SCOPUS 정보 검색 플랫폼

MedChemComm

Volumn 3, Issue 9, 2012, Pages 1125-1137

Identification of a novel nanomolar inhibitor of hIcmt via a carboxylate replacement approach

(5) Majmudar, Jaimeen D a,c Morrison Logue, Amanda b,c Song, Jiao a,c Hrycyna, Christine A b,c Gibbs, Richard A a,c

a PURDUE UNIVERSITY (United States)

b PURDUE UNIVERSITY (United States)

c Purdue University (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(2 AZIDOETHYL)(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)SULFANE; (2 BROMOETHYL)(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)SULFANE; (3 BROMOPROPYL)(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)SULFANE; 1 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPAN 2 OL; 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ACETALDEHYDE; 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ACETAMIDE; 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ACETIC ACID; 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ETHANAMINE; 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ETHANETHIOL; 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ETHANOL; 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ETHYL ACETATE; 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPAN 1 OL; 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANE 1,2 DIOL; 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOIC ACID; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; DIETHYL [2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ETHYL]PHOSPHONATE; DIETHYL [3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPYL]PHOSPHONATE; ENZYME INHIBITOR; FARNESYL THIOPROPIONIC ACID; ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE INHIBITOR; ISOPROPYL(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)SULFANE; METHYL 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ACETATE; METHYL 2 METHYL 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOATE; METHYL 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOATE; N ACETYL S FARNESYLCYSTEINE; N HYDROXY 2 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]ACETAMIDE; N HYDROXY 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANAMIDE; PROPYL(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)SULFANE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; IN VITRO STUDY; PRIORITY JOURNAL;

EID: 84865503435 PISSN: 20402503 EISSN: 20402511 Source Type: Journal
DOI: 10.1039/c2md20108a Document Type: Article

Times cited : (2)

References (36)

1
- 77951709577
- S. Gillen T. Schuster C. M. Zum Buschenfelde H. Friess J. Kleeff PLoS Med. 2010 7 e1000267
- (2010) PLoS Med. , vol.7 , pp. 1000267
- Gillen, S.¹ Schuster, T.² Zum Buschenfelde, C.M.³ Friess, H.⁴ Kleeff, J.⁵

2
- 0024376173
- J. L. Bos Cancer Res. 1989 49 4682 4689
- (1989) Cancer Res. , vol.49 , pp. 4682-4689
- Bos, J.L.¹

3
- 0023068346
- M. Barbacid Annu. Rev. Biochem. 1987 56 779 827
- (1987) Annu. Rev. Biochem. , vol.56 , pp. 779-827
- Barbacid, M.¹

4
- 0030923192
- D. B. Whyte P. Kirschmeier T. N. Hockenberry I. NunezOliva L. James J. J. Catino W. R. Bishop J. K. Pai J. Biol. Chem. 1997 272 14459 14464
- (1997) J. Biol. Chem. , vol.272 , pp. 14459-14464
- Whyte, D.B.¹ Kirschmeier, P.² Hockenberry, T.N.³ Nunezoliva, I.⁴ James, L.⁵ Catino, J.J.⁶ Bishop, W.R.⁷ Pai, J.K.⁸

5
- 30844467746
- A. D. Basso P. Kirschmeier W. R. Bishop J. Lipid Res. 2006 47 15 31
- (2006) J. Lipid Res. , vol.47 , pp. 15-31
- Basso, A.D.¹ Kirschmeier, P.² Bishop, W.R.³

6
- 1042266632
- M. O. Bergo H. D. Lieu B. J. Gavino P. Ambroziak J. C. Otto P. J. Casey Q. M. Walker S. G. Young J. Biol. Chem. 2004 279 4729 4736
- (2004) J. Biol. Chem. , vol.279 , pp. 4729-4736
- Bergo, M.O.¹ Lieu, H.D.² Gavino, B.J.³ Ambroziak, P.⁴ Otto, J.C.⁵ Casey, P.J.⁶ Walker, Q.M.⁷ Young, S.G.⁸

