D.S.4
  • 57
    • 73949123826 scopus 로고    scopus 로고
    • Ubiquitous internal gene duplication and intron creation in eukaryotes
    • 10.1073/pnas.0911093106, 2791625, 19926850
    • Gao X, Lynch M. Ubiquitous internal gene duplication and intron creation in eukaryotes. Proc Natl Acad Sci USA 2009, 106:20818-20823. 10.1073/pnas.0911093106, 2791625, 19926850.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20818-20823
    • Gao, X.1    Lynch, M.2
  • 58
    • 19344368527 scopus 로고    scopus 로고
    • Continued colonization of the human genome by mitochondrial DNA
    • 10.1371/journal.pbio.0020273, 515365, 15361937
    • Ricchetti M, Tekaia F, Dujon B. Continued colonization of the human genome by mitochondrial DNA. PLoS Biol 2004, 2:e273. 10.1371/journal.pbio.0020273, 515365, 15361937.
    • (2004) PLoS Biol , vol.2
    • Ricchetti, M.1    Tekaia, F.2    Dujon, B.3
  • 59
    • 78149334830 scopus 로고    scopus 로고
    • A spliceosomal intron of mitochondrial DNA origin
    • 10.1016/j.cub.2010.09.038, 21056829
    • Curtis BA, Archibald JM. A spliceosomal intron of mitochondrial DNA origin. Curr Biol 2010, 20:R919-R920. 10.1016/j.cub.2010.09.038, 21056829.
    • (2010) Curr Biol , vol.20
    • Curtis, B.A.1    Archibald, J.M.2
  • 60
    • 77950940981 scopus 로고    scopus 로고
    • Nuclear expression of a group II intron is consistent with spliceosomal intron ancestry
    • 10.1101/gad.1905010, 2854396, 20351053
    • Chalamcharla VR, Curcio MJ, Belfort M. Nuclear expression of a group II intron is consistent with spliceosomal intron ancestry. Genes Dev 2010, 24:827-836. 10.1101/gad.1905010, 2854396, 20351053.
    • (2010) Genes Dev , vol.24 , pp. 827-836
    • Chalamcharla, V.R.1    Curcio, M.J.2    Belfort, M.3
  • 61
    • 78650460773 scopus 로고    scopus 로고
    • Primate and rodent specific intron gains and the origin of retrogenes with splice variants
    • 3002245, 20889727
    • Szczesniak MW, Ciomborowska J, Nowak W, Rogozin IB, Makalowska I. Primate and rodent specific intron gains and the origin of retrogenes with splice variants. Mol Biol Evol 2010, 28:33-37. 3002245, 20889727.
    • (2010) Mol Biol Evol , vol.28 , pp. 33-37
    • Szczesniak, M.W.1    Ciomborowska, J.2    Nowak, W.3    Rogozin, I.B.4    Makalowska, I.5
  • 62
    • 79951580190 scopus 로고    scopus 로고
    • De novo origin of new genes with introns in Plasmodium vivax
    • 10.1016/j.febslet.2011.01.017, 21241695
    • Yang Z, Huang J. De novo origin of new genes with introns in Plasmodium vivax. FEBS Lett 2011, 585:641-644. 10.1016/j.febslet.2011.01.017, 21241695.
    • (2011) FEBS Lett , vol.585 , pp. 641-644
    • Yang, Z.1    Huang, J.2
  • 63
    • 0024462103 scopus 로고
    • Evidence that introns arose at proto-splice sites
    • 401080, 2792080
    • Dibb NJ, Newman AJ. Evidence that introns arose at proto-splice sites. EMBO J 1989, 8:2015-2021. 401080, 2792080.
    • (1989) EMBO J , vol.8 , pp. 2015-2021
    • Dibb, N.J.1    Newman, A.J.2
  • 64
    • 3042548834 scopus 로고    scopus 로고
    • The evolutionary gain of spliceosomal introns: sequence and phase preferences
    • 10.1093/molbev/msh120, 15014153
    • Qiu WG, Schisler N, Stoltzfus A. The evolutionary gain of spliceosomal introns: sequence and phase preferences. Mol Biol Evol 2004, 21:1252-1263. 10.1093/molbev/msh120, 15014153.
    • (2004) Mol Biol Evol , vol.21 , pp. 1252-1263
    • Qiu, W.G.1    Schisler, N.2    Stoltzfus, A.3
  • 65
    • 4344639564 scopus 로고    scopus 로고
    • Reconstruction of ancestral protosplice sites
    • 10.1016/j.cub.2004.08.027, 15324669
    • Sverdlov AV, Rogozin IB, Babenko VN, Koonin EV. Reconstruction of ancestral protosplice sites. Curr Biol 2004, 14:1505-1508. 10.1016/j.cub.2004.08.027, 15324669.
