Airway smooth muscle proliferation and mechanics: Effects of AMP kinase agonists

MCB Molecular and Cellular Biomechanics

Volumn 4, Issue 3, 2007, Pages 143-157

  Ratnovsky, Anat ^a,b   Mellema, Matthew ^a   An, Steven S ^a,c   Fredberg, Jeffrey J ^a   Shore, Stephanie A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b AFEKA TEL AVIV ACADEMIC COLLEGE OF ENGINEERING   (Israel)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Airway smooth muscle; Contractility; Cytoskeleton remodeling; Obesity; Proliferation

Indexed keywords

CELL PROLIFERATION; ENZYMES; NEURONS; OPTICAL MICROSCOPY;

ADENOSINE MONOPHOSPHATE; AIRWAY SMOOTH MUSCLE FUNCTION; CYTOSKELETAL REMODELING; KINASE; OPTICAL MAGNETIC TWISTING CYTOMETRY;

NUCLEOTIDES;

MURINAE;

5 AMINO 4 IMIDAZOLECARBOXAMIDE; ADENYLATE KINASE; AICA RIBONUCLEOTIDE; DRUG DERIVATIVE; ENZYME ACTIVATOR; MICROSPHERE; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; PLATELET-DERIVED GROWTH FACTOR BB; RIBONUCLEOTIDE; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOMECHANICS; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MOUSE; RESPIRATORY SYSTEM; SMOOTH MUSCLE FIBER;

ADENYLATE KINASE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; BIOMECHANICS; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATORS; MICE; MICROSPHERES; MYOCYTES, SMOOTH MUSCLE; PLATELET-DERIVED GROWTH FACTOR; RESPIRATORY SYSTEM; RIBONUCLEOTIDES; SEROTONIN;

