-
2
-
-
19344362304
-
Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control
-
Johnson PD, Stinear T, Small PL, Pluschke G, Merritt RW, et al. ((2005)) Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control. PLoS Med 2:: e108.
-
(2005)
PLoS Med
, vol.2
-
-
Johnson, P.D.1
Stinear, T.2
Small, P.L.3
Pluschke, G.4
Merritt, R.W.5
-
3
-
-
0033754029
-
Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence
-
Stinear TP, Jenkin GA, Johnson PD, Davies JK, ((2000)) Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence. J Bacteriol 182:: 6322--6330.
-
(2000)
J Bacteriol
, vol.182
, pp. 6322-6330
-
-
Stinear, T.P.1
Jenkin, G.A.2
Johnson, P.D.3
Davies, J.K.4
-
4
-
-
33846054258
-
Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer
-
Stinear TP, Seemann T, Pidot S, Frigui W, Reysset G, et al. ((2007)) Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res 17:: 192--200.
-
(2007)
Genome Res
, vol.17
, pp. 192-200
-
-
Stinear, T.P.1
Seemann, T.2
Pidot, S.3
Frigui, W.4
Reysset, G.5
-
5
-
-
10744229306
-
Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans
-
Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, et al. ((2004)) Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc Natl Acad Sci U S A 101:: 1345--1349.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 1345-1349
-
-
Stinear, T.P.1
Mve-Obiang, A.2
Small, P.L.3
Frigui, W.4
Pryor, M.J.5
-
6
-
-
23044451316
-
Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans
-
Etuaful S, Carbonnelle B, Grosset J, Lucas S, Horsfield C, et al. ((2005)) Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans. Antimicrob Agents Chemother 49:: 3182--3186.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 3182-3186
-
-
Etuaful, S.1
Carbonnelle, B.2
Grosset, J.3
Lucas, S.4
Horsfield, C.5
-
7
-
-
0037378042
-
Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice
-
Marsollier L, Honore N, Legras P, Manceau AL, Kouakou H, et al. ((2003)) Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice. Antimicrob Agents Chemother 47:: 1228--1232.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 1228-1232
-
-
Marsollier, L.1
Honore, N.2
Legras, P.3
Manceau, A.L.4
Kouakou, H.5
-
8
-
-
77953775139
-
Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains
-
Zhang T, Bishai WR, Grosset JH, Nuermberger EL, ((2010)) Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. Antimicrob Agents Chemother 54:: 2806--2813.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 2806-2813
-
-
Zhang, T.1
Bishai, W.R.2
Grosset, J.H.3
Nuermberger, E.L.4
-
9
-
-
79251537799
-
Comparative genomics allowed the identification of drug targets against human fungal pathogens
-
Abadio AK, Kioshima ES, Teixeira MM, Martins NF, Maigret B, et al. ((2011)) Comparative genomics allowed the identification of drug targets against human fungal pathogens. BMC Genomics 12:: 75.
-
(2011)
BMC Genomics
, vol.12
, pp. 75
-
-
Abadio, A.K.1
Kioshima, E.S.2
Teixeira, M.M.3
Martins, N.F.4
Maigret, B.5
-
10
-
-
10044239624
-
A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa
-
Sakharkar KR, Sakharkar MK, Chow VT, ((2004)) A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. In Silico Biol 4:: 355--360.
-
(2004)
In Silico Biol
, vol.4
, pp. 355-360
-
-
Sakharkar, K.R.1
Sakharkar, M.K.2
Chow, V.T.3
-
11
-
-
38949196018
-
Differential genome analyses of metabolic enzymes in Pseudomonas aeruginosa for drug target identification
-
Perumal D, Lim CS, Sakharkar KR, Sakharkar MK, ((2007)) Differential genome analyses of metabolic enzymes in Pseudomonas aeruginosa for drug target identification. In Silico Biol 7:: 453--465.
-
(2007)
In Silico Biol
, vol.7
, pp. 453-465
-
-
Perumal, D.1
Lim, C.S.2
Sakharkar, K.R.3
Sakharkar, M.K.4
-
12
-
-
84865051001
-
Homology modeling, comparative genomics and functional annotation of Mycoplasma genitalium hypothetical protein MG_237
-
Butt AM, Batool M, Tong Y, ((2011)) Homology modeling, comparative genomics and functional annotation of Mycoplasma genitalium hypothetical protein MG_237. Bioinformation 7:: 299--303.
