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Volumn 7, Issue 8, 2012, Pages

Comparative genomics analysis of mycobacterium ulcerans for the identification of putative essential genes and therapeutic candidates

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMINOACYL TRANSFER RNA; BACTERIAL PROTEIN; CARBOHYDRATE; FOLIC ACID; HISTIDINE; PEPTIDOGLYCAN; POLYKETIDE; THIAMINE;

EID: 84865058687     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043080     Document Type: Article
Times cited : (65)

References (87)
  • 2
    • 19344362304 scopus 로고    scopus 로고
    • Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control
    • Johnson PD, Stinear T, Small PL, Pluschke G, Merritt RW, et al. ((2005)) Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control. PLoS Med 2:: e108.
    • (2005) PLoS Med , vol.2
    • Johnson, P.D.1    Stinear, T.2    Small, P.L.3    Pluschke, G.4    Merritt, R.W.5
  • 3
    • 0033754029 scopus 로고    scopus 로고
    • Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence
    • Stinear TP, Jenkin GA, Johnson PD, Davies JK, ((2000)) Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence. J Bacteriol 182:: 6322--6330.
    • (2000) J Bacteriol , vol.182 , pp. 6322-6330
    • Stinear, T.P.1    Jenkin, G.A.2    Johnson, P.D.3    Davies, J.K.4
  • 4
    • 33846054258 scopus 로고    scopus 로고
    • Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer
    • Stinear TP, Seemann T, Pidot S, Frigui W, Reysset G, et al. ((2007)) Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res 17:: 192--200.
    • (2007) Genome Res , vol.17 , pp. 192-200
    • Stinear, T.P.1    Seemann, T.2    Pidot, S.3    Frigui, W.4    Reysset, G.5
  • 5
    • 10744229306 scopus 로고    scopus 로고
    • Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans
    • Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, et al. ((2004)) Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Proc Natl Acad Sci U S A 101:: 1345--1349.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1345-1349
    • Stinear, T.P.1    Mve-Obiang, A.2    Small, P.L.3    Frigui, W.4    Pryor, M.J.5
  • 6
    • 23044451316 scopus 로고    scopus 로고
    • Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans
    • Etuaful S, Carbonnelle B, Grosset J, Lucas S, Horsfield C, et al. ((2005)) Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of Buruli ulcer in humans. Antimicrob Agents Chemother 49:: 3182--3186.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 3182-3186
    • Etuaful, S.1    Carbonnelle, B.2    Grosset, J.3    Lucas, S.4    Horsfield, C.5
  • 7
    • 0037378042 scopus 로고    scopus 로고
    • Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice
    • Marsollier L, Honore N, Legras P, Manceau AL, Kouakou H, et al. ((2003)) Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice. Antimicrob Agents Chemother 47:: 1228--1232.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 1228-1232
    • Marsollier, L.1    Honore, N.2    Legras, P.3    Manceau, A.L.4    Kouakou, H.5
  • 8
    • 77953775139 scopus 로고    scopus 로고
    • Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains
    • Zhang T, Bishai WR, Grosset JH, Nuermberger EL, ((2010)) Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains. Antimicrob Agents Chemother 54:: 2806--2813.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2806-2813
    • Zhang, T.1    Bishai, W.R.2    Grosset, J.H.3    Nuermberger, E.L.4
  • 9
    • 79251537799 scopus 로고    scopus 로고
    • Comparative genomics allowed the identification of drug targets against human fungal pathogens
    • Abadio AK, Kioshima ES, Teixeira MM, Martins NF, Maigret B, et al. ((2011)) Comparative genomics allowed the identification of drug targets against human fungal pathogens. BMC Genomics 12:: 75.
    • (2011) BMC Genomics , vol.12 , pp. 75
    • Abadio, A.K.1    Kioshima, E.S.2    Teixeira, M.M.3    Martins, N.F.4    Maigret, B.5
  • 10
    • 10044239624 scopus 로고    scopus 로고
    • A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa
    • Sakharkar KR, Sakharkar MK, Chow VT, ((2004)) A novel genomics approach for the identification of drug targets in pathogens, with special reference to Pseudomonas aeruginosa. In Silico Biol 4:: 355--360.
