The GAA triplet-repeat is unstable in the context of the human FXN locus and displays age-dependent expansions in cerebellum and DRG in a transgenic mouse model

Human Genetics

Volumn 120, Issue 5, 2007, Pages 633-640

  Clark, Rhonda M ^a   De Biase, Irene ^a   Malykhina, Anna P ^a   Al Mahdawi, Sahar ^b   Pook, Mark ^b   Bidichandani, Sanjay I ^a,c  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b BRUNEL UNIVERSITY   (United Kingdom)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; GUANINE; THYMIDINE;

ALLELE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; FRIEDREICH ATAXIA; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC STABILITY; HOMOZYGOSITY; HYPOTHESIS; IN VIVO STUDY; MALE; MOUSE; NERVE DEGENERATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOMATIC CELL; SPINAL GANGLION; TRANSGENE; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT;

AGE FACTORS; ALLELES; ANIMALS; CEREBELLUM; DISEASE MODELS, ANIMAL; FEMALE; FRIEDREICH ATAXIA; GANGLIA, SPINAL; GENE FREQUENCY; HUMANS; IRON-BINDING PROTEINS; MALE; MICE; MICE, TRANSGENIC; MUTATION; TRINUCLEOTIDE REPEAT EXPANSION; TRINUCLEOTIDE REPEATS;

MUS MUSCULUS;

EID: 33845652267     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-006-0249-3     Document Type: Article

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