Reversed approach to S-farnesylation and S-palmitoylation: Application to an efficient synthesis of the C-terminus of lipidated human N-Ras hexapeptide

Journal of Organic Chemistry

Volumn 70, Issue 9, 2005, Pages 3720-3723

  Pachamuthu, Kandasamy ^a   Zhu, Xiangming ^a   Schmidt, Richard R ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHEMICAL ANALYSIS; LIPIDS; SULFUR COMPOUNDS;

ELECTROPHILE; NEUCLEOPHILE; PEPTIDES; THIOL;

SYNTHESIS (CHEMICAL);

ALANINE; BROMIDE; ESTER DERIVATIVE; FARNESYL MERCAPTAN; FARNESYL THIOACETATE; HEXAPEPTIDE; LIPID; N ALLYLOXYCARBONYL BROMOALANYL METHIONYLGLYCYL LEUCYL PROLYL(S FARNESYL) CYSTEINE METHYL ESTER; N ALLYLOXYCARBONYL METHIONYL TYROSYL (S FARNESYL) CYSTEINE METHYL ESTER; N ALLYLOXYCARBONYL METHIONYL TYROSYL (S PALMITOYL) CYSTEINE METHYL ESTER; N ALLYLOXYCARBONYL(S PALMITOYL) CYSTEYL METHIONYLGLYCYL LEUCYL PROLYL(S FARNESYL) CYSTEINE METHYL ESTER; N ALLYLOXYCARBONYLGLYCYL LEUCYL PROLYL(S FARNESYL) CYSTEINE METHYL ESTER; RAS PROTEIN; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL MODIFICATION; CHEMICAL REACTION; FARNESYLATION; PALMITOYLATION; SYNTHESIS;

AMINO ACID SEQUENCE; CATALYSIS; HUMANS; INDICATORS AND REAGENTS; LIPOPROTEINS; MOLECULAR STRUCTURE; PALMITATES; PEPTIDE FRAGMENTS; PROTEIN ISOPRENYLATION; RAS PROTEINS; SULFHYDRYL COMPOUNDS;

EID: 17744362296     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0482357     Document Type: Article

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