-
1
-
-
0029563009
-
Telomeres: Beginning to understand the end
-
Zakian VA. Telomeres: beginning to understand the end. Science 1995; 270: 1601-7.
-
(1995)
Science
, vol.270
, pp. 1601-1607
-
-
Zakian, V.A.1
-
2
-
-
0015844590
-
A theory of marginotomy. The incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon
-
Olovnikov AM. A theory of marginotomy. The incomplete copying of template margin in enzymatic synthesis of polynucleotides and biological significance of the phenomenon. J Theor Biol 1973; 41: 181-90.
-
(1973)
J Theor Biol
, vol.41
, pp. 181-190
-
-
Olovnikov, A.M.1
-
3
-
-
0015515155
-
Origin of concatemeric DNA
-
Watson JD. Origin of concatemeric DNA. Nature (New Biol) 1972; 239: 197-201.
-
(1972)
Nature (New Biol)
, vol.239
, pp. 197-201
-
-
Watson, J.D.1
-
4
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990; 345: 458-60.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
5
-
-
0024325562
-
The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
-
Morin GB. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 1989; 59: 521-9.
-
(1989)
Cell
, vol.59
, pp. 521-529
-
-
Morin, G.B.1
-
6
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994; 266: 2011-5.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
-
7
-
-
0031010342
-
A survey of telomerase activity in human cancer
-
Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997; 33: 787-91.
-
(1997)
Eur J Cancer
, vol.33
, pp. 787-791
-
-
Shay, J.W.1
Bacchetti, S.2
-
8
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004; 23: 2919-33.
-
(2004)
Oncogene
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
9
-
-
0035940501
-
Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
-
Gisselsson D, Jonson T, Petersen A, Strombeck B, Dal Cin P, Hoglund M, et al. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors. Proc Natl Acad Sci USA 2001; 98: 12683-8.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 12683-12688
-
-
Gisselsson, D.1
Jonson, T.2
Petersen, A.3
Strombeck, B.4
Dal Cin, P.5
Hoglund, M.6
-
10
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279: 349-52.
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
Ouellette, M.2
Frolkis, M.3
Holt, S.E.4
Chiu, C.P.5
Morin, G.B.6
-
12
-
-
0036782884
-
Telomerase: A target for cancer therapeutics
-
Shay JW, Wright WE. Telomerase: a target for cancer therapeutics. Cancer Cell 2002; 2: 257-65.
-
(2002)
Cancer Cell
, vol.2
, pp. 257-265
-
-
Shay, J.W.1
Wright, W.E.2
-
13
-
-
0035300424
-
Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase
-
Ludwig A, Saretzki G, Holm PS, Tiemann F, Lorenz M, Emrich T, et al. Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase. Cancer Res 2001; 61: 3053-61.
-
(2001)
Cancer Res
, vol.61
, pp. 3053-3061
-
-
Ludwig, A.1
Saretzki, G.2
Holm, P.S.3
Tiemann, F.4
Lorenz, M.5
Emrich, T.6
-
14
-
-
0035929353
-
Switching and signaling at the telomere
-
Blackburn EH. Switching and signaling at the telomere. Cell 2001; 106: 661-73.
-
(2001)
Cell
, vol.106
, pp. 661-673
-
-
Blackburn, E.H.1
-
15
-
-
0032566005
-
Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
-
Kondo S, Kondo Y, Li G, Silverman RH, Cowell JK. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA. Oncogene 1998; 16: 3323-30.
-
(1998)
Oncogene
, vol.16
, pp. 3323-3330
-
-
Kondo, S.1
Kondo, Y.2
Li, G.3
Silverman, R.H.4
Cowell, J.K.5
-
16
-
-
0032828652
-
Inhibition of telomerase limits the growth of human cancer cells
-
Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, et al. Inhibition of telomerase limits the growth of human cancer cells. Nature Med 1999; 5: 1164-70.