-
(2011)
Bioinformation
, vol.7
, pp. 299-303
-
-
Butt, A.M.1
Batool, M.2
Tong, Y.3
-
13
-
-
83555179128
-
Mycoplasma genitalium: A comparative genomics study of metabolic pathways for the identification of drug and vaccine targets
-
Butt AM, Tahir S, Nasrullah I, Idrees M, Lu J, et al. ((2012)) Mycoplasma genitalium: A comparative genomics study of metabolic pathways for the identification of drug and vaccine targets. Infect Genet Evol 12:: 53--62.
-
(2012)
Infect Genet Evol
, vol.12
, pp. 53-62
-
-
Butt, A.M.1
Tahir, S.2
Nasrullah, I.3
Idrees, M.4
Lu, J.5
-
14
-
-
0032728399
-
Searching for drug targets in microbial genomes
-
Galperin MY, Koonin EV, ((1999)) Searching for drug targets in microbial genomes. Curr Opin Biotechnol 10:: 571--578.
-
(1999)
Curr Opin Biotechnol
, vol.10
, pp. 571-578
-
-
Galperin, M.Y.1
Koonin, E.V.2
-
15
-
-
0042667165
-
Essentiality, not expressiveness, drives gene-strand bias in bacteria
-
Rocha EP, Danchin A, ((2003)) Essentiality, not expressiveness, drives gene-strand bias in bacteria. Nat Genet 34:: 377--378.
-
(2003)
Nat Genet
, vol.34
, pp. 377-378
-
-
Rocha, E.P.1
Danchin, A.2
-
16
-
-
33750488443
-
Towards the identification of essential genes using targeted genome sequencing and comparative analysis
-
Gustafson AM, Snitkin ES, Parker SC, DeLisi C, Kasif S, ((2006)) Towards the identification of essential genes using targeted genome sequencing and comparative analysis. BMC Genomics 7:: 265.
-
(2006)
BMC Genomics
, vol.7
, pp. 265
-
-
Gustafson, A.M.1
Snitkin, E.S.2
Parker, S.C.3
DeLisi, C.4
Kasif, S.5
-
17
-
-
33749075731
-
In silico prediction of yeast deletion phenotypes
-
Saha S, Heber S, ((2006)) In silico prediction of yeast deletion phenotypes. Genet Mol Res 5:: 224--232.
-
(2006)
Genet Mol Res
, vol.5
, pp. 224-232
-
-
Saha, S.1
Heber, S.2
-
18
-
-
79951573994
-
Investigating the predictability of essential genes across distantly related organisms using an integrative approach
-
Deng J, Deng L, Su S, Zhang M, Lin X, et al. ((2011)) Investigating the predictability of essential genes across distantly related organisms using an integrative approach. Nucleic Acids Res 39:: 795--807.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 795-807
-
-
Deng, J.1
Deng, L.2
Su, S.3
Zhang, M.4
Lin, X.5
-
19
-
-
79953851912
-
Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification
-
Shanmugam A, Natarajan J, ((2010)) Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification. Bioinformation 4:: 392--395.
-
(2010)
Bioinformation
, vol.4
, pp. 392-395
-
-
Shanmugam, A.1
Natarajan, J.2
-
20
-
-
33748933062
-
In silico analysis of Burkholderia pseudomallei genome sequence for potential drug targets
-
Chong CE, Lim BS, Nathan S, Mohamed R, ((2006)) In silico analysis of Burkholderia pseudomallei genome sequence for potential drug targets. In Silico Biol 6:: 341--346.
-
(2006)
In Silico Biol
, vol.6
, pp. 341-346
-
-
Chong, C.E.1
Lim, B.S.2
Nathan, S.3
Mohamed, R.4
-
21
-
-
83555178838
-
In silico Analysis of Metabolic Pathways for Identification of Putative Drug Targets for Staphylococcus aureus
-
Morya VK, Dewaker V, Mecarty SD, Singh R, ((2010)) In silico Analysis of Metabolic Pathways for Identification of Putative Drug Targets for Staphylococcus aureus. J Comput Sci Syst Biol 3:: 062--069.