    • (2004) Curr Biol , vol.14 , pp. 1505-1508
    • Sverdlov, A.V.1    Rogozin, I.B.2    Babenko, V.N.3    Koonin, E.V.4
  • 66
    • 0025835260 scopus 로고
    • Genomic structure of Chlamydomonas caltractin. Evidence for intron insertion suggests a probable genealogy for the EF-hand superfamily of proteins
    • 10.1016/0022-2836(91)80213-E, 1920403
    • Lee VD, Stapleton M, Huang B. Genomic structure of Chlamydomonas caltractin. Evidence for intron insertion suggests a probable genealogy for the EF-hand superfamily of proteins. J Mol Biol 1991, 221:175-191. 10.1016/0022-2836(91)80213-E, 1920403.
    • (1991) J Mol Biol , vol.221 , pp. 175-191
    • Lee, V.D.1    Stapleton, M.2    Huang, B.3
  • 68
    • 35248901812 scopus 로고    scopus 로고
    • Gene expression, intron density, and splice site strength in Drosophila and Caenorhabditis
    • 10.1007/s00239-007-9015-y, 17763878
    • Fahey ME, Higgins DG. Gene expression, intron density, and splice site strength in Drosophila and Caenorhabditis. J Mol Evol 2007, 65:349-357. 10.1007/s00239-007-9015-y, 17763878.
    • (2007) J Mol Evol , vol.65 , pp. 349-357
    • Fahey, M.E.1    Higgins, D.G.2
  • 69
    • 0035165586 scopus 로고    scopus 로고
    • SpliceDB: database of canonical and non-canonical mammalian splice sites
    • 10.1093/nar/29.1.255, 29840, 11125105
    • Burset M, Seledtsov IA, Solovyev VV. SpliceDB: database of canonical and non-canonical mammalian splice sites. Nucleic Acids Res 2001, 29:255-259. 10.1093/nar/29.1.255, 29840, 11125105.
    • (2001) Nucleic Acids Res , vol.29 , pp. 255-259
    • Burset, M.1    Seledtsov, I.A.2    Solovyev, V.V.3
  • 70
    • 0029791403 scopus 로고    scopus 로고
    • Splice site prediction in Arabidopsis thaliana pre-mRNA by combining local and global sequence information
    • 10.1093/nar/24.17.3439, 146109, 8811101
    • Hebsgaard SM, Korning PG, Tolstrup N, Engelbrecht J, Rouze P, Brunak S. Splice site prediction in Arabidopsis thaliana pre-mRNA by combining local and global sequence information. Nucleic Acids Res 1996, 24:3439-3452. 10.1093/nar/24.17.3439, 146109, 8811101.
    • (1996) Nucleic Acids Res , vol.24 , pp. 3439-3452
    • Hebsgaard, S.M.1    Korning, P.G.2    Tolstrup, N.3    Engelbrecht, J.4    Rouze, P.5    Brunak, S.6
  • 71
    • 0026657738 scopus 로고
    • Splicing signals in Drosophila: intron size, information content, and consensus sequences
    • 10.1093/nar/20.16.4255, 334133, 1508718
    • Mount SM, Burks C, Hertz G, Stormo GD, White O, Fields C. Splicing signals in Drosophila: intron size, information content, and consensus sequences. Nucleic Acids Res 1992, 20:4255-4262. 10.1093/nar/20.16.4255, 334133, 1508718.
    • (1992) Nucleic Acids Res , vol.20 , pp. 4255-4262
    • Mount, S.M.1    Burks, C.2    Hertz, G.3    Stormo, G.D.4    White, O.5    Fields, C.6
  • 72
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • 10.1128/MCB.23.16.5706-5715.2003, 166351, 12897142
    • Rothkamm K, Kruger I, Thompson LH, Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 2003, 23:5706-5715. 10.1128/MCB.23.16.5706-5715.2003, 166351, 12897142.
    • (2003) Mol Cell Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 73
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • 10.1038/cr.2007.111, 18157161
    • Shrivastav M, De Haro LP, Nickoloff JA. Regulation of DNA double-strand break repair pathway choice. Cell Res 2008, 18:134-147. 10.1038/cr.2007.111, 18157161.
    • (2008) Cell Res , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 74
    • 0038799991 scopus 로고    scopus 로고
    • Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
    • 98970, 10357855
    • Paques F, Haber JE. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 1999, 63:349-404. 98970, 10357855.