    • (2004) In Silico Biol , vol.4 , pp. 355-360
    • Sakharkar, K.R.1    Sakharkar, M.K.2    Chow, V.T.3
  • 11
    • 38949196018 scopus 로고    scopus 로고
    • Differential genome analyses of metabolic enzymes in Pseudomonas aeruginosa for drug target identification
    • Perumal D, Lim CS, Sakharkar KR, Sakharkar MK, ((2007)) Differential genome analyses of metabolic enzymes in Pseudomonas aeruginosa for drug target identification. In Silico Biol 7:: 453--465.
    • (2007) In Silico Biol , vol.7 , pp. 453-465
    • Perumal, D.1    Lim, C.S.2    Sakharkar, K.R.3    Sakharkar, M.K.4
  • 12
    • 84865051001 scopus 로고    scopus 로고
    • Homology modeling, comparative genomics and functional annotation of Mycoplasma genitalium hypothetical protein MG_237
    • Butt AM, Batool M, Tong Y, ((2011)) Homology modeling, comparative genomics and functional annotation of Mycoplasma genitalium hypothetical protein MG_237. Bioinformation 7:: 299--303.
    • (2011) Bioinformation , vol.7 , pp. 299-303
    • Butt, A.M.1    Batool, M.2    Tong, Y.3
  • 13
    • 83555179128 scopus 로고    scopus 로고
    • Mycoplasma genitalium: A comparative genomics study of metabolic pathways for the identification of drug and vaccine targets
    • Butt AM, Tahir S, Nasrullah I, Idrees M, Lu J, et al. ((2012)) Mycoplasma genitalium: A comparative genomics study of metabolic pathways for the identification of drug and vaccine targets. Infect Genet Evol 12:: 53--62.
    • (2012) Infect Genet Evol , vol.12 , pp. 53-62
    • Butt, A.M.1    Tahir, S.2    Nasrullah, I.3    Idrees, M.4    Lu, J.5
  • 14
    • 0032728399 scopus 로고    scopus 로고
    • Searching for drug targets in microbial genomes
    • Galperin MY, Koonin EV, ((1999)) Searching for drug targets in microbial genomes. Curr Opin Biotechnol 10:: 571--578.
    • (1999) Curr Opin Biotechnol , vol.10 , pp. 571-578
    • Galperin, M.Y.1    Koonin, E.V.2
  • 15
    • 0042667165 scopus 로고    scopus 로고
    • Essentiality, not expressiveness, drives gene-strand bias in bacteria
    • Rocha EP, Danchin A, ((2003)) Essentiality, not expressiveness, drives gene-strand bias in bacteria. Nat Genet 34:: 377--378.
    • (2003) Nat Genet , vol.34 , pp. 377-378
    • Rocha, E.P.1    Danchin, A.2
  • 16
    • 33750488443 scopus 로고    scopus 로고
    • Towards the identification of essential genes using targeted genome sequencing and comparative analysis
    • Gustafson AM, Snitkin ES, Parker SC, DeLisi C, Kasif S, ((2006)) Towards the identification of essential genes using targeted genome sequencing and comparative analysis. BMC Genomics 7:: 265.
    • (2006) BMC Genomics , vol.7 , pp. 265
    • Gustafson, A.M.1    Snitkin, E.S.2    Parker, S.C.3    DeLisi, C.4    Kasif, S.5
  • 17
    • 33749075731 scopus 로고    scopus 로고
    • In silico prediction of yeast deletion phenotypes
    • Saha S, Heber S, ((2006)) In silico prediction of yeast deletion phenotypes. Genet Mol Res 5:: 224--232.
    • (2006) Genet Mol Res , vol.5 , pp. 224-232
    • Saha, S.1    Heber, S.2
  • 18
    • 79951573994 scopus 로고    scopus 로고
    • Investigating the predictability of essential genes across distantly related organisms using an integrative approach
    • Deng J, Deng L, Su S, Zhang M, Lin X, et al. ((2011)) Investigating the predictability of essential genes across distantly related organisms using an integrative approach. Nucleic Acids Res 39:: 795--807.
