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Volumn 3, Issue 3, 2012, Pages 217-227

MicroRNAs as newer therapeutic targets: A big hope from a tiny player

Author keywords

Antagomere; cancer; cardiovascular; diabetes; microRNAs; target genes

Indexed keywords

MICRORNA; MICRORNA 1; MICRORNA 21; MICRORNA 29; MICRORNA 34A; MICRORNA 375;

EID: 84865060978     PISSN: 0976500X     EISSN: None     Source Type: Journal    
DOI: 10.4103/0976-500X.99416     Document Type: Review
Times cited : (25)

References (106)
  • 1
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • DOI 10.1016/0092-8674(93)90529-Y
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75:843-54. (Pubitemid 24014542)
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 2
    • 0035955406 scopus 로고    scopus 로고
    • Glimpses of a tiny RNA World
    • Gary Ruvkun. Glimpses of a Tiny RNA World. Science 2001;294:797-9.
    • (2001) Science , vol.294 , pp. 797-799
    • Ruvkun, G.1
  • 3
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004;116:281-97.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 5
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee Y, Ahn C, Han J. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003;425:415-6.
    • (2003) Nature , vol.425 , pp. 415-416
    • Lee, Y.1    Ahn, C.2    Han, J.3
  • 6
    • 33847323881 scopus 로고    scopus 로고
    • DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
    • DOI 10.1038/ng1969, PII NG1969
    • Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet 2007;39:380-5. (Pubitemid 46328490)
    • (2007) Nature Genetics , vol.39 , Issue.3 , pp. 380-385
    • Wang, Y.1    Medvid, R.2    Melton, C.3    Jaenisch, R.4    Blelloch, R.5
  • 7
    • 1642499415 scopus 로고    scopus 로고
    • Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
    • DOI 10.1261/rna.5167604
    • Bohnsack MT, Czaplinski K, Gorlich D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 2004;10:185-91. (Pubitemid 38129823)
    • (2004) RNA , vol.10 , Issue.2 , pp. 185-191
    • Bohnsack, M.T.1    Czaplinski, K.2    Gorlich, D.3
  • 8
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme dicer in the maturation of the let-7 small temporal RNA
    • DOI 10.1126/science.1062961
    • Hutvagner G, McLachlan J, Pasquinelli AE, Balint E, Tuschl T, Zamore PD. A cellular function for the RNA interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 2001;293:834-8. (Pubitemid 32743968)
    • (2001) Science , vol.293 , Issue.5531 , pp. 834-838
    • Hutvagner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Balint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 9
    • 10744225153 scopus 로고    scopus 로고
    • Asymmetry in the assembly of the RNAi enzyme complex
    • DOI 10.1016/S0092-8674(03)00759-1
    • Schwarz DS, Hutvagner G, Du T, Xu Z, Aronin N, Zamore PD. Asymmetry in the assembly of the RNAi enzyme complex. Cell 2003;115:199-208. (Pubitemid 37329583)
    • (2003) Cell , vol.115 , Issue.2 , pp. 199-208
    • Schwarz, D.S.1    Hutvagner, G.2    Du, T.3    Xu, Z.4    Aronin, N.5    Zamore, P.D.6
  • 10
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • DOI 10.1016/S0092-8674(03)00801-8
    • Khvorova A, Reynolds A, Jayasena SD. Functional siRNAs and miRNAs exhibit strand bias. Cell 2003;115:209-16. (Pubitemid 37329584)
    • (2003) Cell , vol.115 , Issue.2 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 12
    • 22144478256 scopus 로고    scopus 로고
    • MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
    • DOI 10.1038/ncb1274
    • Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 2005;7:719-23. (Pubitemid 40975754)
    • (2005) Nature Cell Biology , vol.7 , Issue.7 , pp. 719-723
    • Liu, J.1    Valencia-Sanchez, M.A.2    Hannon, G.J.3    Parker, R.4
  • 13
    • 33644850338 scopus 로고    scopus 로고
    • Assessment of the MicroRNA system in salt-sensitive hypertension
    • Naraba H, Iwai N. Assessment of the microRNA system in salt-sensitive hypertension. Hypertens Res 2005;28:819-26. (Pubitemid 47400252)
    • (2005) Hypertension Research , vol.28 , Issue.10 , pp. 819-826
    • Naraba, H.1    Iwai, N.2
  • 14
    • 0037197803 scopus 로고    scopus 로고
    • Identification of tissue-specific MicroRNAs from mouse
    • DOI 10.1016/S0960-9822(02)00809-6, PII S0960982202008096
    • Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol 2002;12:735-9. (Pubitemid 34455427)
    • (2002) Current Biology , vol.12 , Issue.9 , pp. 735-739
    • Lagos-Quintana, M.1    Rauhut, R.2    Yalcin, A.3    Meyer, J.4    Lendeckel, W.5    Tuschl, T.6
  • 15
    • 34250172419 scopus 로고    scopus 로고
    • MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation
    • DOI 10.1161/CIRCRESAHA.106.141986
    • Ji R, Cheng Y, Yue J. MicroRNA expression signature and antisensemediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation. Circ Res 2007;100:1579-88. (Pubitemid 46897261)
    • (2007) Circulation Research , vol.100 , Issue.11 , pp. 1579-1588
    • Ji, R.1    Cheng, Y.2    Yue, J.3    Yang, J.4    Liu, X.5    Chen, H.6    Dean, D.B.7    Zhang, C.8
  • 16
  • 18
    • 33847038668 scopus 로고    scopus 로고
    • MicroRNAs play an essential role in the development of cardiac hypertrophy
    • Sayed D, Hong C, Chen I, Lypowy J, Abdellatif M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 2007;100:416-24.
