Legumes biofarming and biopharmaceutical sciences: A review

Research Journal of Medicinal Plant

Volumn 6, Issue 7, 2012, Pages 466-488

  Nikkhah, Akbar ^a  

^a UNIVERSITY OF ZANJAN   (Iran)

Author keywords

Biofarming; Biotechnology; Ecology; Medicine; Pharmaceuticals; Plant

Indexed keywords

ALKALOID DERIVATIVE; CANAVANINE; DAIDZEIN; ESTROGEN; GENISTEIN; IMMUNOGLOBULIN G; ISOFLAVONOID; LACTOFERRIN; NATURAL PRODUCT; PIPECOLIC ACID; RABIES VACCINE; RECOMBINANT PROTEIN; SAPONIN; VEGETABLE PROTEIN;

ALFALFA; ANTIBODY PRODUCTION; BIOMASS PRODUCTION; BIOTECHNOLOGICAL PRODUCTION; BREAST CANCER; DIET SUPPLEMENTATION; DRUG INDUSTRY; DRUG MECHANISM; DRUG RESEARCH; ESTROGEN ACTIVITY; FUNCTIONAL FOOD; FUNCTIONAL GENOMICS; GENETIC ENGINEERING; HUMAN; LEGUME; METABOLOMICS; MOLECULAR FARMING; NONHUMAN; NUTRIGENOMICS; OSTEOPOROSIS; PHYTOCHEMISTRY; PLANT BIOTECHNOLOGY; PLANT BREEDING; PLANT GENOME; PROSTATE CANCER; PROTEIN SYNTHESIS; REVIEW; VACCINE PRODUCTION;

EID: 84865275753     PISSN: 18193455     EISSN: 21517924     Source Type: Journal    
DOI: 10.3923/rjmp.2012.466.488     Document Type: Review

References (106)

