DNA mismatch repair complex MutSβ promotes GAA·TTC repeat expansion in human cells

Journal of Biological Chemistry

Volumn 287, Issue 35, 2012, Pages 29958-29967

  Halabi, Anasheh ^a   Ditch, Scott ^a,b   Wang, Jeffrey ^a   Grabczyk, Ed ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER PREDISPOSITION; CELLULAR MODEL; DNA REPAIR; DNA REPEATS; DNA-REPAIR ENZYMES; ECTOPIC EXPRESSIONS; EXPANSION PROCESS; EXPANSION RATE; FUNCTIONAL ASSAYS; HETERODIMERS; HUMAN CELLS; MISMATCH REPAIR; NATIVE STATE; THERAPEUTIC TARGETS;

CELL CULTURE; DISEASES; DNA; FIBROBLASTS; GALLIUM ALLOYS; GENES; REPAIR; TISSUE; TRANSCRIPTION;

EXPANSION;

ALANINE; CYSTEINE; GLYCINE; MISMATCH REPAIR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN MSH2; PROTEIN MSH3; PROTEIN MUTS; PROTEIN MUTS BETA; REPETITIVE DNA; SHORT HAIRPIN RNA; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA REPAIR; DNA TRANSCRIPTION; FIBROBLAST; FRIEDREICH ATAXIA; FXN GENE; GENE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; TRINUCLEOTIDE REPEAT;

DNA MISMATCH REPAIR; DNA-BINDING PROTEINS; FIBROBLASTS; FRIEDREICH ATAXIA; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HUMANS; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; MUTS DNA MISMATCH-BINDING PROTEIN; MUTS HOMOLOG 2 PROTEIN; NEOPLASMS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84865505286     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.356758     Document Type: Article

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