    • (2011) Nucleic Acids Res , vol.39 , pp. 795-807
    • Deng, J.1    Deng, L.2    Su, S.3    Zhang, M.4    Lin, X.5
  • 19
    • 79953851912 scopus 로고    scopus 로고
    • Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification
    • Shanmugam A, Natarajan J, ((2010)) Computational genome analyses of metabolic enzymes in Mycobacterium leprae for drug target identification. Bioinformation 4:: 392--395.
    • (2010) Bioinformation , vol.4 , pp. 392-395
    • Shanmugam, A.1    Natarajan, J.2
  • 20
    • 33748933062 scopus 로고    scopus 로고
    • In silico analysis of Burkholderia pseudomallei genome sequence for potential drug targets
    • Chong CE, Lim BS, Nathan S, Mohamed R, ((2006)) In silico analysis of Burkholderia pseudomallei genome sequence for potential drug targets. In Silico Biol 6:: 341--346.
    • (2006) In Silico Biol , vol.6 , pp. 341-346
    • Chong, C.E.1    Lim, B.S.2    Nathan, S.3    Mohamed, R.4
  • 21
    • 83555178838 scopus 로고    scopus 로고
    • In silico Analysis of Metabolic Pathways for Identification of Putative Drug Targets for Staphylococcus aureus
    • Morya VK, Dewaker V, Mecarty SD, Singh R, ((2010)) In silico Analysis of Metabolic Pathways for Identification of Putative Drug Targets for Staphylococcus aureus. J Comput Sci Syst Biol 3:: 062--069.
    • (2010) J Comput Sci Syst Biol , vol.3 , pp. 062-069
    • Morya, V.K.1    Dewaker, V.2    Mecarty, S.D.3    Singh, R.4
  • 22
    • 83555178130 scopus 로고    scopus 로고
    • In silico identification of common putative drug targets in Leptospira interrogans
    • Amineni U, Pradhan D, Marisetty H, ((2010)) In silico identification of common putative drug targets in Leptospira interrogans. J Chem Biol 3:: 165--173.
    • (2010) J Chem Biol , vol.3 , pp. 165-173
    • Amineni, U.1    Pradhan, D.2    Marisetty, H.3
  • 23
    • 73849107815 scopus 로고    scopus 로고
    • Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi
    • Holman AG, Davis PJ, Foster JM, Carlow CK, Kumar S, ((2009)) Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi. BMC Microbiol 9:: 243.
    • (2009) BMC Microbiol , vol.9 , pp. 243
    • Holman, A.G.1    Davis, P.J.2    Foster, J.M.3    Carlow, C.K.4    Kumar, S.5
  • 24
    • 58149197597 scopus 로고    scopus 로고
    • DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes
    • Zhang R, Lin Y, ((2009)) DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucleic Acids Res 37:: D455--458.
    • (2009) Nucleic Acids Res , vol.37
    • Zhang, R.1    Lin, Y.2
  • 26
    • 75549090213 scopus 로고    scopus 로고
    • KEGG for representation and analysis of molecular networks involving diseases and drugs
    • Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M, ((2010)) KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res 38:: D355--360.
    • (2010) Nucleic Acids Res , vol.38
    • Kanehisa, M.1    Goto, S.2    Furumichi, M.3    Tanabe, M.4    Hirakawa, M.5
  • 27
    • 0030801002 scopus 로고    scopus 로고
    • Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    • Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, et al. ((1997)) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:: 3389--3402.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3389-3402
    • Altschul, S.F.1    Madden, T.L.2    Schaffer, A.A.3    Zhang, J.4    Zhang, Z.5
  • 30
    • 78650178724 scopus 로고    scopus 로고
    • Prediction of subcellular location of mycobacterial protein using feature selection techniques
    • Lin H, Ding H, Guo FB, Huang J, ((2010)) Prediction of subcellular location of mycobacterial protein using feature selection techniques. Mol Divers 14:: 667--671.
    • (2010) Mol Divers , vol.14 , pp. 667-671
    • Lin, H.1    Ding, H.2    Guo, F.B.3    Huang, J.4
  • 31
    • 0035910270 scopus 로고    scopus 로고
    • Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes
    • Krogh A, Larsson B, von Heijne G, Sonnhammer EL, ((2001)) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J Mol Biol 305:: 567--580.