    • (1999) Microbiol Mol Biol Rev , vol.63 , pp. 349-404
    • Paques, F.1    Haber, J.E.2
  • 75
    • 0033523903 scopus 로고    scopus 로고
    • Mitochondrial DNA repairs double-strand breaks in yeast chromosomes
    • 10.1038/47076, 10573425
    • Ricchetti M, Fairhead C, Dujon B. Mitochondrial DNA repairs double-strand breaks in yeast chromosomes. Nature 1999, 402:96-100. 10.1038/47076, 10573425.
    • (1999) Nature , vol.402 , pp. 96-100
    • Ricchetti, M.1    Fairhead, C.2    Dujon, B.3
  • 76
    • 0042667066 scopus 로고    scopus 로고
    • Different genome maintenance strategies in human and tobacco cells
    • 10.1016/S0022-2836(03)00839-8, 12909009
    • Pelczar P, Kalck V, Kovalchuk I. Different genome maintenance strategies in human and tobacco cells. J Mol Biol 2003, 331:771-779. 10.1016/S0022-2836(03)00839-8, 12909009.
    • (2003) J Mol Biol , vol.331 , pp. 771-779
    • Pelczar, P.1    Kalck, V.2    Kovalchuk, I.3
  • 77
    • 0037154171 scopus 로고    scopus 로고
    • Ku86 is essential in human somatic cells
    • 117391, 11792868
    • Li G, Nelsen C, Hendrickson EA. Ku86 is essential in human somatic cells. Proc Natl Acad Sci USA 2002, 99:832-837. 117391, 11792868.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 832-837
    • Li, G.1    Nelsen, C.2    Hendrickson, E.A.3
  • 78
    • 0034733497 scopus 로고    scopus 로고
    • Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae
    • 10.1016/S0027-5107(00)00041-5, 10915866
    • Lewis LK, Resnick MA. Tying up loose ends: nonhomologous end-joining in Saccharomyces cerevisiae. Mutat Res 2000, 451:71-89. 10.1016/S0027-5107(00)00041-5, 10915866.
    • (2000) Mutat Res , vol.451 , pp. 71-89
    • Lewis, L.K.1    Resnick, M.A.2
  • 79
    • 79951577730 scopus 로고    scopus 로고
    • Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism
    • Sharma S, Choudhary B, Raghavan SC. Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism. Cell Mol Life Sci 2010, 68:661-676.
    • (2010) Cell Mol Life Sci , vol.68 , pp. 661-676
    • Sharma, S.1    Choudhary, B.2    Raghavan, S.C.3
  • 81
    • 22044435250 scopus 로고    scopus 로고
    • Chromosomal aberrations induced by double strand DNA breaks
    • 10.1016/j.dnarep.2005.05.004, 1237002, 15935739
    • Varga T, Aplan PD. Chromosomal aberrations induced by double strand DNA breaks. DNA Repair 2005, 4:1038-1046. 10.1016/j.dnarep.2005.05.004, 1237002, 15935739.
    • (2005) DNA Repair , vol.4 , pp. 1038-1046
    • Varga, T.1    Aplan, P.D.2
  • 82
    • 0030813154 scopus 로고    scopus 로고
    • Non-homologous DNA end joining in plant cells is associated with deletions and filler DNA insertions
    • 10.1093/nar/25.22.4650, 147090, 9358178
    • Gorbunova V, Levy AA. Non-homologous DNA end joining in plant cells is associated with deletions and filler DNA insertions. Nucleic Acids Res 1997, 25:4650-4657. 10.1093/nar/25.22.4650, 147090, 9358178.
    • (1997) Nucleic Acids Res , vol.25 , pp. 4650-4657
    • Gorbunova, V.1    Levy, A.A.2
  • 83
    • 55449085777 scopus 로고    scopus 로고
    • Numt-mediated double-strand break repair mitigates deletions during primate genome evolution
    • 10.1371/journal.pgen.1000237, 2567098, 18949041
    • Hazkani-Covo E, Covo S. Numt-mediated double-strand break repair mitigates deletions during primate genome evolution. PLoS Genet 2008, 4:e1000237. 10.1371/journal.pgen.1000237, 2567098, 18949041.
    • (2008) PLoS Genet , vol.4
    • Hazkani-Covo, E.1    Covo, S.2
  • 84
    • 4344656805 scopus 로고    scopus 로고
    • Mobile group II introns
    • 10.1146/annurev.genet.38.072902.091600, 15568970
    • Lambowitz AM, Zimmerly S. Mobile group II introns. Annu Rev Genet 2004, 38:1-35. 10.1146/annurev.genet.38.072902.091600, 15568970.
