Fighting cancer by disrupting C-terminal methylation of signaling proteins

Journal of Clinical Investigation

Volumn 113, Issue 4, 2004, Pages 513-515

  Clarke, Steven ^a,b   Tamanoi, Fuyuhiko ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CARBOXYL GROUP; CYCLINE; CYSTEINE; ESTER; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROLASE; ISOPRENE; LAMIN; METHOTREXATE; METHYL GROUP; METHYLTRANSFERASE; PROTEIN; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P21; PROTEIN PRECURSOR; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; S ADENOSYLHOMOCYSTEINE; TETRAPEPTIDE; ZINC; PROTEIN METHYLTRANSFERASE; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE;

CANCER; CARBOXY TERMINAL SEQUENCE; CLINICAL TRIAL; HUMAN; ISOPRENYLATION; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REVIEW; TUMOR; TUMOR GROWTH; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; NEOPLASM; NOTE; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ANIMALS; METHYLATION; NEOPLASMS; PROTEIN ISOPRENYLATION; PROTEIN METHYLTRANSFERASES; PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 1642340687     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200421059     Document Type: Review

References (26)

1. Sattler, I., and Tamanoi, F. 1996. Prenylation of Ras and inhibitors of prenyltransferases. In Regulation of the RAS signaling network. H. Maruta and A.W. Burgess, editors. R.G. Landes. Austin, Texas, USA. 95-137.
2. Sinensky, M. 2000. Recent advances in the study of prenylated proteins. Biochim. Biophys. Acta. 1484:93-106.
3. Young, S.G., Ambroziak, P., Kim, E., and Clarke, S. 2001. Postisoprenylation protein processing: CXXX (CaaX) endoproteases and isoprenylcysteine carboxyl methyltransferase. In The enzymes. 3rd edition. Volume XXI, Protein lipidation. F. Tamanoi and D.S. Sigman, editors. Academic Press. San Diego, California, USA. 155-213.
4. Magee, A.I., and Seabra, M.C. 2003. Are prenyl groups sticky fingers or greasy handles? Biochem. J. 376:3-4.
5. Dietrich, A., et al. 2003. Studies on G-protein alpha-beta-gamma heterotrimer formation reveal a putative S-prenyl-binding site in the alpha subunit. Biochem. J. 376:449-456.
6. Chen, F., Ng, P.S., Faull, K.F., and Lee, R.H. 2003. Cone photoreceptor betagamma-transducin: posttranslational modification and interaction with phosducin. Invest. Ophthalmol. Vis. Sci. 44:4622-4629.
7. Hrycyna, C.A., and Clarke, S. 1993. Modification of eukaryotic signalling proteins by C-terminal methylationreactions. Pharmacol. Ther. 59:281-300.
8. Backlund, P.S., Jr. 1997. Post-translational processing of RhoA: carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of RhoA. J. Biol. Chem. 272:33175-33180.
9. Bergo, M.O., et al. 2004. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J. Clin. Invest. 113:539-550. doi:10.1172/JCI200418829.
10. Fujiyama, A., Matsumoto, K., and Tamanoi, F. 1987. A novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the muration on processing steps. EMBO J. 6:223-228.
11. Sapperstein, S., Berkower, C., and Michaelis, S. 1994. Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export. Mol. Cell. Biol. 14:1438-1449.
12. Chiu, V.K., et al. 2002. Ras signalling on the endoplasmic reticulum and the Golgi. Nat. Cell Biol. 4:354-350.
13. Tamanoi, F., Gau, C.L., Jiang, C., Edamatsu, H., and Kato-Stankiewicz, J. 2001. Protein farnesylation in mammalian cells: effects of farnesylation inhibitors on cancer cells. Cell. Mol. Life Sci. 58:1636-1649.
14. Gibbs, J.B. 2001. Farnesyltransferase inhibitors. In The enzymes. 3rd edition. Volume XXI, Protein lipidation. F. Tamanoi and D.S. Sigman, editors. Academic Press. San Diego, California, USA. 81-103.
15. Hamasaki, A., Naka, H., Tamanoi, F., Umezawa, K., and Otsuka, M. 2003. A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorg. Med. Chem. Lett. 13:1523-1526.
16. Brunner, T.B., et al. 2003. Farnesyltransferase inhibitors: an overview of the results of preclinical and clinical investigations. Cancer Res. 63:5656-5668.
17. Otto, J.C., Kim, E., Young, S.G. and Casey, P.J. 1999. Cloning and characterization of a mammalian prenyl protein-specific protease. J. Biol. Chem. 274:8379-8382.
18. Bergo, M.O., et al. 2001. Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J. Biol. Chem. 276:5841-5845.
19. Bergo, M.O., et al. 2002. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol. Cell. Biol. 22:171-181.
20. Clarke, S., and Banfield, K. 2001. S-adenosylmethionine-dependent methyltransferases: potential targets in homocysteine-linked pathology. In Homocysteine in health and disease. R. Carmel and D. Jacobsen, editors. Cambridge University Press. Cambridge, United Kingdom. 63-78.
21. Gordon, R.K., et al. 2003. Anti-HIV-1 activity of 3-deaza-adenosine analogs. Inhibition of S-adenosylhomocysteine hydrolase and nucleotide congeners. Eur. J. Biochem. 270:3507-3517.
22. Wnuk, S.F. 1997. Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5′-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues. J. Med. Chem. 40:1608-1618.
23. Katz, J.E., Dlakic, M., and Clarke, S. 2003. Automated identification of putative methyltransferases from genomic open reading frames. Mol. Cell. Proteomics. 2:525-540.
24. Winter-Vann, A.M., et al. 2003. Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate. Proc. Natl. Acad. Sci. U. S. A. 100:6529-6534.
25. Scheer, A., and Gierschik, P. 1993. Farnesylcysteine analogs inhibit chemotactic peptide receptor-mediated G-protein activation in human HL-60 granulocyte membranes. FEBS Lett. 319:110-114.
26. Volker, C., et al. 1991. Effects of farnesylcysteine analogs on protein carboxyl methylation and signal transduction. J. Biol. Chem. 266:21515-21522.