    • (2001) J Mol Biol , vol.305 , pp. 567-580
    • Krogh, A.1    Larsson, B.2    von Heijne, G.3    Sonnhammer, E.L.4
  • 35
    • 33846155913 scopus 로고    scopus 로고
    • Structure-based maximal affinity model predicts small-molecule druggability
    • Cheng AC, Coleman RG, Smyth KT, Cao Q, Soulard P, et al. ((2007)) Structure-based maximal affinity model predicts small-molecule druggability. Nat Biotechnol 25:: 71--75.
    • (2007) Nat Biotechnol , vol.25 , pp. 71-75
    • Cheng, A.C.1    Coleman, R.G.2    Smyth, K.T.3    Cao, Q.4    Soulard, P.5
  • 37
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: a comprehensive resource for 'omics' research on drugs
    • Knox C, Law V, Jewison T, Liu P, Ly S, et al. ((2011)) DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39:: D1035--1041.
    • (2011) Nucleic Acids Res , vol.39
    • Knox, C.1    Law, V.2    Jewison, T.3    Liu, P.4    Ly, S.5
  • 38
    • 78149433133 scopus 로고    scopus 로고
    • Predicting conserved essential genes in bacteria: in silico identification of putative drug targets
    • Duffield M, Cooper I, McAlister E, Bayliss M, Ford D, et al. ((2010)) Predicting conserved essential genes in bacteria: in silico identification of putative drug targets. Mol Biosyst 6:: 2482--2489.
    • (2010) Mol Biosyst , vol.6 , pp. 2482-2489
    • Duffield, M.1    Cooper, I.2    McAlister, E.3    Bayliss, M.4    Ford, D.5
  • 39
    • 77952744822 scopus 로고    scopus 로고
    • Functionality of essential genes drives gene strand-bias in bacterial genomes
    • Lin Y, Gao F, Zhang CT, ((2010)) Functionality of essential genes drives gene strand-bias in bacterial genomes. Biochem Biophys Res Commun 396:: 472--476.
    • (2010) Biochem Biophys Res Commun , vol.396 , pp. 472-476
    • Lin, Y.1    Gao, F.2    Zhang, C.T.3
  • 40
    • 84860112417 scopus 로고    scopus 로고
    • Putative essential and core-essential genes in Mycoplasma genomes
    • Lin Y, Zhang RR, ((2011)) Putative essential and core-essential genes in Mycoplasma genomes. Sci Rep 1:: 53.
    • (2011) Sci Rep , vol.1 , pp. 53
    • Lin, Y.1    Zhang, R.R.2
  • 41
    • 41349112730 scopus 로고    scopus 로고
    • Ori-Finder: a web-based system for finding oriCs in unannotated bacterial genomes
    • Gao F, Zhang CT, ((2008)) Ori-Finder: a web-based system for finding oriCs in unannotated bacterial genomes. BMC Bioinformatics 9:: 79.
    • (2008) BMC Bioinformatics , vol.9 , pp. 79
    • Gao, F.1    Zhang, C.T.2
  • 42
    • 50849131231 scopus 로고    scopus 로고
    • ACUA: a software tool for automated codon usage analysis
    • Vetrivel U, Arunkumar V, Dorairaj S, ((2007)) ACUA: a software tool for automated codon usage analysis. Bioinformation 2:: 62--63.
    • (2007) Bioinformation , vol.2 , pp. 62-63
    • Vetrivel, U.1    Arunkumar, V.2    Dorairaj, S.3
  • 43
    • 0023650543 scopus 로고
    • The codon Adaptation Index-a measure of directional synonymous codon usage bias, and its potential applications
    • Sharp PM, Li WH, ((1987)) The codon Adaptation Index-a measure of directional synonymous codon usage bias, and its potential applications. Nucleic Acids Res 15:: 1281--1295.
    • (1987) Nucleic Acids Res , vol.15 , pp. 1281-1295
    • Sharp, P.M.1    Li, W.H.2
  • 45
    • 79959574838 scopus 로고    scopus 로고
    • Enzymes are enriched in bacterial essential genes
    • Gao F, Zhang RR, ((2011)) Enzymes are enriched in bacterial essential genes. PLoS One 6:: e21683.