EID: 39049088263     PISSN: 15565297     EISSN: 15565300     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Shore, S.A. and J.J. Fredberg. Obesity, smooth muscle, and airway hyperresponsiveness. J Allergy Clin Immunol. 115: 925-7, 2005.
2. Guerra, S., A.L. Wright, W.J. Morgan, D.L. Sherrill, C.J. Holberg and F.D. Martinez. Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. Am J Respir Crit Care Med. 170: 78-85, 2004.
3. Thomson, C.C., S. Clark and C.A. Camargo, Jr. Body mass index and asthma severity among adults presenting to the emergency department. Chest. 124: 795-802, 2003.
4. Sood, A. Does obesity weigh heavily on the health of the human airway? J Allergy Clin Immunol. 115: 921-4, 2005.
5. Weiss, S.T. and S. Shore. Obesity and asthma: directions for research. Am J Respir Crit Care Med. 169: 963-8, 2004.
6. Aaron, S.D., F. D., R. Dent, Y. Chen, K.L. Vandemheen and R.E. Dales. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest. 125: 2046-52, 2004.
7. An SS, B.T., Bates JHT, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Pare PD, Pellegrino R, Seow CY, Smith PG, Solway J, Schellenberg RR, Silveira PS, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, and Wang L. Airway smooth muscle dynamics: a final common pathway of airway obstruction in asthma. Eur. Respir. J. 29(5): 834-860, 2007.
8. An, S.S., B. Fabry, M. Mellema, P. Bursac, W.T. Gerthoffer, U.S. Kayyali, M. Gaestel, S.A. Shore and J.J. Fredberg. Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell. J Appl Physiol. 96: 1701-13, 2004.
9. An, S.S., B. Fabry, X. Trepat, N. Wang and J.J. Fredberg. Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am J Respir Cell Mol Biol. 35: 55-64, 2006.
10. Wang, L., RD. Pare and C.Y. Seow. Selected contribution: effect of chronic passive length change on airway smooth muscle length-tension relationship. J Appl Physiol. 90: 734-40, 2001.
11. Gunst, S.J. and M.F. Wu. Selected contribution: plasticity of airway smooth muscle stiffness and extensibility: role of length-adaptive mechanisms. J Appl Physiol. 90: 741-9, 2001.
12. Pratusevich, V.R., C.Y. Seow and L.E. Ford. Plasticity in canine airway smooth muscle. J Gen Physiol. 105: 73-94, 1995.
13. Seow, C.Y., V.R. Pratusevich and L.E. Ford. Series-to-parallel transition in the filament lattice of airway smooth muscle. J Appl Physiol. 89: 869-76, 2000.
14. Guigas, B., L. Bertrand, N. Taleux, M. Foretz, N. Wiernsperger, D. Vertommen, F. Andreelli, B. Viollet and L. Hue. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation. Diabetes. 55: 865-74, 2006.
15. Shaw, R.J., K.A. Lamia, D. Vasquez, S.H. Koo, N. Bardeesy, R.A. Depinho, M. Montminy and L.C. Cantley. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 310: 1642-6, 2005.
16. Dagher, Z., N. Ruderman, K. Tornheim and Y. Ido. The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun. 265: 112-5, 1999.
17. Musi, N., M.F. Hirshman, J. Nygren, M. Svanfeldt, P. Bavenholm, O. Rooyackers, G. Zhou, J.M. Williamson, O. Ljunqvist, S. Efendic, D.E. Moller, A. Thorell, and L.J. Goodyear. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes. 51: 2074-81, 2002.
18. Hardie, D.G. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology. 144: 5179-83, 2003.
19. Hardie, D.G. The AMP-activated protein kinase pathway-new players upstream and downstream. J Cell Sci. 117: 5479-87, 2004.
20. Hardie, D.G., J.W. Scott, D.A. Pan and E.R. Hudson. Management of cellular energy by the AMP-activated protein kinase system. FEBS Lett. 546:113-20, 2003.
21. Halayko, A.J. and Y. Amrani. Mechanisms of inflammation-mediated airway smooth muscle plasticity and airways remodeling in asthma. Respir Physiol Neurobiol. 137: 209-22, 2003.
22. Hirst, S.J., J.G. Martin, J.V. Bonacci, V. Chan, E.D. Fixman, Q.A. Hamid, B. Herszberg, J.P. Lavoie, C.G. McVicker, L.M. Moir, T.T. Nguyen, Q. Peng, D. Ramos-Barbon, and A.G. Stewart. Proliferative aspects of airway smooth muscle. J Allergy Clin Immunol. 114: S2-17, 2004.
23. Hirst, S.J., T.R. Walker and E.R. Chilvers. Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma. Eur Respir J. 16: 159-77, 2000.
24. Igata, M., H. Motoshima, K. Tsuruzoe, K. Kojima, T. Matsumura, T. Kondo, T. Taguchi, K. Nakamaru, M. Yano, D. Kukidome, K. Matsumoto, T. Toyonaga, T. Asano, T. Nishikawa, and E. Araki. Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression. Circ Res. 97: 837-44, 2005.
25. Nagata, D., R. Takeda, M. Sata, H. Satonaka, E. Suzuki, T. Nagano and Y. Hirata. AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. Circulation. 110: 444-51, 2004.
26. Rattan, R., S. Giri, A.K. Singh and I. Singh. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem. 280: 39582-93, 2005.
27. Bursac, P., G. Lenormand, B. Fabry, M. Oliver, D.A. Weitz, V. Viasnoff, J.P. Butler and J.J. Fredberg. Cytoskeletal remodelling and slow dynamics in the living cell. Nat Mater. 4: 557-61, 2005.
28. Corton, J.M., J.G. Gillespie, S.A. Hawley and D.G. Hardie. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem. 229: 558-65, 1995.
29. Hawley, S.A., A.E. Gadalla, G.S. Olsen and D.G. Hardie. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes. 51: 2420-5, 2002.
30. An, S.S., R.E. Laudadio, J. Lai, R.A. Rogers and J.J. Fredberg. Stiffness changes in cultured airway smooth muscle cells. Am J Physiol Cell Physiol. 283: C792-801, 2002.
31. Tolloczko, B., Y.L. Jia and J.G. Martin. Serotonin-evoked calcium transients in airway smooth muscle cells. Am J Physiol. 269: L234-40, 1995.
32. Zang, M., A. Zuccollo, X. Hou, D. Nagata, K. Walsh, H. Herscovitz, P. Brecher, N.B. Ruderman and R.A. Cohen. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem. 279: 47898-905, 2004.
33. Bosse, Y., C. Thompson, J. Stankova and M. Rola-Pleszczynski. Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation. Am J Respir Cell Mol Biol. 34: 746-53, 2006.
