Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals

Free Radical Biology and Medicine

Volumn 42, Issue 1, 2007, Pages 79-89

  Nadal, Rebecca C ^a   Abdelraheim, Salama R ^b   Brazier, Marcus W ^b   Rigby, Stephen E J ^a   Brown, David R ^b   Viles, John H ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

2 Oxo histidine; Hydrogen peroxide; Methionine sulfoxide; Oxidation; Reactive oxygen species

Indexed keywords

ASCORBIC ACID; COPPER CHLORIDE; COPPER ION; HISTIDINE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; METFORMIN; METHIONINE; METHIONINE SULFOXIDE; PRION PROTEIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL MODIFICATION; MOUSE; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE;

ANIMALS; ASCORBIC ACID; COPPER; FREE RADICAL SCAVENGERS; HISTIDINE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; METHIONINE; MICE; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PRIONS; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 33751503526     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.09.019     Document Type: Article

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