-
(1999)
Nature Med
, vol.5
, pp. 1164-1170
-
-
Hahn, W.C.1
Stewart, S.A.2
Brooks, M.W.3
York, S.G.4
Eaton, E.5
Kurachi, A.6
-
17
-
-
0033568462
-
Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
-
Zhang X, Mar V, Zhou W, Harrington L, Robinson MO. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 1999; 13: 2388-99.
-
(1999)
Genes Dev
, vol.13
, pp. 2388-2399
-
-
Zhang, X.1
Mar, V.2
Zhou, W.3
Harrington, L.4
Robinson, M.O.5
-
19
-
-
0043199578
-
Telomerase maintains telomere structure in normal human cells
-
Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, et al. Telomerase maintains telomere structure in normal human cells. Cell 2003; 114: 241-53.
-
(2003)
Cell
, vol.114
, pp. 241-253
-
-
Masutomi, K.1
Yu, E.Y.2
Khurts, S.3
Ben-Porath, I.4
Currier, J.L.5
Metz, G.B.6
-
20
-
-
0029096515
-
The RNA component of human telomerase
-
Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, et al. The RNA component of human telomerase. Science 1995; 269: 1236-41.
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
Wang, S.S.3
Weinrich, S.L.4
Avilion, A.A.5
Chiu, C.P.6
-
21
-
-
0033455559
-
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
-
Herbert BS, Pitts AE, Baker SI, Hamilton SE, Wright WE, Shay JW, et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA 1999; 96: 14276-81.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14276-14281
-
-
Herbert, B.S.1
Pitts, A.E.2
Baker, S.I.3
Hamilton, S.E.4
Wright, W.E.5
Shay, J.W.6
-
22
-
-
0032403264
-
Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells
-
Yokoyama Y, Takahashi Y, Shinohara A, Lian Z, Wan X, Niwa K, et al. Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cells. Cancer Res 1998; 58: 5406-10.
-
(1998)
Cancer Res
, vol.58
, pp. 5406-5410
-
-
Yokoyama, Y.1
Takahashi, Y.2
Shinohara, A.3
Lian, Z.4
Wan, X.5
Niwa, K.6
-
24
-
-
0036562687
-
Telomere maintenance as a target for anticancer drug discovery
-
Neidle S, Parkinson G. Telomere maintenance as a target for anticancer drug discovery. Nat Rev Drug Discov 2002; 1: 383-93.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 383-393
-
-
Neidle, S.1
Parkinson, G.2
-
25
-
-
18544364628
-
Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate
-
Pascole E, Wenz C, Lingner J, Hauel N, Priepke H, Kauffmann I, et al. Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J Biol Chem 2002; 277: 15566-72.
-
(2002)
J Biol Chem
, vol.277
, pp. 15566-15572
-
-
Pascole, E.1
Wenz, C.2
Lingner, J.3
Hauel, N.4
Priepke, H.5
Kauffmann, I.6
-
26
-
-
4243937106
-
A highly selective telomerase inhibitor limiting human cancer cell proliferation
-
Damm K, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann I, Priepke H, et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J 2001; 20: 6958-68.
-
(2001)
EMBO J
, vol.20
, pp. 6958-6968
-
-
Damm, K.1
Hemmann, U.2
Garin-Chesa, P.3
Hauel, N.4
Kauffmann, I.5
Priepke, H.6
-
27
-
-
18744369280
-
A novel carbazole derivative, BMVC: A potential antitumor agent and fluorescence marker of cancer cells
-
Chang CC, Kuo IC, Lin JJ. A novel carbazole derivative, BMVC: a potential antitumor agent and fluorescence marker of cancer cells. Chem Biodivers 2004; 1: 1377-84.