    • (2004) Annu Rev Genet , vol.38 , pp. 1-35
    • Lambowitz, A.M.1    Zimmerly, S.2
  • 85
    • 0022552726 scopus 로고
    • The generality of self-splicing RNA: relationship to nuclear mRNA splicing
    • 10.1016/0092-8674(86)90751-8, 2417724
    • Cech TR. The generality of self-splicing RNA: relationship to nuclear mRNA splicing. Cell 1986, 44:207-210. 10.1016/0092-8674(86)90751-8, 2417724.
    • (1986) Cell , vol.44 , pp. 207-210
    • Cech, T.R.1
  • 86
    • 33646360208 scopus 로고    scopus 로고
    • Selective forces for the origin of the eukaryotic nucleus
    • 10.1002/bies.20413, 16615090
    • Lopez-Garcia P, Moreira D. Selective forces for the origin of the eukaryotic nucleus. Bioessays 2006, 28:525-533. 10.1002/bies.20413, 16615090.
    • (2006) Bioessays , vol.28 , pp. 525-533
    • Lopez-Garcia, P.1    Moreira, D.2
  • 87
    • 33644783626 scopus 로고    scopus 로고
    • Introns and the origin of nucleus-cytosol compartmentalization
    • 10.1038/nature04531, 16511485
    • Martin W, Koonin EV. Introns and the origin of nucleus-cytosol compartmentalization. Nature 2006, 440:41-45. 10.1038/nature04531, 16511485.
    • (2006) Nature , vol.440 , pp. 41-45
    • Martin, W.1    Koonin, E.V.2
  • 88
    • 0037387431 scopus 로고    scopus 로고
    • Messenger RNA surveillance and the evolutionary proliferation of introns
    • 10.1093/molbev/msg068, 12654936
    • Lynch M, Kewalramani A. Messenger RNA surveillance and the evolutionary proliferation of introns. Mol Biol Evol 2003, 20:563-571. 10.1093/molbev/msg068, 12654936.
    • (2003) Mol Biol Evol , vol.20 , pp. 563-571
    • Lynch, M.1    Kewalramani, A.2
  • 89
    • 0035368207 scopus 로고    scopus 로고
    • The ins and outs of group II introns
    • 10.1016/S0168-9525(01)02324-1, 11377794
    • Bonen L, Vogel J. The ins and outs of group II introns. Trends Genet 2001, 17:322-331. 10.1016/S0168-9525(01)02324-1, 11377794.
    • (2001) Trends Genet , vol.17 , pp. 322-331
    • Bonen, L.1    Vogel, J.2
  • 90
    • 33748796735 scopus 로고    scopus 로고
    • Origins and evolution of spliceosomal introns
    • 10.1146/annurev.genet.40.110405.090625, 17094737
    • Rodriguez-Trelles F, Tarrio R, Ayala FJ. Origins and evolution of spliceosomal introns. Annu Rev Genet 2006, 40:47-76. 10.1146/annurev.genet.40.110405.090625, 17094737.
    • (2006) Annu Rev Genet , vol.40 , pp. 47-76
    • Rodriguez-Trelles, F.1    Tarrio, R.2    Ayala, F.J.3
  • 91
    • 3042599701 scopus 로고    scopus 로고
    • Accelerated rates of intron gain/loss and protein evolution in duplicate genes in human and mouse malaria parasites
    • 10.1093/molbev/msh143, 15084679
    • Castillo-Davis CI, Bedford TB, Hartl DL. Accelerated rates of intron gain/loss and protein evolution in duplicate genes in human and mouse malaria parasites. Mol Biol Evol 2004, 21:1422-1427. 10.1093/molbev/msh143, 15084679.
    • (2004) Mol Biol Evol , vol.21 , pp. 1422-1427
    • Castillo-Davis, C.I.1    Bedford, T.B.2    Hartl, D.L.3
  • 92
    • 3142749596 scopus 로고    scopus 로고
    • Prevalence of intron gain over intron loss in the evolution of paralogous gene families
    • 10.1093/nar/gkh686, 484173, 15254274
    • Babenko VN, Rogozin IB, Mekhedov SL, Koonin EV. Prevalence of intron gain over intron loss in the evolution of paralogous gene families. Nucleic Acids Res 2004, 32:3724-3733. 10.1093/nar/gkh686, 484173, 15254274.
    • (2004) Nucleic Acids Res , vol.32 , pp. 3724-3733
    • Babenko, V.N.1    Rogozin, I.B.2    Mekhedov, S.L.3    Koonin, E.V.4
  • 93
    • 56849118754 scopus 로고    scopus 로고
    • Where do introns come from?
