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Volumn 16, Issue 9, 2010, Pages 1786-1796

Retention of spliceosomal components along ligated exons ensures efficient removal of multiple introns

Author keywords

Alternative splicing; Exon definition; Exon junction complex; Kinetics; U1 snRNP

Indexed keywords

MESSENGER RNA; DROSOPHILA PROTEIN; FRU PROTEIN, DROSOPHILA; HEMOGLOBIN BETA CHAIN; NERVE PROTEIN; TRANSCRIPTION FACTOR;

EID: 77956052286     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.2186510     Document Type: Article
Times cited : (12)

References (50)
  • 2
    • 0027957779 scopus 로고
    • Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription
    • DOI 10.1016/0092-8674(94)90182-1
    • Baurén G, Wieslander L. 1994. Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription. Cell 76: 183-192. (Pubitemid 24035291)
    • (1994) Cell , vol.76 , Issue.1 , pp. 183-192
    • Bauren, G.1    Wieslander, L.2
  • 3
    • 0028895417 scopus 로고
    • Exon recognition in vertebrate splicing
    • Berget SM. 1995. Exon recognition in vertebrate splicing. J Biol Chem 270: 2411-2414.
    • (1995) J Biol Chem , vol.270 , pp. 2411-2414
    • Berget, S.M.1
  • 4
    • 0024021747 scopus 로고
    • Splice site selection, rate of splicing, and alternative splicing on nascent transcripts
    • Beyer AL, Osheim YN. 1988. Splice site selection, rate of splicing, and alternative splicing on nascent transcripts. Genes Dev 2: 754-765.
    • (1988) Genes Dev , vol.2 , pp. 754-765
    • Beyer, A.L.1    Osheim, Y.N.2
  • 6
    • 3142675143 scopus 로고    scopus 로고
    • Ser/Arg-rich protein-mediated communication between U1 and U2 small nuclear ribonucleoprotein particles
    • Boukis LA, Liu N, Furuyama S, Bruzik JP. 2004. Ser/Arg-rich protein-mediated communication between U1 and U2 small nuclear ribonucleoprotein particles. J Biol Chem 279: 29647-29653.
    • (2004) J Biol Chem , vol.279 , pp. 29647-29653
    • Boukis, L.A.1    Liu, N.2    Furuyama, S.3    Bruzik, J.P.4
  • 7
    • 33744994837 scopus 로고    scopus 로고
    • EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length
    • Buhler M, Steiner S, Mohn F, Paillusson A, Mühlemann O. 2006. EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length. Nat Struct Mol Biol 13: 462-464.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 462-464
    • Buhler, M.1    Steiner, S.2    Mohn, F.3    Paillusson, A.4    Mühlemann, O.5
  • 8
    • 0001468848 scopus 로고    scopus 로고
    • Splicing of precursors to mRNAs by the spliceosome
    • 2nd ed. (ed. RF Gesteland et al.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • Burge CB, Tuschl T, Sharp PA. 1999. Splicing of precursors to mRNAs by the spliceosome. In The RNA world, 2nd ed. (ed. RF Gesteland et al.), pp. 525-560. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
    • (1999) The RNA World , pp. 525-560
    • Burge, C.B.1    Tuschl, T.2    Sharp, P.A.3
  • 9
    • 34247197937 scopus 로고    scopus 로고
    • The nonsense-mediated decay RNA surveillance pathway
    • Chang YF, Imam JS, Wilkinson MF. 2007. The nonsense-mediated decay RNA surveillance pathway. Annu Rev Biochem 76: 51-74.
    • (2007) Annu Rev Biochem , vol.76 , pp. 51-74
    • Chang, Y.F.1    Imam, J.S.2    Wilkinson, M.F.3
  • 10
    • 0029006578 scopus 로고
    • A two-step mechanism for 5′ and 3′ splice-site pairing
    • Chiara MD, Reed R. 1995. A two-step mechanism for 5′ and 3′ splice-site pairing. Nature 375: 510-513.