-
(2004)
Chem Biodivers
, vol.1
, pp. 1377-1384
-
-
Chang, C.C.1
Kuo, I.C.2
Lin, J.J.3
-
28
-
-
0035942270
-
Structure-based design of selective and potent G-quadruplex-mediated telomerase inhibitors
-
Read M, Harrison RJ, Romagnoli B, Tanious FA, Gowan SH, Reszka AP. Structure-based design of selective and potent G-quadruplex-mediated telomerase inhibitors. Proc Natl Acad Sci USA 2001; 98: 4844-9.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4844-4849
-
-
Read, M.1
Harrison, R.J.2
Romagnoli, B.3
Tanious, F.A.4
Gowan, S.H.5
Reszka, A.P.6
-
29
-
-
0000529609
-
The structure of telomeric DNA: DNA quardruplex formation
-
Sen D, Gilbert W. The structure of telomeric DNA: DNA quardruplex formation. Curr Opin Struct Biol 1991; 1: 435-8.
-
(1991)
Curr Opin Struct Biol
, vol.1
, pp. 435-438
-
-
Sen, D.1
Gilbert, W.2
-
30
-
-
3543039438
-
Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative
-
Chang CC, Kuo IC, Ling IF, Chen CT, Chen HC, Lou PJ. Detection of quadruplex DNA structures in human telomeres by a fluorescent carbazole derivative. Anal Chem 2004; 76: 4490-4.
-
(2004)
Anal Chem
, vol.76
, pp. 4490-4494
-
-
Chang, C.C.1
Kuo, I.C.2
Ling, I.F.3
Chen, C.T.4
Chen, H.C.5
Lou, P.J.6
-
31
-
-
0037015078
-
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
-
Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci USA 2004; 99: 11593-8.
-
(2004)
Proc Natl Acad Sci USA
, vol.99
, pp. 11593-11598
-
-
Siddiqui-Jain, A.1
Grand, C.L.2
Bearss, D.J.3
Hurley, L.H.4
-
32
-
-
0033553536
-
Mammalian telomeres end in large duplex loop
-
Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, et al. Mammalian telomeres end in large duplex loop. Cell 1999; 97: 503-14.
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
-
34
-
-
0032495774
-
Cationic porphyrins as telomerase inhibitors: The interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA
-
Wheelhouse RT, Sun D, Han H, Han FX, Hurley LH. Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J Am Chem Soc 1998; 120: 3261-2.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 3261-3262
-
-
Wheelhouse, R.T.1
Sun, D.2
Han, H.3
Han, F.X.4
Hurley, L.H.5
-
35
-
-
0037203972
-
Antitumor polycyclic acridines. 8. Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts
-
Heald RA, Modi C, Cookson JC, Hutchinson I, Laughton CA, Gowan SM, et al. Antitumor polycyclic acridines. 8. Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts. J Med Chem 2002; 45: 590-7.
-
(2002)
J Med Chem
, vol.45
, pp. 590-597
-
-
Heald, R.A.1
Modi, C.2
Cookson, J.C.3
Hutchinson, I.4
Laughton, C.A.5
Gowan, S.M.6
-
36
-
-
0030786928
-
Inhibition of human telomerase by a G-quadruple-interactive compound
-
Sun D, Thompson B, Cathers BE, Salazar M, Kerwin SM, Trent JO, et al. Inhibition of human telomerase by a G-quadruple-interactive compound. J Med Chem 1997; 40: 2113-28.
-
(1997)
J Med Chem
, vol.40
, pp. 2113-2128
-
-
Sun, D.1
Thompson, B.2
Cathers, B.E.3
Salazar, M.4
Kerwin, S.M.5
Trent, J.O.6
-
37
-
-
0037022658
-
Cell senesscence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
-
Riou JF, Guittat L, Mailliet P, Laoui A, Renou E, Petitgenet O, et al. Cell senesscence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proc Natl Acad Sci USA 2002; 99: 2672-7.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2672-2677
-
-
Riou, J.F.1
Guittat, L.2
Mailliet, P.3
Laoui, A.4
Renou, E.5
Petitgenet, O.6
-
38
-
-
0033566092
-
2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase
-
Perry PJ, Read MA, Davies RT, Gowan SM, Reszka AP, Wood AA, et al. 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase. J Med Chem 1999; 42: 2679-84.
