c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway

Journal of Biological Chemistry

Volumn 286, Issue 35, 2011, Pages 30263-30273

  Oshikawa, Gaku ^a   Nagao, Toshikage ^a   Wu, Nan ^a   Kurosu, Tetsuya ^a   Miura, Osamu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE MYELOID LEUKEMIA; BASAL EXPRESSION; COEXPRESSED; E3 UBIQUITIN LIGASES; INTERNAL TANDEM DUPLICATIONS; JUXTAMEMBRANE DOMAINS; LEUKEMIC CELLS; LIGASES; OVER-EXPRESSION; POLYUBIQUITINATION; PROTEASOMAL DEGRADATION; PROTEASOMES; RECEPTOR-TYROSINE KINASE; UBIQUITIN; UBIQUITIN-PROTEASOME SYSTEM; WILD TYPES;

AMINO ACIDS; CELLS; ENZYMES;

DEGRADATION;

CBL PROTEIN; FLT3 LIGAND; HEAT SHOCK PROTEIN 90; PROTEIN CBL B; TANESPIMYCIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME DEGRADATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYSOSOME; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; UBIQUITINATION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOQUINONES; CELL LINE, TUMOR; FMS-LIKE TYROSINE KINASE 3; GENE EXPRESSION REGULATION, LEUKEMIC; HSP90 HEAT-SHOCK PROTEINS; HUMANS; KINETICS; LACTAMS, MACROCYCLIC; LEUKEMIA, MYELOID, ACUTE; LYSOSOMES; MICE; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-CBL; UBIQUITIN;

EID: 80052221156     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.232348     Document Type: Article

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