Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 283-295

  Majmudar, Jaimeen D ^a,b   Hodges Loaiza, Heather B ^b,c   Hahne, Kalub ^b,c   Donelson, James L ^a,c   Song, Jiao ^a,c   Shrestha, Liza ^a,c   Harrison, Marietta L ^a,c   Hrycyna, Christine A ^b,c   Gibbs, Richard A ^a,c  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c Purdue University   (United States)

Author keywords

Anti cancer agents; Enzyme inhibition; Icmt; Isoprenylcysteine carboxyl methyltransferase; Methyl transferase; Methylesterification; Prenylation; Ras proteins

Indexed keywords

1 (BENZYLOXY) 2 BROMOBENZENE; 1 BROMO 2 (PHENOXYMETHYL)BENZENE; 1[(BENZYLOXY)METHYL] 2 BROMOBENZENE; 2 (2 BENZYLBENZAMIDO) 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOIC ACID; 2 (2 PHENOXYBENZAMIDO) 3 (UNDECYLTHIO)PROPANOIC ACID; 2 (2 PHENOXYBENZAMIDO) 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOIC ACID; 2 (2 PHENOXYBENZAMIDO) 3 [(3,7,11,15 TETRAMETHYLDODECA 2,6,10,14 TETRAEN 1 YL)THIO]PROPANOIC ACID; 2 (4 PHENOXYBENZAMIDO) 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOIC ACID; 2 (BENZYLOXY)BENZOIC ACID; 2 (DIBENZO[B,D]FURAN 4 CARBOXAMIDO) 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOIC ACID; 2 (PHENOXYMETHYL)BENZOIC ACID; 2 (PHENYLTHIO)BENZOIC ACID; 2 [2 (PHENOXYMETHYL)BENZAMIDO] 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOIC ACID; 2 [2 (PHENYLTHIO)BENZYLBENZAMIDO] 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOIC ACID; 2 [2 [(BENZYLOXY)METHYL]BENZAMIDO] 3 [(3,7,11 TRIMETHYLDODECA 2,6,10 TRIEN 1 YL)THIO]PROPANOIC ACID; CYSTEINE; GREEN FLUORESCENT PROTEIN; K RAS PROTEIN; METHYLTRANSFERASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PRENYLCYSTEINE; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE; PROTEIN S ISOPRENYLCYSTEINE O METHYLTRANSFERASE INHIBITOR DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELLULAR DISTRIBUTION; CHENG PRUSOFF METHOD; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVATION; IC 50; LEUKEMIA CELL LINE; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMIDES; CYSTEINE; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; KINETICS; PHOSPHORYLATION; PROTEIN METHYLTRANSFERASES; RAS PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855202806     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.10.087     Document Type: Article

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