    • (2007) Circ Res , vol.100 , pp. 416-424
    • Sayed, D.1    Hong, C.2    Chen, I.3    Lypowy, J.4    Abdellatif, M.5
  • 19
    • 22444437609 scopus 로고    scopus 로고
    • Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis
    • DOI 10.1038/nature03817
    • Zhao Y, Samal E, Srivastava D. Serum response factor regulates a musclespecific microRNA that targets Hand2 during cardiogenesis. Nature 2005;436:214-20. (Pubitemid 41021266)
    • (2005) Nature , vol.436 , Issue.7048 , pp. 214-220
    • Zhao, Y.1    Samal, E.2    Srivastava, D.3
  • 20
    • 34247589595 scopus 로고    scopus 로고
    • Control of stress-dependent cardiac growth and gene expression by a microRNA
    • DOI 10.1126/science.1139089
    • Van Rooij E, Sutherland L, Qi X, Richardson J, Hill J, Olson E. Control of stress dependent cardiac growth and gene expression by a microRNA. Science 2007;316:575-9. (Pubitemid 46683138)
    • (2007) Science , vol.316 , Issue.5824 , pp. 575-579
    • Van Rooij, E.1    Sutherland, L.B.2    Qi, X.3    Richardson, J.A.4    Hill, J.5    Olson, E.N.6
  • 25
    • 25844460031 scopus 로고    scopus 로고
    • Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth
    • DOI 10.1101/gad.1356105
    • Sokol N, Ambros V. Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth. Genes Dev 2005;19:2343-54. (Pubitemid 41396911)
    • (2005) Genes and Development , vol.19 , Issue.19 , pp. 2343-2354
    • Sokol, N.S.1    Ambros, V.2
  • 33
    • 84865050001 scopus 로고    scopus 로고
    • MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
    • Thum T, Gross C, Fiedler J. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008;21:253-60.
    • (2008) Nature , vol.21 , pp. 253-260
    • Thum, T.1    Gross, C.2    Fiedler, J.3
  • 36
    • 0032491494 scopus 로고    scopus 로고
    • Genetic neurodegenerative diseases: The human illness and transgenic models
    • Price DL, Sisodia SS, Borchelt DR. Genetic neurodegenerative diseases: The human illness and transgenic models. Science 1998;282:1079-83. (Pubitemid 28516230)
    • (1998) Science , vol.282 , Issue.5391 , pp. 1079-1083
    • Price, D.L.1    Sisodia, S.S.2    Borchelt, D.R.3
  • 37
    • 33745314092 scopus 로고    scopus 로고
    • Genetics: What is a gene
    • Pearson H. Genetics: What is a gene? Nature 2006;441:398-401.
    • (2006) Nature , vol.441 , pp. 398-401
    • Pearson, H.1
  • 39
    • 9644262551 scopus 로고    scopus 로고
    • Alzheimer's disease as a disorder of dynamic brain selforganization
    • Arendt T. Alzheimer's disease as a disorder of dynamic brain selforganization. Prog Brain Res 2005;147:355-78.
