Comorbidities of asthma during childhood: Possibly important, yet poorly studied

European Respiratory Journal

Volumn 36, Issue 3, 2010, Pages 671-678

  De Groot, E P ^a   Duiverman, E J ^b   Brand, P L P ^a,c  

^a Princess Amalia Children's Clinic   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Asthma; Childhood; Comorbidity prevalence; Diagnosis; Treatment

Indexed keywords

CORTICOSTEROID; PROKINETIC AGENT; PROTON PUMP INHIBITOR; RANITIDINE;

ADOLESCENT; ADULT; AGED; ALLERGIC RHINITIS; ARTICLE; ASTHMA; BREATHING DISORDER; BREATHING PATTERN; BRONCHUS HYPERREACTIVITY; CHILD; CHILDHOOD DISEASE; COMORBIDITY; CORTICOSTEROID THERAPY; DEPRESSION; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; FEMALE; FOOD ALLERGY; GASTROESOPHAGEAL REFLUX; HUMAN; LUNG VOLUME; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; OBESITY; PREVALENCE; PRIORITY JOURNAL; VOCAL CORD;

ADOLESCENT; ASTHMA; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS AS TOPIC; COMORBIDITY; FOOD HYPERSENSITIVITY; HUMANS; HYPERSENSITIVITY; MENTAL DISORDERS; OBESITY; PEDIATRICS; PREVALENCE; PULMONARY MEDICINE; RESPIRATION DISORDERS; RHINITIS;

EID: 77956584475     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00185709     Document Type: Article

References (118)