7
- 0034625181
- M. O. Bergo G. K. Leung P. Ambroziak J. C. Otto P. J. Casey S. G. Young J. Biol. Chem. 2000 275 17605 17610
- (2000) J. Biol. Chem. , vol.275 , pp. 17605-17610
- Bergo, M.O.¹ Leung, G.K.² Ambroziak, P.³ Otto, J.C.⁴ Casey, P.J.⁵ Young, S.G.⁶

8
- 0037637529
- A. M. Winter-Vann B. A. Kamen M. O. Bergo S. G. Young S. Melnyk S. J. James P. J. Casey Proc. Natl. Acad. Sci. U. S. A. 2003 100 6529 6534
- (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 6529-6534
- Winter-Vann, A.M.¹ Kamen, B.A.² Bergo, M.O.³ Young, S.G.⁴ Melnyk, S.⁵ James, S.J.⁶ Casey, P.J.⁷

9
- 0025764049
- C. A. Hrycyna S. K. Sapperstein S. Clarke S. Michaelis EMBO J. 1991 10 1699 1709
- (1991) EMBO J. , vol.10 , pp. 1699-1709
- Hrycyna, C.A.¹ Sapperstein, S.K.² Clarke, S.³ Michaelis, S.⁴

10
- 1642326112
- M. O. Bergo B. J. Gavino C. Hong A. P. Beigneux M. McMahon P. J. Casey S. G. Young J. Clin. Invest. 2004 113 539 550
- (2004) J. Clin. Invest. , vol.113 , pp. 539-550
- Bergo, M.O.¹ Gavino, B.J.² Hong, C.³ Beigneux, A.P.⁴ McMahon, M.⁵ Casey, P.J.⁶ Young, S.G.⁷

11
- 1642340687
- S. Clarke F. Tamanoi J. Clin. Invest. 2004 113 513 515
- (2004) J. Clin. Invest. , vol.113 , pp. 513-515
- Clarke, S.¹ Tamanoi, F.²

12
- 16344396081
- D. Michaelson W. Ali V. K. Chiu M. Bergo J. Silletti L. Wright S. G. Young M. Philips Mol. Biol. Cell 2005 16 1606 1616
- (2005) Mol. Biol. Cell , vol.16 , pp. 1606-1616
- Michaelson, D.¹ Ali, W.² Chiu, V.K.³ Bergo, M.⁴ Silletti, J.⁵ Wright, L.⁶ Young, S.G.⁷ Philips, M.⁸

13
- 35848958344
- M. S. Buchanan A. R. Carroll G. A. Fechner A. Boyle M. M. Simpson R. Addepalli V. M. Avery J. N. A. Hooper N. Su H. W. Chen R. J. Quinn Bioorg. Med. Chem. Lett. 2007 17 6860 6863
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 6860-6863
- Buchanan, M.S.¹ Carroll, A.R.² Fechner, G.A.³ Boyle, A.⁴ Simpson, M.M.⁵ Addepalli, R.⁶ Avery, V.M.⁷ Hooper, J.N.A.⁸ Su, N.⁹ Chen, H.W.¹⁰ Quinn, R.J.¹¹

14
- 20144365360
- A. M. Winter-Vann R. A. Baron W. H. Wong J. dela Cruz J. D. York D. M. Gooden M. O. Bergo S. G. Young E. J. Toone P. J. Casey Proc. Natl. Acad. Sci. U. S. A. 2005 102 4336 4341
- (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 4336-4341
- Winter-Vann, A.M.¹ Baron, R.A.² Wong, W.H.³ Dela Cruz, J.⁴ York, J.D.⁵ Gooden, D.M.⁶ Bergo, M.O.⁷ Young, S.G.⁸ Toone, E.J.⁹ Casey, P.J.¹⁰

