Small molecule inhibitors of smoothened ciliary localization and ciliogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages 13644-13649

  Wu, Victoria M ^a   Chen, Steven C ^b   Arkin, Michelle R ^b   Reiter, Jeremy F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fluorescence cell based assay; High content analysis; High throughput screening; Medulloblastoma; Sufu

Indexed keywords

ANTINEOPLASTIC AGENT; CILIOGENESIS INHIBITOR; CYCLOPAMINE; INHIBITOR PROTEIN; SMOOTHENED PROTEIN; SMOOTHENED PROTEIN ANTAGONIST 1; SMOOTHENED PROTEIN ANTAGONIST 10; SMOOTHENED PROTEIN ANTAGONIST 2; SMOOTHENED PROTEIN ANTAGONIST 3; SMOOTHENED PROTEIN ANTAGONIST 4; SMOOTHENED PROTEIN ANTAGONIST 5; SMOOTHENED PROTEIN ANTAGONIST 6; SMOOTHENED PROTEIN ANTAGONIST 7; SMOOTHENED PROTEIN ANTAGONIST 8; SMOOTHENED PROTEIN ANTAGONIST 9; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL SURFACE; CENTROSOME; CILIOGENESIS; CONTROLLED STUDY; EUKARYOTIC FLAGELLUM; HIGH THROUGHPUT SCREENING; INTRACELLULAR SIGNALING; INTRACELLULAR TRANSPORT; MICROTUBULE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CARCINOMA, BASAL CELL; CELL LINE, TUMOR; CELL MEMBRANE; CELL PROLIFERATION; CILIA; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICROTUBULES; NIH 3T3 CELLS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84865286372     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207170109     Document Type: Article

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