1. Adlercreutz, H., 1998. Epidemiology of phytoestrogens. Baillieres Clin. Endocrinol. Metab, 12: 605-623.
2. Barbulova, A., A. Iancheva, M. Zhiponova, M. Vlahova and A. Atanassov, 2002. Establishment of embryogenic potential of economically important Bulgarian alfalfa cultivars (Medicago sativa L.). Biotechnol. Biotechnological Equipment, 16: 55-63.
3. Bardor, M., C. Loutelier-Bourhis, T. Paccalet, P. Cosette and A.C. Fitchette et al., 2003. Monoclonal C5-1 antibody produced in transgenic alfalfa plants exhibits a N glycosylation that is homogenous and suitable for glyco-engineering into human-compatible structures. Plant Biotechnol. J, 1:451-462.
4. Barnes, S., 1997. The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Res. Treat., 46: 169-179.
5. Bednarek, P., R. Franski, L. Kerhoas, J. Einhorn, P. Wojtaszek and M. Stobiecki, 2001. Profiling changes in metabolism of isoflavonoids and their conjugates in Lupinus albus treated with biotic elicitor. Phytochemistry, 56: 77-85.
6. Bouea, S.M., T.E. Wiese, S. Nehils, M.E. Burow and S. Elliott et al., 2003. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens. J. Agric. Food Chem., 51:2193-2199.
7. Carroll, K.K. and E. Kurowska, 1995. Soy consumption and cholesterol reduction: Review of animal and human studies. J. Nutr, 125: 594S-597S.
8. Collms-Burow, B.M., M.E. Burow, B.N. Duong and J.A. McLachlan, 2000. Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and independent mechanisms. Nutr. Cane, 38: 229-244.
9. Commandeur, U., R.M. Twyman and R. Fischer, 2003. The biosafety of molecular farming in plants. AgBiotechNet., Vol. 5.
10. Cramer, C.J., G.E. Boothe and K.K. Oishi, 1999. Transgenic plants for therapeutic proteins: Linking upstream and downstream strategies. Curr. Top. Microbiol. Immunol., 240: 95-118.
11. D'Aoust, M.A., P. Lerouge, U. Busse, P. Bilodeau, S. TrEpanier, V. Gomord, L. Faye and L.P. Vezina, 2004. Efficient and Reliable Production of Pharmaceuticals in Alfalfa. In: Molecular Farming. Rainer Fischer, Stefan Schillberg Ed., WILEY-VCH Verlag GmbH and Co, KGaA, Weinheim.
12. Daniell, T. and R. Edwards, 1995. Changes in protein methylation associated with the elicitation response in cell cultures of alfalfa (Medicago saliva L.). FEBS Lett., 360: 57-61.
13. Daniell, H., R. Datta, S. Varma and S. Gray, 1998. Containment of herbicide resistance through genetic engineering of the chloroplast genome. Nat. Biotechnol., 16: 345-348.
14. Daniell, H., 1999a. Environmentally friendly approaches to genetic engineering. In vitro Cell Dev. Biol, 35: 361-368.
15. Daniell, H, 1999b. GM crops: Public perception and scientific solutions. Trends Plant Sci, 4: 467-469.
16. Daniell, H, S. Streatfield and K. Wycoff, 2001. Medical molecular farming: Production of antibodies biopharmaceuticals and edible vaccines in plants. Trends Plant Sci, 6: 219-226.
17. Dixon, R.A, 1999. Isoflavonoids: Biochemistry, molecular biology and biological functions. In: Comprehensive Natural Products Chemistry, Sankawa, U, Ed, Vol 1, Elsevier, Oxford, pp: 773-823.
18. Dixon, R.A. and D. Ferreira, 2000. Molecules of interest: Genistein. Phytochem, 60: 205-211.
19. Dixon, R.A, 2001. Natural products and disease resistance. Nature, 411: 843-847.
20. Dixon, R.A. and L.W. Sumner, 2003. Legume natural products: Understanding and manipulating complex pathways for human and animal health. Plant Physiol, 131: 878-885.
21. Du, S, L. Erickon and S. Bowley, 1994. Effect of plant genotype on the transformation of cultivated alfalfa (Medicago sativa) by Agrobacterium tumefaciens. Plant Cell Rep, 13: 330-334.