15
- 79960621449
- W. R. Judd P. M. Slattum K. C. Hoang L. Bhoite L. Valppu G. Alberts B. Brown B. Roth K. Ostanin L. Huang D. Wettstein B. Richards J. A. Willardsen J. Med. Chem. 2011 54 5031 5047
- (2011) J. Med. Chem. , vol.54 , pp. 5031-5047
- Judd, W.R.¹ Slattum, P.M.² Hoang, K.C.³ Bhoite, L.⁴ Valppu, L.⁵ Alberts, G.⁶ Brown, B.⁷ Roth, B.⁸ Ostanin, K.⁹ Huang, L.¹⁰ Wettstein, D.¹¹ Richards, B.¹² Willardsen, J.A.¹³

16
- 33745713224
- J. L. Donelson H. B. Hodges D. D. MacDougall B. S. Henriksen C. A. Hrycyna R. A. Gibbs Bioorg. Med. Chem. Lett. 2006 16 4420 4423
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 4420-4423
- Donelson, J.L.¹ Hodges, H.B.² MacDougall, D.D.³ Henriksen, B.S.⁴ Hrycyna, C.A.⁵ Gibbs, R.A.⁶

17
- 65249132627
- J. L. Donelson H. B. Hodges-Loaiza B. S. Henriksen C. A. Hrycyna R. A. Gibbs J. Org. Chem. 2009 74 2975 2981
- (2009) J. Org. Chem. , vol.74 , pp. 2975-2981
- Donelson, J.L.¹ Hodges-Loaiza, H.B.² Henriksen, B.S.³ Hrycyna, C.A.⁴ Gibbs, R.A.⁵

18
- 79955479634
- J. D. Majmudar K. Hahne C. A. Hrycyna R. A. Gibbs Bioorg. Med. Chem. Lett. 2011 21 2616 2620
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 2616-2620
- Majmudar, J.D.¹ Hahne, K.² Hrycyna, C.A.³ Gibbs, R.A.⁴

19
- 80051945458
- J. A. Bergman K. Hahne C. A. Hrycyna R. A. Gibbs Bioorg. Med. Chem. Lett. 2011 21 5616 5619
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 5616-5619
- Bergman, J.A.¹ Hahne, K.² Hrycyna, C.A.³ Gibbs, R.A.⁴

20
- 84855202806
- J. D. Majmudar H. B. Hodges-Loaiza K. Hahne J. L. Donelson J. Song L. Shrestha M. L. Harrison C. A. Hrycyna R. A. Gibbs Bioorg. Med. Chem. 2012 20 283 295
- (2012) Bioorg. Med. Chem. , vol.20 , pp. 283-295
- Majmudar, J.D.¹ Hodges-Loaiza, H.B.² Hahne, K.³ Donelson, J.L.⁴ Song, J.⁵ Shrestha, L.⁶ Harrison, M.L.⁷ Hrycyna, C.A.⁸ Gibbs, R.A.⁹

21
- 0001512821
- B. A. Gilbert E. W. Tan D. Perezsala R. R. Rando J. Am. Chem. Soc. 1992 114 3966 3973
- (1992) J. Am. Chem. Soc. , vol.114 , pp. 3966-3973
- Gilbert, B.A.¹ Tan, E.W.² Perezsala, D.³ Rando, R.R.⁴

22
- 0001396301
- M. J. Brown P. D. Milano D. C. Lever W. W. Epstein C. D. Poulter J. Am. Chem. Soc. 1991 113 3176 3177
- (1991) J. Am. Chem. Soc. , vol.113 , pp. 3176-3177
- Brown, M.J.¹ Milano, P.D.² Lever, D.C.³ Epstein, W.W.⁴ Poulter, C.D.⁵

23
- 17744362296
- K. Pachamuthu X. M. Zhu R. R. Schmidt J. Org. Chem. 2005 70 3720 3723
- (2005) J. Org. Chem. , vol.70 , pp. 3720-3723
- Pachamuthu, K.¹ Zhu, X.M.² Schmidt, R.R.³

24
- 0001050338
- P. Kocienski S. Wadman K. Cooper J. Org. Chem. 1989 54 1215 1217
- (1989) J. Org. Chem. , vol.54 , pp. 1215-1217
- Kocienski, P.¹ Wadman, S.² Cooper, K.³

