The potential efficacy of 3,3′-diindolylmethane in prevention of prostate cancer development

European Journal of Cancer Prevention

Volumn 19, Issue 3, 2010, Pages 199-203

  Fares, Fuad ^a,b   Azzam, Naiel ^b   Appel, Boaz ^c   Fares, Basem ^a   Stein, Avi ^c  

^a UNIVERSITY OF HAIFA   (Israel)

^b CARMEL MEDICAL CENTER   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

3,3 diindolylmethane; Cancer prevention; Indoles; Prostate cancer

Indexed keywords

3,3' DIINDOLYLMETHANE;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; C57BL 6 MOUSE; CARCINOGENESIS; CONTROLLED STUDY; DRUG EFFICACY; KIDNEY FUNCTION; LIVER FUNCTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR VOLUME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTICARCINOGENIC AGENTS; CELL LINE, TUMOR; INDOLES; MALE; MICE; MICE, INBRED C57BL; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 77950219389     PISSN: 09598278     EISSN: None     Source Type: Journal    
DOI: 10.1097/CEJ.0b013e328333fbce     Document Type: Article

References (41)

1. Aggarwal BB, Ichikawa H (2005). Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4:1201-1215.
2. Baade PD, Youlden DR, Krnjacki LJ (2009). International epidemiology of prostate cancer: geographical distribution and secular trends. Mol Nutr Food Res 53:171-184. Review.
3. Bradfield CA, Bjeldanes LF (1987). High-performance liquid chromatographic analysis of anticarcinogenic indoles in Brassica oleracea. J Agric Food Chem 35:46-49.
4. Bradlow HL (2008). Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. In Vivo 22:441-445. Review.
5. Bradlow HL, Michnovicz JJ, Telang NT, Osborne MP (1991). Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumours in mice. Carcinogenesis 12:1571-1574.
6. Chen I, McDougal A, Wang F, Safe S (1998). Aryl hydrocarbon receptormediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis 19:1631-1639.
7. Chinni SR, Sarkar FH (2005). Selective growth regulatory and pro-apoptotic effect of DIM is mediated by AKTand NF-kappa B pathway in prostate cancer cells. Front Biosci 10:236-243.
8. Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH (2001). Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene 20:2927-2936.
9. Cinnakannu K, Chen D, Li Y,Wang Z, Dou QP, Reddy GP, Sarkar FH (2009). Cell cycle-dependent effect of 3,3-ddindolylmethane on proliferation and apoptosis of prostate cancer cells. J Cell Physiol 219:94-99.
10. Cohen JH, Kristal AR, Stanford JL (2000). High consumption of vegetables associated with reduced risk of prostate cancer. Evid based Oncol 1:69-70.
11. Cookson MS (2001). Prostate cancer: screening and early detection. Cancer Control 8:133-140.
12. Crawford ED (2003). Epidemiology of prostate cancer. Urology 2262 (6 Suppl 1): 3-12. Review.
13. Deapen D, Lium L, Perkins C, Bernstein L, Ross RK (2002). Rapidly rising breast cancer incidence rates among Asian-American women. Int J Cancer 99:747-750.
14. Dhom G (1991). Epidemiologic and morphogenetic aspects of prostate cancer. Urologe A 30 (3 Suppl):3-4.
15. Fares FA, Ge X, Yannai S, Rennert G (1998). Dietary indole derivatives induce apoptosis in human breast cancer cells. Adv Exp Med Biol 451:153-157.
16. Fenwick GR, Heaney RK, Mullin WJ (1982). Glucosinolates and their breakdown products in food and food plants. CRC Crit Rev Food Sci Nutr 18:123-200.
17. Foster BA, Gingrich JR, Kwon ED, Madias C, Greenberg NM, Madias C, Greenberg NM (1997). Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Can Res 57:3325-3330.
18. Fresno Vara JA, Casado E, De Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M (2004). PI3K/Akt signaling pathway and cancer. Can Treat Rev 30:193-204.
19. Garikapaty VP, Ashok BT, Tadi K, Mittelman A, Tiwari RK (2006). 3,30- Diindolylmethane downregulates pro-survival pathway in hormone independent prostate cancer. Biochem Biophys Res Commun 340:718-725.