1. British Thoracic Society, Scottish Intercollediate Guidelines Network, British Guideline on the Management of Asthma. Thorax 2008; 63: Suppl. 4, iv1-iv121.
2. Global Initiative for Asthma. Global strategy for asthma management and prevention. www.ginasthma.com/GuidelineItem.asp?intId=60 Date last updated: 2008.
3. Reddel HK, Taylor DR, Bateman ED, et al. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med 2009; 180: 59-99.
4. Adams NP, Jones PW. The dose-response characteristics of inhaled corticosteroids when used to treat asthma: an overview of Cochrane systematic reviews. Respir Med 2006; 100: 1297-1306.
5. British Thoracic Society, Scottish Intercollediate Guidelines Network, British guideline on the management of asthma. Thorax 2003; 58: Suppl. 1, i1-i94.
6. Kuehni CE, Frey U. Age-related differences in perceived asthma control in childhood: guidelines and reality. Eur Respir J 2002; 20: 880-889.
7. Rabe KF, Adachi M, Lai CK, et al. Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol 2004; 114: 40-47.
8. Smith LA, Bokhour B, Hohman KH, et al. Modifiable risk factors for suboptimal control and controller medication underuse among children with asthma. Pediatrics 2008; 122: 760-769.
9. Weinberger M. Seventeen years of asthma guidelines: why hasn't the outcome improved for children? J Pediatr 2009; 154: 786-788.
10. Wennergren G, Strannegard IL. Asthma hospitalizations continue to decrease in schoolchildren but hospitalization rates for wheezing illnesses remain high in young children. Acta Paediatr 2002; 91: 1239-1245.
11. Wennergren G, Kristjansson S, Strannegard IL. Decrease in hospitalization for treatment of childhood asthma with increased use of antiinflammatory treatment, despite an increase in prevalence of asthma. J Allergy Clin Immunol 1996; 97: 742-748.
12. Malmstrom K, Korhonen K, Kaila M, et al. Acute childhood asthma in Finland: a retrospective review of hospital admissions from 1976 to 1995. Pediatr Allergy Immunol 2000; 11: 236-240.
13. Hjern A, Haglund B, Bremberg S, et al. Social adversity, migration and hospital admissions for childhood asthma in Sweden. Acta Paediatr 1999; 88: 1107-1112.
14. Engelsvold DH, Oymar K. Hospital admissions for childhood asthma in Rogaland, Norway, from 1984 to 2000. Acta Paediatr 2003; 92: 610-616.
15. Saynajakangas O, Valmari P, Tuuponen T, et al. Trends in hospitalization for childhood asthma in Finland in 1996-2004. Acta Paediatr 2007; 96: 919-923.
16. Priftis K, Panagiotopoulou-Gartagani P, Tapratzi-Potamianou P, et al. Hospitalizations for childhood asthma in Athens, Greece, from 1978 to 2000. Pediatr Allergy Immunol 2005; 16: 82-85.
17. Kamps AW, Brand PL, Kimpen JL, et al. Outpatient management of childhood asthma by paediatrician or asthma nurse: randomised controlled study with one year follow up. Thorax 2003; 58: 968-973.
18. Lasmar L, Camargos P, Champs NS, et al. Adherence rate to inhaled corticosteroids and their impact on asthma control. Allergy 2009; 64: 784-789.
19. Bender B, Zhang L. Negative affect, medication adherence, and asthma control in children. J Allergy Clin Immunol 2008; 122: 490-495.
20. De Boeck BK, Moens M, Van Der AN, et al. "Difficult asthma": can symptoms be controlled in a structured environment? Pediatr Pulmonol 2009; 44: 743-748.
21. Gruchalla RS, Sampson HA, Matsui E, et al. Asthma morbidity among inner-city adolescents receiving guidelines-based therapy: role of predictors in the setting of high adherence. J Allergy Clin Immunol 2009; 124: 213-221.
22. Morgan WJ, Crain EF, Gruchalla RS, et al. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 2004; 351: 1068-1080.
23. Brouwer AF, Brand PL. Asthma education and monitoring: what has been shown to work. Paediatr Respir Rev 2008; 9: 193-199.
24. Bracken M, Fleming L, Hall P, et al. The importance of nurse-led home visits in the assessment of children with problematic asthma. Arch Dis Child 2009; 94: 780-784.
25. Bush A, Hedlin G, Carlsen KH, et al. Severe childhood asthma: a common international approach? Lancet 2008; 372: 1019-1021.
26. Platts-Mills TA, Erwin EA, Heymann PW, et al. Pro: the evidence for a causal role of dust mites in asthma. Am J Respir Crit Care Med 2009; 180: 109-113.
27. Custovic A, Wijk RG. The effectiveness of measures to change the indoor environment in the treatment of allergic rhinitis and asthma: ARIA update (in collaboration with GA(2)LEN). Allergy 2005; 60: 1112-1115.