-
(1999)
J Med Chem
, vol.42
, pp. 2679-2684
-
-
Perry, P.J.1
Read, M.A.2
Davies, R.T.3
Gowan, S.M.4
Reszka, A.P.5
Wood, A.A.6
-
39
-
-
0036152654
-
Molecular modeling and cytotoxicity of substituted anthraquinones as inhibitors of human telomerase
-
Cairns D, Michalitsi E, Jenkins TC, Mackay SP. Molecular modeling and cytotoxicity of substituted anthraquinones as inhibitors of human telomerase. Bioorgan Med Chem 2002; 10: 803-7.
-
(2002)
Bioorgan Med Chem
, vol.10
, pp. 803-807
-
-
Cairns, D.1
Michalitsi, E.2
Jenkins, T.C.3
Mackay, S.P.4
-
40
-
-
0242480943
-
A carbazole derivative synthesis for stabilizing the quadruplex structure
-
Chang CC, Wu JY, Chang TC. A carbazole derivative synthesis for stabilizing the quadruplex structure. J Chin Chem Soc 2003; 50: 185-8.
-
(2003)
J Chin Chem Soc
, vol.50
, pp. 185-188
-
-
Chang, C.C.1
Wu, J.Y.2
Chang, T.C.3
-
41
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 1997; 277: 955-9.
-
(1997)
Science
, vol.277
, pp. 955-959
-
-
Nakamura, T.M.1
Morin, G.B.2
Chapman, K.B.3
Weinrich, S.L.4
Andrews, W.H.5
Lingner, J.6
-
42
-
-
0037148401
-
Regulation of the human telomerase reverse transcriptase gene
-
Ducrest AL, Szutorisz H, Lingner J, Nabholz M. Regulation of the human telomerase reverse transcriptase gene. Oncogene 2002; 21: 541-52.
-
(2002)
Oncogene
, vol.21
, pp. 541-552
-
-
Ducrest, A.L.1
Szutorisz, H.2
Lingner, J.3
Nabholz, M.4
-
43
-
-
0033988011
-
Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium
-
Ulaner GA, Hu JF, Vu TH, Oruganti H, Giudice LC, Hoffman AR. Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium. Int J Cancer 2000; 85: 330-5.
-
(2000)
Int J Cancer
, vol.85
, pp. 330-335
-
-
Ulaner, G.A.1
Hu, J.F.2
Vu, T.H.3
Oruganti, H.4
Giudice, L.C.5
Hoffman, A.R.6
-
44
-
-
0034523665
-
An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity
-
Yi X, White DM, Aisner DL, Baur JA, Wright WE, Shay JW. An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia 2000; 2: 433-40.
-
(2000)
Neoplasia
, vol.2
, pp. 433-440
-
-
Yi, X.1
White, D.M.2
Aisner, D.L.3
Baur, J.A.4
Wright, W.E.5
Shay, J.W.6
-
45
-
-
0031590739
-
Inhibition of telomerase activity by PKC inhibitors on human nasopharyngeal cancer cells in culture
-
Ku WC, Cheng AJ, Wang TCV. Inhibition of telomerase activity by PKC inhibitors on human nasopharyngeal cancer cells in culture. Biochem Biophys Res Commun 1997; 241: 730-6.
-
(1997)
Biochem Biophys Res Commun
, vol.241
, pp. 730-736
-
-
Ku, W.C.1
Cheng, A.J.2
Wang, T.C.V.3
-
46
-
-
0030755955
-
Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells
-
Li H, Zhao LL, Funder JW, Liu JP. Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells. J Biol Chem 1997; 272: 16729-32.