22. Dus-Santos, M.J, C. Carrillo, F. Ardila, R.D. Rios and P. Franzone et al., 2005. Development of transgenic alfalfa plants containing the foot and mouth disease virus structural polyprotein gene PI and its utilization as an experimental immunogen. Vaccine, 23: 1838-1843.
23. Fiehn, O, 2002. Metabolomics the link between genotypes and phenotypes. Plant Mol. Biol, 48: 155-171.
24. Fischer, R. and N. Emans, 2000. Molecular farming of pharmaceutical proteins. Tansgen. Res, 9: 279-299.
25. Fischer, R, E. Stoger, S. Schillberg, P. Christou, R.M. Twyman, 2004. Plant-based production of biopharmaceuticals. Curr. Opin. Plant Biol, 7: 152-158.
26. Franke, A.A, L.J. Custer, CM. Cerna and K.K. Narala, 1994. Quantitation of phytoestrogens in legumes by HPLC. J. Agric. Food Chem, 9: 1905-1913.
27. Friedman, M. and D.L. Brandon, 2001. Nutritional and health benefits of soy proteins. J. Agric. Food Chem, 49: 1069-1086.
28. Graham, T, 1995. Cellular biochemistry of phenylpropanoid responses of soybean to infection by Phytophthora sojae. In: Handbook of Phytoalexin Metabolism and Action, Daniel, M, R. Purkayastha, (Eds.), Marcel Dekker, New York, US.
29. Hall, R, M. Beale, O. Fiehn, N. Hardy, L.W. Sumner and R. Brno, 2002. Plant metabolomics as the missing link in functional genomics strategies. Plant Cell, 14: 1437-1440.
30. Hanbury, CD, C.L. White, B.P. Mullan and K.H.M. Siddique, 2000. A review of the potential of Lathyrus sativus L. and Lathyrus cicera L. grain for use as animal feed. J. Anim. Feed. Sci. Technol, 87: 1-27.
31. Hiatt, A, 1990. Antibodies produced in plants. Nature, 344: 469-470.
32. James, C, 2004. Preview: Global Status of Commercialized Biotech/GM Crops: 2004. ISAAA Briefs No. 32, International Service for the Acquisition of Agri-Biotech Applications, Ithaca, New York, ISBN: 1-892456-36-2.
33. Jelaska, S., S. Mihaljevic and N. Bauer, 2005. Production of biopharmaceuticals, antibodies and edible vaccines in transgenic plants. Cur. Stud. Biotechnol., 5: 121-127.
34. Jung, W, O. Yu, S.C. Lau, D.P. O'Keefe, J. Odell, G. Fader and B. McGomgle, 2000. Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes. Nature Biotechnol., 18: 208-212.
35. Kapusta, J., T. Pniewski, M. Letellier, O. Lisowa and A.B. Legocki et al., 1999. A plant-derived edible vaccine against hepatitis B virus. FASEB J., 13: 1796-1799.
36. Kaur, C. and H.C. Kapoor, 2001. Antioxidants in fruits and vegetables-the millenniums health. Int. J. Food Sci. Technol., 36: 703-725.
37. Khoudi, H., S. Laberge, J.M. Ferullo, R. Bazin and A. Darveau et al., 1999. Production of a diagnostic monoclonal antibody in perennial alfalfa plants. Biotechnol. Bioeng., 64: 135-143.
38. Kumar, G.B. S., T.R. Ganapathi, L. Srinivas and V.A. Bapat, 2007. Plant Molecular Farming: Host Systems, Technology and Products. In: Application of Plant Metabolic Engineering, Verpoorte, R., A.W. Alfermann Application of Plant Metabolic Engineering T.S. Johnson, (Eds.). Spinger Publisher, New York, pp: 45-77.
39. Kusnadi, A.R., Z.L. Nikolov and J.A. Howard, 1997. Production of recombinant proteins in transgenic plants: Practical considerations. Biotechnol. Bioeng., 56: 473-484.
40. Lamartiniere, C.A., 2000. Protection against breast cancer with genistein: A component of soy. Am. J. Clin. Nutr, 71: 1705S-1707S.
41. Lamphear, B.J., S.J. Streatfield, J.M. Jilka, 2002. Delivery of sub unit vaccines in maize seed. J. Control. Release, 85: 169-180.
42. Laurent, M.S., A. Marcil, S. Verrette, 1993. Functional cooperation among human IgG-specific murine monoclonal antibodies for the detection of weak blood group antibodies in routine agglutination Tests. Vox Sang, 64: 99-105.