    • (1995) Nature , vol.375 , pp. 510-513
    • Chiara, M.D.1    Reed, R.2
  • 11
    • 0033636518 scopus 로고    scopus 로고
    • Functional association of U2 snRNP with the ATP-independent spliceosomal complex E
    • Das R, Zhou Z, Reed R. 2000. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. Mol Cell 5: 779-787.
    • (2000) Mol Cell , vol.5 , pp. 779-787
    • Das, R.1    Zhou, Z.2    Reed, R.3
  • 12
    • 33745132168 scopus 로고    scopus 로고
    • Functional coupling of RNAP II transcription to spliceosome assembly
    • Das R, Dufu K, Romney B, Feldt M, Elenko M, Reed R. 2006. Functional coupling of RNAP II transcription to spliceosome assembly. Genes Dev 20: 1100-1109.
    • (2006) Genes Dev , vol.20 , pp. 1100-1109
    • Das, R.1    Dufu, K.2    Romney, B.3    Feldt, M.4    Elenko, M.5    Reed, R.6
  • 15
    • 21244493903 scopus 로고    scopus 로고
    • Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex
    • Gornemann J, Kotovic KM, Hujer K, Neugebauer KM. 2005. Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex. Mol Cell 19: 53-63.
    • (2005) Mol Cell , vol.19 , pp. 53-63
    • Gornemann, J.1    Kotovic, K.M.2    Hujer, K.3    Neugebauer, K.M.4
  • 16
    • 0034743627 scopus 로고    scopus 로고
    • The role of U2AF35 and U2AF65 in enhancer-dependent splicing
    • Graveley BR, Hertel KJ, Maniatis T. 2001. The role of U2AF35 and U2AF65 in enhancer-dependent splicing. RNA 7: 806-818.
    • (2001) RNA , vol.7 , pp. 806-818
    • Graveley, B.R.1    Hertel, K.J.2    Maniatis, T.3
  • 17
    • 0025008005 scopus 로고
    • Ordered splicing of thymidine kinase pre-mRNA during the S phase of the cell cycle
    • Gudas JM, Knight GB, Pardee AB. 1990. Ordered splicing of thymidine kinase pre-mRNA during the S phase of the cell cycle. Mol Cell Biol 10: 5591-5595.
    • (1990) Mol Cell Biol , vol.10 , pp. 5591-5595
    • Gudas, J.M.1    Knight, G.B.2    Pardee, A.B.3
  • 18
    • 38349127601 scopus 로고    scopus 로고
    • Combinatorial control of exon recognition
    • Hertel KJ. 2008. Combinatorial control of exon recognition. J Biol Chem 283: 1211-1215.
    • (2008) J Biol Chem , vol.283 , pp. 1211-1215
    • Hertel, K.J.1
  • 19
    • 27944471762 scopus 로고    scopus 로고
    • Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays
    • Hicks MJ, Lam BJ, Hertel KJ. 2005. Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays. Methods 37: 306-313.
    • (2005) Methods , vol.37 , pp. 306-313
    • Hicks, M.J.1    Lam, B.J.2    Hertel, K.J.3
  • 20
    • 33745220323 scopus 로고    scopus 로고
    • Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns
    • doi: 10.1371/journal.pbio.0040147
    • Hicks MJ, Yang CR, Kotlajich MV, Hertel KJ. 2006. Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns. PLoS Biol 4: e147. doi: 10.1371/journal.pbio.0040147.
    • (2006) PLoS Biol , vol.4
    • Hicks, M.J.1    Yang, C.R.2    Kotlajich, M.V.3    Hertel, K.J.4
  • 21
    • 0027090479 scopus 로고
    • U1 snRNP targets an essential splicing factor, U2AF65, to the 3′ splice site by a network of interactions spanning the exon
    • Hoffman BE, Grabowski PJ. 1992. U1 snRNP targets an essential splicing factor, U2AF65, to the 3′ splice site by a network of interactions spanning the exon. Genes Dev 6: 2554-2568.