    • (2005) Prog Brain Res , vol.147 , pp. 355-378
    • Arendt, T.1
  • 40
    • 0842281547 scopus 로고    scopus 로고
    • Tau protein and neurodegeneration
    • DOI 10.1016/j.semcdb.2003.12.015
    • Goedert M. Tau protein and neurodegeneration. Semin Cell Dev Biol 2004;15:45-9. (Pubitemid 38177367)
    • (2004) Seminars in Cell and Developmental Biology , vol.15 , Issue.1 , pp. 45-49
    • Goedert, M.1
  • 41
    • 34447279020 scopus 로고    scopus 로고
    • Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment
    • DOI 10.1001/archneur.64.7.954
    • Markesbery WR, Lovell MA. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol 2007;64:954-6. (Pubitemid 47047994)
    • (2007) Archives of Neurology , vol.64 , Issue.7 , pp. 954-956
    • Markesber, W.R.1    Lovell, M.A.2
  • 42
    • 34249874344 scopus 로고    scopus 로고
    • RNA in brain disease: No longer just "the messenger in the middle"
    • DOI 10.1097/01.jnen.0000240474.27791.f3, PII 0000507220070600000001
    • Nelson PT, Keller JN. RNA in brain disease: No longer just "the messenger in the middle". J Neuropathol Exp Neurol 2007;66:461-8. (Pubitemid 46869688)
    • (2007) Journal of Neuropathology and Experimental Neurology , vol.66 , Issue.6 , pp. 461-468
    • Nelson, P.T.1    Keller, J.N.2
  • 43
    • 33845694258 scopus 로고    scopus 로고
    • Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease
    • DOI 10.1212/01.wnl.0000247041.63081.98, PII 0000611420061212000010
    • Williams MM, Xiong C, Morris JC, Galvin JE. Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology 2006;67:1935-41. (Pubitemid 44967367)
    • (2006) Neurology , vol.67 , Issue.11 , pp. 1935-1941
    • Williams, M.M.1    Xiong, C.2    Morris, J.C.3    Galvin, J.E.4
  • 45
    • 84880187014 scopus 로고    scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis - An update and reappraisal
    • Hardy J. Alzheimer's disease: The amyloid cascadehypothesis: An update and reappraisal. J Alzheimers Dis 2006;9:151-3. (Pubitemid 44253307)
    • (2006) Journal of Alzheimer's Disease , vol.9 , Issue.SUPPL. 3 , pp. 151-153
    • Hardy, J.1
  • 46
    • 34548537836 scopus 로고    scopus 로고
    • MiRNAs in neurodegeneration
    • Hebert SS, De Strooper B. MiRNAs in neurodegeneration. Science 2007;317:1179-80.
    • (2007) Science , vol.317 , pp. 1179-1180
    • Hebert, S.S.1    De Strooper, B.2
  • 47
    • 46749083029 scopus 로고    scopus 로고
    • Regulatory RNA goes awry in Alzheimer's disease
    • DOI 10.1038/nm0708-711, PII NM0708711
    • St George-Hyslop P, Haass C. Regulatory RNA goes awry in Alzheimer's disease. Nat Med 2008;14:711-2 (Pubitemid 351951508)
    • (2008) Nature Medicine , vol.14 , Issue.7 , pp. 711-712
    • St. George-Hyslop, P.1    Haass, C.2
  • 48
    • 34249874344 scopus 로고    scopus 로고
    • RNA in brain disease: No longer just "the messenger in the middle"
    • DOI 10.1097/01.jnen.0000240474.27791.f3, PII 0000507220070600000001
    • Nelson PT, Keller JN. RNA in brain disease: No longer just 'the messenger in the middle'. J Neuropathol Exp Neurol 2007;66:461-8. (Pubitemid 46869688)
    • (2007) Journal of Neuropathology and Experimental Neurology , vol.66 , Issue.6 , pp. 461-468
    • Nelson, P.T.1    Keller, J.N.2
  • 49
    • 46749083733 scopus 로고    scopus 로고
    • Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of bsecretase
    • Faghihi MA. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of bsecretase. Nat Med 2008;14:723-30.