28. Spencer N, Blackburn C, Bonas S, et al. Parent reported home smoking bans and toddler (18-30 month) smoke exposure: a cross-sectional survey. Arch Dis Child 2005; 90: 670-674.
29. Johansson A, Hermansson G, Ludvigsson J. How should parents protect their children from environmental tobacco-smoke exposure in the home? Pediatrics 2004; 113: e291-e295.
30. Curry SJ, Ludman EJ, Graham E, et al. Pediatric-based smoking cessation intervention for low-income women: a randomized trial. Arch Pediatr Adolesc Med 2003; 157: 295-302. (Pubitemid 36343391)
31. Borrelli B, Riekert KA, Weinstein A, et al. Brief motivational interviewing as a clinical strategy to promote asthma medication adherence. J Allergy Clin Immunol 2007; 120: 1023-1030.
32. Charles T, Quinn D, Weatherall M, et al. An audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma. J Allergy Clin Immunol 2007; 119: 811-816.
33. Kamps AW, Roorda RJ, Kimpen JL, et al. Impact of nurse-led outpatient management of children with asthma on healthcare resource utilisation and costs. Eur Respir J 2004; 23: 304-309.
34. Global Initiative for Asthma (GINA). Global Strategy for the Diagnosis and Management of Asthma in Children 5 Years and Younger. Updated 2009. www.ginasthma.com/GuidelineItem.asp??l1=2&$2=1&intId=1689
35. de Groot H, Brand PL, Fokkens WF, et al. Allergic rhinoconjunctivitis in children. BMJ 2007; 335: 985-988.
36. Asher MI, Montefort S, Bjorksten B, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006; 368: 733-743.
37. Hamouda S, Karila C, Connault T, et al. Allergic rhinitis in children with asthma: a questionnaire-based study. Clin Exp Allergy 2008; 38: 761-766.
38. Masuda S, Fujisawa T, Katsumata H, et al. High prevalence and young onset of allergic rhinitis in children with bronchial asthma. Pediatr Allergy Immunol 2008; 19: 517-522.
39. Simons FER. What's in a name? The allergic rhinitis-asthma connection. Clin Exp Allergy Rev 2003; 3: 9-17.
40. Brouwer AF, Visser CAN, Duiverman EJ, et al. Is home spirometry useful in diagnosing asthma in children with nonspecific respiratory symptoms? Pediatr Pulmonol 2010; 45: 326-332.
41. Weiner JM, Abramson MJ, Puy RM. Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials. BMJ 1998; 317: 1624-1629.
42. Wood RA, Eggleston PA. The effects of intranasal steroids on nasal and pulmonary responses to cat exposure. Am J Respir Crit Care Med 1995; 151: 315-320.
43. Dhillon S, Wagstaff AJ. Ciclesonide nasal spray: in allergic rhinitis. Drugs 2008; 68: 875-883.
44. McCormack PL, Scott LJ. Fluticasone furoate: intranasal use in allergic rhinitis. Drugs 2007; 67: 1905-1915.
45. Corren J, Manning BE, Thompson SF, et al. Rhinitis therapy and the prevention of hospital care for asthma: a case-control study. J Allergy Clin Immunol 2004; 113: 415-419.
46. Kang HY, Park CS, Bang HR, et al. Effect of allergic rhinitis on the use and cost of health services by children with asthma. Yonsei Med J 2008; 49: 521-529.
47. Ozol D, Mete E. Asthma and food allergy. Curr Opin Pulm Med 2008; 14: 9-12.
48. Beausoleil JL, Fiedler J, Spergel JM. Food intolerance and childhood asthma: what is the link? Paediatr Drugs 2007; 9: 157-163.
49. Nauta AJ, Engels F, Knippels LM, et al. Mechanisms of allergy and asthma. Eur J Pharmacol 2008; 585: 354-360.
50. James JM. Respiratory manifestations of food allergy. Pediatrics 2003; 111: 1625-1630.
51. Sicherer SH, Furlong TJ, Munoz-Furlong A, et al. A voluntary registry for peanut and tree nut allergy: characteristics of the first 5149 registrants. J Allergy Clin Immunol 2001; 108: 128-132.
52. Macdougall CF, Cant AJ, Colver AF. How dangerous is food allergy in childhood? The incidence of severe and fatal allergic reactions across the UK and Ireland. Arch Dis Child 2002; 86: 236-239.
53. Simpson AB, Glutting J, Yousef E. Food allergy and asthma morbidity in children. Pediatr Pulmonol 2007; 42: 489-495.
54. Ogden CL, Carroll MD, Flegal KM. High body mass index for age among US children and adolescents, 2003-2006. JAMA 2008; 299: 2401-2405.
55. Ogden CL, Flegal KM, Carroll MD, et al. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 2002; 288: 1728-1732.
56. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006; 295: 1549-1555.
57. Kopel SJ, Klein RB. Childhood asthma and obesity. Med Health R I 2008; 91: 161-164.
58. Harbers MM, van der Wilk EA, de Beer J. Differences between The Netherlands and other countries? www.nationaalkompas.nl/bevolking/verschillen- internationaal/ Date last accessed: February 17 2010. Date last updated: December 8 2009.
