Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair

EMBO Journal

Volumn 27, Issue 21, 2008, Pages 2896-2906

  Kim, Hyun Min ^a   Narayanan, Vidhya ^a   Mieczkowski, Piotr A ^b,e   Petes, Thomas D ^b   Krasilnikova, Maria M ^c   Mirkin, Sergei M ^d   Lobachev, Kirill S ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d TUFTS UNIVERSITY   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Chromosomal fragility; Chromosomal rearrangements; DNA secondary structure; Mismatch repair; Trinucleotide repeats

Indexed keywords

DOUBLE STRANDED DNA; ENDONUCLEASE; FRATAXIN; PROTEIN MUTL; PROTEIN MUTL ALPHA; PROTEIN MUTS; PROTEIN MUTS BETA; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME FRAGILITY; CHROMOSOME REARRANGEMENT; CHROMOSOME REPLICATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVATION; EUKARYOTE; GENOME; MISMATCH REPAIR; MOLECULAR GENETICS; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; YEAST;

ALLELES; BASE SEQUENCE; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILITY; DNA MISMATCH REPAIR; DNA REPLICATION; GENE REARRANGEMENT; GENES, FUNGAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; RECOMBINATION, GENETIC; REPETITIVE SEQUENCES, NUCLEIC ACID; SACCHAROMYCES CEREVISIAE;

EUKARYOTA;

EID: 55549095970     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.205     Document Type: Article

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