New Class of Bacterial Phenylalanyl-tRNA Synthetase Inhibitors with High Potency and Broad-Spectrum Activity

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 2, 2004, Pages 525-532

  Beyer, Dieter ^a   Kroll, Hein Peter ^a   Endermann, Rainer ^a   Schiffer, Guido ^a   Siegel, Stephan ^a   Bauser, Marcus ^a   Pohlmann, Jens ^a   Brands, Michael ^a   Ziegelbauer, Karl ^a   Haebich, Dieter ^a   Eymann, Christine ^b   Brötz Oesterhelt, Heike ^a  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYL 3 (2 THIAZOLYL)THIOUREA; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; PHENYLALANINE; PHENYLALANYL TRANSFER RNA SYNTHETASE INHIBITOR; PROTEOME; SULFONAMIDE; TRANSCRIPTION FACTOR RELA; TRANSFER RNA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL COUNT; BACTERIUM; BINDING COMPETITION; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; ENZYMOLOGY; ESCHERICHIA COLI; FEMALE; GENE MUTATION; GENETICS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; HAMSTER; HIGH THROUGHPUT SCREENING; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RAT STRAIN; SEPSIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BACTERIA; CHO CELLS; COLONY COUNT, MICROBIAL; CRICETINAE; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICE; MICROBIAL SENSITIVITY TESTS; PNEUMOCOCCAL INFECTIONS; PROTEOME; RATS; RATS, WISTAR; STAPHYLOCOCCAL INFECTIONS; SUBSTRATE SPECIFICITY;

EID: 9144253860     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.2.525-532.2004     Document Type: Article

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