-
(1997)
J Biol Chem
, vol.272
, pp. 16729-16732
-
-
Li, H.1
Zhao, L.L.2
Funder, J.W.3
Liu, J.P.4
-
47
-
-
0032509350
-
Telomerase is controlled by protein kinase Ca in human breast cancer cells
-
Li H, Zhao L, Yang Z, Funder JW, Liu JP. Telomerase is controlled by protein kinase Ca in human breast cancer cells. J Biol Chem 1998; 273: 33436-42.
-
(1998)
J Biol Chem
, vol.273
, pp. 33436-33442
-
-
Li, H.1
Zhao, L.2
Yang, Z.3
Funder, J.W.4
Liu, J.P.5
-
48
-
-
0033532056
-
Akt protein kinase enhances human telomerase activity through phosphorylation of telo-merase reverse transcriptase subunit
-
Kang SS, Kwon T, Kwon DY, Do SI. Akt protein kinase enhances human telomerase activity through phosphorylation of telo-merase reverse transcriptase subunit. J Biol Chem 1999; 274: 13085-90.
-
(1999)
J Biol Chem
, vol.274
, pp. 13085-13090
-
-
Kang, S.S.1
Kwon, T.2
Kwon, D.Y.3
Do, S.I.4
-
49
-
-
0036711651
-
Subnuclear shuttling of human telomerase induced by transformation and DNA damage
-
Wong JMY, Kusdra L, Collins K. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nature Cell Biol 2002; 4: 731-6.
-
(2002)
Nature Cell Biol
, vol.4
, pp. 731-736
-
-
Wong, J.M.Y.1
Kusdra, L.2
Collins, K.3
-
50
-
-
0035811032
-
Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation
-
Pendino F, Flexor M, Delhommeau F, Buet D, Lanotte M, Segal-Bendirdjian E. Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation. Proc Natl Acad Sci USA 2001; 98: 6662-7.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6662-6667
-
-
Pendino, F.1
Flexor, M.2
Delhommeau, F.3
Buet, D.4
Lanotte, M.5
Segal-Bendirdjian, E.6
-
51
-
-
0033859678
-
Synergistic downregulation of telomerase activity and hTERT mRNA expression by combination of retinoic acid and GM-CSF in human myeloblastic leukemia ML-1 cells
-
Mano Y, Shimizu T, Tanuma S, Takeda K. Synergistic downregulation of telomerase activity and hTERT mRNA expression by combination of retinoic acid and GM-CSF in human myeloblastic leukemia ML-1 cells. Anticancer Res 2000; 20: 1649-52.
-
(2000)
Anticancer Res
, vol.20
, pp. 1649-1652
-
-
Mano, Y.1
Shimizu, T.2
Tanuma, S.3
Takeda, K.4
-
52
-
-
0038155211
-
Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone
-
Huang HS, Chiou JF, Fong Y, Hou CC, Lu YC, Wang JY, et al. Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone. J Med Chem 2003; 46: 3300-7.
-
(2003)
J Med Chem
, vol.46
, pp. 3300-3307
-
-
Huang, H.S.1
Chiou, J.F.2
Fong, Y.3
Hou, C.C.4
Lu, Y.C.5
Wang, J.Y.6
-
53
-
-
0034681457
-
Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
-
Rudolph KL, Chang S, Millard M, Schreiber-Agus N, DePinho RA. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 2000; 287: 1253-8.
-
(2000)
Science
, vol.287
, pp. 1253-1258
-
-
Rudolph, K.L.1
Chang, S.2
Millard, M.3
Schreiber-Agus, N.4
DePinho, R.A.5
-
54
-
-
0033987424
-
Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts
-
Wyllie FS, Jones CJ, Skinner JW, Haughton MF, Wallis C, Wynford-Thomas D, et al. Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts. Nat Genet 2000; 24: 16-7.