-
(2010)
J Comput Sci Syst Biol
, vol.3
, pp. 062-069
-
-
Morya, V.K.1
Dewaker, V.2
Mecarty, S.D.3
Singh, R.4
-
22
-
-
83555178130
-
In silico identification of common putative drug targets in Leptospira interrogans
-
Amineni U, Pradhan D, Marisetty H, ((2010)) In silico identification of common putative drug targets in Leptospira interrogans. J Chem Biol 3:: 165--173.
-
(2010)
J Chem Biol
, vol.3
, pp. 165-173
-
-
Amineni, U.1
Pradhan, D.2
Marisetty, H.3
-
23
-
-
73849107815
-
Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi
-
Holman AG, Davis PJ, Foster JM, Carlow CK, Kumar S, ((2009)) Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi. BMC Microbiol 9:: 243.
-
(2009)
BMC Microbiol
, vol.9
, pp. 243
-
-
Holman, A.G.1
Davis, P.J.2
Foster, J.M.3
Carlow, C.K.4
Kumar, S.5
-
24
-
-
58149197597
-
DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes
-
Zhang R, Lin Y, ((2009)) DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucleic Acids Res 37:: D455--458.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Zhang, R.1
Lin, Y.2
-
25
-
-
33644874819
-
From genomics to chemical genomics: new developments in KEGG
-
Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, et al. ((2006)) From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res 34:: D354--357.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Kanehisa, M.1
Goto, S.2
Hattori, M.3
Aoki-Kinoshita, K.F.4
Itoh, M.5
-
26
-
-
75549090213
-
KEGG for representation and analysis of molecular networks involving diseases and drugs
-
Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M, ((2010)) KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 38:: D355--360.
-
(2010)
Nucleic Acids Res
, vol.38
-
-
Kanehisa, M.1
Goto, S.2
Furumichi, M.3
Tanabe, M.4
Hirakawa, M.5
-
27
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
-
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, et al. ((1997)) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:: 3389--3402.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
Zhang, J.4
Zhang, Z.5
-
28
-
-
55349104084
-
Genomic-scale prioritization of drug targets: the TDR Targets database
-
Aguero F, Al-Lazikani B, Aslett M, Berriman M, Buckner FS, et al. ((2008)) Genomic-scale prioritization of drug targets: the TDR Targets database. Nat Rev Drug Discov 7:: 900--907.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 900-907
-
-
Aguero, F.1
Al-Lazikani, B.2
Aslett, M.3
Berriman, M.4
Buckner, F.S.5
-
29
-
-
0037255072
-
The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003
-
Boeckmann B, Bairoch A, Apweiler R, Blatter MC, Estreicher A, et al. ((2003)) The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res 31:: 365--370.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 365-370
-
-
Boeckmann, B.1
Bairoch, A.2
Apweiler, R.3
Blatter, M.C.4
Estreicher, A.5
-
30
-
-
78650178724
-
Prediction of subcellular location of mycobacterial protein using feature selection techniques
-
Lin H, Ding H, Guo FB, Huang J, ((2010)) Prediction of subcellular location of mycobacterial protein using feature selection techniques. Mol Divers 14:: 667--671.
-
(2010)
Mol Divers
, vol.14
, pp. 667-671
-
-
Lin, H.1
Ding, H.2
Guo, F.B.3
Huang, J.4
-
31
-
-
0035910270
-
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
-
Krogh A, Larsson B, von Heijne G, Sonnhammer EL, ((2001)) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305:: 567--580.
-
(2001)
J Mol Biol
, vol.305
, pp. 567-580
-
-
Krogh, A.1
Larsson, B.2
von Heijne, G.3
Sonnhammer, E.L.4
-
33
-
-
0017751668
-
The Protein Data Bank. A computer-based archival file for macromolecular structures
-
Bernstein FC, Koetzle TF, Williams GJ, Meyer EF Jr, Brice MD, et al. ((1977)) The Protein Data Bank. A computer-based archival file for macromolecular structures. Eur J Biochem 80:: 319--324.