34. Hubmayr, R.D., S.A. Shore, J.J. Fredberg, E. Planus, R.A. Panettieri, Jr., W. Moller, J. Heyder and N. Wang. Pharmacological activation changes stiffness of cultured human airway smooth muscle cells. Am J Physiol. 271: C1660-8, 1996.
35. Fabry, B., G.N. Maksym, S.A. Shore, P.E. Moore, R.A. Panettieri, Jr., J.P. Butler and J.J. Fredberg. Selected contribution: time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells. J Appl Physiol. 91: 986-94, 2001.
36. Trepat X, D.L., An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, Butler JP, and Fredberg JJ. Universal physical responses to stretch in the living cell. Nature. 447: 592-5, 2007.
37. Fabry, B., G.N. Maksym, J.P. Butler, M. Glogauer, D. Navajas and J.J. Fredberg. Scaling the microrheology of living cells. Phys Rev Lett. 87: 148102, 2001.
38. Fabry, B., G.N. Maksym, J.P. Butler, M. Glogauer, D. Navajas, N.A. Taback, E.J. Millet and J.J. Fredberg. Time scale and other invariants of integrative mechanical behavior in living cells. Phys Rev E Star Nonlin Soft Matter Phys. 68: 041914, 2003.
39. Lu, F.L., R.A. Johnston, L. Flynt, T.A. Theman, R.D. Terry, I.N. Schwartzman, A. Lee and S.A. Shore. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol. 290: L856-65, 2006.
40. Li, L., J.C. Mamputu, N. Wiernsperger and G. Renier. Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin. Diabetes. 54: 2227-34, 2005.
41. Fryer, L.G., A. Parbu-Patel and D. Carling. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem. 277: 25226-32, 2002.
42. Zou, M.H., S.S. Kirkpatrick, B.J. Davis, J.S. Nelson, W.G.t. Wiles, U. Schlattner, D. Neumann, M. Brownlee, M.B. Freeman and M.H. Goldman. Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem. 279: 43940-51, 2004.
43. Imamura, K., T. Ogura, A. Kishimoto, M. Kaminishi and H. Esumi. Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun. 287: 562-7, 2001.
44. Xiang, X., A.K. Saha, R. Wen, N.B. Ruderman and Z. Luo. AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun. 321: 161-7, 2004.
45. Wang, W., J. Fan, X. Yang, S. Furer-Galban, I. Lopez de Silanes, C. von Kobbe, J. Guo, S.N. Georas, F. Foufelle, D.G. Hardie, D. Carling, and M. Gorospe. AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol. 22: 3425-36, 2002.
46. Reiter, A.K., D.R. Bolster, S.J. Crozier, S.R. Kimball and L.S. Jefferson. Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Am J Physiol Endocrinol Metab. 288: E980-8, 2005.
47. Fredberg, J.J., D.S. Inouye, S.M. Mijailovich and J.P. Butler. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med. 159: 959-67, 1999.
48. Seow, C.Y. and J.J. Fredberg. Historical perspective on airway smooth muscle: the saga of a frustrated cell. J Appl Physiol. 91: 938-52, 2001.
49. Bai, T.R., J.H. Bates, V. Brusasco, B. Camoretti-Mercado, P. Chitano, L.H. Deng, M. Dowell, B. Fabry, L.E. Ford, J.J. Fredberg, W.T. Gerthoffer, S.H. Gilbert, S.J. Gunst, C.M. Hai, A.J. Halayko, S.J. Hirst, A.L. James, L.J. Janssen, K.A. Jones, G.G. King, O.J. Lakser, R.K. Lambert, A.M. Lauzon, K.R. Lutchen, G.N. Maksym, R.A. Meiss, S.M. Mijailovich, H.W. Mitchell, R.W. Mitchell, W. Mitzner, T.M. Murphy, P.D. Pare, R.R. Schellenberg, C.Y. Seow, G.C. Sieck, P.G. Smith, A.V. Smolensky, J. Solway, N.L. Stephens, A.G. Stewart, D.D. Tang, and L. Wang. On the terminology for describing the length-force relationship and its changes in airway smooth muscle. J Appl Physiol. 97: 2029-34, 2004.
50. Fredberg, J.J. Bronchospasm and its biophysical basis in airway smooth muscle. Respir Res. 5: 2, 2004.
51. Silveira, P.S. and J.J. Fredberg. Smooth muscle length adaptation and actin filament length: a network model of the cytoskeletal dysregulation. Can J Physiol Pharmacol. 83: 923-31,2005.
52. Deng, L., X. Trepat, J.P. Butler, E. Millet, K.G. Morgan, D.A. Weitz and J.J. Fredberg. Fast and slow dynamics of the cytoskeleton. Nat Mater. 5: 636-40, 2006.
53. Hoffman, B.D., G. Massiera, K.M. Van Citters and J.C. Crocker. The consensus mechanics of cultured mammalian cells. Proc Natl Acad Sci U S A. 103: 10259-64, 2006.
54. Van Citters, K.M., B.D. Hoffman, G. Massiera and J.C. Crocker. The role of F-actin and myosin in epithelial cell rheology. Biophys J. 91: 3946-56, 2006.
55. Camargo, C.A., Jr., S.T. Weiss, S. Zhang, W.C. Willett and F.E. Speizer. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med. 159: 2582-8, 1999.
56. Shaheen, S.O., J.A. Sterne, S.M. Montgomery and H. Azima. Birth weight, body mass index and asthma in young adults. Thorax. 54: 396-402, 1999.
57. von Mutius, E., J. Schwartz, L.M. Neas, D. Dockery and S.T. Weiss. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax. 56: 835-8, 2001.
58. Celedon, J.C., L.J. Palmer, A.A. Litonjua, S.T. Weiss, B. Wang, Z. Fang and X. Xu. Body mass index and asthma in adults in families of subjects with asthma in Anqing, China. Am J Respir Crit Care Med. 164: 1835-40, 2001.
59. Engeli, S., M. Feldpausch, K. Gorzelniak, F. Hartwig, U. Heintze, J. Janke, M. Mohlig, A.F. Pfeiffer, F.C. Luft and A.M. Sharma. Association between adiponectin and mediators of inflammation in obese women. Diabetes. 52: 942-7, 2003.
60. Hu, E., P. Liang and B.M. Spiegelman. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 271: 10697-703, 1996.
61. Shore, S.A., R.D. Terry, L. Flynt, A. Xu and C. Hug. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol. 118: 389-95, 2006.
62. Tomas, E., T.S. Tsao, A.K. Saha, H.E. Murrey, C. Zhang Cc, S.I. Itani, H.F. Lodish and N.B. Ruderman. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A. 99: 16309-13, 2002.
63. Wu, X., H. Motoshima, K. Mahadev, T.J. Stalker, R. Scalia and B.J. Goldstein. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes. 52: 1355-63, 2003.