    • (1992) Genes Dev , vol.6 , pp. 2554-2568
    • Hoffman, B.E.1    Grabowski, P.J.2
  • 22
    • 0026655649 scopus 로고
    • The spliceosome assembly pathway in mammalian extracts
    • Jamison SF, Crow A, Garcia-Blanco MA. 1992. The spliceosome assembly pathway in mammalian extracts. Mol Cell Biol 12: 4279-4287.
    • (1992) Mol Cell Biol , vol.12 , pp. 4279-4287
    • Jamison, S.F.1    Crow, A.2    Garcia-Blanco, M.A.3
  • 23
    • 0027495952 scopus 로고
    • Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA
    • Kessler O, Jiang Y, Chasin LA. 1993. Order of intron removal during splicing of endogenous adenine phosphoribosyltransferase and dihydrofolate reductase pre-mRNA. Mol Cell Biol 13: 6211-6222.
    • (1993) Mol Cell Biol , vol.13 , pp. 6211-6222
    • Kessler, O.1    Jiang, Y.2    Chasin, L.A.3
  • 24
    • 59449100357 scopus 로고    scopus 로고
    • Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex
    • Kotlajich MV, Crabb TL, Hertel KJ. 2009. Spliceosome assembly pathways for different types of alternative splicing converge during commitment to splice site pairing in the A complex. Mol Cell Biol 29: 1072-1082.
    • (2009) Mol Cell Biol , vol.29 , pp. 1072-1082
    • Kotlajich, M.V.1    Crabb, T.L.2    Hertel, K.J.3
  • 25
    • 21244469725 scopus 로고    scopus 로고
    • Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5′ss base pairing in yeast
    • DOI 10.1016/j.molcel.2005.05.006, PII S1097276505013122
    • Lacadie SA, Rosbash M. 2005. Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5′ss base pairing in yeast. Mol Cell 19: 65-75. (Pubitemid 40884658)
    • (2005) Molecular Cell , vol.19 , Issue.1 , pp. 65-75
    • Lacadie, S.A.1    Rosbash, M.2
  • 26
    • 0036792889 scopus 로고    scopus 로고
    • A general role for splicing enhancers in exon definition
    • Lam BJ, Hertel KJ. 2002. A general role for splicing enhancers in exon definition. RNA 8: 1233-1241.
    • (2002) RNA , vol.8 , pp. 1233-1241
    • Lam, B.J.1    Hertel, K.J.2
  • 27
    • 0023428459 scopus 로고
    • In vitro splicing pathways of pre-mRNAs containing multiple intervening sequences?
    • Lang KM, Spritz RA. 1987. In vitro splicing pathways of pre-mRNAs containing multiple intervening sequences? Mol Cell Biol 7: 3428-3437.
    • (1987) Mol Cell Biol , vol.7 , pp. 3428-3437
    • Lang, K.M.1    Spritz, R.A.2
  • 28
    • 0023695462 scopus 로고
    • Early commitment of yeast pre-mRNA to the spliceosome pathway
    • Legrain P, Seraphin B, Rosbash M. 1988. Early commitment of yeast pre-mRNA to the spliceosome pathway. Mol Cell Biol 8: 3755-3760.
    • (1988) Mol Cell Biol , vol.8 , pp. 3755-3760
    • Legrain, P.1    Seraphin, B.2    Rosbash, M.3
  • 29
    • 39149089317 scopus 로고    scopus 로고
    • Structural insights into the exon junction complex
    • Le Hir H, Andersen GR. 2008. Structural insights into the exon junction complex. Curr Opin Struct Biol 18: 112-119.