-
(1977)
Eur J Biochem
, vol.80
, pp. 319-324
-
-
Bernstein, F.C.1
Koetzle, T.F.2
Williams, G.J.3
Meyer Jr., E.F.4
Brice, M.D.5
-
34
-
-
78651290702
-
ModBase, a database of annotated comparative protein structure models, and associated resources
-
Pieper U, Webb BM, Barkan DT, Schneidman-Duhovny D, Schlessinger A, et al. ((2011)) ModBase, a database of annotated comparative protein structure models, and associated resources. Nucleic Acids Res 39:: D465--474.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Pieper, U.1
Webb, B.M.2
Barkan, D.T.3
Schneidman-Duhovny, D.4
Schlessinger, A.5
-
35
-
-
33846155913
-
Structure-based maximal affinity model predicts small-molecule druggability
-
Cheng AC, Coleman RG, Smyth KT, Cao Q, Soulard P, et al. ((2007)) Structure-based maximal affinity model predicts small-molecule druggability. Nat Biotechnol 25:: 71--75.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 71-75
-
-
Cheng, A.C.1
Coleman, R.G.2
Smyth, K.T.3
Cao, Q.4
Soulard, P.5
-
37
-
-
78651287426
-
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
-
Knox C, Law V, Jewison T, Liu P, Ly S, et al. ((2011)) DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39:: D1035--1041.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Knox, C.1
Law, V.2
Jewison, T.3
Liu, P.4
Ly, S.5
-
38
-
-
78149433133
-
Predicting conserved essential genes in bacteria: in silico identification of putative drug targets
-
Duffield M, Cooper I, McAlister E, Bayliss M, Ford D, et al. ((2010)) Predicting conserved essential genes in bacteria: in silico identification of putative drug targets. Mol Biosyst 6:: 2482--2489.
-
(2010)
Mol Biosyst
, vol.6
, pp. 2482-2489
-
-
Duffield, M.1
Cooper, I.2
McAlister, E.3
Bayliss, M.4
Ford, D.5
-
39
-
-
77952744822
-
Functionality of essential genes drives gene strand-bias in bacterial genomes
-
Lin Y, Gao F, Zhang CT, ((2010)) Functionality of essential genes drives gene strand-bias in bacterial genomes. Biochem Biophys Res Commun 396:: 472--476.
-
(2010)
Biochem Biophys Res Commun
, vol.396
, pp. 472-476
-
-
Lin, Y.1
Gao, F.2
Zhang, C.T.3
-
40
-
-
84860112417
-
Putative essential and core-essential genes in Mycoplasma genomes
-
Lin Y, Zhang RR, ((2011)) Putative essential and core-essential genes in Mycoplasma genomes. Sci Rep 1:: 53.
-
(2011)
Sci Rep
, vol.1
, pp. 53
-
-
Lin, Y.1
Zhang, R.R.2
-
41
-
-
41349112730
-
Ori-Finder: a web-based system for finding oriCs in unannotated bacterial genomes
-
Gao F, Zhang CT, ((2008)) Ori-Finder: a web-based system for finding oriCs in unannotated bacterial genomes. BMC Bioinformatics 9:: 79.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 79
-
-
Gao, F.1
Zhang, C.T.2
-
42
-
-
50849131231
-
ACUA: a software tool for automated codon usage analysis
-
Vetrivel U, Arunkumar V, Dorairaj S, ((2007)) ACUA: a software tool for automated codon usage analysis. Bioinformation 2:: 62--63.
-
(2007)
Bioinformation
, vol.2
, pp. 62-63
-
-
Vetrivel, U.1
Arunkumar, V.2
Dorairaj, S.3
-
43
-
-
0023650543
-
The codon Adaptation Index-a measure of directional synonymous codon usage bias, and its potential applications
-
Sharp PM, Li WH, ((1987)) The codon Adaptation Index-a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Res 15:: 1281--1295.
-
(1987)
Nucleic Acids Res
, vol.15
, pp. 1281-1295
-
-
Sharp, P.M.1
Li, W.H.2
-
44
-
-
33748253652
-
Predicting essential genes in fungal genomes
-
Seringhaus M, Paccanaro A, Borneman A, Snyder M, Gerstein M, ((2006)) Predicting essential genes in fungal genomes. Genome Res 16:: 1126--1135.
-
(2006)
Genome Res
, vol.16
, pp. 1126-1135
-
-
Seringhaus, M.1
Paccanaro, A.2
Borneman, A.3
Snyder, M.4
Gerstein, M.5
-
45
-
-
79959574838
-
Enzymes are enriched in bacterial essential genes
-
Gao F, Zhang RR, ((2011)) Enzymes are enriched in bacterial essential genes. PLoS One 6:: e21683.
-
(2011)
PLoS One
, vol.6
-
-
Gao, F.1
Zhang, R.R.2
-
46
-
-
70449380022
-
In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae
-
Barh D, Kumar A, ((2009)) In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae. In Silico Biol 9:: 225--231.
