Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 24, 2007, Pages 6860-6863

  Buchanan, Malcolm S ^a   Carroll, Anthony R ^a   Fechner, Gregory A ^a   Boyle, Anthony ^a   Simpson, Moana M ^a   Addepalli, Rama ^a   Avery, Vicky M ^a   Hooper, John N A ^b   Su, Nancy ^c   Chen, Huawei ^c   Quinn, Ronald J ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b QUEENSLAND MUSEUM   (Australia)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Cancer target; Isoprenylcysteine methyltransferase (Icmt); Natural products; Pseudoceratina sp.; Spermine alkaloid; Structure elucidation

Indexed keywords

ALKALOID; ISOPRENYLCYSTEINE CARBOXYLMETHYLTRANSFERASE INHIBITOR; METHYLTRANSFERASE INHIBITOR; ONCOPROTEIN; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; SPERMATINAMINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; AUSTRALIA; CANCER INHIBITION; CATALYSIS; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; INHIBITION KINETICS; METHYLATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PROCESSING; PSEUDOCERATINA; SPONGE (PORIFERA);

ANTINEOPLASTIC AGENTS; BIOLOGICAL PRODUCTS; ENZYME INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NEOPLASMS; PROTEIN METHYLTRANSFERASES; SPERMINE; TYROSINE;

PSEUDOCERATINA;

EID: 35848958344     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.10.021     Document Type: Article

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