    • (2008) Curr Opin Struct Biol , vol.18 , pp. 112-119
    • Le Hir, H.1    Andersen, G.R.2
  • 30
    • 0034193569 scopus 로고    scopus 로고
    • Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
    • Le Hir H, Moore MJ, Maquat LE. 2000. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions. Genes Dev 14: 1098-1108.
    • (2000) Genes Dev , vol.14 , pp. 1098-1108
    • Le Hir, H.1    Moore, M.J.2    Maquat, L.E.3
  • 31
    • 0035801373 scopus 로고    scopus 로고
    • The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay
    • Le Hir H, Gatfield D, Izaurralde E, Moore MJ. 2001. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J 20: 4987-4997.
    • (2001) EMBO J , vol.20 , pp. 4987-4997
    • Le Hir, H.1    Gatfield, D.2    Izaurralde, E.3    Moore, M.J.4
  • 32
    • 0141752774 scopus 로고    scopus 로고
    • Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1
    • Li C, Lin RI, Lai MC, Ouyang P, Tarn WY. 2003. Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1. Mol Cell Biol 23: 7363-7376.
    • (2003) Mol Cell Biol , vol.23 , pp. 7363-7376
    • Li, C.1    Lin, R.I.2    Lai, M.C.3    Ouyang, P.4    Tarn, W.Y.5
  • 33
    • 4143078172 scopus 로고    scopus 로고
    • Commitment to splice site pairing coincides with a complex formation
    • Lim SR, Hertel KJ. 2004. Commitment to splice site pairing coincides with A complex formation. Mol Cell 15: 477-483.
    • (2004) Mol Cell , vol.15 , pp. 477-483
    • Lim, S.R.1    Hertel, K.J.2
  • 34
    • 33748351186 scopus 로고    scopus 로고
    • Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells
    • DOI 10.1038/nsmb1135, PII NSMB1135
    • Listerman I, Sapra AK, Neugebauer KM. 2006. Cotranscriptional coupling of splicing factor recruitment and precursor messenger RNA splicing in mammalian cells. Nat Struct Mol Biol 13: 815-822. (Pubitemid 44338776)
    • (2006) Nature Structural and Molecular Biology , vol.13 , Issue.9 , pp. 815-822
    • Listerman, I.1    Sapra, A.K.2    Neugebauer, K.M.3
  • 35
    • 0037062982 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing and proteome expansion in metazoans
    • Maniatis T, Tasic B. 2002. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 418: 236-243.
    • (2002) Nature , vol.418 , pp. 236-243
    • Maniatis, T.1    Tasic, B.2
  • 37
    • 0025362714 scopus 로고
    • A sequential splicing mechanism promotes selection of an optional exon by repositioning a downstream 5′ splice site in preprotachykinin pre-mRNA
    • Nasim FH, Spears PA, Hoffmann HM, Kuo HC, Grabowski PJ. 1990. A sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5′ splice site in preprotachykinin pre-mRNA. Genes Dev 4: 1172-1184. (Pubitemid 120012685)
    • (1990) Genes and Development , vol.4 , Issue.7 , pp. 1172-1184
    • Nasim, F.-U.H.1    Spears, P.A.2    Hoffmann, H.M.3    Kuo, H.-C.4    Grabowski, P.J.5
  • 38
    • 44649196386 scopus 로고    scopus 로고
    • Functional integration of transcriptional and RNA processing machineries
    • Pandit S, Wang D, Fu XD. 2008. Functional integration of transcriptional and RNA processing machineries. Curr Opin Cell Biol 20: 260-265.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 260-265
    • Pandit, S.1    Wang, D.2    Fu, X.D.3
  • 39
    • 0034069505 scopus 로고    scopus 로고
    • Mechanisms of fidelity in pre-mRNA splicing
    • Reed R. 2000. Mechanisms of fidelity in pre-mRNA splicing. Curr Opin Cell Biol 12: 340-345.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 340-345
    • Reed, R.1
  • 40
    • 1642540255 scopus 로고    scopus 로고
    • Human RNPS1 and its associated factors: A versatile alternative pre-mRNA splicing regulator in vivo
    • Sakashita E, Tatsumi S, Werner D, Endo H, Mayeda A. 2004. Human RNPS1 and its associated factors: A versatile alternative pre-mRNA splicing regulator in vivo. Mol Cell Biol 24: 1174-1187.
