A p27 Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation

Oncogene

Volumn 31, Issue 35, 2012, Pages 3989-3998

  Sharma, S S ^a   Ma, L ^a   Bagui, T K ^a   Forinash, K D ^a   Pledger, W J ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

centrosome amplification; cyclin F; micronuclei; p 27Kip1

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN F; CYCLINE; DOXYCYCLINE; MUTANT PROTEIN; PHOSPHORUS 32; UNCLASSIFIED DRUG; CCNF PROTEIN, HUMAN; CDKN1B PROTEIN, HUMAN; CELL CYCLE PROTEIN; CP110 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PHOSPHOPROTEIN;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CENTROSOME; ENZYME ACTIVITY; ENZYME ASSAY; HUMAN; HUMAN CELL; MICRONUCLEUS; MITOSIS; MUTANT; OSTEOSARCOMA CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; APOPTOSIS; CELL NUCLEUS; DNA DAMAGE; DRUG ANTAGONISM; GENETICS; METABOLISM; OSTEOSARCOMA; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CENTROSOME; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA DAMAGE; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; OSTEOSARCOMA; PHOSPHOPROTEINS;

EID: 84865618467     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.550     Document Type: Article

References (58)

1. Kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells. Mol Cell Biol 16: 4327-4336.
2. Kip1 gene transcription by mitogens. Cell Cycle 8: 115-124.
3. Cip1. Mol Cell Biol 20: 8748-8757.
4. Bai C, Richman R, Elledge SJ. (1994). Human cyclin F. EMBO J 13: 6087-6098.
5. Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW et al. (1996). SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86: 263-274.
6. Kip1-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell 7: 51-63.
7. Kip1 stability, subcellular localization, and tumor suppression. Genes Dev 20: 47-64.
8. Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 18: 862-876.
9. Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev 21: 1731-1746.
10. Carrano AC, Eytan E, Hershko A, Pagano M. (1999). SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1: 193-199.
11. Caruso R, Fedele F, Luciano R, Branca G, Parisi C, Paparo D et al. (2011). Mitotic catastrophe in malignant epithelial tumors: the pathologist's viewpoint. Ultrastruct Pathol 35: 66-71.
12. Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. (2004). Cell death by mitotic catastrophe: a molecular definition. Oncogene 23: 2825-2837.
13. Kip1 protein: prognostic implications in primary breast cancer. Nat Med 3: 227-230.
14. Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD. (2002). CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell 3: 339-350.
15. D'Angiolella V, Donato V, Vijayakumar S, Saraf A, Florens L, Washburn MP et al. (2010). SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466: 138-142.
16. Dodson H, Wheatley SP, Morrison CG. (2007). Involvement of centrosome amplification in radiation-induced mitotic catastrophe. Cell Cycle 6: 364-370.
17. Duensing A, Liu Y, Tseng M, Malumbres M, Barbacid M, Duensing S. (2006). Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centro-some overduplication. Oncogene 25: 2943-2949.
18. Fadok VA, Voelker DR, Campbell PA, Cohen JJ, Bratton DL, Henson PM. (1992). Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148: 2207-2216.
19. Kip1-deficient mice. Cell 85: 733-744.
20. Fukasawa K. (2008). p53, cyclin-dependent kinase and abnormal amplification of centrosomes. Biochim Biophys Acta 1786: 15-23.
21. Kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc Natl Acad Sci USA 101: 17204-17209.
22. Kip1 accumulation during the cell cycle. Science 271: 1861-1864.
23. Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G. (1999). Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283: 851-854.
24. Kip1 at G1 phase. Nat Cell Biol 6: 1229-1235.
25. Kip1 gene is mediated by AP-1 transcription factors. J Biol Chem 285: 4554-4561.
26. Kitagawa M, Higashi H, Jung HK, Suzuki-Takahashi I, Ikeda M, Tamai K et al. (1996). The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 15: 7060-7069.
27. Kip1. Cell 85: 721-732.
28. Kong M, Barnes EA, Ollendorff V, Donoghue DJ. (2000). Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction. EMBO J 19: 1378-1388.
29. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. (1994). Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84: 1415-1420.
30. Korzeniewski N, Cuevas R, Duensing A, Duensing S. (2010). Daughter centriole elongation is controlled by proteolysis. Mol Biol Cell 21: 3942-3951.
31. Larrea MD, Wander SA, Slingerland JM. (2009). p27 as Jekyll and Hyde: regulation of cell cycle and cell motility. Cell Cycle 8: 3455-3461.
32. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF et al. (1997). Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med 3: 231-234.
33. Kip1 in G1 and S phase. Nature 413: 323-327.
34. Meraldi P, Lukas J, Fry AM, Bartek J, Nigg EA. (1999). Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat Cell Biol 1: 88-93.
35. Morgan DO. (1995). Principles of CDK regulation. Nature 374: 131-134.
36. Muraoka RS, Lenferink AE, Law B, Hamilton E, Brantley DM, Roebuck LR et al. (2002). ErbB2/Neu-induced, cyclin D1-depen-dent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells. Mol Cell Biol 22: 2204-2219.
37. Kip1 induces cell migration. Nat Med 4: 1449-1452.
38. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85: 707-720.
39. Kip1, polyploidy and centrosome overduplication. EMBO J 19: 2069-2081.
40. Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S et al. (2004). Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell 6: 661-672.
41. Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication. FEBS Lett 579: 6529-6536.
42. Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev 20: 1511-1524.
43. Portugal J, Mansilla S, Bataller M. (2010). Mechanisms of drug-induced mitotic catastrophe in cancer cells. Curr Pharm Des 16: 69-78.
44. Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382: 325-331.
45. Schmidt TI, Kleylein-Sohn J, Westendorf J, Le Clech M, Lavoie SB, Stierhof YD et al. (2009). Control of centriole length by CPAP and CP110. Curr Biol 19: 1105-1011.
46. Schulman BA, Lindstrom DL, Harlow E. (1998). Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci USA 95: 10453-10458.
47. Singhal S, Amin KM, Kruklitis R, DeLong P, Friscia ME, Litzky LA et al. (2003). Alterations in cell cycle genes in early stage lung adenocarcinoma identified by expression profiling. Cancer Biol Ther 2: 291-298.
48. Slingerland J, Pagano M. (2000). Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 183: 10-17.
49. Sugihara E, Kanai M, Saito S, Nitta T, Toyoshima H, Nakayama K et al. (2006). Suppression of centrosome amplification after DNA damage depends on p27 accumulation. Cancer Res 66: 4020-4029.
50. Tetzlaff MT, Bai C, Finegold M, Wilson J, Harper JW, Mahon KA et al. (2004). Cyclin F disruption compromises placental development and affects normal cell cycle execution. Mol Cell Biol 24: 2487-2498.
51. Toyoshima H, Hunter T. (1994). p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67-74.
52. Skp2 complex through phosphorylated Thr187 in p27. Curr Biol 9: 661-664.
53. Kip1 by PKB/Akt-mediated phosphor-ylation in breast cancer. Nat Med 8: 1136-1144.
54. Vlach J, Hennecke S, Amati B. (1997). Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J 16: 5334-5344.
55. Wang IC, Chen YJ, Hughes D, Petrovic V, Major ML, Park HJ et al. (2005). Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol 25: 10875-10894.
56. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW. (1999). A family of mammalian F-box proteins. Curr Biol 9: 1180-1182.
57. Wonsey DR, Follettie MT. (2005). Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe. Cancer Res 65: 5181-5189.
58. Kip1 inhibits cancer cell motility, survival, and tumorigenicity. Cancer Res 66: 2162-2172.