-
(2000)
Nat Genet
, vol.24
, pp. 16-17
-
-
Wyllie, F.S.1
Jones, C.J.2
Skinner, J.W.3
Haughton, M.F.4
Wallis, C.5
Wynford-Thomas, D.6
-
55
-
-
0035984715
-
Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression
-
Shi S, Gronthos S, Chen S, Reddi A, Counter CM, Robey PG, et al. Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. Nat Biotechnol 2002; 20: 587-91.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 587-591
-
-
Shi, S.1
Gronthos, S.2
Chen, S.3
Reddi, A.4
Counter, C.M.5
Robey, P.G.6
-
56
-
-
0035984714
-
Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells
-
Simonsen JL, Rosada C, Serakinci N, Justesen J, Stenderup K, Rattan SI, et al. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat Biotechnol 2002; 20: 592-6.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 592-596
-
-
Simonsen, J.L.1
Rosada, C.2
Serakinci, N.3
Justesen, J.4
Stenderup, K.5
Rattan, S.I.6
-
57
-
-
0032485416
-
Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
-
Counter CM, Meyerson M, Eaton EN, Ellisen ZW, Caddle SD, Haber DA, et al. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene 1998; 16: 1217-22.
-
(1998)
Oncogene
, vol.16
, pp. 1217-1222
-
-
Counter, C.M.1
Meyerson, M.2
Eaton, E.N.3
Ellisen, Z.W.4
Caddle, S.D.5
Haber, D.A.6
-
58
-
-
3042699460
-
Adult human mesenchymal stem cell as a target for neoplastic transformation
-
Serakinci N, Guldberg P, Burns JS, Abdallah B, Schrodder H, Jensen T, et al. Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene 2004; 23: 5095-8.
-
(2004)
Oncogene
, vol.23
, pp. 5095-5098
-
-
Serakinci, N.1
Guldberg, P.2
Burns, J.S.3
Abdallah, B.4
Schrodder, H.5
Jensen, T.6
-
59
-
-
0032923742
-
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
-
Jiang XR, Jimenez G, Chang E, Kaur KJ, Yan Y, Wilson KS, et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 1999; 21: 111-4.
-
(1999)
Nat Genet
, vol.21
, pp. 111-114
-
-
Jiang, X.R.1
Jimenez, G.2
Chang, E.3
Kaur, K.J.4
Yan, Y.5
Wilson, K.S.6
-
60
-
-
0032924343
-
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
-
Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet 1999; 21: 115-8.
-
(1999)
Nat Genet
, vol.21
, pp. 115-118
-
-
Morales, C.P.1
Holt, S.E.2
Ouellette, M.3
Kaur, K.J.4
Yan, Y.5
Wilson, K.S.6
-
61
-
-
0035355340
-
Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes
-
Gonzalez-Suarez E, Samper E, Ramirez A, Flores JM, Martin-Caballero J, Jorcano JL, et al. Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J 2001; 20: 2619-30.
-
(2001)
EMBO J
, vol.20
, pp. 2619-2630
-
-
Gonzalez-Suarez, E.1
Samper, E.2
Ramirez, A.3
Flores, J.M.4
Martin-Caballero, J.5
Jorcano, J.L.6
-
62
-
-
0037062454
-
Constitutive telomerase expression promotes mammary carcinomas in aging mice
-
Artandi SE, Alson S, Tietze MK, Sharpless NE, Yes, Greenberg RA, et al. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci USA 2002; 99: 8191-6.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8191-8196
-
-
Artandi, S.E.1
Alson, S.2
Tietze, M.K.3
Sharpless, N.E.4
Yes5
Greenberg, R.A.6
-
63
-
-
0033572577
-
DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene
-
Devereux TR, Horikawa I, Anna CH, Annab LA, Afshari CA, Barrett JC, et al. DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res 1999; 59: 6087-90.