    • (2011) PLoS One , vol.6
    • Gao, F.1    Zhang, R.R.2
  • 46
    • 70449380022 scopus 로고    scopus 로고
    • In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae
    • Barh D, Kumar A, ((2009)) In silico identification of candidate drug and vaccine targets from various pathways in Neisseria gonorrhoeae. In Silico Biol 9:: 225--231.
    • (2009) In Silico Biol , vol.9 , pp. 225-231
    • Barh, D.1    Kumar, A.2
  • 48
    • 79953891009 scopus 로고    scopus 로고
    • Identification and modeling of a drug target for Clostridium perfringens SM101
    • Chhabra G, Sharma P, Anant A, Deshmukh S, Kaushik H, et al. ((2010)) Identification and modeling of a drug target for Clostridium perfringens SM101. Bioinformation 4:: 278--289.
    • (2010) Bioinformation , vol.4 , pp. 278-289
    • Chhabra, G.1    Sharma, P.2    Anant, A.3    Deshmukh, S.4    Kaushik, H.5
  • 49
    • 84887212447 scopus 로고    scopus 로고
    • A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni
    • Caffrey CR, Rohwer A, Oellien F, Marhofer RJ, Braschi S, et al. ((2009)) A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. PLoS One 4:: e4413.
    • (2009) PLoS One , vol.4
    • Caffrey, C.R.1    Rohwer, A.2    Oellien, F.3    Marhofer, R.J.4    Braschi, S.5
  • 50
    • 78149249050 scopus 로고    scopus 로고
    • Identification of attractive drug targets in neglected-disease pathogens using an in silico approach
    • Crowther GJ, Shanmugam D, Carmona SJ, Doyle MA, Hertz-Fowler C, et al. ((2010)) Identification of attractive drug targets in neglected-disease pathogens using an in silico approach. PLoS Negl Trop Dis 4:: e804.
    • (2010) PLoS Negl Trop Dis , vol.4
    • Crowther, G.J.1    Shanmugam, D.2    Carmona, S.J.3    Doyle, M.A.4    Hertz-Fowler, C.5
  • 51
    • 25444491937 scopus 로고    scopus 로고
    • Protein subcellular localization prediction for Gram-negative bacteria using amino acid subalphabets and a combination of multiple support vector machines
    • Wang J, Sung WK, Krishnan A, Li KB, ((2005)) Protein subcellular localization prediction for Gram-negative bacteria using amino acid subalphabets and a combination of multiple support vector machines. BMC Bioinformatics 6:: 174.
    • (2005) BMC Bioinformatics , vol.6 , pp. 174
    • Wang, J.1    Sung, W.K.2    Krishnan, A.3    Li, K.B.4
  • 52
    • 33748878164 scopus 로고    scopus 로고
    • Methods for predicting bacterial protein subcellular localization
    • Gardy JL, Brinkman FS, ((2006)) Methods for predicting bacterial protein subcellular localization. Nat Rev Microbiol 4:: 741--751.
    • (2006) Nat Rev Microbiol , vol.4 , pp. 741-751
    • Gardy, J.L.1    Brinkman, F.S.2
  • 54
    • 0030790687 scopus 로고    scopus 로고
    • Common themes in microbial pathogenicity revisited
    • Finlay BB, Falkow S, ((1997)) Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev 61:: 136--169.
    • (1997) Microbiol Mol Biol Rev , vol.61 , pp. 136-169
    • Finlay, B.B.1    Falkow, S.2
  • 55
    • 60849116153 scopus 로고    scopus 로고
    • Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology
    • Tseng TT, Tyler BM, Setubal JC, ((2009)) Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology. BMC Microbiol 9 (Suppl 1):: S2.
    • (2009) BMC Microbiol , vol.9 , Issue.SUPPL. 1
    • Tseng, T.T.1    Tyler, B.M.2    Setubal, J.C.3
  • 56
    • 0035019730 scopus 로고    scopus 로고
    • Type II secretion and pathogenesis
    • Sandkvist M, ((2001)) Type II secretion and pathogenesis. Infect Immun 69:: 3523--3535.