-
(2009)
In Silico Biol
, vol.9
, pp. 225-231
-
-
Barh, D.1
Kumar, A.2
-
47
-
-
33748959163
-
Essential genes on metabolic maps
-
Gerdes S, Edwards R, Kubal M, Fonstein M, Stevens R, et al. ((2006)) Essential genes on metabolic maps. Curr Opin Biotechnol 17:: 448--456.
-
(2006)
Curr Opin Biotechnol
, vol.17
, pp. 448-456
-
-
Gerdes, S.1
Edwards, R.2
Kubal, M.3
Fonstein, M.4
Stevens, R.5
-
48
-
-
79953891009
-
Identification and modeling of a drug target for Clostridium perfringens SM101
-
Chhabra G, Sharma P, Anant A, Deshmukh S, Kaushik H, et al. ((2010)) Identification and modeling of a drug target for Clostridium perfringens SM101. Bioinformation 4:: 278--289.
-
(2010)
Bioinformation
, vol.4
, pp. 278-289
-
-
Chhabra, G.1
Sharma, P.2
Anant, A.3
Deshmukh, S.4
Kaushik, H.5
-
49
-
-
84887212447
-
A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni
-
Caffrey CR, Rohwer A, Oellien F, Marhofer RJ, Braschi S, et al. ((2009)) A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One 4:: e4413.
-
(2009)
PLoS One
, vol.4
-
-
Caffrey, C.R.1
Rohwer, A.2
Oellien, F.3
Marhofer, R.J.4
Braschi, S.5
-
50
-
-
78149249050
-
Identification of attractive drug targets in neglected-disease pathogens using an in silico approach
-
Crowther GJ, Shanmugam D, Carmona SJ, Doyle MA, Hertz-Fowler C, et al. ((2010)) Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PLoS Negl Trop Dis 4:: e804.
-
(2010)
PLoS Negl Trop Dis
, vol.4
-
-
Crowther, G.J.1
Shanmugam, D.2
Carmona, S.J.3
Doyle, M.A.4
Hertz-Fowler, C.5
-
51
-
-
25444491937
-
Protein subcellular localization prediction for Gram-negative bacteria using amino acid subalphabets and a combination of multiple support vector machines
-
Wang J, Sung WK, Krishnan A, Li KB, ((2005)) Protein subcellular localization prediction for Gram-negative bacteria using amino acid subalphabets and a combination of multiple support vector machines. BMC Bioinformatics 6:: 174.
-
(2005)
BMC Bioinformatics
, vol.6
, pp. 174
-
-
Wang, J.1
Sung, W.K.2
Krishnan, A.3
Li, K.B.4
-
52
-
-
33748878164
-
Methods for predicting bacterial protein subcellular localization
-
Gardy JL, Brinkman FS, ((2006)) Methods for predicting bacterial protein subcellular localization. Nat Rev Microbiol 4:: 741--751.
-
(2006)
Nat Rev Microbiol
, vol.4
, pp. 741-751
-
-
Gardy, J.L.1
Brinkman, F.S.2
-
53
-
-
58049161622
-
In silico analysis of potential diagnostic targets from Burkholderia pseudomallei
-
Thompson DB, Crandall K, Harding SV, Smither SJ, Kitto GB, et al. ((2008)) In silico analysis of potential diagnostic targets from Burkholderia pseudomallei. Trans R Soc Trop Med Hyg 102 Suppl 1: S61--65.
-
(2008)
Trans R Soc Trop Med Hyg
, vol.102
-
-
Thompson, D.B.1
Crandall, K.2
Harding, S.V.3
Smither, S.J.4
Kitto, G.B.5
-
54
-
-
0030790687
-
Common themes in microbial pathogenicity revisited
-
Finlay BB, Falkow S, ((1997)) Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 61:: 136--169.
-
(1997)
Microbiol Mol Biol Rev
, vol.61
, pp. 136-169
-
-
Finlay, B.B.1
Falkow, S.2
-
55
-
-
60849116153
-
Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology
-
Tseng TT, Tyler BM, Setubal JC, ((2009)) Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology. BMC Microbiol 9 (Suppl 1):: S2.
