Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in β-catenin that are independent of β-catenin mutation status

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 601, Issue 1-2, 2006, Pages 11-18

  Wang, Rong ^a   Dashwood, W Mohaiza ^a   Bailey, George S ^a,b   Williams, David E ^a,b   Dashwood, Roderick H ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Catenin Wnt signaling; Chlorophyllin; Colon cancer; DMH; Indole 3 carbinol

Indexed keywords

1,2 DIMETHYLHYDRAZINE; 3 INDOLEMETHANOL; BETA CATENIN; CHLOROPHYLL; CYCLIN D1; MESSENGER RNA; MYC PROTEIN; PROTEIN C JUN; SERINE; T CELL FACTOR PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CODON; COLON TUMOR; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMALL INTESTINE TUMOR; TRANSCRIPTION REGULATION;

1,2-DIMETHYLHYDRAZINE; ANIMALS; ANTICARCINOGENIC AGENTS; BETA CATENIN; CARCINOGENS; CHLOROPHYLLIDES; COLONIC NEOPLASMS; CYCLIN D1; DNA MUTATIONAL ANALYSIS; INDOLES; MALE; MUTATION; NEOPLASMS, EXPERIMENTAL; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

RODENTIA;

EID: 33749531010     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2006.05.026     Document Type: Article

References (25)

1. Katoh M. WNT/PCP signaling pathway and human cancer. Oncol. Rep. 14 (2005) 1583-1588
2. Fuchs S.Y., Ougolkov A.V., Spiegelman V.S., and Minamoto T. Oncogenic β-catenin signaling networks in colorectal cancer. Cell Cycle 4 (2005) 1522-1539
3. Aberle H., Bauer A., Stappert J., Kispert A., and Kemler R. β-Catenin is a target for the ubiquitin-proteosome pathway. EMBO J. 16 (1997) 3797-3804
4. He T.-C., Sparks A.B., Rago C., Hermeking H., Zawel L., da Costa L.T., Morin P.J., Vogelstein B., and Kinzler K.W. Identification of c-MYC as a target of the APC pathway. Science 281 (1998) 1509-1512
5. Mann B., Gelos M., Siedow A., Hanski M.L., Gratchev A., Ilyas M., Bodmer W.F., Moey M.P., Reicken E.O., Buhr H.J., and Hanski C. Target genes of β-catenin-T-cell factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 1603-1608
6. Tetsu O., and McCormick F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398 (1999) 422-426
7. Dashwood R.H., Suzui M., Nakagama H., Sugimura T., and Nagao M. High frequency of β-catenin (Ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Cancer Res. 58 (1998) 1127-1129
8. Suzui M., Ushijima T., Dashwood R.H., Yoshimi N., Sugimura T., Mori H., and Nagao M. Frequent mutations of the rat β-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. Mol. Carcinog. 24 (1999) 232-237
9. Blum C.A., Xu M., Orner G.A., Fong A.T., Bailey G.S., Stoner G.D., Horio D.T., and Dashwood R.H. β-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. Carcinogenesis 22 (2001) 315-320
10. Koesters R., Hans M.A., Benner A., Prosst R., Boehm J., Gahlen J., and Doeberitz M.V.K. Predominant mutation of codon 41 of the β-catenin proto-oncogene in rat colon tumors induced by 1,2-dimethylhydrazine using a complete carcinogenic protocol. Carcinogenesis 22 (2001) 1885-1890
11. Blum C.A., Tanaka T., Zhong X., Li Q., Dashwood W.-M., Pereira C., Xu M., and Dashwood R.H. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of β-catenin and c-jun. Mol. Carcinog. 36 (2003) 195-203
12. Leibelt D.A., Hedstrom O.R., Fischer K.A., Pereira C.B., and Williams D.E. Evaluation of chronic dietary exposure to indole-3-carbinol and absorption-enhanced 3,3′-diindolylmethane in Sprague-Dawley rats. Toxicol. Sci. 74 (2003) 10-21
13. Anderton M.J., Manson M.M., Verschoyle R.D., Gescher A., Lamb J.H., Farmer P.B., Steward W.P., and Williams M.L. Pharmacokinetics and tissue disposition of indole-3-carbinol and its acid condensation products after oral administration to mice. Clin. Cancer Res. 10 (2004) 5233-5241
14. Dashwood R.H. Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?. Chem. Biol. Interact. 110 (1998) 1-5
15. Ferguson L.R., Philpott M., and Karunasinghe N. Dietary cancer and prevention using antimutagens. Toxicology 198 (2004) 147-159
16. Diaz G.D., Li Q., and Dashwood R.H. Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin. Cancer Res. 63 (2003) 1254-1261
17. Harttig U., and Bailey G.S. Chemoprotection by natural chlorophylls in vivo: inhibition of dibenzo[a,l]pyrene-DNA adducts in rainbow trout liver. Carcinogenesis 19 (1998) 1323-1326
18. Al-Fageeh M., Li Q., Dashwood W.M., Myzak M.C., and Dashwood R.H. Phosphorylation and ubiquitination of oncogenic mutants of β-catenin containing substitutions at Asp32. Oncogene 23 (2004) 4839-4846
19. Xu M., Orner G.A., Bailey G.S., Stoner G.D., Horio D.T., and Dashwood R.H. Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline. Carcinogenesis 22 (2001) 309-314
20. Li Q., and Dashwood R.H. Activator protein 2α associates with adenomatous polyposis coli/β-catenin and inhibits β-catenin/T-cell factor transcriptional activity in colorectal cancer cells. J. Biol. Chem. 279 (2004) 45669-45675
21. Ubagai T., Ochiai M., Kawamori T., Imai H., Sugimura T., Nagao M., and Nakagama H. Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet. Carcinogenesis 23 (2002) 197-200
22. Ochiai M., Ushigome M., Fujiwara K., Ubagai T., Kawamori T., Sugimura T., Nagao M., and Nakagama H. Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Am. J. Pathol. 163 (2003) 1607-1614
23. Sugiyama Y., Farrow B., Murillo C., Li J., Watanabe H., Sugiyama K., and Evers B.M. Analysis of differential gene expression in colon cancer and cancer stroma using microdissected tissues. Gastroenterology 128 (2005) 480-486
24. Notterman D.A., Alon U., Sierk A.J., and Levine A.J. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res. 61 (2001) 3124-3130
25. Li Q., Dashwood W.M., Zhong X., Al-Fageeh M., and Dashwood R.H. Cloning of the rat β-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters. Genomics 83 (2004) 231-242