20. Ge X, Yannai S, Rennert G, Gruener N, Fares FA (1996). 3,30-Diindolylmethane induces apoptosis in human cancer cells. Biochem Biophys Res Commun 228:153-158.
21. Ge X, Fares FA, Yannai S (1999). Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax. Anticancer Res 19:3199-3204.
22. Haas GP, Delongchamps N, Brawley OW, Wang CY (2008). The worldwide epidemiology of prostate cancer: perspectives from autopsy studies. Can J Urol 15:3866-3871.
23. Hsu JC, Dev A, Wing A, Bjeldanes LF, Firestone GL (2006a). Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein. Biochem Pharmacol 72:1714-1723.
24. Hsu JC, Dev A,Wing A, Brew CT, Bjeldanes LF, Firestone GL (2006b). Indole-3- carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein. Biochem Pharmacol 72:1714-1723.
25. Jain MG, Hislop GT, Howe GR, Ghadirian P (1999). Plant foods, antioxidants, and prostate cancer risk: findings from case-control studies in Canada. Nutr Cancer 34:173-184.
26. Jeon KI, Rih JK, Kim HJ, Lee YJ, Cho CH, Goldberg ID, et al. (2003). Pretreatment of indole-3-carbinol augments TRAIL-induced apoptosis in a prostate cancer cell line, LNCaP. FEBS Lett 544:246-251.
27. Jia L, Patwari Y, Srinivasula SM, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey SM (2001). Bax translocation is crucial for the sensitivity of leukaemia cells to etoposide-induced apoptosis. Oncogene 20:4817-4826.
28. Kolonel LN, Hankin JH, Whittemore AS, Newland AC, Fernandes-Alnemri T, Alnemri ES, Kelsey S. (2000). Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study. Cancer Epidemiol Biomarkers Prev 9:795-804.
29. Le GM, Gomez SL, Clarke CA, Glaser SL, West DW (2002). Cancer incidence patterns among Vietnamese in the United States and Ha Noi, Vietnam. Int J Cancer 102:412-417.
30. Le HT, Schaldach CM, Firestone GL, Bjeldanes LF (2003). Plant-derived 3,30 - diindolylmethane is a strong androgen antagonist in human prostate cancer cells. J Biol Chem 278:21136-21145.
31. Nachshon M, Yannai S, Haj A, Fares FA (2003). Indole-3-carbinol and 3,30- diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol 41:745-752.
32. Nachshon M, Yannai S, Fares FA (2004a). Induction of apoptosis in human prostate cancer cell line, PC3, by 3,30-diindolylmethane through the mitochondrial pathway. Br J Cancer 91:1358-1363.
33. Nachshon M, Fares FA, Yannai S (2004b). Therapeutic activity of 3,30- diindolylmethane on prostate cancer in an in vivo model. The Prostate 61:153-160.
34. Neave AS, Sarup SM, Seidelin M, Duuse F, Vang O (2005). Characterization of the N-methoxyindole-3-carbinol (NI3C)-induced cell cycle arrest in human colon cancer cell lines. Toxicol Sciences 83:126-135.
35. Romier C, Coocchiarella F, Mantovani R, Moras D. (2003). The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. J Biol Chem 278:1336-1345.
36. Smith S, Sepkovic D, Bradlow HL, Auborn K (2008). 3,30-Diindolylmethane and genistein decrease the adverse effects of estrogen in LNCaP and PC-3 prostate cancer cells. J Nutr 138:2379-2385.
37. Tavani A, Vecchia CL (1995). Fruit and vegetable consumption and cancer risk in Mediterranean population. Am J Clin Nutr 61:1374S-1377S.
38. Verhoeven DTH, Verhagen H, Goldbohm RA, Brandt PA, Poppel G (1997). A review of mechanisms underlying anticarcinogenicity by brassica vegetables. ChemBiol Int 103:79-129.
39. Yasui K, Okamoto H, Arii S, Inazawa J (2003). Association of over-expressed TFDP1 with progression of hepatocellular carcinoma. J Hum Genet 48:609-613.
40. Zhang J, Hsu BAJC, Kinseth BAMA, Bjeldanes LF, Firestone GL (2003). Indole-3- carbinol induces a G1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells. Cancer 98:2511-2520.
41. Zhao YY, Zhou L, Pan YZ, Zhao LJ, Liu YN, Yu H, et al. (2008). 3,3- diindolylmethane enhances the inhibitory effect of idarubicin on the growth of human prostate cancer cells. Zhonghua Yi Xue Za Zhi 88:661-664. Chinese.