-
(1999)
Cancer Res
, vol.59
, pp. 6087-6090
-
-
Devereux, T.R.1
Horikawa, I.2
Anna, C.H.3
Annab, L.A.4
Afshari, C.A.5
Barrett, J.C.6
-
64
-
-
0033953573
-
Methylation of the human telomerase gene CpG island
-
Dessain SK, Yu H, Reddel RR, Beijersbergen RL, Weinberg RA. Methylation of the human telomerase gene CpG island. Cancer Res 2000; 60: 537-41.
-
(2000)
Cancer Res
, vol.60
, pp. 537-541
-
-
Dessain, S.K.1
Yu, H.2
Reddel, R.R.3
Beijersbergen, R.L.4
Weinberg, R.A.5
-
65
-
-
0034680840
-
Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells
-
Cong YS, Bacchetti S. Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J Biol Chem 2000; 275: 35665-8.
-
(2000)
J Biol Chem
, vol.275
, pp. 35665-35668
-
-
Cong, Y.S.1
Bacchetti, S.2
-
66
-
-
0035878721
-
Telomerase activation by histone deacetylase inhibitor in normal cells
-
Takakura M, Kyo S, Sowa Y, Wang Z, Yatabe N, Maida Y, et al. Telomerase activation by histone deacetylase inhibitor in normal cells. Nucleic Acids Res 2001; 29: 3006-11.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 3006-3011
-
-
Takakura, M.1
Kyo, S.2
Sowa, Y.3
Wang, Z.4
Yatabe, N.5
Maida, Y.6
-
67
-
-
0034107095
-
Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells
-
Misiti S, Nanni S, Fontemaggi G, Cong YS, Wen J, Hirte HW, et al. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol 2000; 20: 3764-71.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3764-3771
-
-
Misiti, S.1
Nanni, S.2
Fontemaggi, G.3
Cong, Y.S.4
Wen, J.5
Hirte, H.W.6
-
68
-
-
0033406452
-
Estrogen activates telomerase
-
Kyo S, Takakura M, Kanaya T, Cong YS, Wen J, Hirte HW, et al. Estrogen activates telomerase. Cancer Res 1999; 59: 5917-21.
-
(1999)
Cancer Res
, vol.59
, pp. 5917-5921
-
-
Kyo, S.1
Takakura, M.2
Kanaya, T.3
Cong, Y.S.4
Wen, J.5
Hirte, H.W.6
-
69
-
-
0034307337
-
Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway
-
Wang Z, Kyo S, Takakura M, Tanaka M, Yatabe N, Maida Y, et al. Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway. Cancer Res 2000; 60: 5376-81.
-
(2000)
Cancer Res
, vol.60
, pp. 5376-5381
-
-
Wang, Z.1
Kyo, S.2
Takakura, M.3
Tanaka, M.4
Yatabe, N.5
Maida, Y.6
-
70
-
-
3843065441
-
Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells
-
Won J, Chang S, Oh S, Kim TK. Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells. Proc Natl Acad Sci USA 2004; 101: 11328-33.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 11328-11333
-
-
Won, J.1
Chang, S.2
Oh, S.3
Kim, T.K.4
-
71
-
-
0347356413
-
hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin
-
Nakamura M, Kyo S, Kanaya T, Yatabe N, Maida Y, Tanaka M, et al. hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin. Cancer Gene Ther 2004; 11: 1-7.
-
(2004)
Cancer Gene Ther
, vol.11
, pp. 1-7
-
-
Nakamura, M.1
Kyo, S.2
Kanaya, T.3
Yatabe, N.4
Maida, Y.5
Tanaka, M.6
-
72
-
-
0034307303
-
Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers
-
Gu J, Kagawa S, Takakura M, Kyo S, Inoue M, Roth JA, et al. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res 2000; 60: 5359-64.
-
(2000)
Cancer Res
, vol.60
, pp. 5359-5364
-
-
Gu, J.1
Kagawa, S.2
Takakura, M.3
Kyo, S.4
Inoue, M.5
Roth, J.A.6
-
73
-
-
0035422652
-
Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter
-
Komata T, Kondo Y, Kanzawa T, Hirohata S, Koga S, Sumiyoshi H, et al. Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter. Cancer Res 2001; 61: 5796-802.