59. Martinez-Vizcaino V, Sanchez LM, Moya MP, et al. Trends in excess weight and thinness among Spanish schoolchildren in the period 1992-2004: the Cuenca study. Public Health Nutr 2009; 12: 1015-1018.
60. Vuorela N, Saha MT, Salo M. Prevalence of overweight and obesity in 5- and 12-year-old Finnish children in 1986 and 2006. Acta Paediatr 2009; 98: 507-512.
61. Schaub B, von Mutius E. Obesity and asthma, what are the links? Curr Opin Allergy Clin Immunol 2005; 5: 185-193.
62. Castro-Rodriguez JA, Holberg CJ, Morgan WJ, et al. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 2001; 163: 1344-1349.
63. Scholtens S, Wijga AH, Seidell JC, et al. Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age. J Allergy Clin Immunol 2009; 123: 1312-1318.
64. Belamarich PF, Luder E, Kattan M, et al. Do obese inner-city children with asthma have more symptoms than nonobese children with asthma? Pediatrics 2000; 106: 1436-1441.
65. Tantisira KG, Weiss ST. Complex interactions in complex traits: obesity and asthma. Thorax 2001; 56: Suppl. 2, ii64-ii73.
66. Schachter LM, Peat JK, Salome CM. Asthma and atopy in overweight children. Thorax 2003; 58: 1031-1035.
67. Brenner JS, Kelly CS, Wenger AD, et al. Asthma and obesity in adolescents: is there an association? J Asthma 2001; 38: 509-515.
68. Story RE. Asthma and obesity in children. Curr Opin Pediatr 2007; 19: 680-684.
69. Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 2008; 121: 1087-1093.
70. Mai XM, Bottcher MF, Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 2004; 15: 523-530.
71. Guler N, Kirerleri E, Ones U, et al. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol 2004; 114: 254-259.
72. Sutherland ER, Goleva E, Strand M, et al. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med 2008; 178: 682-687.
73. Milgrom H, Taussig LM. Keeping children with exercise-induced asthma active. Pediatrics 1999; 104: e38.
74. Berntsen S, Carlsen KC, Anderssen SA, et al. Norwegian adolescents with asthma are physical active and fit. Allergy 2009; 64: 421-426.
75. Stenius-Aarniala B, Poussa T, Kvarnstrom J, et al. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ 2000; 320: 827-832.
76. Sampson MG, Grassino AE. Load compensation in obese patients during quiet tidal breathing. J Appl Physiol 1983; 55: 1269-1276.
77. Fredberg JJ, Inouye DS, Mijailovich SM, et al. Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm. Am J Respir Crit Care Med 1999; 159: 959-967.
78. Lucas SR, Platts-Mills TA. Paediatric asthma and obesity. Paediatr Respir Rev 2006; 7: 233-238.
79. Reilly JJ, Methven E, McDowell ZC, et al. Health consequences of obesity. Arch Dis Child 2003; 88: 748-752.
80. Whitlock EP, Williams SB, Gold R, et al. Screening and interventions for childhood overweight: a summary of evidence for the US Preventive Services Task Force. Pediatrics 2005; 116: e125-e144.
81. Morgan MD. Dysfunctional breathing in asthma: is it common, identifiable and correctable? Thorax 2002; 57: Suppl. 2, 1131-1135.
82. Thomas M, McKinley RK, Freeman E, et al. Breathing retraining for dysfunctional breathing in asthma: a randomised controlled trial. Thorax 2003; 58: 110-115.
83. Enzer NB, Walker PA. Hyperventilation syndrome in childhood. A review of 44 cases. J Pediatr 1967; 70: 521-532.
84. Baranes T, Rossignol B, Stheneur C, et al. [Hyperventilation syndrome in children.] Arch Pediatr 2005; 12: 1742-1747.
85. Herman SP, Stickler GB, Lucas AR. Hyperventilation syndrome in children and adolescents: long-term follow-up. Pediatrics 1981; 67: 183-187.
86. Brouwer AF, Roorda RJ, van Reijn DA, et al. Inspanningsgebonden benauwdheid bij kinderen: disfunctionele ademhaling? [Exercise induced dyspnoea in children: dysfunctional breathing?] Tijdschr Kindergeneeskd 2004; 72: 209-212.
87. Abu-Hassan M, Tannous B, Weinberger M. Exercise induced dyspnea in children and adolescents: if not asthma then what? Ann Allergy Asthma Immunol 2005; 94: 366-371.
88. Seear M, Wensley D, West N. How accurate is the diagnosis of exercise induced asthma among Vancouver schoolchildren? Arch Dis Child 2005; 90: 898-902.
89. van Dixhoorn DJ, Duivenvoorden HJ. Efficacy of Nijmegen Questionnaire in recognition of the hyperventilation syndrome. J Psychosom Res 1985; 29: 199-206.
90. Thomas M, McKinley RK, Freeman E, et al. The prevalence of dysfunctional breathing in adults in the community with and without asthma. Prim Care Respir J 2005; 14: 78-82.