    • (2008) Nat Med , vol.14 , pp. 723-730
    • Faghihi, M.A.1
  • 51
    • 2342466734 scopus 로고    scopus 로고
    • Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030
    • DOI 10.2337/diacare.27.5.1047
    • Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27:1047-53. (Pubitemid 38579764)
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 52
    • 30044434823 scopus 로고    scopus 로고
    • MicroRNAs: 'Ribo-regulators' of glucose homeostasis
    • DOI 10.1038/nm0106-36
    • Gauthier BR, Wollheim CB. MicroRNAs: 'Ribo-regulators' of glucose homeostasis. Nat Med 2006;12:36-8. (Pubitemid 43050057)
    • (2006) Nature Medicine , vol.12 , Issue.1 , pp. 36-38
    • Gauthier, B.R.1    Wollheim, C.B.2
  • 55
    • 29644432901 scopus 로고    scopus 로고
    • MicroRNA and endocrine biology
    • Cuellar TL, McManus MT. MicroRNA and endocrine biology. J Endocrinol 2005;187:327-32.
    • (2005) J Endocrinol , vol.187 , pp. 327-332
    • Cuellar, T.L.1    McManus, M.T.2
  • 56
    • 58149350343 scopus 로고    scopus 로고
    • MiR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucoseinduced biological responses in pancreatic beta-cells
    • Ouaamari AE, Baroukh N, Martens GA, Lebrun P, Pipeleers D, Van OE. MiR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucoseinduced biological responses in pancreatic beta-cells. Diabetes 2008;57:2708-17.
    • (2008) Diabetes , vol.57 , pp. 2708-2717
    • Ouaamari, A.E.1    Baroukh, N.2    Martens, G.A.3    Lebrun, P.4    Pipeleers, D.5    Van, O.E.6
  • 59
    • 26444479437 scopus 로고    scopus 로고
    • Granuphilin molecularly docks insulin granules to the fusion machinery
    • DOI 10.1083/jcb.200505179
    • Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T. Granuphilin molecularly docks insulin granules to the fusion machinery. J Cell Biol 2005;171:99-109. (Pubitemid 41434605)
    • (2005) Journal of Cell Biology , vol.171 , Issue.1 , pp. 99-109
    • Gomi, H.1    Mizutani, S.2    Kasai, K.3    Itohara, S.4    Izumi, T.5
  • 63
    • 0037147215 scopus 로고    scopus 로고
    • Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic β-cells (INS-1)
    • DOI 10.1074/jbc.M208756200
    • Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells INS-1. J Biol Chem 2002;277:49676-84. (Pubitemid 36014411)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.51 , pp. 49676-49684
    • Wrede, C.E.1    Dickson, L.M.2    Lingohr, M.K.3    Briaud, I.4    Rhodes, C.J.5
  • 64
    • 24344453811 scopus 로고    scopus 로고
    • Synergistic activation of JNK/SAPK induced by TNF-α and IFN-γ: Apoptosis of pancreatic β-cells via the p53 and ROS pathway
    • DOI 10.1016/j.cellsig.2005.03.020, PII S0898656805000586
    • Kim WH, Lee JW, Gao B, Jung MH. Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: Apoptosis of pancreatic beta-cells via the p53 and ROS pathway. Cell Signal 2005;17:1516-32. (Pubitemid 41253991)
    • (2005) Cellular Signalling , vol.17 , Issue.12 , pp. 1516-1532
    • Kim, W.H.1    Lee, J.W.2    Gao, B.3    Jung, M.H.4
  • 66
    • 0037465251 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
    • Dunne A, O'Neill LA. The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense. Sci STKE 2003;171: re3.