-
(2009)
BMC Microbiol
, vol.9
, Issue.SUPPL. 1
-
-
Tseng, T.T.1
Tyler, B.M.2
Setubal, J.C.3
-
56
-
-
0035019730
-
Type II secretion and pathogenesis
-
Sandkvist M, ((2001)) Type II secretion and pathogenesis. Infect Immun 69:: 3523--3535.
-
(2001)
Infect Immun
, vol.69
, pp. 3523-3535
-
-
Sandkvist, M.1
-
57
-
-
47049087178
-
Independent loss of immunogenic proteins in Mycobacterium ulcerans suggests immune evasion
-
Huber CA, Ruf MT, Pluschke G, Kaser M, ((2008)) Independent loss of immunogenic proteins in Mycobacterium ulcerans suggests immune evasion. Clin Vaccine Immunol 15:: 598--606.
-
(2008)
Clin Vaccine Immunol
, vol.15
, pp. 598-606
-
-
Huber, C.A.1
Ruf, M.T.2
Pluschke, G.3
Kaser, M.4
-
58
-
-
78449263722
-
Protein export systems of Mycobacterium tuberculosis: novel targets for drug development
-
Feltcher ME, Sullivan JT, Braunstein M, ((2010)) Protein export systems of Mycobacterium tuberculosis: novel targets for drug development? Future Microbiol 5:: 1581--1597.
-
(2010)
Future Microbiol
, vol.5
, pp. 1581-1597
-
-
Feltcher, M.E.1
Sullivan, J.T.2
Braunstein, M.3
-
59
-
-
73649122749
-
An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway
-
Schneider T, Sahl HG, ((2010)) An oldie but a goodie- cell wall biosynthesis as antibiotic target pathway. Int J Med Microbiol 300:: 161--169.
-
(2010)
Int J Med Microbiol
, vol.300
, pp. 161-169
-
-
Schneider, T.1
Sahl, H.G.2
-
61
-
-
80052446723
-
Peptidoglycan biosynthesis machinery: a rich source of drug targets
-
Gautam A, Vyas R, Tewari R, ((2011)) Peptidoglycan biosynthesis machinery: a rich source of drug targets. Crit Rev Biotechnol 31:: 295--336.
-
(2011)
Crit Rev Biotechnol
, vol.31
, pp. 295-336
-
-
Gautam, A.1
Vyas, R.2
Tewari, R.3
-
62
-
-
0016194384
-
The mechanism of action of fosfomycin (phosphonomycin)
-
Kahan FM, Kahan JS, Cassidy PJ, Kropp H, ((1974)) The mechanism of action of fosfomycin (phosphonomycin). Ann N Y Acad Sci 235:: 364--386.
-
(1974)
Ann N Y Acad Sci
, vol.235
, pp. 364-386
-
-
Kahan, F.M.1
Kahan, J.S.2
Cassidy, P.J.3
Kropp, H.4
-
63
-
-
0033939999
-
Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria
-
Du W, Brown JR, Sylvester DR, Huang J, Chalker AF, et al. ((2000)) Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria. J Bacteriol 182:: 4146--4152.
-
(2000)
J Bacteriol
, vol.182
, pp. 4146-4152
-
-
Du, W.1
Brown, J.R.2
Sylvester, D.R.3
Huang, J.4
Chalker, A.F.5
-
64
-
-
84865048556
-
In the case of transmission of mycobacterium ulcerans in buruli ulcer disease acanthamoeba species stand accused
-
Wilson MD, Boakye DA, Mosi L, Asiedu K, ((2011)) In the case of transmission of mycobacterium ulcerans in buruli ulcer disease acanthamoeba species stand accused. Ghana Med J 45:: 31--34.
-
(2011)
Ghana Med J
, vol.45
, pp. 31-34
-
-
Wilson, M.D.1
Boakye, D.A.2
Mosi, L.3
Asiedu, K.4
-
65
-
-
32644490022
-
rmlB and rmlC genes are essential for growth of mycobacteria
-
Li W, Xin Y, McNeil MR, Ma Y, ((2006)) rmlB and rmlC genes are essential for growth of mycobacteria. Biochem Biophys Res Commun 342:: 170--178.