    • (2001) Infect Immun , vol.69 , pp. 3523-3535
    • Sandkvist, M.1
  • 57
    • 47049087178 scopus 로고    scopus 로고
    • Independent loss of immunogenic proteins in Mycobacterium ulcerans suggests immune evasion
    • Huber CA, Ruf MT, Pluschke G, Kaser M, ((2008)) Independent loss of immunogenic proteins in Mycobacterium ulcerans suggests immune evasion. Clin Vaccine Immunol 15:: 598--606.
    • (2008) Clin Vaccine Immunol , vol.15 , pp. 598-606
    • Huber, C.A.1    Ruf, M.T.2    Pluschke, G.3    Kaser, M.4
  • 58
    • 78449263722 scopus 로고    scopus 로고
    • Protein export systems of Mycobacterium tuberculosis: novel targets for drug development
    • Feltcher ME, Sullivan JT, Braunstein M, ((2010)) Protein export systems of Mycobacterium tuberculosis: novel targets for drug development? Future Microbiol 5:: 1581--1597.
    • (2010) Future Microbiol , vol.5 , pp. 1581-1597
    • Feltcher, M.E.1    Sullivan, J.T.2    Braunstein, M.3
  • 59
    • 73649122749 scopus 로고    scopus 로고
    • An oldie but a goodie - cell wall biosynthesis as antibiotic target pathway
    • Schneider T, Sahl HG, ((2010)) An oldie but a goodie- cell wall biosynthesis as antibiotic target pathway. Int J Med Microbiol 300:: 161--169.
    • (2010) Int J Med Microbiol , vol.300 , pp. 161-169
    • Schneider, T.1    Sahl, H.G.2
  • 61
    • 80052446723 scopus 로고    scopus 로고
    • Peptidoglycan biosynthesis machinery: a rich source of drug targets
    • Gautam A, Vyas R, Tewari R, ((2011)) Peptidoglycan biosynthesis machinery: a rich source of drug targets. Crit Rev Biotechnol 31:: 295--336.
    • (2011) Crit Rev Biotechnol , vol.31 , pp. 295-336
    • Gautam, A.1    Vyas, R.2    Tewari, R.3
  • 63
    • 0033939999 scopus 로고    scopus 로고
    • Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria
    • Du W, Brown JR, Sylvester DR, Huang J, Chalker AF, et al. ((2000)) Two active forms of UDP-N-acetylglucosamine enolpyruvyl transferase in gram-positive bacteria. J Bacteriol 182:: 4146--4152.
    • (2000) J Bacteriol , vol.182 , pp. 4146-4152
    • Du, W.1    Brown, J.R.2    Sylvester, D.R.3    Huang, J.4    Chalker, A.F.5
  • 64
    • 84865048556 scopus 로고    scopus 로고
    • In the case of transmission of mycobacterium ulcerans in buruli ulcer disease acanthamoeba species stand accused
    • Wilson MD, Boakye DA, Mosi L, Asiedu K, ((2011)) In the case of transmission of mycobacterium ulcerans in buruli ulcer disease acanthamoeba species stand accused. Ghana Med J 45:: 31--34.
    • (2011) Ghana Med J , vol.45 , pp. 31-34
    • Wilson, M.D.1    Boakye, D.A.2    Mosi, L.3    Asiedu, K.4
  • 65
    • 32644490022 scopus 로고    scopus 로고
    • rmlB and rmlC genes are essential for growth of mycobacteria
    • Li W, Xin Y, McNeil MR, Ma Y, ((2006)) rmlB and rmlC genes are essential for growth of mycobacteria. Biochem Biophys Res Commun 342:: 170--178.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 170-178
    • Li, W.1    Xin, Y.2    McNeil, M.R.3    Ma, Y.4
  • 66
    • 0035038011 scopus 로고    scopus 로고
    • Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose
    • Ma Y, Stern RJ, Scherman MS, Vissa VD, Yan W, et al. ((2001)) Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose. Antimicrob Agents Chemother 45:: 1407--1416.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 1407-1416
    • Ma, Y.1    Stern, R.J.2    Scherman, M.S.3    Vissa, V.D.4    Yan, W.5
  • 67
    • 0014408816 scopus 로고
    • The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose
    • Melo A, Glaser L, ((1968)) The mechanism of 6-deoxyhexose synthesis. II. Conversion of deoxythymidine diphosphate 4-keto-6-deoxy-D-glucose to deoxythymidine diphosphate L-rhamnose. J Biol Chem 243:: 1475--1478.
