Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: The unstructured N terminus facilitates the coordination of six copper2+ ions at physiological concentrations

Journal of Molecular Biology

Volumn 346, Issue 5, 2005, Pages 1393-1407

  Jones, Christopher E ^a   Klewpatinond, Mark ^a   Abdelraheim, Salama R ^b   Brown, David R ^b   Viles, John H ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

Copper; Nickel; NMR; Prion protein; Structure

Indexed keywords

AMIDE; COPPER; HISTIDINE DERIVATIVE; IMIDAZOLE; NICKEL; NITROGEN; PRION PROTEIN; PROTEIN DERIVATIVE; HISTIDINE; PLACENTA PROTEIN; PLFR PROTEIN, MOUSE; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; AMYLOIDOSIS; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; FRAGMENTATION REACTION; GENE CONSTRUCT; GENE CONTROL; GENE DELETION; IONIZATION; MAGNETISM; METAL BINDING; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR PROBE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRION DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTON NUCLEAR MAGNETIC RESONANCE; RING OPENING; SPECTRAL SENSITIVITY; STRUCTURE ANALYSIS; ANIMAL; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CIRCULAR DICHROISM; COPPER; HISTIDINE; MAGNETIC RESONANCE SPECTROSCOPY; MAGNETICS; MICE; MODELS, MOLECULAR; NICKEL; PREGNANCY PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 13844299350     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.12.043     Document Type: Article

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