-
(2006)
Biochem Biophys Res Commun
, vol.342
, pp. 170-178
-
-
Li, W.1
Xin, Y.2
McNeil, M.R.3
Ma, Y.4
-
66
-
-
0035038011
-
Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose
-
Ma Y, Stern RJ, Scherman MS, Vissa VD, Yan W, et al. ((2001)) Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob Agents Chemother 45:: 1407--1416.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 1407-1416
-
-
Ma, Y.1
Stern, R.J.2
Scherman, M.S.3
Vissa, V.D.4
Yan, W.5
-
67
-
-
0014408816
-
The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose
-
Melo A, Glaser L, ((1968)) The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose. J Biol Chem 243:: 1475--1478.
-
(1968)
J Biol Chem
, vol.243
, pp. 1475-1478
-
-
Melo, A.1
Glaser, L.2
-
68
-
-
0032901233
-
Thiamin biosynthesis in prokaryotes
-
Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, et al. ((1999)) Thiamin biosynthesis in prokaryotes. Arch Microbiol 171:: 293--300.
-
(1999)
Arch Microbiol
, vol.171
, pp. 293-300
-
-
Begley, T.P.1
Downs, D.M.2
Ealick, S.E.3
McLafferty, F.W.4
Van Loon, A.P.5
-
69
-
-
79952467900
-
Thiamin (vitamin B1) biosynthesis and regulation: a rich source of antimicrobial drug targets
-
Du Q, Wang H, Xie J, ((2011)) Thiamin (vitamin B1) biosynthesis and regulation: a rich source of antimicrobial drug targets? Int J Biol Sci 7:: 41--52.
-
(2011)
Int J Biol Sci
, vol.7
, pp. 41-52
-
-
Du, Q.1
Wang, H.2
Xie, J.3
-
70
-
-
72149097595
-
Vitamin B metabolism in Plasmodium falciparum as a source of drug targets
-
Muller IB, Hyde JE, Wrenger C, ((2010)) Vitamin B metabolism in Plasmodium falciparum as a source of drug targets. Trends Parasitol 26:: 35--43.
-
(2010)
Trends Parasitol
, vol.26
, pp. 35-43
-
-
Muller, I.B.1
Hyde, J.E.2
Wrenger, C.3
-
71
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagenesis
-
Sassetti CM, Boyd DH, Rubin EJ, ((2003)) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48:: 77--84.
-
(2003)
Mol Microbiol
, vol.48
, pp. 77-84
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
72
-
-
28844499031
-
Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents
-
Hurdle JG, O'Neill AJ, Chopra I, ((2005)) Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents. Antimicrob Agents Chemother 49:: 4821--4833.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 4821-4833
-
-
Hurdle, J.G.1
O'Neill, A.J.2
Chopra, I.3
-
73
-
-
0033782994
-
Aminoacyl-tRNA synthesis
-
Ibba M, Soll D, ((2000)) Aminoacyl-tRNA synthesis. Annu Rev Biochem 69:: 617--650.
-
(2000)
Annu Rev Biochem
, vol.69
, pp. 617-650
-
-
Ibba, M.1
Soll, D.2
-
74
-
-
0035819917
-
Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use
-
Raczniak G, Ibba M, Soll D, ((2001)) Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use. Toxicology 160:: 181--189.
-
(2001)
Toxicology
, vol.160
, pp. 181-189
-
-
Raczniak, G.1
Ibba, M.2
Soll, D.3
-
75
-
-
0034633290
-
A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology
-
Macarron R, Mensah L, Cid C, Carranza C, Benson N, et al. ((2000)) A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology. Anal Biochem 284:: 183--190.
-
(2000)
Anal Biochem
, vol.284
, pp. 183-190
-
-
Macarron, R.1
Mensah, L.2
Cid, C.3
Carranza, C.4
Benson, N.5
-
76
-
-
80051995882
-
The identification of quality antibacterial drug discovery targets: a case study with aminoacyl-tRNA synthetases
-
Gallant P, Finn J, Keith D, Wendler P, ((2000)) The identification of quality antibacterial drug discovery targets: a case study with aminoacyl-tRNA synthetases. Expert Opinion on Therapeutic Targets 4:: 1--9.
-
(2000)
Expert Opinion on Therapeutic Targets
, vol.4
, pp. 1-9
-
-
Gallant, P.1
Finn, J.2
Keith, D.3
Wendler, P.4
-
77
-
-
9144263033
-
New aminoacyl-tRNA synthetase inhibitors as antibacterial agents
-
Pohlmann J, Brotz-Oesterhelt H, ((2004)) New aminoacyl-tRNA synthetase inhibitors as antibacterial agents. Curr Drug Targets Infect Disord 4:: 261--272.