43. Liang, Q. and T. Richardson, 1993. Expression and characterization of human lactoferrin in yeast Saccharomyces cerevisiae. J. Agric. Food Chem., 41: 1800-1807.
44. Lin, L.Z, X.G He, M. Lmdenmaier, J. Yang, M. Cleary, S.X. Qiu and G.A. Cordell, 2000. LC-ESI- MS study of the flavonoid glycoside malonates of red clover (Trifolium pratense). J. Agric. Food Chem, 48: 354-365.
45. Ling, H.Y, A. Pelosi and A.M. Walmsley, 2010. Current status of plant-made vaccines for veterinary purposes. Exp. Rev. Vaccines, 9: 971-982.
46. Liu, C.J, J.W. Blount, C.L. Steele and R.A. Dixon, 2002. Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis. Proc. Natl. Acad. Sci. USA, 99: 14578-14583.
47. Ma, J.K, B.Y. Hikmat, K. Wycoff, N.D. Vine and D. Chargelegue et al, 1998. Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans. Nat. Med, 4: 601-606.
48. Ma, J.K.C, P.M.W. Drake and P. Christou, 2003. The production of recombinant pharmaceutical proteins in plants. Nat. Rev. Genet, 4: 794-805.
49. Ma, J.K, E. Barros, R. Bock, P. Christou and P.J. Dale et al., 2005a. Molecular farming for new drugs and vaccines. Current perspectives on the production of pharmaceuticals in transgenic plants. EMBO Rep, 6: 593-599.
50. Ma, J.K.C, R. Chikwamba, P. Sparrow, R. Fischer, R. Mahoney and R.M. Twyman, 2005b. Plant-derived pharmaceuticals: The road forward. Trends Plant Sci, 10: 580-585.
51. Magnuson, N.S, P.M. Linzmaier, R. Reeves, G. An, K. HayGlas and J.M. Lee, 1998. Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture. Protein Expr. Purif, 13: 45-52.
52. Malinow, M.R, P. Mclaughlin, C. Stafford, A.L. Livingstone, CO. Cohler and P.R. Cheek, 1979. Comparative effects of alfalfa saponins and alfalfa fiber on cholesterol in rats. Am. J. Clin. Nutr, 32: 1810-1812.
53. Mariani, C, M. DeBeuckeleer, J. Trueltner, J. Leemnas and R.B. Goldberg, 1990. Induction of male sterility in plants by a chimaeric ribonuclease gene. Nature, 347: 737-741.
54. Mazur, W.M., J.A. Duke, K. Wahala, S. Rasku and H. Adlercreutz, 1998. Isoflavonoids and lignans in legumes: Nutritional and health aspects in humans. J. Nutr. Biochem., 6: 193-200.
55. McCormick, A.A., 1999. Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fvepitopes in tobacco plants. Proc. Natl. Acad. Sci. USA, 96: 703-708.
56. Medicago, 2008. Product development, http://www.medicago.com/en/product/
57. Messina, M. and S. Barnes, 1991. The role of soy products in reducing risk of cancer. J. Nat. Cancer Inst, 83: 541-546.
58. Moloney, M, J. Boothe and G. Van Rooijen, 2003. Oil bodies and associated proteins as affinity matrices. US Patent 6: 509.
59. Muntz, K, 1998. Deposition of storage proteins. Plant Mol. Biol, 38: 77-99.
60. Nikkhah, A, 2012a. Alfalfa biopharming andbiopharmaceutical sciences: A biotechnology review. AAPS Pharm SciTech, USA.
61. Nikkhah, A, 2012b. Alfalfa the Bountiful Leading Crop of All Times Ecologies: Emerging Biopharm and Medicinal Implications. In: Alfalfa and Clovers: Properties, Medicinal Uses and Health Benefits, Fiala, J. and D. Pospisil (Eds.). Nova Science Publishers, New York, USA.
62. Nikkhah, A, 2012c. Crossroads of Plant-Human-Animal Biotechnologies in the New Era: A Leguminous Perspective. In: Alfalfa and Clovers: Properties, Medicinal Uses and Health Benefits, Fiala, J. and D. Pospisil (Eds.). Nova Science Publishers, New York, USA.
63. Nikkhah, A, 2012d. Legume Biotechnopharmaceutics: Legume Biofarming. LAP Lambert Academic Publishing, Germany, ISBN: 9783847340256, Pages: 80.
64. Ninkovic, S, J. Miljus-Djukis and M. Neskovic, 1995. Genetic transformation of alfalfa somatic embryos and their clonal propagation through repetitive somatic embryogenesis. Plant Cell Tissue Organ Culture, 42: 255-260.