91. Thomas M, McKinley RK, Freeman E, et al. Prevalence of dysfunctional breathing in patients treated for asthma in primary care: cross sectional survey. BMJ 2001; 322: 1098-1100.
92. De Baets F, Bodart E, Dramaix-Wilmet M, et al. Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction. Pediatr Pulmonol 2005; 39: 301-305.
93. Brouwer AF, Roorda RJ, Brand PL. [Treatment of asthma in children: more than merely "puffing".] Ned Tijdschr Geneeskd 2004; 148: 865-868.
94. Weinberger M, Abu-Hasan M. Pseudo-asthma: when cough, wheezing, and dyspnea are not asthma. Pediatrics 2007; 120: 855-864.
95. Doshi DR, Weinberger MM. Long-term outcome of vocal cord dysfunction. Ann Allergy Asthma Immunol 2006; 96: 794-799.
96. Ford T, Goodman R, Meltzer H. The British Child and Adolescent Mental Health Survey 1999: the prevalence of DSM-IV disorders. J Am Acad Child Adolesc Psychiatry 2003; 42: 1203-1211.
97. Galil N. Depression and asthma in children. Curr Opin Pediatr 2000; 12: 331-335.
98. Sorensen MJ, Thomsen PH. [Depression in children and adolescents.] Ugeskr Laeger 2006; 168: 679-682.
99. Katon W, Lozano P, Russo J, et al. The prevalence of DSM-IV anxiety and depressive disorders in youth with asthma compared with controls. J Adolesc Health 2007; 41: 455-463.
100. Chen E, Hermann C, Rodgers D, et al. Symptom perception in childhood asthma: the role of anxiety and asthma severity. Health Psychol 2006; 25: 389-395.
101. Mancuso CA, Peterson MG, Charlson ME. Effects of depressive symptoms on health-related quality of life in asthma patients. J Gen Intern Med 2000; 15: 301-310.
102. Eisner MD, Katz PP, Lactao G, et al. Impact of depressive symptoms on adult asthma outcomes. Ann Allergy Asthma Immunol 2005; 94: 566-574.
103. Katon WJ, Richardson L, Russo J, et al. Quality of mental health care for youth with asthma and comorbid anxiety and depression. Med Care 2006; 44: 1064-1072.
104. Glazebrook C, McPherson AC, Macdonald IA, et al. Asthma as a barrier to children's physical activity: implications for body mass index and mental health. Pediatrics 2006; 118: 2443-2449.
105. Chawla S, Seth D, Mahajan P, et al. Gastroesophageal reflux disorder: a review for primary care providers. Clin Pediatr (Phila) 2006; 45: 7-13.
106. Nelson SP, Chen EH, Syniar GM, et al. Prevalence of symptoms of gastroesophageal reflux during childhood: a pediatric practice-based survey. Pediatric Practice Research Group. Arch Pediatr Adolesc Med 2000; 154: 150-154.
107. Gustafsson PM, Kjellman NI, Tibbling L. Oesophageal function and symptoms in moderate and severe asthma. Acta Paediatr Scand 1986; 75: 729-736.
108. Gustafsson PM, Kjellman NI, Tibbling L. Bronchial asthma and acid reflux into the distal and proximal oesophagus. Arch Dis Child 1990; 65: 1255-1258.
109. Tolia V, Vandenplas Y. Systematic review: the extra-oesophageal symptoms of gastro-oesophageal reflux disease in children. Aliment Pharmacol Ther 2009; 29: 258-272.
110. Khoshoo V, Mohnot S, Haydel R Jr, et al. Bronchial hyperreactivity in non-atopic children with asthma and reflux: effect of anti-reflux treatment. Pediatr Pulmonol 2009; 44: 1070-1074.
111. El Serag HB, Gilger M, Kuebeler M, et al. Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology 2001; 121: 1294-1299.
112. Wilson NM, Charette L, Thomson AH, et al. Gastro-oesophageal reflux and childhood asthma: the acid test. Thorax 1985; 40: 592-597.
113. Hancox RJ, Poulton R, Taylor DR, et al. Associations between respiratory symptoms, lung function and gastro-oesophageal reflux symptoms in a population-based birth cohort. Respir Res 2006; 7: 142.
114. Stordal K, Johannesdottir GB, Bentsen BS, et al. Asthma and overweight are associated with symptoms of gastro-oesophageal reflux. Acta Paediatr 2006; 95: 1197-1201.
115. Stordal K, Johannesdottir GB, Bentsen BS, et al. Acid suppression does not change respiratory symptoms in children with asthma and gastro-oesophageal reflux disease. Arch Dis Child 2005; 90: 956-960.
116. Khoshoo V, Haydel R Jr. Effect of antireflux treatment on asthma exacerbations in nonatopic children. J Pediatr Gastroenterol Nutr 2007; 44: 331-335.
117. Gustafsson PM, Kjellman NI, Tibbling L. A trial of ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux. Eur Respir J 1992; 5: 201-206.
118. Sopo SM, Radzik D, Calvani M. Does treatment with proton pump inhibitors for gastroesophageal reflux disease (GERD) improve asthma symptoms in children with asthma and GERD? A systematic review. J Investig Allergol Clin Immunol 2009; 19: 1-5.