25
- 0028016099
- C. A. Hrycyna M. C. Yang S. Clarke Biochemistry 1994 33 9806 9812
- (1994) Biochemistry , vol.33 , pp. 9806-9812
- Hrycyna, C.A.¹ Yang, M.C.² Clarke, S.³

26
- 0025051169
- C. A. Hrycyna S. Clarke Mol. Cell. Biol. 1990 10 5071 5076
- (1990) Mol. Cell. Biol. , vol.10 , pp. 5071-5076
- Hrycyna, C.A.¹ Clarke, S.²

27
- 14844337433
- J. L. Anderson H. Frase S. Michaelis C. A. Hrycyna J. Biol. Chem. 2005 280 7336 7345
- (2005) J. Biol. Chem. , vol.280 , pp. 7336-7345
- Anderson, J.L.¹ Frase, H.² Michaelis, S.³ Hrycyna, C.A.⁴

28
- 84855907701
- J. A. Bergman K. Hahne J. Song C. A. Hrycyna R. A. Gibbs ACS Med. Chem. Lett. 2011 3 15 19
- (2011) ACS Med. Chem. Lett. , vol.3 , pp. 15-19
- Bergman, J.A.¹ Hahne, K.² Song, J.³ Hrycyna, C.A.⁴ Gibbs, R.A.⁵

29
- 0033546689
- R. R. Desrosiers Q. T. Nguyen R. Beliveau Biochem. Biophys. Res. Commun. 1999 261 790 797
- (1999) Biochem. Biophys. Res. Commun. , vol.261 , pp. 790-797
- Desrosiers, R.R.¹ Nguyen, Q.T.² Beliveau, R.³

30
- 25844452832
- B. S. Henriksen J. L. Anderson C. A. Hrycyna R. A. Gibbs Bioorg. Med. Chem. Lett. 2005 15 5080 5083
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 5080-5083
- Henriksen, B.S.¹ Anderson, J.L.² Hrycyna, C.A.³ Gibbs, R.A.⁴

31
- 34547600604
- A. J. Krzysiak D. S. Rawat S. A. Scott J. E. Pais M. Handley M. L. Harrison C. A. Fierke R. A. Gibbs ACS Chem. Biol. 2007 2 385 389
- (2007) ACS Chem. Biol. , vol.2 , pp. 385-389
- Krzysiak, A.J.¹ Rawat, D.S.² Scott, S.A.³ Pais, J.E.⁴ Handley, M.⁵ Harrison, M.L.⁶ Fierke, C.A.⁷ Gibbs, R.A.⁸

32
- 0035236688
- E. Choy M. Philips Methods Enzymol. 2001 332 50 64
- (2001) Methods Enzymol. , vol.332 , pp. 50-64
- Choy, E.¹ Philips, M.²

33
- 49649092042
- M. Wang W. Tan J. Zhou J. Leow M. Go H. S. Lee P. J. Casey J. Biol. Chem. 2008 283 18678 18684
- (2008) J. Biol. Chem. , vol.283 , pp. 18678-18684
- Wang, M.¹ Tan, W.² Zhou, J.³ Leow, J.⁴ Go, M.⁵ Lee, H.S.⁶ Casey, P.J.⁷

34
- 0032744491
- J. B. McCabe L. G. Berthiaume Mol. Biol. Cell 1999 10 3771 3786
- (1999) Mol. Biol. Cell , vol.10 , pp. 3771-3786
- McCabe, J.B.¹ Berthiaume, L.G.²

35
- 34848874825
- R. Haklai G. Elad-Sfadia Y. Egozi Y. Kloog Cancer Chemother. Pharmacol. 2008 61 89 96
- (2008) Cancer Chemother. Pharmacol. , vol.61 , pp. 89-96
- Haklai, R.¹ Elad-Sfadia, G.² Egozi, Y.³ Kloog, Y.⁴

36
- 79955419410
- N. A. Meanwell J. Med. Chem. 2011 54 8 2529 2591
- (2011) J. Med. Chem. , vol.54 , Issue.8 , pp. 2529-2591
- Meanwell, N.A.¹

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