65. Nuijens, J.H, P.H. van Berkel, M.E. Geerts, P.P. Hartevelt, H.A. de Boer, H.A. van Veen and F.R. Pieper, 1997. Characterization of recombinant human lactoferrin secreted in milk of transgenic Mice. J. Biol. Chem, 272: 8802-8807.
66. O'Neill, G, 2005. Farmacule grows proteins in tobacco, http://www.biotechnews.com.au/index.php?id=33469691
67. Palevitz, B.A, 2000. Soybeans hit main street. Scientist, 14: 8-9.
68. Perrin, Y, C. Vaquero, I. Gerrad, M. Sack and J. Drossard et al, 2000. Transgenic pea seeds as bioreactors for the production of a single-chain Fv fragment (scFV) antibody used in cancer diagnosis and therapy. Mol. Breeding, 6: 345-352.
69. Peterson, R.K. and C.J. Arntzen, 2004. On risk and plant-based biopharmaceuticals. Trends Biotechnol, 22: 64-66.
70. Pezzotti, M, F. Pupilli, F. Damiani and S. Arcioni, 1991. Transformation of Medicago sativa L. using a Ti Plasmid derived vector. Plant Breeding, 106: 39-46.
71. Philip, R, D.W. Darnowski, P.J. Maughan and L.O. Vodkin, 2001. Processing and localization of bovine b-casein expressed in transgenic soybean seeds under control of a soybean lectin expression cassette. Plant Sci, 161: 323-335.
72. Price, K.R., I.T. Johnson and G.R. Fenwick, 1987. The chemistry and biological significance of saponins in food and feedstuffs. Crit. Rev. Food Sci. Nutr., 26: 127-135.
73. Pujol, M., N.I. Ramirez, M. Ayala, J.V. Gavilondo and R. Valdes et al., 2005. An integral approach towards a practical application for a plant-made monoclonal antibody in vaccine purification. Vaccine, 23: 1833-1837.
74. Raju, T.S., 2003. Glycosylation variations with expression systems and their impact on biological activity of therapeutic immunoglobulins. Bioprocess. Int., 1: 44-54.
75. Rao, A.V. and M.K. Sung, 1995. Saponins as anticarcmogens. J. Nutr., 125: 717S-724S.
76. Rice, J., W.M. Ainley and P. Shewen, 2005. Plant-made vaccines: Biotechnology and immunology in animal health. Anim. Health Res. Rev., 6: 199-209.
77. Richter, L.J., Y. Thanavala, C.J. Arntzen and H.S. Mason, 2000. Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nature Biotechnol., 18: 1167-1171.
78. Rose, R.C., C. Lane, S. Wilson, J.A. Suzich, E. Rybicki and A.L. Williamson, 1999. Oral immunization of mice with human papillomavirus virus-like particles (VLPs) induces systemic neutralizing antibodies. Vaccine, 17: 2129-2135.
79. Rybicki, E.P., 2009. Plant-produced vaccines: Promise and reality. Drug Discov. Today, 14: 16-24.
80. Saalbach, I., M. Giersberg and U. Conrad, 2001. High-level expression of a single-chain Fv fragment (scFv) antibody in transgenic pea seeds. J. Plant Physiol., 158: 529-533.
81. Salmon, V., D. Legrand, M.C. Slomianny, I. El-Yazidi and G. Spik et al., 1998. Production of human lactoferrin in transgenic tobacco plants. Prot. Exp. Purif., 13: 127-135.
82. Sautier, C, C. Flament, C. Doucet and J.P. Suquet, 1986. Effect of eight dietary proteins and their amino acid content on serum, hepatic and fecal steroids in the rat. Nutr. Rep. Int., 34: 1051-1059.
83. Schillberg, S., N. Emans and R. Fischer, 2002. Antibody molecular farming in plants and plant cells. Phytochem. Rev., 1: 45-54.
84. Setchell, K.D. and A. Cassidy, 1999. Dietary isoflavones: Biological effects and relevance to human health. J. Nutr, 129: 758s-767s.
85. Sparrow, P.A, J.A. Irwin, P.J. Dale, R.M. Twyman and J.K. Ma, 2007. Pharma-planta: Road testing the developing regulatory guidelines for plant-made pharmaceuticals. Transgen. Res, 16: 147-161.
86. Stoger, E, M. Sack, Y. Perrin, C. Vaquero, E. Torres, R.M. Twyman, P. Christou and R. Fischer, 2002. Practical considerations for pharmaceutical antibody production in different crop systems. Mol. Breed, 9: 149-158.