    • (1968) J Biol Chem , vol.243 , pp. 1475-1478
    • Melo, A.1    Glaser, L.2
  • 69
    • 79952467900 scopus 로고    scopus 로고
    • Thiamin (vitamin B1) biosynthesis and regulation: a rich source of antimicrobial drug targets
    • Du Q, Wang H, Xie J, ((2011)) Thiamin (vitamin B1) biosynthesis and regulation: a rich source of antimicrobial drug targets? Int J Biol Sci 7:: 41--52.
    • (2011) Int J Biol Sci , vol.7 , pp. 41-52
    • Du, Q.1    Wang, H.2    Xie, J.3
  • 70
    • 72149097595 scopus 로고    scopus 로고
    • Vitamin B metabolism in Plasmodium falciparum as a source of drug targets
    • Muller IB, Hyde JE, Wrenger C, ((2010)) Vitamin B metabolism in Plasmodium falciparum as a source of drug targets. Trends Parasitol 26:: 35--43.
    • (2010) Trends Parasitol , vol.26 , pp. 35-43
    • Muller, I.B.1    Hyde, J.E.2    Wrenger, C.3
  • 71
    • 0345701347 scopus 로고    scopus 로고
    • Genes required for mycobacterial growth defined by high density mutagenesis
    • Sassetti CM, Boyd DH, Rubin EJ, ((2003)) Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48:: 77--84.
    • (2003) Mol Microbiol , vol.48 , pp. 77-84
    • Sassetti, C.M.1    Boyd, D.H.2    Rubin, E.J.3
  • 72
    • 28844499031 scopus 로고    scopus 로고
    • Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents
    • Hurdle JG, O'Neill AJ, Chopra I, ((2005)) Prospects for Aminoacyl-tRNA Synthetase Inhibitors as New Antimicrobial Agents. Antimicrob Agents Chemother 49:: 4821--4833.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 4821-4833
    • Hurdle, J.G.1    O'Neill, A.J.2    Chopra, I.3
  • 73
    • 0033782994 scopus 로고    scopus 로고
    • Aminoacyl-tRNA synthesis
    • Ibba M, Soll D, ((2000)) Aminoacyl-tRNA synthesis. Annu Rev Biochem 69:: 617--650.
    • (2000) Annu Rev Biochem , vol.69 , pp. 617-650
    • Ibba, M.1    Soll, D.2
  • 74
    • 0035819917 scopus 로고    scopus 로고
    • Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use
    • Raczniak G, Ibba M, Soll D, ((2001)) Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use. Toxicology 160:: 181--189.
    • (2001) Toxicology , vol.160 , pp. 181-189
    • Raczniak, G.1    Ibba, M.2    Soll, D.3
  • 75
    • 0034633290 scopus 로고    scopus 로고
    • A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology
    • Macarron R, Mensah L, Cid C, Carranza C, Benson N, et al. ((2000)) A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology. Anal Biochem 284:: 183--190.
    • (2000) Anal Biochem , vol.284 , pp. 183-190
    • Macarron, R.1    Mensah, L.2    Cid, C.3    Carranza, C.4    Benson, N.5
  • 76
    • 80051995882 scopus 로고    scopus 로고
    • The identification of quality antibacterial drug discovery targets: a case study with aminoacyl-tRNA synthetases
    • Gallant P, Finn J, Keith D, Wendler P, ((2000)) The identification of quality antibacterial drug discovery targets: a case study with aminoacyl-tRNA synthetases. Expert Opinion on Therapeutic Targets 4:: 1--9.
    • (2000) Expert Opinion on Therapeutic Targets , vol.4 , pp. 1-9
    • Gallant, P.1    Finn, J.2    Keith, D.3    Wendler, P.4
  • 77
    • 9144263033 scopus 로고    scopus 로고
    • New aminoacyl-tRNA synthetase inhibitors as antibacterial agents
    • Pohlmann J, Brotz-Oesterhelt H, ((2004)) New aminoacyl-tRNA synthetase inhibitors as antibacterial agents. Curr Drug Targets Infect Disord 4:: 261--272.