-
(2001)
Cancer Res
, vol.61
, pp. 5796-5802
-
-
Komata, T.1
Kondo, Y.2
Kanzawa, T.3
Hirohata, S.4
Koga, S.5
Sumiyoshi, H.6
-
74
-
-
0034235413
-
A novel telomerase-specific gene therapy: Gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter
-
Koga S, Hirohata S, Kondo Y, Komata T, Takakura M, Inoue M, et al. A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter. Hum Gene Ther 2000; 11: 1397-406.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 1397-1406
-
-
Koga, S.1
Hirohata, S.2
Kondo, Y.3
Komata, T.4
Takakura, M.5
Inoue, M.6
-
75
-
-
0034575796
-
Use of a transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells
-
Abdul-Ghani R, Ohana P, Matouk I, Ayesh S, Ayesh B, Laster M, et al. Use of a transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells. Mol Ther 2000; 2: 539-44.
-
(2000)
Mol Ther
, vol.2
, pp. 539-544
-
-
Abdul-Ghani, R.1
Ohana, P.2
Matouk, I.3
Ayesh, S.4
Ayesh, B.5
Laster, M.6
-
76
-
-
0242538317
-
Xenoantigen, an aGal epitope-expression construct driven by the hTERT-promoter, specifically kills human pancreatic cancer cell line
-
Sawada T, Yamada O, Yoshimuta N, Hatori K, Fuchinoue S, Teraoka S, et al. Xenoantigen, an aGal epitope-expression construct driven by the hTERT-promoter, specifically kills human pancreatic cancer cell line. Cancer Cell Int 2002; 2: 14-20.
-
(2002)
Cancer Cell Int
, vol.2
, pp. 14-20
-
-
Sawada, T.1
Yamada, O.2
Yoshimuta, N.3
Hatori, K.4
Fuchinoue, S.5
Teraoka, S.6
-
77
-
-
0035030329
-
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters
-
Majumdar AS, Hughes DE, Lichtsteiner SP, Wang Z, Lebkowski JS, Vasserot AP, et al. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters. Gene Ther 2001; 8: 568-78.
-
(2001)
Gene Ther
, vol.8
, pp. 568-578
-
-
Majumdar, A.S.1
Hughes, D.E.2
Lichtsteiner, S.P.3
Wang, Z.4
Lebkowski, J.S.5
Vasserot, A.P.6
-
78
-
-
3242878021
-
Adenovirus-mediated suicide gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter induced apoptosis of ovarian cancer cell line
-
Song JS, Kim HP, Yoon WS, Lee KW, Kim MH, Kim KT, et al. Adenovirus-mediated suicide gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter induced apoptosis of ovarian cancer cell line. Biosci Biotechnol Biochem 2003; 67: 2344-50.
-
(2003)
Biosci Biotechnol Biochem
, vol.67
, pp. 2344-2350
-
-
Song, J.S.1
Kim, H.P.2
Yoon, W.S.3
Lee, K.W.4
Kim, M.H.5
Kim, K.T.6
-
79
-
-
0033151591
-
The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes
-
Vonderheide RH, Hahn WC, Schultze JL, Nadler LM. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity 1999; 10: 673-9.
-
(1999)
Immunity
, vol.10
, pp. 673-679
-
-
Vonderheide, R.H.1
Hahn, W.C.2
Schultze, J.L.3
Nadler, L.M.4
-
80
-
-
0037148344
-
Telomerase as a universal tumor-associated antigen for cancer immunotherapy
-
Vonderheide RH. Telomerase as a universal tumor-associated antigen for cancer immunotherapy. Oncogene 2002; 21: 674-9.
-
(2002)
Oncogene
, vol.21
, pp. 674-679
-
-
Vonderheide, R.H.1
|