Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: Sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 9, 2011, Pages 2616-2620

  Majmudar, Jaimeen D ^a   Hahne, Kalub ^b   Hrycyna, Christine A ^b   Gibbs, Richard A ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Anti cancer agents; Enzymes; Inhibitor; Isoprenoid; Methyltransferase; Signal transduction

Indexed keywords

METHYLTRANSFERASE INHIBITOR; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; SULFONAMIDE; SULFONAMIDE MODIFIED FARNESYL CYSTEINE DERIVATIVE; UNCLASSIFIED DRUG;

BINDING AFFINITY; CHEMICAL BOND; CONFERENCE PAPER; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MOLECULAR PROBE; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CYSTEINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN METHYLTRANSFERASES; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 79955479634     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.078     Document Type: Conference Paper

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