-
(2004)
Curr Drug Targets Infect Disord
, vol.4
, pp. 261-272
-
-
Pohlmann, J.1
Brotz-Oesterhelt, H.2
-
78
-
-
0015230679
-
Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens
-
Fuller AT, Mellows G, Woolford M, Banks GT, Barrow KD, et al. ((1971)) Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens. Nature 234:: 416--417.
-
(1971)
Nature
, vol.234
, pp. 416-417
-
-
Fuller, A.T.1
Mellows, G.2
Woolford, M.3
Banks, G.T.4
Barrow, K.D.5
-
79
-
-
9144253860
-
New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity
-
Beyer D, Kroll HP, Endermann R, Schiffer G, Siegel S, et al. ((2004)) New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity. Antimicrob Agents Chemother 48:: 525--532.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 525-532
-
-
Beyer, D.1
Kroll, H.P.2
Endermann, R.3
Schiffer, G.4
Siegel, S.5
-
80
-
-
12944335304
-
Drug target validation: lethal infection blocked by inducible peptide
-
Tao J, Wendler P, Connelly G, Lim A, Zhang J, et al. ((2000)) Drug target validation: lethal infection blocked by inducible peptide. Proc Natl Acad Sci U S A 97:: 783--786.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 783-786
-
-
Tao, J.1
Wendler, P.2
Connelly, G.3
Lim, A.4
Zhang, J.5
-
81
-
-
0036142732
-
Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group
-
Smith HO, Blessing JA, Vaccarello L, ((2002)) Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group. Gynecol Oncol 84:: 140--144.
-
(2002)
Gynecol Oncol
, vol.84
, pp. 140-144
-
-
Smith, H.O.1
Blessing, J.A.2
Vaccarello, L.3
-
82
-
-
0036605892
-
The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis
-
Aspinall TV, Joynson DH, Guy E, Hyde JE, Sims PF, ((2002)) The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis. J Infect Dis 185:: 1637--1643.
-
(2002)
J Infect Dis
, vol.185
, pp. 1637-1643
-
-
Aspinall, T.V.1
Joynson, D.H.2
Guy, E.3
Hyde, J.E.4
Sims, P.F.5
-
83
-
-
33748746654
-
Inhibitors of de novo folate enzymes in Plasmodium falciparum
-
Nzila A, ((2006)) Inhibitors of de novo folate enzymes in Plasmodium falciparum. Drug Discov Today 11:: 939--944.
-
(2006)
Drug Discov Today
, vol.11
, pp. 939-944
-
-
Nzila, A.1
-
84
-
-
0032059055
-
Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania
-
Zuccotto F, Martin AC, Laskowski RA, Thornton JM, Gilbert IH, ((1998)) Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania. J Comput Aided Mol Des 12:: 241--257.
-
(1998)
J Comput Aided Mol Des
, vol.12
, pp. 241-257
-
-
Zuccotto, F.1
Martin, A.C.2
Laskowski, R.A.3
Thornton, J.M.4
Gilbert, I.H.5
-
85
-
-
33745607880
-
Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis
-
Hasan S, Daugelat S, Rao PS, Schreiber M, ((2006)) Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol 2:: e61.
-
(2006)
PLoS Comput Biol
, vol.2
-
-
Hasan, S.1
Daugelat, S.2
Rao, P.S.3
Schreiber, M.4
-
86
-
-
53549091061
-
Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening
-
Cho Y, Ioerger TR, Sacchettini JC, ((2008)) Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem 51:: 5984--5992.
-
(2008)
J Med Chem
, vol.51
, pp. 5984-5992
-
-
Cho, Y.1
Ioerger, T.R.2
Sacchettini, J.C.3
-
87
-
-
77955334006
-
Identification of novel bacterial histidine biosynthesis inhibitors using docking, ensemble rescoring, and whole-cell assays
-
Henriksen ST, Liu J, Estiu G, Oltvai ZN, Wiest O, ((2010)) Identification of novel bacterial histidine biosynthesis inhibitors using docking, ensemble rescoring, and whole-cell assays. Bioorg Med Chem 18:: 5148--5156.
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 5148-5156
-
-
Henriksen, S.T.1
Liu, J.2
Estiu, G.3
Oltvai, Z.N.4
Wiest, O.5
|