A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells

Journal of Biological Chemistry

Volumn 283, Issue 27, 2008, Pages 18678-18684

  Wang, Mei ^a   Tan, Wanloo ^a   Zhou, Jin ^a   Leow, Jolene ^b   Go, Meilin ^b   How, Sung Lee ^b   Casey, Patrick J ^a,c  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NONE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CELL DEATH; CELL GROWTH; CHEMOTHERAPY; CYTOLOGY; DRUG THERAPY; ENZYME ACTIVITY; GROWTH (MATERIALS); GROWTH KINETICS; MAMMALS; TUMORS;

ANTITUMOR ACTIVITIES; APOPTOSIS; AUTOPHAGIC CELLS; AUTOPHAGY; C TERMINUSES; CANCER CELLS; CANCER CHEMOTHERAPIES; CELL CYCLES; CHEMICAL LIBRARIES; DUAL EFFECTS; GTPASES; IN VITRO; IN VIVO MODELS; INHIBITED GROWTHS; MAMMALIAN TARGET OF RAPAMYCIN; ONCOGENESIS; POSTTRANSLATIONAL PROCESSES; POTENTIAL MECHANISMS; PRENYLATION; PROSTATE CANCER CELLS; SMALL MOLECULES; TUMOR SIZES; TUMORIGENESIS; XENOGRAFT TUMORS;

CELLS;

ANTINEOPLASTIC AGENT; CYCLIN D1; CYSMETHYNIL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GROWTH FACTOR; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; METHYLTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN P27; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; RETINOBLASTOMA PROTEIN; RHEB PROTEIN; S6 KINASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; INDOLE DERIVATIVE; PROTEIN KINASE; PROTEIN METHYLTRANSFERASE; PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE; RAS PROTEIN; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER INHIBITION; CANCER MODEL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; SIGNAL TRANSDUCTION; TUMOR VOLUME; TUMOR XENOGRAFT; DIET THERAPY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; METABOLISM; PROSTATE TUMOR; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

MAMMALIA; MUS;

APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; G1 PHASE; HUMANS; INDOLES; MALE; NEOPLASM PROTEINS; PROSTATIC NEOPLASMS; PROTEIN KINASES; PROTEIN METHYLTRANSFERASES; PROTEIN PRENYLATION; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 49649092042     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801855200     Document Type: Article

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