Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5616-5619

  Bergman, Joel A ^a   Hahne, Kalub ^b   Hrycyna, Christine A ^b   Gibbs, Richard A ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Amino acid analogs; Click chemistry; Enzyme inhibitors; Isoprenoids; Isoprenylcysteine carboxylmethyltransferase

Indexed keywords

CYSTEINE DERIVATIVE; ENZYME INHIBITOR; N ACETYL S FARNESYL LEVO CYSTEINE; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION;

CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; LIPIDS; MOLECULAR STRUCTURE; PROTEIN METHYLTRANSFERASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR;

EID: 80051945458     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.053     Document Type: Article

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