    • (2003) Sci STKE , vol.171 , pp. 3
    • Dunne, A.1    O'Neill, L.A.2
  • 67
    • 35649011441 scopus 로고    scopus 로고
    • Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes
    • DOI 10.1210/me.2007-0167
    • He A, Zhu L, Gupta N, Chang Y, Fang F. Overexpression of micro ribonucleic acid 29 highly up-regulated in diabetic rats leads to insulin resistance in 3T3-L1 adipocytes. Mol Endocrinol 2007;21:2785-94. (Pubitemid 350035159)
    • (2007) Molecular Endocrinology , vol.21 , Issue.11 , pp. 2785-2794
    • He, A.1    Zhu, L.2    Gupta, N.3    Chang, Y.4    Fang, F.5
  • 68
  • 69
    • 36348994146 scopus 로고    scopus 로고
    • Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells
    • DOI 10.1074/jbc.M702806200
    • Shi B, Sepp-Lorenzino L, Prisco M, Linsley P, deAngelis T, Baserga R. Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells. J Biol Chem 2007;282:32582-90. (Pubitemid 350159311)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.45 , pp. 32582-32590
    • Shi, B.1    Sepp-Lorenzino, L.2    Prisco, M.3    Linsley, P.4    Deangelis, T.5    Baserga, R.6
  • 70
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • DOI 10.1210/er.23.2.201
    • Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 2002;23:201-29. (Pubitemid 34299024)
    • (2002) Endocrine Reviews , vol.23 , Issue.2 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 71
    • 0037694970 scopus 로고    scopus 로고
    • The Drosophila microRNA mir-14 suppresses cell death and is required for normal fat metabolism
    • DOI 10.1016/S0960-9822(03)00250-1
    • Xu P, Vernooy SY, Guo M, Hay BA. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol 2003;13:790-5. (Pubitemid 36531030)
    • (2003) Current Biology , vol.13 , Issue.9 , pp. 790-795
    • Xu, P.1    Vernooy, S.Y.2    Guo, M.3    Hay, B.A.4
  • 72
    • 32644435565 scopus 로고    scopus 로고
    • Drosophila lacking microRNA miR-278 are defective in energy homeostasis
    • DOI 10.1101/gad.374406
    • Teleman AA, Maitra S, Cohen SM. Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev 2006;20:417-22. (Pubitemid 43244395)
    • (2006) Genes and Development , vol.20 , Issue.4 , pp. 417-422
    • Teleman, A.A.1    Cohen, S.M.2
  • 73
    • 33645075443 scopus 로고    scopus 로고
    • MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
    • Esau C, Davis S, Murray SF. MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006;3:87-98.
    • (2006) Cell Metab , vol.3 , pp. 87-98
    • Esau, C.1    Davis, S.2    Murray, S.F.3
  • 74
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with'antagomirs'
    • Krutzfeldt J, Rajewsky N, Braich K. Silencing of microRNAs in vivo with 'antagomirs'. Nature 2005;438:685-9.
    • (2005) Nature , vol.438 , pp. 685-689
    • Krutzfeldt, J.1    Rajewsky, N.2    Braich, K.3
  • 77
    • 33748745006 scopus 로고    scopus 로고
    • Advances in congenital long QT syndrome
    • DOI 10.1097/01.mop.0000245349.30089.bf, PII 0000848020061000000005
    • Collins KK, Van Hare GF. Advances in congenital long QT syndrome. Curr Opin Pediatr 2006;18:497-02. (Pubitemid 44401285)
    • (2006) Current Opinion in Pediatrics , vol.18 , Issue.5 , pp. 497-502
    • Collins, K.K.1    Van Hare, G.F.2
  • 78
    • 12144284874 scopus 로고    scopus 로고
    • Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium
    • Chen HS, Shan YX, Yang TL, Lin HD, Chen JW, Lin SJ. Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium. Diabetes 2005;54:175-81.
    • (2005) Diabetes , vol.54 , pp. 175-181
    • Chen, H.S.1    Shan, Y.X.2    Yang, T.L.3    Lin, H.D.4    Chen, J.W.5    Lin, S.J.6
  • 79
    • 0242413155 scopus 로고    scopus 로고
    • Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: Implications on decreased myocardial protection in diabetic cardiomyopathy
    • DOI 10.1074/jbc.M304498200
    • Shan YX, Yang TL, Mestril R, Wang PH. Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulinlike growth factor-1 receptor signaling in cardiac muscle: Implications on decreased myocardial protection in diabetic cardiomyopathy. J Biol Chem 2003;278:45492-8. (Pubitemid 37432688)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.46 , pp. 45492-45498
    • Shan, Y.-X.1    Yang, T.-L.2    Mestril, R.3    Wang, P.H.4
  • 80
    • 58849094980 scopus 로고    scopus 로고
    • MicroRNAs-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats
    • Wang XH, Qian RZ, Zhang W, Chen SF, Jin HM, Hu RM. MicroRNAs-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin Exp Pharmacol Physiol 2009;36:181-8.
    • (2009) Clin Exp Pharmacol Physiol , vol.36 , pp. 181-188
    • Wang, X.H.1    Qian, R.Z.2    Zhang, W.3    Chen, S.F.4    Jin, H.M.5    Hu, R.M.6
  • 84
    • 57349186092 scopus 로고    scopus 로고
    • MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy
    • Wang Q, Wang Y, Minto AW, Wang J, Shi Q, Li X. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J 2008;22:4126-35.