    • 10.1371/journal.pbio.0060283, 2586383, 19067485
    • Catania F, Lynch M. Where do introns come from?. PLoS Biol 2008, 6:e283. 10.1371/journal.pbio.0060283, 2586383, 19067485.
    • (2008) PLoS Biol , vol.6
    • Catania, F.1    Lynch, M.2
  • 95
    • 0036809882 scopus 로고    scopus 로고
    • Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay
    • 10.1016/S1097-2765(02)00635-4, 12419238
    • Wang J, Chang YF, Hamilton JI, Wilkinson MF. Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay. Mol Cell 2002, 10:951-957. 10.1016/S1097-2765(02)00635-4, 12419238.
    • (2002) Mol Cell , vol.10 , pp. 951-957
    • Wang, J.1    Chang, Y.F.2    Hamilton, J.I.3    Wilkinson, M.F.4
  • 96
    • 0036207384 scopus 로고    scopus 로고
    • Listening to silence and understanding nonsense: exonic mutations that affect splicing
    • 10.1038/nrg775, 11967553
    • Cartegni L, Chew SL, Krainer AR. Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet 2002, 3:285-298. 10.1038/nrg775, 11967553.
    • (2002) Nat Rev Genet , vol.3 , pp. 285-298
    • Cartegni, L.1    Chew, S.L.2    Krainer, A.R.3
  • 97
    • 0037025175 scopus 로고    scopus 로고
    • Alternatively spliced TCR mRNA induced by disruption of reading frame
    • 10.1126/science.1069757, 12098701
    • Wang J, Hamilton JI, Carter MS, Li S, Wilkinson MF. Alternatively spliced TCR mRNA induced by disruption of reading frame. Science 2002, 297:108-110. 10.1126/science.1069757, 12098701.
    • (2002) Science , vol.297 , pp. 108-110
    • Wang, J.1    Hamilton, J.I.2    Carter, M.S.3    Li, S.4    Wilkinson, M.F.5
  • 98
    • 34347398058 scopus 로고    scopus 로고
    • Evolutionarily conserved genes preferentially accumulate introns
    • 10.1101/gr.5978207, 1899115, 17495009
    • Carmel L, Rogozin IB, Wolf YI, Koonin EV. Evolutionarily conserved genes preferentially accumulate introns. Genome Res 2007, 17:1045-1050. 10.1101/gr.5978207, 1899115, 17495009.
    • (2007) Genome Res , vol.17 , pp. 1045-1050
    • Carmel, L.1    Rogozin, I.B.2    Wolf, Y.I.3    Koonin, E.V.4
  • 100
    • 84863723204 scopus 로고    scopus 로고
    • Birth of New Spliceosomal Introns in Fungi by Multiplication of Introner-like Elements
    • 10.1016/j.cub.2012.05.011, 22658596
    • van der Burgt A, Severing E, de Wit PJ, Collemare J. Birth of New Spliceosomal Introns in Fungi by Multiplication of Introner-like Elements. Curr Biol 2012, 22:1260-1265. 10.1016/j.cub.2012.05.011, 22658596.
    • (2012) Curr Biol , vol.22 , pp. 1260-1265
    • van der Burgt, A.1    Severing, E.2    de Wit, P.J.3    Collemare, J.4
  • 101
    • 84866329751 scopus 로고    scopus 로고
    • Genome evolution: where do new introns come from?
    • 10.1016/j.cub.2012.05.017, 22790002
    • Roy SW, Irimia M. Genome evolution: where do new introns come from?. Curr Biol 2012, 22:R529-R531. 10.1016/j.cub.2012.05.017, 22790002.
    • (2012) Curr Biol , vol.22
    • Roy, S.W.1    Irimia, M.2
  • 102
    • 0027215749 scopus 로고
    • Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem
    • Abbotts J, Bebenek K, Kunkel TA, Wilson SH. Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem. J Biol Chem 1993, 268:10312-10323.
    • (1993) J Biol Chem , vol.268 , pp. 10312-10323
    • Abbotts, J.1    Bebenek, K.2    Kunkel, T.A.3    Wilson, S.H.4
  • 103
    • 0027238697 scopus 로고
    • Template-directed pausing of DNA synthesis by HIV-1 reverse transcriptase during polymerization of HIV-1 sequences in vitro
    • Klarmann GJ, Schauber CA, Preston BD. Template-directed pausing of DNA synthesis by HIV-1 reverse transcriptase during polymerization of HIV-1 sequences in vitro. J Biol Chem 1993, 268:9793-9802.
    • (1993) J Biol Chem , vol.268 , pp. 9793-9802
    • Klarmann, G.J.1    Schauber, C.A.2    Preston, B.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.