    • (2004) Mol Cell Biol , vol.24 , pp. 1174-1187
    • Sakashita, E.1    Tatsumi, S.2    Werner, D.3    Endo, H.4    Mayeda, A.5
  • 41
    • 38849187162 scopus 로고    scopus 로고
    • Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome
    • Sharma S, Kohlstaedt LA, Damianov A, Rio DC, Black DL. 2008. Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome. Nat Struct Mol Biol 15: 183-191.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 183-191
    • Sharma, S.1    Kohlstaedt, L.A.2    Damianov, A.3    Rio, D.C.4    Black, D.L.5
  • 42
    • 1842577707 scopus 로고    scopus 로고
    • EIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay
    • DOI 10.1038/nsmb750
    • Shibuya T, Tange TØ, Sonenberg N, Moore MJ. 2004. eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay. Nat Struct Mol Biol 11: 346-351. (Pubitemid 38436799)
    • (2004) Nature Structural and Molecular Biology , vol.11 , Issue.4 , pp. 346-351
    • Shibuya, T.1    Tange, T.O.2    Sonenberg, N.3    Moore, M.J.4
  • 45
    • 0036724443 scopus 로고    scopus 로고
    • Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-α1(V) N-propeptides and Ehlers-Danlos syndrome type I
    • Takahara K, Schwarze U, Imamura Y, Hoffman GG, Toriello H, Smith LT, Byers PH, Greenspan DS. 2002. Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-α1(V) N-propeptides and Ehlers-Danlos syndrome type I. Am J Hum Genet 71: 451-465.
    • (2002) Am J Hum Genet , vol.71 , pp. 451-465
    • Takahara, K.1    Schwarze, U.2    Imamura, Y.3    Hoffman, G.G.4    Toriello, H.5    Smith, L.T.6    Byers, P.H.7    Greenspan, D.S.8
  • 46
    • 28344456363 scopus 로고    scopus 로고
    • Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core
    • Tange TØ, Shibuya T, Jurica MS, Moore MJ. 2005. Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. RNA 11: 1869-1883.
    • (2005) RNA , vol.11 , pp. 1869-1883
    • Tange, T.Ø.1    Shibuya, T.2    Jurica, M.S.3    Moore, M.J.4
  • 47
    • 33845643952 scopus 로고    scopus 로고
    • A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly post-transcriptional
    • Tardiff DF, Lacadie SA, Rosbash M. 2006. A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly post-transcriptional. Mol Cell 24: 917-929.
    • (2006) Mol Cell , vol.24 , pp. 917-929
    • Tardiff, D.F.1    Lacadie, S.A.2    Rosbash, M.3
  • 48
    • 0032761672 scopus 로고    scopus 로고
    • DNA cloning without restriction enzyme and ligase
    • Tseng H. 1999. DNA cloning without restriction enzyme and ligase. Biotechniques 27: 1240-1244.
    • (1999) Biotechniques , vol.27 , pp. 1240-1244
    • Tseng, H.1
  • 49
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Luhrmann R. 2009. The spliceosome: Design principles of a dynamic RNP machine. Cell 136: 701-718.
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Luhrmann, R.3
  • 50
    • 0030575916 scopus 로고    scopus 로고
    • U1-mediated exon definition interactions between AT-AC and GT-AG introns
    • DOI 10.1126/science.274.5289.1005
    • Wu Q, Krainer AR. 1996. U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science 274: 1005-1008. (Pubitemid 26398427)
    • (1996) Science , vol.274 , Issue.5289 , pp. 1005-1008
    • Wu, Q.1    Krainer, A.R.2


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