    • (2004) Curr Drug Targets Infect Disord , vol.4 , pp. 261-272
    • Pohlmann, J.1    Brotz-Oesterhelt, H.2
  • 78
    • 0015230679 scopus 로고
    • Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens
    • Fuller AT, Mellows G, Woolford M, Banks GT, Barrow KD, et al. ((1971)) Pseudomonic acid: an antibiotic produced by Pseudomonas fluorescens. Nature 234:: 416--417.
    • (1971) Nature , vol.234 , pp. 416-417
    • Fuller, A.T.1    Mellows, G.2    Woolford, M.3    Banks, G.T.4    Barrow, K.D.5
  • 79
    • 9144253860 scopus 로고    scopus 로고
    • New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity
    • Beyer D, Kroll HP, Endermann R, Schiffer G, Siegel S, et al. ((2004)) New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity. Antimicrob Agents Chemother 48:: 525--532.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 525-532
    • Beyer, D.1    Kroll, H.P.2    Endermann, R.3    Schiffer, G.4    Siegel, S.5
  • 80
    • 12944335304 scopus 로고    scopus 로고
    • Drug target validation: lethal infection blocked by inducible peptide
    • Tao J, Wendler P, Connelly G, Lim A, Zhang J, et al. ((2000)) Drug target validation: lethal infection blocked by inducible peptide. Proc Natl Acad Sci U S A 97:: 783--786.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 783-786
    • Tao, J.1    Wendler, P.2    Connelly, G.3    Lim, A.4    Zhang, J.5
  • 81
    • 0036142732 scopus 로고    scopus 로고
    • Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group
    • Smith HO, Blessing JA, Vaccarello L, ((2002)) Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group. Gynecol Oncol 84:: 140--144.
    • (2002) Gynecol Oncol , vol.84 , pp. 140-144
    • Smith, H.O.1    Blessing, J.A.2    Vaccarello, L.3
  • 82
    • 0036605892 scopus 로고    scopus 로고
    • The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis
    • Aspinall TV, Joynson DH, Guy E, Hyde JE, Sims PF, ((2002)) The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis. J Infect Dis 185:: 1637--1643.
    • (2002) J Infect Dis , vol.185 , pp. 1637-1643
    • Aspinall, T.V.1    Joynson, D.H.2    Guy, E.3    Hyde, J.E.4    Sims, P.F.5
  • 83
    • 33748746654 scopus 로고    scopus 로고
    • Inhibitors of de novo folate enzymes in Plasmodium falciparum
    • Nzila A, ((2006)) Inhibitors of de novo folate enzymes in Plasmodium falciparum. Drug Discov Today 11:: 939--944.
    • (2006) Drug Discov Today , vol.11 , pp. 939-944
    • Nzila, A.1
  • 85
    • 33745607880 scopus 로고    scopus 로고
    • Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis
    • Hasan S, Daugelat S, Rao PS, Schreiber M, ((2006)) Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. PLoS Comput Biol 2:: e61.
    • (2006) PLoS Comput Biol , vol.2
    • Hasan, S.1    Daugelat, S.2    Rao, P.S.3    Schreiber, M.4
  • 86
    • 53549091061 scopus 로고    scopus 로고
    • Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening
    • Cho Y, Ioerger TR, Sacchettini JC, ((2008)) Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem 51:: 5984--5992.
    • (2008) J Med Chem , vol.51 , pp. 5984-5992
    • Cho, Y.1    Ioerger, T.R.2    Sacchettini, J.C.3
  • 87
    • 77955334006 scopus 로고    scopus 로고
    • Identification of novel bacterial histidine biosynthesis inhibitors using docking, ensemble rescoring, and whole-cell assays
    • Henriksen ST, Liu J, Estiu G, Oltvai ZN, Wiest O, ((2010)) Identification of novel bacterial histidine biosynthesis inhibitors using docking, ensemble rescoring, and whole-cell assays. Bioorg Med Chem 18:: 5148--5156.
    • (2010) Bioorg Med Chem , vol.18 , pp. 5148-5156
    • Henriksen, S.T.1    Liu, J.2    Estiu, G.3    Oltvai, Z.N.4    Wiest, O.5


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