87. Stowel, K.M, T.A. Rado, W.D. Funk and M.J. Tweedie, 1991. Expression of cloned human lactoferrin in baby-hamster kidney cells. Biochem. J, 276: 349-355.
88. Streatfield, S.J, J.R. Lane, C.A. Brooks, D.K. Barker and M.L. Poage et al., 2003. Corn as a production system for human and animal vaccines. Vaccine, 21: 812-815.
89. Streatfield, S.j, 2006. Mucosal immunization using recombinant plant-based oral vaccines. Methods, 38: 150-157.
90. Sumner, L.W, A.L. Duran, D.V. Huhman and J.T. Smith, 2002. Metabolomics: A Developing and Integral Component in Functional Genomic studies of Medicago truncatula. In: Phytochemistry in the Genomics and Post-Genomics Eras, Romeo, J.T. and RA. Dixon (Eds.), Elsevier, Oxford, pp: 31-61.
91. Suzuki, H., L. Achnine, R. Xu, S.P.T. Matsuda and R.A. Dixon, 2002. A genomics approach to the early stages of triterpene saponin biosynthesis in Medicago truncatula. Plant J., 32: 1033-1048.
92. Tacket, CO., H.S. Mason, G. Losonsky, J.D. Clements, M.M. Levine and C.J. Arntzen, 1998. Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat. Med, 4: 607-609.
93. Tacket, CO, H.S. Mason, G. Losonsky, M.K. Estes, M.M. Levine and C J. Arntzen, 2000. Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J. Infect. Dis, 182:302-305.
94. Tacket, CO, M.F. Pasetti, R. Edelman, J.A. Howard, S. Streatfield, 2004. Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn. Vaccine, 2: 4385-4389.
95. Tham, D.M, CD. Gardner and W.L. Haskell, 1998. Potential health benefits of dietary phytoestrogens A review of the clinical, epidemiological and mechanistic evidence. J. Clin. Endocrinol. Metabolism, 83: 2223-2235.
96. Tuboly, T, W. Yu, A. Baily, L. Erickson and E. Nagy, 2000. Molecular farming. Proceedings of the OECD Workshop, September 3-6, 2000, La Grande Motte, France, pp: 239-248.
97. Twyman, R.M, E. Stoger, S. Schillberg, P. Christou and R. Fischer, 2003. Molecular farming in plants: host systems and expression technology. Trends Biotechnol, 21: 570-578.
98. Twyman, R.M, S. Schillberg and R. Fischer, 2005. The transgenic plant market in the pharmaceutical industry. Expert Opin. Emerg. Drugs, 10: 185-218.
99. Vlahova, M, G. Stefanova, P. Petkov, A. Barbulova, D. Petkova, P. Kalushkov and A. Atanassov, 2005. Genetic modification of alfalfa (Medicago Sativa L.) for quality improvement and production of ovel compounds. Biotechnol. Biotechnol, 19: 56-62.
100. Walmsley, A.M. and C.J. Arntzen, 2003. Plant cell factories and mucosal vaccines. Curr. Opin. Biotechnol, 14: 145-150.
101. Wigdorovitz, A, C Carrillo, M. Dus Santos, K. Trono and A. Peralta et al., 1999. Induction of a protective antibody response to foot and mouth disease virus in mice following oral or parenteral immunization with alfalfa transgenic plants expressing the viral structural protein VP1. Virology, 255: 347-353.
102. Williamson, J.S. and CM. Wyandt, 1997. Herbal therapies: The facts and the fiction. Trends Pharm. Pharmacol. Care, 4: 78-87.
103. Yamauchi, K, M. Tomita, T. Giehl and R. Ellison, 1993. Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect. Immunity, 61: 719-728.
104. Yoshida, K, T. Matsui and A. Shinmyo, 2004. The plant vesicular transport engineering for production of useful recombinant proteins. J. Mol. Catal. B-Enzym, 28: 167-171.
105. Yusibov, V, D.C. Hooper, S.V. Spitsin, N. Fleysh and R.B. Kean et al., 2002. Expression in plants and immunogenicity of plant virus-based xperimental rabies vaccine. Vaccine, 20: 3155-3164.
106. Zeitlm, L, S.S. Olmsted, T.R. Moench, M.S. Co and B.J. Martmell et al, 1998. A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes. Nat. Biotechnol, 16: 1361-1364.