    • (2008) FASEB J , vol.22 , pp. 4126-4135
    • Wang, Q.1    Wang, Y.2    Minto, A.W.3    Wang, J.4    Shi, Q.5    Li, X.6
  • 87
    • 68049114782 scopus 로고    scopus 로고
    • Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells
    • Shimono Y, Zabala M, Cho RW. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009;138:592-603.
    • (2009) Cell , vol.138 , pp. 592-603
    • Shimono, Y.1    Zabala, M.2    Cho, R.W.3
  • 88
    • 33846188098 scopus 로고    scopus 로고
    • MicroRNAs as oncogenes and tumor suppressors
    • DOI 10.1016/j.ydbio.2006.08.028, PII S0012160606010967
    • Zhang B, Pan X, Cobb GP, Anderson TA. MicroRNAs as oncogenes and tumor suppressors. Dev Biol 2007;302:1-12. (Pubitemid 46096921)
    • (2007) Developmental Biology , vol.302 , Issue.1 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3    Anderson, T.A.4
  • 91
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • DOI 10.1158/0008-5472.CAN-05-0137
    • Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005;65:6029-33. (Pubitemid 40994386)
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 92
    • 34247495591 scopus 로고    scopus 로고
    • MiR-21-mediated tumor growth
    • DOI 10.1038/sj.onc.1210083, PII 1210083
    • Si ML, Zhu S, Wu H. MiR-21-mediated tumor growth. Oncogene 2007;26:2799-803. (Pubitemid 46663837)
    • (2007) Oncogene , vol.26 , Issue.19 , pp. 2799-2803
    • Si, M.-L.1    Zhu, S.2    Wu, H.3    Lu, Z.4    Wu, F.5    Mo, Y.-Y.6
  • 93
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • DOI 10.1038/sj.onc.1210856, PII 1210856
    • Asangani IA, Rasheed SA, Nikolova DA. MicroRNA-21 (miR-21) posttranscriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008;27:2128-36. (Pubitemid 351485639)
    • (2008) Oncogene , vol.27 , Issue.15 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.K.2    Nikolova, D.A.3    Leupold, J.H.4    Colburn, N.H.5    Post, S.6    Allgayer, H.7
  • 94
    • 67849103555 scopus 로고    scopus 로고
    • MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme
    • Li Y, Li W, Yang Y. MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res 2009;1286:13-8.
    • (2009) Brain Res , vol.1286 , pp. 13-18
    • Li, Y.1    Li, W.2    Yang, Y.3
  • 96
    • 73449134501 scopus 로고    scopus 로고
    • Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
    • Greither T, Grochola LF, Udelnow A. Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int J Cancer 2010;126:73-80.
    • (2010) Int J Cancer , vol.126 , pp. 73-80
    • Greither, T.1    Grochola, L.F.2    Udelnow, A.3
  • 98
    • 33646056975 scopus 로고    scopus 로고
    • A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors
    • Voorhoeve PM, le SC, Schrier M. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006;124:1169-81.
    • (2006) Cell , vol.124 , pp. 1169-1181
    • Voorhoeve, P.M.1    Le, S.C.2    Schrier, M.3
  • 102
    • 74149083873 scopus 로고    scopus 로고
    • Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via down regulation of multiple cell-cycle genes
    • Takeshita F, Patrawala L, Osaki M. Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via down regulation of multiple cell-cycle genes. Mol Ther 2010;18:181-7.
    • (2010) Mol Ther , vol.18 , pp. 181-187
    • Takeshita, F.1    Patrawala, L.2    Osaki, M.3
  • 103
    • 55549114664 scopus 로고    scopus 로고
    • The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
    • Bonci D, Coppola V, Musumeci M. The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med 2008;14:1271-7.
    • (2008) Nat Med , vol.14 , pp. 1271-1277
    • Bonci, D.1    Coppola, V.2    Musumeci, M.3
  • 105
    • 34249817549 scopus 로고    scopus 로고
    • Trans activation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    • Chang TC, Wentzel EA, Kent OA. Trans activation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007;26:745-52.
    • (2007) Mol Cell , vol.26 , pp. 745-752
    • Chang, T.C.1    Wentzel, E.A.2    Kent, O.A.3
  • 106
    • 69949087531 scopus 로고    scopus 로고
    • MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
    • Ji Q, Hao X, Zhang M, Tang W, Yang M, Li L, Xiang D, et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One 2009;4: e6816.
    • (2009) PLoS One , vol.4
    • Ji, Q.1    Hao, X.2    Zhang, M.3    Tang, W.4    Yang, M.5    Li, L.6    Xiang, D.7


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